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Query: sp|P31512|FMO4_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 4 OS=Homo sapiens GN=FMO4 PE=2 SV=3, from H.sapiens

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAKKVAVIGAGVSGLSSIKCCVDEDLEPTCFERSDDIGGLWKFTESSKDGMTRVYKSLVTNVCKEMSCYSDFPFHEDYPNFMNHEKFWDYLQEFAEHFDLLKYIQFKTTVCSITKRPDFSETGQWDVVTETEGKQNRAVFDAVMVCTGHFLNPHLPLEAFPGIHKFKGQILHSQEYKIPEGFQGKRVLVIGLGNTGGDIAVELSRTAAQVLLSTRTGTWVLGRSSDWGYPYNMMVTRRCCSFIAQVLPSRFLNWIQERKLNKRFNHEDYGLSITKGKKAKFIVNDELPNCILCGAITMKTSVIEFTETSAVFEDGTVEENIDVVIFTTGYTFSFPFFEEPLKSLCTKKIFLYKQVFPLNLERATLAIIGLIGLKGSILSGTELQARWVTRVFKGLCKIPPSQKLMMEATEKEQLIKRGVFKDTSKDKFDYIAYMDDIAACIGTKPSIPLLFLKDPRLAWEVFFGPCTPYQYRLMGPGKWDGARNAILTQWDRTLKPLKTRIVPDSSKPASMSHYLKAWGAPVLLASLLLICKSSLFLKLVRDKLQDRMSPYLVSLWRGLast
1 -135.000sp|P31512|FMO4_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 4 OS=Homo sapiens GN=FMO4 PE=2 SV=3  ali  100  1MAKKVAVIGAGVSGLSSIKCCVDEDLEPTCFERSDDIGGLWKFTESSKDGMTRVYKSLVTNVCKEMSCYSDFPFHEDYPNFMNHEKFWDYLQEFAEHFDLLKYIQFKTTVCSITKRPDFSETGQWDVVTETEGKQNRAVFDAVMVCTGHFLNPHLPLEAFPGIHKFKGQILHSQEYKIPEGFQGKRVLVIGLGNTGGDIAVELSRTAAQVLLSTRTGTWVLGRSSDWGYPYNMMVTRRCCSFIAQVLPSRFLNWIQERKLNKRFNHEDYGLSITKGKKAKFIVNDELPNCILCGAITMKTSVIEFTETSAVFEDGTVEENIDVVIFTTGYTFSFPFFEEPLKSLCTKKIFLYKQVFPLNLERATLAIIGLIGLKGSILSGTELQARWVTRVFKGLCKIPPSQKLMMEATEKEQLIKRGVFKDTSKDKFDYIAYMDDIAACIGTKPSIPLLFLKDPRLAWEVFFGPCTPYQYRLMGPGKWDGARNAILTQWDRTLKPLKTRIVPDSSKPASMSHYLKAWGAPVLLASLLLICKSSLFLKLVRDKLQDRMSPYLVSLWRG 558
2 -124.000sp|P31513|FMO3_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 3 OS=Homo sapiens GN=FMO3 PE=1 SV=5  ali follow..  51  1MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWF-GKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT.......................... 532
3 -123.000sp|Q99518|FMO2_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 2 OS=Homo sapiens GN=FMO2 PE=1 SV=3  ali follow..  54  1MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVTNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS......................... 535
4 -123.000sp|Q01740|FMO1_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 1 OS=Homo sapiens GN=FMO1 PE=2 SV=3  ali follow..  49  1MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL............................ 532
5 -122.000sp|P49326|FMO5_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 5 OS=Homo sapiens GN=FMO5 PE=2 SV=2  ali follow..  51  3.KKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGKPKHRALSQHPTLNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDAVIFATGYSFDFPFLEDSVKV-VKNKISLYKKVFPPNLERPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDKRYESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSMTSTMTIGKFMLALAFFAIIIAYF........................... 533
6 -116.000sp|O60774|FMO6_HUMAN(removed signalp:1-17) Putative dimethylaniline monooxygenase [N-oxide-forming] 6 OS=Homo sapiens GN=FMO6P PE=5 SV=1  ali follow..  50  1.................IWCCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDYPNYIHHSKLQEYIKTYAQKKDLLRYIQFETLVSGIKKCPSFLVTGQWVVVTEKDGKQESTIFDAVMICSGHHVYPNLPTDSFPGLDQFRGNYLHSRDYKNPEAFKGKRVLVIGLGNSGSDIAVELSRLATQVIISTRSASWVMSRVWDDGYPWDMMYVTRFASFLRNVLPSFISDWLYVQKMNTWFKHENYLMPLNGSLRKEPVFNDELPSRILCGTLSIKPSVKEFTETSAVFEDGTMFEAIDSVIFATGYDYSYPFLDETIMKSRNNEVTLFKGIFPPLMEKPTLAVIGLVQSLGAAIPTADLQAWWAAKVFANSCTLPTTNEMMDDTDEKMGKKLKCMFGQSQTLQTDYITYVDELGSFIGAKPNIPWLFLTDPRLALEVYFGPCSPYQFRLMGPGKWDGARNAILTQWNRTVKPTRTRVVSEVQRPHPFYNLLKMLSFPLLLLAVTLTF........................... 521
7 -42.300sp|Q8IWF2|FXRD2_HUMAN(removed signalp:1-26) FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=FOXRED2 PE=1 SV=1  ali   21  4.RRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFTRYPSINKRYTGKANAEFNLRHDWNSLLSHDP-HYSRAYFPDARDMVRYLGDFADTLGL--RVQYNTTIAHVTLDKD-RQAWNGHYFILTDQKGQVHQCSVLFVATG-LSVPNQV--DFPGSEYAEG---YESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWA............................................................................................................................................................................................................................................................................................................................................... 226
