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Query: sp|Q8WU10|PYRD1_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens GN=PYROXD1 PE=1 SV=1, from H.sapiens

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEAARPPPTAGKFVVVGGGIAGVTCAEQLATHFPSEDILLVTASPVIKAVTNFKQISKILEEFDVEEQSSTMLGKRFPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFLTSKLIAEKSEAKIAHKRTRYTTEGRKKEARSKSKADNVGSALGPDWHEGLNLKGTKEFSHKIHLETMCEVKKIYLQDEFRILKKKSFTFPRDHKSVTADTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFDLGEDGGLKVDDHMHTSLPDIYAAGDICTTSWQLSPVWQQMRLWTQARQMGWYAAKCMAAASSGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGREYIKVVMQNGRMMGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFDLast
1 -112.000sp|Q8WU10|PYRD1_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens GN=PYROXD1 PE=1 SV=1  ali  100  1MEAARPPPTAGKFVVVGGGIAGVTCAEQLATHFPSEDILLVTASPVIKAVTNFKQISKILEEFDVEEQSSTMLGKRFPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFLTSKLIAEKSEAKIAHKRTRYTTEGRKKEARSKSKADNVGSALGPDWHEGLNLKGTKEFSHKIHLETMCEVKKIYLQDEFRILKKKSFTFPRDHKSVTADTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFDLGEDGGLKVDDHMHTSLPDIYAAGDICTTSWQLSPVWQQMRLWTQARQMGWYAAKCMAAASSGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGREYIKVVMQNGRMMGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFD 500
2 -43.200sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   14  6.......................................................................................................................CKGKEVENVFTIRTPEDANRVV-RLARGRNVVVVGAGFLGMEVAAYLTAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQ-----------------------------------------------------------------------------EGKLKEVVLKSSKVVRADVCVVGIGAVPATGFL-RQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGY-----------GEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIR--KREVELFVLHSKTGD. 296
3 -42.600sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   15  1.....................................................................................................................................................................................................................................................................................................................................................VNKMMQTNVPGVFAAGDAVTFPLAWNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGY-----------GEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREFVLHSKTGDMSWLT. 151
4 -39.400sp|O95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens GN=AIFM1 PE=1 SV=1  ali   18  1.............................RARDPGARVLIVSEDPEL--PYMRPPLSKELKERSIYFQPPSFYIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALLGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSV------------------------------------------------------------------------------GVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRR.................................................................................................................................. 300
5 -37.700sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   18  35ISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHL--PYDRPKLSKLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKCKGKEVENVFTIRTPEDANRVV-RLARGRNVVVVGAGFLGMEVAAYLKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQ-----------------------------------------------------------------------------EGKLKEVVLKSSKVVRADVCVVGIGAVPATGFL---RQSGIGLDSRGFI.............................................................................................................................................................. 299
6 -37.300sp|Q9BRQ8|AIFM2_HUMAN Apoptosis-inducing factor 2 OS=Homo sapiens GN=AIFM2 PE=2 SV=1  ali follow..  14  1MGSQVSESGALHVVIVGGGFGGIAAASQLQAL--NVPFMLVDMKDSFHHNVAALRASVETGFAKKTFISYSVTFKDN----FRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNL-------------------------------------------------------------------------EELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVGHSNVYAIGDCADVRTP--------KMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTF---------LLSMGRNDG......................................................................... 337
