current user: public |
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Query: gi|238922438|ref|YP_002935951.1| DNA gyrase, A subunit (EUBREC_0006) [Eubacterium rectale ATCC 33656], from E.rectale |
. 10 . 20 . 30 . 40 . 50 . 60 . 70 . 80 . 90 . 100 . 110 . 120 . 130 . 140 . 150 . 160 . 170 . 180 . 190 . 200 . 210 . 220 . 230 . 240 . 250 . 260 . 270 . 280 . 290 . 300 . 310 . 320 . 330 . 340 . 350 . 360 . 370 . 380 . 390 . 400 . 410 . 420 . 430 . 440 . 450 . 460 . 470 . 480 . 490 . 500 . 510 . 520 . 530 . 540 . 550 . 560 . 570 . 580 . 590 . 600 . 610 . 620 . 630 . 640 . 650 . 660 . 670 . 680 . 690 . 700 . 710 . 720 . 730 . 740 . 750 . 760 . 770 . 780 . 790 . 800 . 810 . 820 . 830 . 840 . 850 | |||||||
# | Score | Template | Links and tools | %id | First | MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTPDKPHRKCARIVGDTMGKYHPHGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAAMRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVLPSRYPNLLVNGTTGIAVGMATNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRTGRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDETSREGMRIVVELRRDVNPSVVLNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLIHQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISIIRSSQTTQQAKTRLMERFGLTDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIADKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGMETIEDDYIVEMLMTTSHHYLMFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEKITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNGLAAINLREDDKLIEVKVTDNSEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSNGLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVSDVTVLGRITTGVKLINLKEGVSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNNSHAEAIENNTEA | Last |
1 | -161.000 | [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit | ali follow.. | 42 | 2 | ..FNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLAN----PQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKIKVRARLHVEENEKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHKVARRTTIEFDADIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDEIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLNEEDKVVSCQIVTENQSVLIVCDQGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENVLSGSEEECSDTVSLR...................... | 834 |
2 | -9.500 | [D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins | ali follow.. | 17 | 336 | ......................................KRLLHKNAEKLRKTLESFGVK--------AHVSGPAVTKYEVNPHVGVVSRIVNLADDLALALAAIPGKSAIGEVPNQEVAIVTLREV--NVLSVGLGRDISGEPV-----------------NKMPHLLVAGATGIITSILLKAKPHEVK-MIDPKMVELNVYNGIPHL----LTPVVTEPKKASQALKKVVAEMERRYDSHSGTRNIEGYNEMITRQNEKEDAKQPTLPYIV----IVDELADLVASGDVEDIARLAQMARAAGIHMILATQRDVITGVIKANIPSRIAFGVSSQTDSRTILDGAEKLLGRGDML--YLPMGATKPTR---------------VQGAFLSDEEVETIVEFVVAQQKAQYAEEMTPTE-ELYDDAVNLVIEMNSASVSMLQ-RRFRIGYTRAARLIDEMEA........................................................................................................................................................................................................................................................................................................................................................................................................ | 762 |
3 | -9.200 | [L] COG0417 DNA polymerase elongation subunit (family B) | ali follow.. | 12 | 498 | .....KDAYLPQRLMDKLMCFVNYTEMARVTGVPFNFLLARGQQVISQLFRKALQHDVPNIRVNGTDEQYEGATV--IEP--IKGYYDTPI-ATLDFSSLYPSIMQAHNYTTLLDSTPNGDYFVKPHVRKLLPIILADLARKKAKADLKKETDPFKKAVLDGR--KVSANGFTGATNGISSSVTSYG-RQMIEKTKDVVEKRYRIENGYSHDA-VVIYG-DTDSVMVKFGVKTLPEAMKLGE-SDQFPNPIKLEFEKVYFPYLLISKKRY----AGLFWTRTDTYDKMDSKGIETVR----RDNCPLVSYVIDT-----ALRKMLIDQDVEGAQLFTKKVISDLLQNKIDMSQLVYAAKMAHVELAERMRKRDAGSAPAIGDRVAYVIIKGAQGDQFYMRSEDPIYVLENNIPIDAKYYLENQLSKPLLRI..................................................................................................................................................................................................................................................................................................................................................................................................................................... | 952 |
4 | -8.570 | [L] COG4581 Superfamily II RNA helicase | ali follow.. | 16 | 234 | .....KRSIVSLPPSTLNLHKQPDYAHVVDSSAPIENFQQ-LDNFQKEAIYHLEMGDSVFVAAHTSAGKTV---VAEY--HMTKAIYTSPIKALSNQKFR-DFKHKFEDVGILTGDGSCLLMTTEILRSMLGADLIRDVE-DEVHYVNDLEGVVWEEVILPPHVTLILLSATVPNTKEFATLKRPVPLEHYLQNMFKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDNKNSARGRGAARGRGV---MRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDLNNHQEKSEVHVVIELSRGLAVKEIVEILFQRGLVKVLFATETFAMGVNMPAKSVVFSGTQKHDGRNFRDLLPGEYTQCSRAGRRGLDVTGTVIILSR-SELPDTASLRHMIMGPSSKLISQFRLTYNMILNLLRVETLRIEDM-IKRSFSENVNQTLVPQHEEKIKSFEEKLSALKKEMSDVDLKEIKSCLLSSESFKEYTKKMHFRAITTANGKRIFKDGRVIVF.......................................................................................................................................................................................................................................................................................................................................... | 831 |