8 -41.000sp|Q8IWF2|FXRD2_HUMAN(removed signalp:1-26) FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=FOXRED2 PE=1 SV=1  ali   15  2..............................................................................................................................................LFVATG-LSVPNQV--DFPGSEYAEGYESVSVDPED---FVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAIN----------NGLLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTPKFF--------LEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAFGKKIRASYESKGSRGLFILGTAKSAGGFIHGFRYTVRAVHRLLEHRHHSVTWPATELPITQLTSSIVRRVEASGLYQMFGVLEYLEEFPIQM..................................................................................................................... 300
9 -40.500sp|Q9Y236|OSGI2_HUMAN Oxidative stress-induced growth inhibitor 2 OS=Homo sapiens GN=OSGIN2 PE=2 SV=1  ali follow..  10  92LLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGP-PGGAW----------HNMEGSMLTISFGSWMELPGLKFKDLKGDRVMPEEIARYYKHYVKVMGLQKNFRENTYITSVSRLYRDFIKRNWEIRGDGSHVPFCLFAENVALATGTLDSPAHL--EIEGEDFHSMPEFGAAINKGKLRGKVDPVLIVGSGLTAADAVLCAYNSNIPVIHVFRRRVTDPSLIFKQLPKKLYPEYHKVYHMMCTQSYS---------------------VDSNLLSDYTSFPEHRVLSFKSDMKCVLQS------------VSGLKKIKLSAAVVLIGSHPNLSFLKDQGCYLGHKSSQPITCKG--CIKEANLFALGPLV--DNFVRFLKGGALGVTRCLATRQKKKHLFVERGGGDG.................................................................................................................................................... 503
10 -37.600sp|Q9UJX0|OSGI1_HUMAN Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=2 SV=2  ali follow..  11  98EPLPVIIVGNGPSGICLSYLLKEHAIPHVVLGRNL-PGGAW----------HSIEGSMVILSQGQWMGLPDLEVKDLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDDSSPLFQVSRNQAQQPFSLWARNVVLATGTFDSPARL--GIPGEAHHELSALEAATRVGAVTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSI----------------------LSPSPYEGYRSLPRHQLLCFKEDCQAVFQDL-----------EGVEKVFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSAKR--STRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP.............................................................................................................................................................. 560
11 -21.000sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens GN=DPYD PE=1 SV=2  ali   19  37.SAKIALFGAGPASISCASFLARLGYDITIFEKQEYVGGLSTS---------------------------------EIPQFRLPYDVVNFEIELMKDLGV--KIICGKSL----------------VNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQ--GLTQDQG-FYTSKDFHSPLPSIRGVVIVLGAGDTAFDCATSALRCARRVFIVFRKGFVNIR----------------------------AVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVA-----------MQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEA.......................................................................................................................................................................................................................... 300
12 -18.200sp|P22570|ADRO_HUMAN(removed signalp:1-24) NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens GN=FDXR PE=1 SV=3  ali follow..  12  14.TPQICVVGSGPAGFYTAQHLLKHQAHVDIYEKQPVPFGLVRFG---------------------------------APDHPEVKNVINTFTQTAHS----GRCAFWGNV---------------EVGRDVTVPELREAYHAVVLSYGAEDHRAL---EIPG-EELPG-VCSARAFELEPDLSCDTAVILGQGNVALDVARILLTPPEHVWLVGRRGPLQVAREMIQLPGARPILDPV-PRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYK-SVPFDSKLGVIPNVEGRVM---------DVPGLYCSGWVKVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVR------PVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLL................................................................................................ 465
13 -16.200sp|Q9BRQ8|AIFM2_HUMAN Apoptosis-inducing factor 2 OS=Homo sapiens GN=AIFM2 PE=2 SV=1  ali follow..  13  11.ALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSF----------------NVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVG--------------IDLKNQMVLLQ-------------------GGEALPFSHLILATGS----TGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQ-------------VALADKELLPSVRQEVKEILLRKGVQLLLSERVSN------------------------------LEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRKMAYLAGLHANIAVANIVNSVKQRPLQAYK......................................................................................................................................................... 322