7 -36.900sp|Q8NHU2|CT026_HUMAN Uncharacterized protein C20orf26 OS=Homo sapiens GN=C20orf26 PE=2 SV=3  ali   11  1.............................................................................................AKHVVLSTDEIVPYDHLILCTGQQYQVPGKVPCNHFTLNEEEDCFKALIWIRNEGNIIVYGNTIDTYTTVETLLNLGVLVQPPPASTITCINNYSVESAVADALGAAGVTMYRDAILAQWNDGLHPDPIY------------------------------------------------------------------------SASFTTPTKPFRLQCSMFFSFCEKNVDYETFKALNDACLVYDSRLVIDTNFHTNDIAIRAAGSLTKFSNRYYSNEWTHSNF-SSKEIGFQLAAAMLHLFDPTLEPVTEPPANLDRLIPMYKGAKIQGGILPGS........................................................................ 298
8 -34.600sp|O95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens GN=AIFM1 PE=1 SV=1  ali   17  1...................................................................................................................................................KSITIIGGGFLGSELACALLGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSV------------------------------------------------------------------------------GVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGR-RRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLG------PDVGYEAIGLVDS-----------SLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPP--STPAVPQAPVQGE.. 258
9 -29.700sp|O95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens GN=AIFM1 PE=1 SV=1  ali   19  124..PQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPEL--PYMRPPLSKELKERSIYFQPPSFYIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSA-KSRTTLFRKIGDFRSLEKISRE.................................................................................................................................................................................................................................................................................................................................................................. 299
10 -29.100sp|P00390|GSHR_HUMAN Glutathione reductase, mitochondrial OS=Homo sapiens GN=GSR PE=1 SV=2  ali follow..  13  55PPPAAGAVASYDYLVIGGGSGGLASA--RRAAELGARAAVVESHKL-KVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHSQIPGASLGITSDGFFQLEEL----GRSVIVGAGYIAVEMAGILSGSKTSLMIRHDKVLRS-FDSMISTNCTEELENAGVEVLKFSQVKEVKKT---------------------------------------------------------------------LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCG----------KALLTPVAIAAGRKLAHRLFEYKEDSKLDYN--------TVVFSHPPIGTVGLTEDEAIHKYGIEAVTKRKTKCVMKMVCKEEKVVGIHMQGLDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV. 519
11 -28.300sp|Q9Y6N5|SQRD_HUMAN Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1  ali follow..  11  35.GASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTLVGAGAKQLSSSGRPTASVIPSG--VEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKHPKIGSNYSVKTVEKTWKALQDFKENAIFTFPNTPVKCAGAPQKI--------------------MYLSEAYFRKTGKR--------------------------------------------SKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFEPGETQVISYEMLHVTPPMSPPDVL----KTSPVADAAGVDVDKE-HRRYPNVFGIGDCTNLPTSKTA--------AAVAAQSGILDRTISVIMKNQTPTKKYDGYTSCPLVTGYNRVILAEFDYKAEPLETFPFDQSKERLSMYLMKADLMPFLYWNMMLRGYWGGPAFLRKLFHLGMS.................... 450
12 -27.000sp|Q8NHU2|CT026_HUMAN Uncharacterized protein C20orf26 OS=Homo sapiens GN=C20orf26 PE=2 SV=3  ali   13  56LTLEPKITVNAKIIVVGASSVGISFLETLVFCSHMKNLTLISTHGLPGKKLLDTEQRKFLASDHCFNDKDYALMSLCSWVNVVVGRMTGIDRAAKHVVLSTDEIVPYDHLILCTGQQYQVPCPTECNHFTLNEEEDCFKALIWIRNEGNIIVYGNTIDTYTTVETLSGSRIHLVQPPPASTITCINYSVESAVADALGAAGVTMYRD..................................................................................................................................................................................................................................................................................................... 300
13 -25.800sp|Q9NNW7|TRXR2_HUMAN Thioredoxin reductase 2, mitochondrial OS=Homo sapiens GN=TXNRD2 PE=1 SV=3  ali follow..  13  30ARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVCIPKKLMHQAALLGGLIRKMAEAVQNHVKSLNWGHRQDRKVKYFNIKASFVDEHTVCGVAKGGKELSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLK---ESPGKTLVVGASYVALECAGFLTGLDTTIMMRSIPL--RGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRL-----------------------------------------------------------------------------PDGQLQVTWEDSTTGTFDTVLWAIGRVPDTRLNLEKAGVDTSPDTQILVDSREATSVPHIYAIGDVVE----------RPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTP-------EYGCVGLSEEEAVARHEFTVAGRDASQCYVKMVCLPQLVLGLHFLGPGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVK 506
