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Query: gi|238922438|ref|YP_002935951.1| DNA gyrase, A subunit (EUBREC_0006) [Eubacterium rectale ATCC 33656], from E.rectale

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTPDKPHRKCARIVGDTMGKYHPHGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAAMRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVLPSRYPNLLVNGTTGIAVGMATNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRTGRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDETSREGMRIVVELRRDVNPSVVLNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLIHQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISIIRSSQTTQQAKTRLMERFGLTDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIADKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGMETIEDDYIVEMLMTTSHHYLMFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEKITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNGLAAINLREDDKLIEVKVTDNSEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSNGLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVSDVTVLGRITTGVKLINLKEGVSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNNSHAEAIENNTEALast
1 -58.300sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   23  1.................................................LFTCFKRND---KREVKVAQLAGSVAESAYHHGEQALMMTIVNLAQNFSNNINLLQPIGQFGTHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHP-----------MLPNYKNFKGTIQELGQNQYAVSGEIFVV------------DRNTVEITELPVRTWTQVYKEQVLEPMTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMKKYETVQDILKEFFDLRLS........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 299
2 -57.900sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   23  1......................................................................VAE-MSSYH-HGEMSLMMTIINLAQNFSNNLNLLQPIGQFGTHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLP-----------MLPSYKNFKGTIEELAPNQYVISGEVAIL------------NSTTIEISELPVRTWTQTYKEQVLEPMTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNN.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 300
3 -46.900sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   26  87.....GQTTTYLTYNDFINKELILFS-NSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEM--SSYHHGEMSLMMTIINLAQNFSNNLNLLQPIGQFGTRGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL-YDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLP-------------PSYKKGTI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 299
4 -46.300sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   27  108.....GTATKHLTYNDFINKELILFSNSDNE-RSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEM--SAYHHGEQALMMTIVNLAQNFSNNINLLQPIGQFGTRGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL-YDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 300
5 -28.000sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   12  7.......................................................................................................................................................................................................................................HPMLPNYKNFKGTIQELGQNQYAVSGEDRNTVEITELPVRTWTQVYKEQVLEPMTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKTVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMS--LWSLTKEKVEELIKQRDAKGRELKRKSPSDLWKEDLAAFVEEL...................................................................................................................................................................................................................................................................................................................................................... 296
6 -27.800sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   13  1..............................................................................................................................................................................................................................................ELAPNQYVISGEVAIL----NSTTIEISELPVRTWTQTYKEQVLEPMTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCL-TVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENDNEKETEKSDSVTDSGPTFNYLLDMPWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDE----QVGLPGKGGKA............................................................................................................................................................................................................................................................................................................................ 300
7 -7.480sp|O96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 OS=Homo sapiens GN=PAK4 PE=1 SV=1  ali follow..  15  297...........................................................QRVSHEQFRAALQLVVDPGDP---RSYLDNFIKI------------GEGSTGIVSSGKLVAVKKMDLRKQQRRELLFNEVHENVVEMYNSYLVGDELWVVME------FLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI------------DIKSDSILLTHDGRVKLSDFG---------AQVSKEVPRRKSLVGT--PYWMAP--------ELISRLPYGPEVDI-------GI-MVIEMVDGEPP------YFNEPPLKAMK----MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 591
8 -6.650sp|Q96RR4|KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 OS=Homo sapiens GN=CAMKK2 PE=1 SV=2  ali follow..  14  155.GMQDCVQLNQYTLKDEIGKG--SYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAQVYQEIA---HPN--VKLVEVLDDPNED---HLYMVFELVNQGPV--EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRD-------IKPS---NLLVGEDGHI------KIADFGVSNEFKGSDALLSNTVGTPAFMAPESLKIFSGKDVWAMGVTL--------Y-----------------------CFVFGQCPFM-RIMCLHSKIKS--QALEFPDQPDIAEDLKDLITRM---LDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLS....................................................................................................................................................................................................................................................................................................................................................................................................................................................... 529
9 -6.430sp|P15863|PAX1_HUMAN Paired box protein Pax-1 OS=Homo sapiens GN=PAX1 PE=2 SV=4  ali follow..  19  103...............NQLGGVFVN-------GRPLPNA------IRLRIV-ELAQLGIRPSRQLRVSHGCVSKILARYNETG---------------SIL----------GAIGGSKP--------RVT--TPNVVKHIRD-----------KQGDPGIFAWEIRDRLL--ADGVC---KYNVPS------VSSISRILRNKIGSLAQPGPY................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 234
10 -6.330sp|P23759|PAX7_HUMAN Paired box protein Pax-7 OS=Homo sapiens GN=PAX7 PE=1 SV=3  ali follow..  16  39...............NQLGGVFIN-------GRPLPNH------IRHKIV-EMAHHGIRPSRQLRVSHGCVSKILCRYQETG---------------SIR----------GAIGGSKPRQV---------ATPDVEKKIEE-----------KRENPGMFSWEIRDRLL--KDGHC---RSTVPS------GLVSSISRVLRIKFGKKEEED................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 171
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.