14 -15.100sp|P00390|GSHR_HUMAN Glutathione reductase, mitochondrial OS=Homo sapiens GN=GSR PE=1 SV=2  ali follow..  14  67....YLVIGGGSGGLASARRAAELGARAAVVES-HKLGGT---------NVGCVPKKVMWNTAEFMHDHADYGFPSCEGKF-NWRVIKEKRDAYVSRLN-YQNNLTKSHIEIIRGHAAFTSDPKPTIEVSG----KKYTAPHILIATG--GMPSTPESQIPGASL----GITSDGFFQLEEL--GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL--------RSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-----------------------------------EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKE................................................................................................................................................................. 402
15 -14.300sp|P09622|DLDH_HUMAN Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens GN=DLD PE=1 SV=2  ali follow..  12  44....VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGT---------PSKALLNNSHYYHMAHGKDFASRGIEMSEVRL-NLDKMMEQKSTAVKALGIAHLFK-QNKVVHVNGYGKITGKNQVTAT-KADGGTQVIDTKNILIATGSEVT------PFPGITIDEDTIVSSTGALSLKKVP-EKMVVIGAGVIGVELGSVWQRLGADVTAVE-----FLGHVGGVGIDMEI---------------------------------------SKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVVPSVIYTHPEVAW---KSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVL----------HILGPGAGEMVNEAALALEYGA................................................................. 475
16 -14.300sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens GN=TXNRD1 PE=1 SV=3  ali   11  15....LIIIGGGSGGLAAAKEAAQYGKKVMVLDFRWGLGGT---------NVGCIPKKLMHQAALLGQALQDYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGE-------RPRYLGIPGDKEYCISSDDLFSLPYC--GKTLVVGASYVALECAGFLAGIGLDVTVMVRS---LLRGF-------DQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAG--------------------------TPGRLRVVAQSTN--------SEEIIEGEYNTVMLAIGRDACTRKI............................................................................................................................................................................................................................. 300
17 -14.200sp|Q86VQ6|TRXR3_HUMAN Thioredoxin reductase 3 (Fragment) OS=Homo sapiens GN=TXNRD3 PE=1 SV=3  ali   15  48....LIIIGGGSGGLSCAKEAAILGKKVMVLDFSWGLGGT---------NVGCIPKKLMHQAALLGQALCDFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGE-------RPRYLGIQGDKEYCITSDDLFSLPYCP-GKTLVVGASYVALECAGFLAGFGLDVTVMVRS...................................................................................................................................................................................................................................................................................................................................................... 255
18 -13.900sp|Q9NNW7|TRXR2_HUMAN Thioredoxin reductase 2, mitochondrial OS=Homo sapiens GN=TXNRD2 PE=1 SV=3  ali follow..  12  42....LLVVGGGSGGLACAKEAAQLGRKVAVVDYRWGLGGT---------NVGCIPKKLMHQAALLGGLIQDYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATG--GRPRYP----THIEGALEYGITSDDIFWLKES--GKTLVVGASYVALECAGFLTGIGLDTTIMMRS---PLRGF-------DQQMSSMVIEHMASHGTRFLRGCAPSR-----------------------------VRRLPDGQLQVTWEDST--------TGKEDTGTFDTVLWAIGRVPDTRSLNEKAGVDTSPDTQKILVDSREATSVPHIYAIGVVEGRPELTPIAIMAGRLLVQRLFGGSSVPT.............................................................................................................................................................. 397
19 -13.700sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   14  44.STNVLIVGAGAAGLVCAETLRQEGFS----------------------------DRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRP--KEFFRAYGI--EVLTEAQVVTVDVRT----------KKVVFKDGFKLEYSKLLLAPG--SSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEE-----------TPFRRFLGERVGRALMKMFENNRV------------------------------------------KFYMQTEVSELRGQEEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSR................................................................................................................................................................................................................... 296