14 -25.600sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   22  185ISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHL--PYDRPKLSKSLTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS............................................................................................................................................................................................................................................................................................................................................................................................... 300
15 -25.500sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens GN=TXNRD1 PE=1 SV=3  ali   15  2........................................................................................................YSAERFLIATGERPRYLGIPGDKEYCISS----DDLFSLPYCPGKTLVVGASYVALECAGFLAGLDVTVMVRSILL--RGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNS---------------------------------------------------------------------EEIIEGEYNTVMLAIGRDACTRIGLETVGVKINEKTGIPVTDEEQTNVPYIYAIGDILE----------KVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTP-------EYGACGLSEEKAVEKFGEEIPSRDNNKCYAKIICDNERVVGFHVLG..................................... 292
16 -25.000sp|P09622|DLDH_HUMAN Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens GN=DLD PE=1 SV=2  ali follow..  15  32LRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKK-----EKMVVIGAGVIGVELGSQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAAS-------------------------------------------------------------------------GKAEVITCDVLLVCIGRRPFTKLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA-----------PMLAHKAEDEGIICVEGMAGGAVHIDYNC---------SVIYTHPEVAWVGKSEEQLKEEGIEYAKTNADTDGMVKILGSTDRVLGAHILGPGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFRE 496
17 -24.400sp|Q8NHU2|CT026_HUMAN Uncharacterized protein C20orf26 OS=Homo sapiens GN=C20orf26 PE=2 SV=3  ali   14  10...................................................................................................................................................................................................................................................................................................LHPDPIYSASFTTPTRLQCSMFFSFCEKNVDYETFKALNDACLVYDSRLVIDTNFHTNDIAIRAAGSLTKFSNRYYSNEWTHSNF-SSKEIGFQLAAAMLHLFDPTLEPVTEPPANLDRLIPMYKGAKIQGGILPGSQPNYGLELVTGSAKNGTYFRIHINKKMVETITCLSREPPASNYIRLFGQHEQLNNLCARYDENLIDLYSYFT 244
18 -23.900sp|Q86VQ6|TRXR3_HUMAN Thioredoxin reductase 3 (Fragment) OS=Homo sapiens GN=TXNRD3 PE=1 SV=3  ali   15  4...........................................................................REKAVAYVNSYGEFVEHHKIKATNKKGQEYTAAQFVIATGERPRYLGIQGDKEYCITS----DDLFSLPYCPGKTLVVGASYVALECAGFLAGLDVTVMVRSILL--RGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEG---------------------------------------------------------------------TETIEGVYNTVLLAIGRDSCTRIGLEKIGVKINEKSGIPVNDVEQTNVPYVYAVGDILE----------KPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTP-------EYGCCGLSEEKAIEV.................................................................... 276
19 -23.800sp|O95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens GN=AIFM1 PE=1 SV=1  ali   10  1...................................................................................................................................................................................................................................................................................................................................................................................RVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLPDVGYEAIGLPTVGVFAKATPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDL--NEVAKLFNIHE... 162
20 -20.800sp|Q86VQ6|TRXR3_HUMAN Thioredoxin reductase 3 (Fragment) OS=Homo sapiens GN=TXNRD3 PE=1 SV=3  ali   15  1........................................................................................................................................................................................................................................................................................................KVLAKSTEGTEGVYNTVLLAIGRDSCTRIGLEKIGVKINEKSGIPVNDVEQTNVPYVYAVGDILE----------KPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTP-------EYGCCGLSEEKAIEV-EWTVAGRENNTCYAKIICDHDRVIGFHILGPGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTT 214
