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Query: sp|P04424|ARLY_HUMAN Argininosuccinate lyase OS=Homo sapiens GN=ASL PE=1 SV=4, from H.sapiens

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQALast
1 -130.000[E] COG0165 Argininosuccinate lyase  ali follow..  42  2....TKKTWSDRFEGTLHPAIALFNASIGFDIELIEYDLDGSIAHGKMLAKTGIISPGEAEQLVQGLEQIRQEYRAGNFNPGVDQEDVHFAVERRLTELVGDVGKKLHTARSRNDQVGTDVRLYLRAQIDDIRQRLRDFQAVLLQLAETNVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQRDWQRLGEIRARTNVSPLGSGALAGTTFPIDRHYSAELLGFAGVYANSLDGVSDRDFAIEFLNAASLIMVHLSRLSEEMILWASQEFSFISLTDSCATGSSIMPQKKNPDVPELIRGKAGRVMGHLQGMLVLMKGLPLAYNKDLQEDKEALFDAVKTVQVSLEAMTILLDEGIVFRQERLAEAEDFSNATDVADYLAAKGVPFREAYNLVGKVVKTSLAAGKLLKDLTLAEWQALHPAFEEDIYQAITPQQVVAARNSYGGTGFEQVKMAIANAKAELSQT.. 461
2 -127.000[E] KOG1316 Argininosuccinate lyase  ali follow..  49  4IPESCYKMWGGRFTEGPHEALHSLNNSLPYDSRLYADDLDASKAYAEALHRAGLINSAEADKLVKNLELLRFDWIEGTVKILPGDEDVHTVNERLLVEITGELGQRLHTGRSRNDQVVTDMKLWLRKAIRETLGRLSGIIETATRQAELHLGVLMPGYTHLQRAQTVQFSHWLLSHAGALAGNPLGI------------------------DRLWLAERLGFSGVTANSMHAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYSTKEFDFIKLADGFSSGSSLMPQKRNPDSLELIRGMAGVITANLTGIMMTIKGTPSTYNKDLQYDKQFCFQSFDKLSQVLEVTDGVLQTIQVKQESMEAALSTDMLATDWAYYLVKKGVPFRQAHHIIGRVVSEAEKRGVDITDLPLGDLQKFSPLFGSDIVAVADYSNNVQQYNAIGGTASSSIVEQLRLLKKCARDLAK 443
3 -94.200[F] COG0015 Adenylosuccinate lyase  ali follow..  17  3..........ERYTLP--------MGKIWTDTYKLQTWLDVEIAVCEAQAELGYIPQAAVDEIKAKAKFDPQRVLEIE---AEVRHDVIAFLTN-VNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLDLILEQLEKLIQAIRYQAQQHRYTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRVAQSIAVGKISGAVGTYANIDPKEAIACQKLGLEPDTAS--TQVISRDRHAEYVQQLALLAASLERFAVEIRNLQRTDVLEVEEYSKGQKGSSAMPHKRNPIRSERLTGMARLVRGHAVAALENVALWHERDISHSSVERVAFPDCCILTHFMLKETTDLVKNLLVYPENMKRNMNGVIFSQKVLLALVEKGMNREDAYRVVQGSAHQAWNEGGNFEELVRADAQVTALLSAEEIDQCFDPQQHL-------TNLAEIYSRL............. 429
4 -89.300[F] KOG2700 Adenylosuccinate lyase  ali follow..  15  1MEDYYSTPLTARYASAE-------MSHLFSREMRINTWRQLWLNLAIAEKQLGLITDEAIEQLKAHVKITAPEFEIAAKEEKRQRHDVMAHIYT-YGLAAPAASGIIHLGATSCFVTDNADLIFLRSAMDLLIPKLVNVINRLSQWSLRYKDIPTLGFTHYQPAQLTTVGKRATLWIQELLWDLRNFVRARNDIGFRGVKGTTGTQASFLEELDKLVAKLSGFDNVYPVTGQTYDRKIDIDVLQPLASFGATAHKIATDIRLLANLKEVE-EPFEAGQIGSSAMAYKRNPMRCERICSQARYIMNLIPNALNTASVQWERTLDDSSNRRSLLPEAFLFTDSVLKILLNVISGMVIYPKVIQKHIRPFMATENIIMAMTKHGASRHECHEQIRVLSHQAGRVVKEEGGIERIKNTPYFAPIYDELDSLLDASTFV-------GRAPEQTESFVNKDVSQALAPFK 470
5 -70.800[C] COG0114 Fumarase  ali follow..  12  48IEVQADRYWGAQAQRSLGGIVKQAAARANMALAGLDPKVGDAIIAAAQEVIDGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGTKKPV---HPNDHVNMSQSSNDTYPTAMHIACEEIVHHLLPALKHLHTALEAKVKQFEKIIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGGTAVGTGL-EKVAEEISEITGLSVTAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGSGPRAGLGELPENEPGSSIMPGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHFELNVYNPMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRKGVE--------NSLMLVTALNGKLGYDICAKIAKTAHKNGTTLREEAVGG----GYLTNEEFDQYVRPENMIGPK........................... 497