20 -13.600sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens GN=DPYD PE=1 SV=2  ali   17  187.SAKIALFGAGPASISCASFLARLGYDITIFEKQEYVGGLSTS---------------------------------EIPQFRLPYDVVNFEIELMKDLGV--KIICGKSL----------------VNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD.......................................................................................................................................................................................................................................................................................................................................................................................................... 300
21 -13.300sp|Q8NB78|KDM1B_HUMAN Lysine-specific histone demethylase 1B OS=Homo sapiens GN=KDM1B PE=1 SV=3  ali   11  82.NKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGQIVNGCI-NNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYAC----------GSNLHQVSARSWDHNEFFAQFAGDHTLLTGYSVIIEKLAEGLDIQLKSPVQC......................................................................................................................................................................................................................................................................................................................................................... 300
22 -13.200sp|Q8WU10|PYRD1_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens GN=PYROXD1 PE=1 SV=1  ali follow..  10  10.AGKFVVVGGGIAGVTCAEQLATHF-DILLVTASPVI--------------KAVTNFKQISKI-----------------LEEFDVEEQSSTMLGKRFPNIKVI--ESGVKQLKSEE----------HCIVTEDGNQHVYKKLCLCAG--AKPKLICEGNPYVLGIRD--TDSAQEFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWFFDAGAAEFLTSKLIAEKSEAKIAHKRTRYTTEGRKKEARSKSDWHEGLNLKGTKEFSHKIHLETMCEVKKIYLQDEFRILKKKSFTFPRDHKSVTADTYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFDLGEDGGLKVDDH-MHTSLPDIYAAG--WQQMRLWTQARQMGWYAAKCMAAASGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGREYIKVVMQNGRMMGAVLIGETDLEE--ILNQMNLSSYGEDLLDPNIDIED............................................................... 497
23 -12.900sp|Q8TDZ2|MICA1_HUMAN NEDD9-interacting protein with calponin homology and LIM domains OS=Homo sapiens GN=MICAL1 PE=1 SV=2  ali   13  83TSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRT---------KFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVE--IHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPE----GFKVRE-MRGK..................................................................................................................................................................................................................................................................................................................................................................................................... 235
24 -11.800sp|Q6QHF9|PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3  ali   12  2.VPSVGEYLKKEIGQHVARLCGHSAFHLRVLEATARAGGHWIHGPSRGNPVFQLAAEYGLLGEKELSQGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLKLAVL--SGTHSMDLVALAPFGEYTVLPGLDC-MAALPEDTVVFEKPVKTIHWNGSFQEAAFP--GETFPVSVECEDGDRFPAHHVIVTVPLGFL.................................................................................................................................................................................................................................................................................................................................... 280
25 -11.400sp|Q7RTP6|MICA3_HUMAN Protein MICAL-3 OS=Homo sapiens GN=MICAL3 PE=1 SV=2  ali   13  86.NTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA-------FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAG--AIDHISIRQLQLILLKVALILGIE--IHVNVEFQGLIQPPEDERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLE----GFRRKE-FRGKLAIA................................................................................................................................................................................................................................................................................................................................................................................................. 244