21 -18.800sp|Q9UJX0|OSGI1_HUMAN Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=2 SV=2  ali follow..  9  91.HLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPAIPHVVLGRNLYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQAQQPFSLWARNVVLATGTRLGIPGEALPFIHELSALEAATRVGAVTPASDPVLIIGAGLSAADAVLYAYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYH---------------------------------------------------------------KVHQMMREQSILSPSPYEGYRSLPRHQLLCFKEDCQAVFQDLEGVVFGVSLVLVLIGSHPDLSFLVDPDQPLSAKRNPIDVDPFTSTRQEGLYAMGPLAG------------NFVRFVQGGALAVASSLLRKETRKP...................................................................................................... 559
22 -18.100sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens GN=TXNRD1 PE=1 SV=3  ali   17  2......................................................................................................................................................................................................................................................................................................................................LETVGVKINEKTGIPVTDEEQTNVPYIYAIGDILE----------KVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTP-------EYGACGLSEEKAVEKFGEEIPSRDNNKCYAKIICDNERVVGFHVLGPGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTT 181
23 -15.900sp|Q9Y236|OSGI2_HUMAN Oxidative stress-induced growth inhibitor 2 OS=Homo sapiens GN=OSGIN2 PE=2 SV=1  ali follow..  10  8.SLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPDQDLEYLSEGLEGRSSNPVAVLFDTLVMPEEIARYYKHYVKVMGLQKNFNTYITSVSRLYRD--SHVPFCLFAENVALATGTHLEIEGEDFPFVFSMPEFGAAINKGKLRGKVDPVLIVGSGLTAADAVLCASNIPVIHVFRRRVTDPSLIFKQLPKKLYPEYHKV--------------------------------------------------------------YHMMCTQSYSVDSNLLSDYTSFPEHRVLSFKSDMKCVLQSVSGLIFKLSAAVVLIGSHPNLSFL-KDQGCYLGHKSSIDTYTYECIKEANLFALGPLVG------------NFVRFLKGGALGVTRCLATRQKKKHLFV................................................................................................... 496
24 -15.600sp|P22570|ADRO_HUMAN(removed signalp:1-24) NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens GN=FDXR PE=1 SV=3  ali follow..  11  5CHHFSTQEKTPQICVVGSGPAGFYTAQHLLKH-PQAHVDIYEKQPV----LVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEV------GRDVTVPE----AYHAVVLSYGAED-IPGEELPGVCSARAF---NQELEPDLSCDTAVILGQGNVALDVARILPPEHLERTDITKAALGVLRQSRTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAG-----VRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSR----PVDPSVPFDSKLGVIPNVERVMDVPGLYCSGWVKRGPTGVIA---------TTMTDSFLTGQMLLQKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEK----DAEEVARGQGTGKPREKLVDPQEML............................................ 462
25 -14.600sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens GN=TXNRD1 PE=1 SV=3  ali   10  1MNGPEDLPKSYDYIIIGGGSGGLAAAKEAAQYGKKVMVLCIPKKLMHQAALLGQALDRMIEAVQNHIGSLNWGYRREKKVVYENAYGQFIGPHRIKATNNKGKIYSAERFLIATGERPRYLGIPGDKEYCISS----DDLFSLPYCPGKTLVVGASYVALECAGFLAGLDVTVMVRSILL--RGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNS---------------------------------------------------------------------EEIIEGEYNTVMLAIGRDACTR................................................................................................................................................................................ 298
26 -13.900sp|Q86VQ6|TRXR3_HUMAN Thioredoxin reductase 3 (Fragment) OS=Homo sapiens GN=TXNRD3 PE=1 SV=3  ali   12  38..LQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLCIPKKLMHQAALLGQALETMTKAIQNHISSLNWGYRREKAVAYVNSYGEFVEHHKIKATNKKGQEYTAAQFVIATGERPRYLGIQGDKEYCITS----DDLFSLPYCPGKTLVVGASYVALECAGFLAGLDVTVMVRSILL--RGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQL............................................................................................................................................................................................................................................................................................ 292