6 -70.400[C] KOG1317 Fumarase  ali follow..  14  18......................................................VPADKYYGAQTMRSQINFPIGGATERMPA--MGILKKAAAEVNKEFGLDSKVSEAISKAADDVISGKLYDDHFPLVIWQTGSGTQSNMNVNESEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALGGTAV-GTGLNTRKAKIAELTSLPVTAPNKFEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSGPRCGLGELPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHFELNVFKPLIVSNVLRSIRLLDGSRTFTANCVNGIQANRENIAKIMNESLLVTALNPHI---------GYDKAAKIAKTAHKNGTTLKEEAINL----GYLTEQQFNDWVRPEQMLGPK........................... 396
7 -69.500[E] COG1027 Aspartate ammonia-lyase  ali follow..  15  15REVPAEAYYGVHTLRAIE-NFYISNSKISDVPEFVRGMVMVKKAAAMANKELHTIPRKIADIIIQACDEVLDKGKNMNTNEVLANIGLELMGHQKGEYQYLNPNDHLNKCQSTNDAYPTGFRIAVYASILKLIDAINQLGEGFGRKSKEFEKILKMGRTQLQDAVPMTLGQEFRAFQVLLNEETKNLQRTAELLLEVNLGATAIGTALNTPEGQKLAEISGLAVPAEDLIEATSDCGAYVMVHSALKRLAVKMSKICNDLRLLSSGPRTGLNEINELQAGSSIMPAKVNPVIPEVVNQVCFKVIGNDTCITMAAEAGQLQLNLMEPVIGQAMFESIHILTNACNLLEKCINGITANKEVCERYVFNSGIVTYLNPFIGHNGDIVGKICAETGKNVREVVLERGLLTEAELDDI---------SVENLMHPAYKAKRYTD......................... 474
8 -5.640[S] COG4746 Uncharacterized protein conserved in archaea  ali follow..  13  5...................................................................................................................................................................................................................................................................................................................................VKEDIRGQIIGALAGADFPINSPEELMAALPNGPDTTCKSGDVELKASDAGQVLTADDFPFKSAEEVADTIVNKA.................................................................. 79
9 -4.960[G] COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID  ali follow..  11  1...................................................................................................................................MSENKVTLDKKIRRSVMWRSMFLQGSWNY-ERMQNGGWAYSLIPALKKLYPSGEEAKEALKRFNTHPYVAAPIIGVTLALEEERANGMMGPLAGIGDPVFWFTVRPIVGAIAASLATGGSIIAPLF--VWNAIRIAFLWYTQEFGYKSGSAITKDLGGGLLQTVTKGASILGMFVLGVLIQRWVTINFNGPNAVVSKIPLQKGAYLEFPKGSVSGTQLHDILGQVGNKLSLDPTKVTYLQDNLNQLIPGLAGL-----LITFLCMWLLKKKVSPIVIIF...................................................... 292
10 -4.810[S] COG3177 Uncharacterized conserved protein  ali follow..  14  43..................VIFLQLKSIFHMLESLGSARIEGNHTTLADYVESHL-QLEEIRNIENAMRFIDEHLKVGEPISELFIKELHALTVTGLAK-----EGDKTPGQYRTHQVAIAQSSHLPPESIFVPAYMGELVEFINNNDKPKYDLMKIALAHHRFGHPFGNGN------GRTVRLLTYALLVKYGFNVQAGGRVLNPTAVFCSDRNRYYEML-------SQADKGTEEDLEAWCTYVLSGISRELQKVDKLTSQQFLNENILFPAIQYSQKRQFINEDEAK--ILRFAVEQREFKAGDLAKLFSKM--------------------NANQRTYQIKKLSGFISPLEENSRIYIPNFSQSYLIRGVIYALRENGF.................................................................................. 377
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.