26 -11.300sp|Q96RQ9|OXLA_HUMAN(removed signalp:1-21) L-amino-acid oxidase OS=Homo sapiens GN=IL4I1 PE=1 SV=1  ali follow..  15  38.PQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGIFTYRDQNTGWIGELGAMRMPSSHRILHKLCQ-LGCRKAMKKFERHTLLEYLDLLPRALSLSGLVLLNAPVVAMTQGPHDVH----IETSPPARNLKVLKADVVLLTA----SPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRM..................................................................................................................................................................................................................................................................................................................................................................... 361
27 -11.300sp|Q6QHF9|PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3  ali   9  13.GPRVLVVGGGIAGLGAAQRLCGHFPHLRVLEATARAGGHWIHGPSRGNPVFQLAAEYGLEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVARLCGHSAFPHLRVLEATARAGG---RIRSERCFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKENQLVETGGHSSGASVSLQLVAEMGLIDQTREFLHAAETPVPSVGEYLKK...................................................................................................................................................................................................................................................................................................................................................... 299
28 -11.200sp|Q8NBM8|PCYXL_HUMAN(removed signalp:1-22) Prenylcysteine oxidase-like OS=Homo sapiens GN=PCYOX1L PE=1 SV=2  ali follow..  16  4.PGKIAVVGAGIGGSAVAHFLQQPRVQIDVYEK-GTVGG--SVNKQHYESGAASFHSLSLHMQDFVKLLG-YKYQAHGYAFSGVEELLESLQRFIDDVLTKANVIHATVTSVTLHSTEGKAL--YQVAYENEVGNSSDFYDIVVIAT........................................................................................................................................................................................................................................................................................................................................................................................................................... 280
29 -11.200sp|O94851|MICA2_HUMAN Protein MICAL-2 OS=Homo sapiens GN=MICAL2 PE=1 SV=1  ali   13  86.NTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRD---------SFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVE--IHVNVEFVKVLEPPEDQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLE----GFRRKE-FRGK..................................................................................................................................................................................................................................................................................................................................................................................................... 240
30 -11.100sp|Q9Y6N5|SQRD_HUMAN Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1  ali follow..  11  43.HYEVLVLGGGSGGITMAARMKRKAENVAIVEPSER-----------------FYQPIWTLVGAGAKQLSSSGRPTA----------------------IPSGVEWKARVTELNPDKN-------CIHTDDDEKIS---YRYLIIALGI----QLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALIFTFPNTPVKCAGAPQKIMYLSEAYFRKTG----------------------------------KRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDKPGETQVISYEMLHVTPPMSPP-DVLKTSPVADAAGWVDV---ETLQHRRYPNVFGIGTNLPTSKTAAAVAAQSGILDRTISVIMK................................................................................................................................................................. 365
31 -11.000sp|O15229|KMO_HUMAN Kynurenine 3-monooxygenase OS=Homo sapiens GN=KMO PE=1 SV=2  ali follow..  15  8.RKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDT-GL----EDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYP---KMHFNHRLLKCNPEEGM------ITVLGSDKVPKDVTCDLIVGCDGAYSTVR-PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFE..................................................................................................................................................................................................................................................................................................................................................... 242
