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Query: sp|Q53H96|P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens GN=PYCRL PE=1 SV=2, from H.sapiens

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETNLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRKLast
1 -101.000sp|Q53H96|P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens GN=PYCRL PE=1 SV=2  ali  100  1MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETNLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRK 274
2 -86.400sp|Q96C36|P5CR2_HUMAN(removed signalp:1-16) Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens GN=PYCR2 PE=1 SV=1  ali follow..  44  1........................RGFTAAGILSAHKIIASSPEMNLPSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSM 255
3 -84.400sp|P32322|P5CR1_HUMAN(removed signalp:1-26) Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens GN=PYCR1 PE=1 SV=2  ali follow..  45  1..................................AHKIMASSPDMDLASALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSM 245
4 -58.400sp|Q6NXP6|CN148_HUMAN Pyrroline-5-carboxylate reductase-like protein C14orf148 OS=Homo sapiens GN=C14orf148 PE=2 SV=2  ali follow..  19  69LNSATPEEFKVGIIGGGHLGKQLAGTLLQLGPIPAESLRISTRRPETLGELQKLGIKCFYHNADLVSWADVIFLCCLPSQLPNICVEIYTSLEKASIVYSFVAAIPLPRLKLLLNHT-NILRPQYQYDE---DSVSVWGANKGVIAA----------------LQDPTILQATCPYSPAGGIILNIWLEGVFYAALNICTARNMAHSQVLQLLLFLSVHFEDCGKDTASCPKLQLTDFVSKAYGKNLSQERPFPWFDLTAVQKETPFSQHLSSS 326
5 -14.500sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  16  33.SRSVASKTPVGFIGLGNMGNPMAKNLMKHGY----PLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLTSINAIEAYNGILKKVKKGSLLISTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNV--------VYCGAVGTGQA-MIGTAEAMN--GIRLGLDPKLLAKILNMSS-GRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKD-----LGLAQDSATSTKSPI... 300
6 -12.700sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1 PE=1 SV=3  ali follow..  16  261.GSITPTDKKIGFLGLGLMGSGIVSNLLKMGH----TVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSPKAAKDLVSGVLQGIRPGKCYVTVDADTVTELAQVIVSRGGRFLEAVSGNQQLSNDGMLVILAAG--DRGLYEDCSSCFQAMGKTS--------FFLGEVGNAAKVQGSFMATIAEGAHVTGQSQQTLLDILNQGQLASCQNILQGNFKPDFYLKYIQKDLRL---AIALGDAVNHPTPMAAAANEVYKRAKALD.. 538
7 -11.600sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  13  1.....MAQADIALIGLAVMGQNLILNMNDHGF----VVCAFNRTVSKVDDFLAVGAQSLKEMVSKLKKPRRIILLVKGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFV---GSGVSGGEEGARYGPSLNKEAWPHIKTIFQGIAAKVGTGEPCCDWV-GDEGAG-GDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTTANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAV......... 285
8 -11.200sp|P21695|GPDA_HUMAN Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic OS=Homo sapiens GN=GPD1 PE=1 SV=4  ali follow..  13  1.....MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQTMWVFEEDIGGKKLTEIINVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPIGERLGIPMSVLM--ANIASEVADEKFCETTIGCKDPAQGQLLKELMQT-GALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLV 316
9 -10.800sp|Q8N335|GPD1L_HUMAN Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens GN=GPD1L PE=1 SV=1  ali follow..  14  4......APLKVCIVGSGNWGSAVAKIIGNNTVNGRKLTDIINNDHENVKYLPGHNVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPIREKMGIDISVLM--ANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDD----ADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAV-----IRLGLMEMI...................................................... 238
10 -10.600sp|Q8NFT2|STEA2_HUMAN Metalloreductase STEAP2 OS=Homo sapiens GN=STEAP2 PE=1 SV=3  ali follow..  14  24.GIKDARKVTVGVIGSGDFAKSLTIRLIRCG----YHVVIGSRNPKFASEFFPHVVDVT-HHEDALTKTNIIFVAIHREHYTSLWDLRHLL--VGKILIDVSYPESNAEYLASLFPDSLIVKGFNVVSAWADASRQVYICSN--NIQARQQVIELARQLN-FIPIDLGSLSSAREIENLPLRFLYSFVRDVIHPYARNQQSDKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRLQCRKQLGLLSFFFAMVHVAYS........ 320
11 -10.400sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  13  21.SAKKIIVKHVTVIGGGLMGAGIAQVAAATGH----TVVLVDQTEDILAKSKK--IATSTDAASVVHSTDLVVEAINLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMK-LVEVIKTPMTSQKTFESLVDFSKALGKH-----------PVSCKDTPGFI--------------------VNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTK................. 271
12 -10.200sp|Q658P3|STEA3_HUMAN Metalloreductase STEAP3 OS=Homo sapiens GN=STEAP3 PE=1 SV=2  ali follow..  16  21LAKVPDEAPKVGILGSGDFARSLATRLVGSG----FKVVVGSRNPKRTARLFPSAAQVT-FQEEAVSSPEVIFVAVFREHYSSLCSLSDQL--AGKILVDVSHRESNAEYLASLFPTCTVVKAFNVISAWTDGNRQVPICGD--QPEAKRAVSEMALAMG-FMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLFVCFYKLPVSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRLQHRKQIGLLSFFCAALHALYS........ 320
13 -9.500sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens GN=STEAP4 PE=1 SV=1  ali follow..  12  13.MNSSEKQETVCIFGTGDFGRSLGLKMLQCG----YSVVFGSRNPQKTTLLPS---AEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVL--NGKILVDISNNLKINQYPESNAEGAHVVKAFNTISAWADASRQVFVCGN--DSKAKQRVMDIVRNLG-LTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVF-FRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRMLCRKQLGLVALGFAFLHVLYT........ 308
14 -9.280sp|A6ND91|ASPD_HUMAN Putative L-aspartate dehydrogenase OS=Homo sapiens GN=ASPDH PE=2 SV=2  ali follow..  15  1..MADRGPWRVGVVGYGRLGQSLVSRLLAQGPELGLELVFVWNRDPGRMAGSVPPSLQLQNLAALGERPDLVVEVAHPKIIHESGAQI---LRHANLLVGSPSALSDQTTERQLLEASQHWDHAVFVARGALWGAEDIRRLDAAGGLRSLRVTM-AHSPGPCTVLYEGPVRAAAALAAPSLGFDGVIGVLVADTSL----TDMHVVDVELSGPRGPTGRSFARRENPAEPGAVTGS---TVTAFWQSLLA........................ 270
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.