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Query: sp|P49448|DHE4_HUMAN Glutamate dehydrogenase 2, mitochondrial OS=Homo sapiens GN=GLUD2 PE=1 SV=2, from H.sapiens

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFTLast
1 -133.000sp|P49448|DHE4_HUMAN Glutamate dehydrogenase 2, mitochondrial OS=Homo sapiens GN=GLUD2 PE=1 SV=2  ali  100  1MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT 558
2 -128.000sp|P00367|DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens GN=GLUD1 PE=1 SV=2  ali follow..  95  1MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT 558
3 -7.990sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   13  1................................................................................................................................................................................................................................................................GQWAGVAGMINILHGMGLNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGD----KVYGTVLSRHHHLVRKTDAVYDPAEYDKHPTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTGGSI------------------EFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLPYVEEMILSDATQPLESQNFSPVVRDAVIT.................. 300
4 -7.230sp|Q9UBT2|SAE2_HUMAN SUMO-activating enzyme subunit 2 OS=Homo sapiens GN=UBA2 PE=1 SV=2  ali   16  12.......................................................................................................................................................................................................................................................................................................AEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDL-------DTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFQFILVMNALNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTI....................................................................................................................... 151
5 -7.100sp|O60774|FMO6_HUMAN(removed signalp:1-17) Putative dimethylaniline monooxygenase [N-oxide-forming] 6 OS=Homo sapiens GN=FMO6P PE=5 SV=1  ali follow..  13  21...................................................................................................................................................GGLKFSDHTEEGRASIYQSVFT-MMCFPDFPYPDD-------PNYIHHSKLQEYIKTYAQKKDLLRYIQFETLVSGIKKCPSFLVTGQWVVVTEKDGKQESTIFDAVMSGH-----VYPNLPTDSFPGLDQFRGNYLHSRDYKN----PEAFKGKRVLVIGLGNSGSDIAVELSRLATQVIISTRSASWVMSRDGYPWDMMYVTRFASFLRNVLPSFISDWVQKMNTWFKHENYGLMPLNGSLRKEPVFNDELPSRILCGTLSIKPSKEFTETSAVFEDDSVIFATGYDYSY....................................................................................................................... 318
6 -7.090sp|A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens GN=UBA6 PE=1 SV=1  ali   15  6........................................................................................................................................................................................................................................................................................................QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGM--TVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKI-DAHLNKVCPTTETIYKQDVIITALNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIV...................................................................................................................... 154
7 -6.930sp|P23368|MAOM_HUMAN NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens GN=ME2 PE=1 SV=1  ali follow..  11  73..........................................KKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTP--TVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTGERILGLGDLGVYGMGI---PVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPKRDRTQQYDDLIDEFMKAITDR--YGRNTLIQFEDFGNHN-----FLRKYREKYCTFNDDIQGTAA---VALAGLLAAQKVIS-----------------------KPISEHKILFLGAGEAALGIANLIVMSMVE-LSEQEAQKKIWDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAPSTIIGVAGAGRLFTPDVIRAMASPVIFALSN---TAQAECTAEEAYTLTEGRCLFASG----SPFGPVKLTDGRVFTPGQGNNVY----------------------------VALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAI-KVTEYLYANKMA.. 540
8 -6.880sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   16  1................................................................................................................................................................................................................................................................................SNGTLPDKYKYIQTLRESRERAQSLSMG-RKVLVLGSGYISEPVLEYLSRDGNIEITVGS----------DMKNQIEQLGKKYNINPVSMDICKQEEKLGFLKQDLVIPYVLHPLV-AKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEV............................................................................................................. 172
9 -6.670sp|P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3  ali   10  13.......................................................................................................................................................................................................................................................................................................QEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEI--IVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRV-TSHQNRVGPDTERIYNLDGVANALNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHH-------HTQYSNNIRQLLHNFPPDQLTSS 287
10 -6.600sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens GN=DPYD PE=1 SV=2  ali   13  1.................................................................................................................................................................................................................................................................................QGFYTSKD-FLPLVAKGSKAGMCACHSRGVVIVLGAGDTAFDCATSALRCGARRVFIVPEEMELAKEEKCEFLRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVI-SAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVES........................................................................................................................ 192
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.