32 -11.000sp|Q6NUM9|RETST_HUMAN(removed signalp:1-18) All-trans-retinol 13,14-reductase OS=Homo sapiens GN=RETSAT PE=2 SV=2  ali follow..  9  49.KLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCLEFDTGIHSGEKAYIQGLKEKFPQEEAIIDKYSLAEVLQQLGASSELQAVLSYIFPTYGVTPAVLTKATVQSVLLDSAGKACG---VSVKKGHELVNIYCPIVVSNAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGM------SVFICLRGTKEDLHLPSTNYDTDMDQAMERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQLE----GKVESVTAGSPLTNQFYLAAPGADHDLGRLHPCVMASLRAQSPI-----------PNLYLTGQDIFTCGLVGAL-QGALLCSSAILKRNLYSDLKNLDSRIRAQKKKN............................................................................................................................................... 592
33 -10.800sp|O60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A OS=Homo sapiens GN=KDM1A PE=1 SV=2  ali   20  128.TGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGMVVTGLG-GNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 238
34 -10.800sp|P27338|AOFB_HUMAN Amine oxidase [flavin-containing] B OS=Homo sapiens GN=MAOB PE=1 SV=3  ali follow..  10  1MSNKVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGG--TYTLRNQKVKYVDLGGSYVGPTQ------------------------NRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGG-------------------------------------------QERKFVGGSGQVSERIMDLL-GDRVKLERPVIYIDQTRLVETLNHEMYEAKYVISAI-FNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAEGNYAAIMGFILAHKARKTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGPPGILTQYGRVLRQ--PVDRIYFAGTETATHWS----GYMEGAVEAGERAAREILHAMGKIPEDEIWQSE................................................. 466
35 -10.700sp|Q9UHG3|PCYOX_HUMAN(removed signalp:1-27) Prenylcysteine oxidase 1 OS=Homo sapiens GN=PCYOX1 PE=1 SV=3  ali follow..  10  7.PDKIAIIGAGIGGTSAAYYLRQKDVKIDLFER-EEVGG--MVQGQEYEAGGSVIHPLNLHMKRFVKDLG--QASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLL-------ETLQKAGFSEKEMIAPVMRVNYGQSTDINAFVGAVSLSCSD-LWAVEGGNKLVCSGLLQASKSN-------------------------------------------------LISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITF........................................................................................................................................................................................................................... 299
36 -10.400sp|Q16134|ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Homo sapiens GN=ETFDH PE=1 SV=2  ali   13  71....VVIVGAGPAGLSAAVRLKQKDIRVCLVEKAAQIGG---KEKGAPLNTPVTEDRFGILTEKYRIPVPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVE--VYPGYAAAEVLFHDDGSVKG---APKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWVDHTVG............................................................................................................................................................................................................................................................................................................................................................................. 296
37 -10.200sp|P21397|AOFA_HUMAN Amine oxidase [flavin-containing] A OS=Homo sapiens GN=MAOA PE=1 SV=1  ali follow..  9  13.MFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG--TYTIRNEHVDYVDVGGAYVGPTQ------------------------NRILRLSKELGI-ETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGG-------------------------------------------QERKFVGGSGQVSERIMDLL-GDQVKLNHPVTHVDQSSIIETLNHEHYECKYVINAI-FRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISDGSLPAIMGFILARKADRHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGPPGIMTQYGRVIRQ--PVGRIFFAGTETATKWS----GYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEP................................................ 476
38 -10.000sp|Q8NHU2|CT026_HUMAN Uncharacterized protein C20orf26 OS=Homo sapiens GN=C20orf26 PE=2 SV=3  ali   10  64VNAKIIVVGASSVGISFLETLVFCSNNLTLISTHG-------------------LPGKKLLDTEQRKFLAS----------------HCFNDKDYALMSLCSWVNVVGRMTGIDRAAK-------HVVLSTDEIVP---YDHLILCTGQ----QYQVPCPTEADISQHLTNREIWIRNNSITTEGNIIVYGNTIDTYTTVETLLNLGSRIHLV......................................................................................................................................................................................................................................................................................................................................................... 266