5 | -7.850 | [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain | ali follow.. | 15 | 328 | .............................VTKEVEAENRDTLTGLANRTNF-REQLDARLAAPEARLGKLVNDTKG--HRAGDALLERVAQRLRAVCDRPGMAIARLG------GDEFAVL--DADRAATLATALIEALG---------------APYALGAD--NVRIGASIGIALAPAHGRDTENLLARADIALYAAKETRIQARALLEQLRAALEHQD-AERGWVPPDEFVPIAEQSG-GRFVLHRACREATRWEDGARVAVNVSPMQLGKATLAQTVHAALIDSGLAP-------------RLEIEVTETANEAESFEDLRQLYDM-DDFGTGYSSLAHLRAFPFDKIKIDRSFVR------------DLLERPDSAVLVRAIADLGRQLG--VTTVAEGVETQAHVRGIREA-GCTEAQG........................................................................................................................................................................................................................................................................................................................................................................................................................................... | 743 |
6 | -7.840 | [O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain | ali follow.. | 14 | 659 | ........TAKEDFTKALDRSKKRNASALGAPK-VPNVKGGLEDVKTSILDTV-QLPLLHKDLFSSGLRKRSGVL--YGPPGTGKTLLAKA-VATECSLNFLSVKGPELINMYIGESEKNVRFEKARSARPCVIFFDELDSLAPARGASGDSGGVMDRVVSQMLAEILSDSSQDLFIIGASNRPPGRFDKLLRVLKALTRKFKLSEDVSLYSVAKKCPGADMYA---LCADAWFQAA----KRKVSKSDSGDMPTEEDDPDSVVVEYVDFI----KAMDQLSPSLSITELKKYEMLRDQFQGR..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 971 |
7 | -7.690 | [TW] KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) | ali follow.. | 14 | 65 | ....................................DLKENLLK-PESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQDDSKNFSIQVRQVEDYPV-YYLM-----------DLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGF-GAFVDKPVSPYISPPEALENPC--YDMKTTCLPMFGYKHVLT-----LTDQVTRFNEEVKK-QSVSRNRDAPEGGF----DAIMQA------------------------TVCDEKIGWRNDASHLLVFTTDIALDGRLAGIVQPNDGQ-----------------HVGSDNHYSASTTMD-------------PSLGLMTEKLS---QKNINLIFAVTENVVNLYQNYSELIPGTTVGVMDSSNVLQLIVDAYGKIRSKVEL...................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 383 |
8 | -7.510 | [L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) | ali follow.. | 13 | 380 | TAENDKGEREPSEAARFYQEQF---------HEVLVDEYQDTNLVQESILQLVTSGPEETGNLF-----MVGDV--------KQSIYGRKIDLNKNFRSRADILDSGGKIGEVDYDEQAELKYPDNDETETELLLINAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFRDIVI-IMEELRAQGIPVYANLTSGYFEAVEVA---VALSVLKVIDNPDIPLASVLRS--GADE----------------------------LSLIRLENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVG----GMPGGKQRQANLRVLYDRARQYESTAFRGLFRF-IERMQERGDDLGTARGLSEQEDVVLMTIHSSKGLEVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMRRELLSEELRVLYVALTRAKEKL................................................................................................................................................................................................................................................................................................................................................................................. | 878 |
9 | -7.330 | [T] KOG4721 Serine/threonine protein kinase, contains leucine zipper domain | ali follow.. | 15 | 134 | .....................................................................LFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISGSGAQGAV-----GKFRAEEVAIKKVREQNETDIKPNIIAF---KGVCTQAPCY--CIIMEYCAHGQLYEVLRAGRKITPRLL-GIASGMNYLHLHKIIHRDLKSPNVLDAVKISDF----------GTSKELSSFAGTVVIRNEPVSEKVDIWSFGVVLWELPYKVDSSAIIWGVGS-------------------NSLHLPVPSTCPDGFKILMKQTWQSKP-------------RNRP---SFRQTLMHLDIASADVLATQETYFKSQAEWREEV-----------KKHFEKIKEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN--NLYMELSAIMLQLEMREKELIKREQ................................................................................................................................................................................................................................................................................................................................................................................................. | 505 |
10 | -7.260 | [Z] COG5022 Myosin heavy chain | ali follow.. | 12 | 74 | ............DADDLTDLSYLN-----------PSVLDALS-YNQLQIYTYSGIVLIAVNPFQRLPNLYTEIVRAYSPHAEDS-YKCMNQEHKNQTI---IISGESGAGKTV-SARYIMRY----FASVQAL-----QSTDSNFHEAPQLTAVENEILATN-PIM--------AFGNSKTSRNDN-ATIIGAKIYLLERSQPNQERNYHIFYQILAGSSSEQLEKWKLVENSQENYLKQGNCSTIEGVNDKEEFKATVDALKTVGIDND-TCECIFSLLAALLHIGNIEVKHSRNDAYKNENLINATSLARDSVAKFLYASLFDWLVATINKALSFIGVLD---KKNSFEQFCINYANEKLQQEFYRHVFKLEQEEYAAEGLNWSYIDYQDNQQCISMIESRLG---ILSLLDEECRMPTNSDENWVS------------KLNDAFSKPEFKNSYQKSRFGNKEFTIKHYALDVVYCAEGFIDKNRDTISDELLE------------LFTNSDVPFVKDLVLFRLEQTAPPADTKKIKTKPKSNTLGSMFKSSLVSLMSTINETNAHY-----------RCIKPNEEKEAWKFDNQMVVSQLRACGVLET----IKISCAGFPSRWTFDEFVSR........................................................................................................................................................................................................................ | 713 |
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9. Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018. Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A,Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15;393(Pt 2):503-11. |