39 -9.970sp|Q8NB78|KDM1B_HUMAN Lysine-specific histone demethylase 1B OS=Homo sapiens GN=KDM1B PE=1 SV=3  ali   30  231HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGG--VWDDKSFKGVTVGRGAQIVN................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 290
40 -9.920sp|Q9Y2Z2|MTO1_HUMAN Protein MTO1 homolog, mitochondrial OS=Homo sapiens GN=MTO1 PE=1 SV=2  ali   16  39....VIVIGGGHAGTEAATAAARCGSRTLLLTHRVDTIGQMSCNPSFGGIGKGHLMREVDALDGLCSRICD-PAVWGLRAQIDRKLYKQNMQKEILNTPLL--TVQEGAVEDLILTEPEPEHTG-RVSGVVLVDGSTVYAESVILTTGTFLRGMI------GLETHPAGRLGDQPSIGLAQTLEKLGFVVGRLKTGTP-SINFSILNKH............................................................................................................................................................................................................................................................................................................................................................. 256
41 -9.860sp|P50336|PPOX_HUMAN Protoporphyrinogen oxidase OS=Homo sapiens GN=PPOX PE=1 SV=1  ali follow..  11  1MGRTVVVLGGGISGLAASYHLSRAPPKVVLVESSERLGG-WIRSVRGPNG---------------------AIFELGPRGIRPAGALGARTLLLVSELGLDSEV----------------------LPVRGDHPAAQNRF--LYVGGALHALPTGLRGLLRPSPPFSKPLFWAELTKPRGKEPDETVHSFAQRRLGPEVASLAMDAGNSRELSIRS---CFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWS----------LRGGLEMLPQALETHLTSRGVSVLRGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARA---------LSAITAVSVAVVNLLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLK--------EMPSHCLVHLHKNCIP-QYTLGHWQKLESARQFLTAHRLPLT................................................................ 445
42 -9.770sp|Q8N2H3|PYRD2_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=PYROXD2 PE=2 SV=2  ali follow..  10  34.EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDLELPMLEEGAGSKVPRCLMAENQKQIAQFSQKDAQVFPKYEEFMHRLALAIDPLLDAAPVDMAAFQHGSLLQRMRSLSTLKPLLKAGRILGAQLPRYYEVLTAPITKVLDQWFESEPLVIGAMTSPHTPGSGYVLLHHVMGGLEGMQGAWGYVQ---GGM----------------------------------------------------ALSDAIASSATTASIFTEKTVAKVQVNSGVVLEDGTEVRSKMVLSNTSPQITFLKL------TPQEWLPEEFLERISQLDTRSPVTKINVAVDRLPSFLAAPNAPRGQPLPHHQCSIHLNCEDTLLLHQAFEDAMDGLPSHRPVIELCIPSSLDPTLAPPG-----------CHVVSLFTQYMPYTLAGGKAWDEQERDAYADRVFDCIEVYAPGFKDSVVGRD..................................................... 502
43 -9.630sp|Q9NWM0|SMOX_HUMAN Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1  ali follow..  11  24.QPRVVVIGAGLAGLAAAKALLEQGFDVTVLEASSHIGG-WIHGSHGNPIYHLAEAEETTDGERSVGRISLYSKNGVACYLTNHGRRIDVVEEFSDLYNVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHII-GFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKI--------LEFEEPFWGPECPPELWYRKICGFDVLYPPERYGHVLICGEEALVMEKCDDEAVAEICTEMLFTGNPNIPKPRRILRS-GSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFS----------GEATHRKY----YSTTHGALLSGQREAARLIEMYRDLFQQGT..................................................... 555
44 -9.570sp|Q14534|ERG1_HUMAN(removed signalp:1-43) Squalene monooxygenase OS=Homo sapiens GN=SQLE PE=2 SV=3  ali follow..  10  82...EVIIVGAGVLGSALAAVLSRDGRKVTVIERDKDLG----LGDTVEGLDAQVVNGYMIHDQESKSEVQPYPLSEQSGRAFHHGRFIMSLRKAAMAEPNAK-FIEGVVLQLLE---EDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLG------DAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSAIYAVYFCFKSEPWITKPRALVLYKACSVIFPLIYSEM......................................................................................................................................................................................................................... 526
45 -9.230sp|O95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens GN=AIFM1 PE=1 SV=1  ali   10  131.HVPFLLIGGGTAAFAAARSIRARDPGARVYMR-PPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSF--------YVSAQDLPHIENGGVA-------VLTGKKVVQLDVRD----------NMVKLNDGSQITYEKCLIATG--GTPRLSAIDRAGAE-VKSRTTLFRKIGDFRSLEKREV................................................................................................................................................................................................................................................................................................................................................................................... 300
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.