27 -13.800sp|Q8IWF2|FXRD2_HUMAN(removed signalp:1-26) FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=FOXRED2 PE=1 SV=1  ali   13  2.......PPRRDYCVLGAGPAGLQMAYFLQRAG---DYAVFERAPRPGSFFTRYYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDILTDQKGQVHQCSVLFVATGSVPNQVDFPGSEYAEGYESVSVDPED----VGQNVLILGRGNSAFETAENILGVFIHMLSRSR.................................................................................................................................................................................................................................................................................................................................. 220
28 -13.700sp|P49326|FMO5_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 5 OS=Homo sapiens GN=FMO5 PE=2 SV=2  ali follow..  11  2........TKKRIAVIGGGVSGLSSIKCCVEEG---EPVCFERTDDIASIYKSVIINTSFMHNAQVLEYFRMYAKEFDLLKYIKTTVCSVKKQPDEVVTESEGKKEFDGVMVCTGTNAHLPLESFPGIEKFKGFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQV----------FLSTRRGAWILNRVGDYGADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRALSQHPTLNDDLPNRIIS-------------------LVKVKGNVKEFTETAAIFEDGSREDIDAVIFATGYSFDFPFLEDSVKVVKNKISLYKKVFPPNLERPTLAIIGLIQPL-----------AIMPISELQGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDKRYVESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIH-----VQGPGKWDGARKAILTTDDRIRKPLM 500
29 -13.500sp|Q01740|FMO1_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 1 OS=Homo sapiens GN=FMO1 PE=2 SV=3  ali follow..  9  2.........AKRVAIVGAGVSGLASIKCCLEEG---EPTCFERSDDLASLYKSVVSNSCYVPNSQFLEYLKMYANHFDLLKHIKTKVCSVTKCSVTMHEEKQESAIFDAVMVCTGTNPYLPLDSFPGINAFKGFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKV----------FLSTTGGGWVISRIFDSGYP--WDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPS-------------IKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPHLQKPTLAIIGLIKPL-----------SMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQ-----LTGPGKWEGARNAIMTQWDRTFKVIK 500
30 -13.200sp|Q99518|FMO2_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 2 OS=Homo sapiens GN=FMO2 PE=1 SV=3  ali follow..  10  2.........AKKVAVIGAGVSGLISLKCCVDEG---EPTCFERTEDIASIYQSVVTNPNFLHNSKLLEYFRIFAKKFDLLKYIQTTVLSVRKCPDKVVTQSNQSAVFDAVMVCSGILPHIPLKSFPGMERFKGFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQV----------FISTRHGTWVMSRISEDGYPW-----------DSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCG-----AIKVKSTVKELTETSAIFEDGTVENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPHLDKSTLACIG------------QPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQ-----LVGPGQWEGARNAIFTQKQRILKPLK 500
31 -13.200sp|P31512|FMO4_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 4 OS=Homo sapiens GN=FMO4 PE=2 SV=3  ali follow..  10  2.........AKKVAVIGAGVSGLSSIKCCVDED---EPTCFERSDDITRVYKSLVTNVCFMNHEKFWDYLQEFAEHFDLLKYIKTTVCSITKRPVTETEGKQNRAVFDAVMVCTGLNPHLPLEAFPGIHKFKGLHSQEYKIPEGFQGKRVLVIGLGNTGGDIAVELSRTAAQV----------LLSTRTGTWVLGRSSDWGYPYNMMVTRRCCSFIAQVLPSRFLN-----------WIQERKLNKRFNHEDYGLSITKGKKAKFIVNDELPNCILCGAITMKTSVIEFTETS-----AVFEDGTVEENIDVVIFTTGYTFSFPFFEEPLKSLCTKKIFLYKQVFLNLERATLAIIG------------GLKGSILSGTELQARWVTRVFKGL-CKIPPSQKLMMEATEKEQLIKRGVFKDTSKDKFDYIAYMDDIAACIGTKPSIPLLFLKDPRLAWEVFFGPCTPYQ-----LMGPGKWDGARNAILTQWDRTLK... 495
32 -13.200sp|P31513|FMO3_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 3 OS=Homo sapiens GN=FMO3 PE=1 SV=5  ali follow..  9  2.........GKKVAIIGAGVSGLASIRSCLEEG---EPTCFEKSNDIASIYKSVFSNSSFMHNSKIQEYIIAFAKEKNLLKYIKTFVSSVNKHPTTERDGKKESAVFDAVMVCSGVYPNLPKESFPGLNHFKGFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQV----------MISSRSGSWVMSRVWDNGYPW-----------DMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCG-----IVSVKPNVKEFTETSAIFEDGTIFGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPLLEKSTIAVIGFVQSLG----------AAIPTVDLQSRWAAQVIKGTCTLPSMED--MMNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQ-----LVGPGQWPGARNAILTQWDRSLKPMQ 498
33 -12.900sp|Q8IWF2|FXRD2_HUMAN(removed signalp:1-26) FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=FOXRED2 PE=1 SV=1  ali   10  2.............................................................................................................LFVATGLSVDFPGSEYAEGYESVSVDPED-------VGQNVLILGRGNSAFETAENILGVTNFI---------HMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESD-----------------------------------LTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAFGLIRASYESKGSRGLFILGTASHSVD----RKSAGGFIHGFRYTVRAVHRLLEHR........................................................................................................... 240
34 -11.000sp|P50336|PPOX_HUMAN Protoporphyrinogen oxidase OS=Homo sapiens GN=PPOX PE=1 SV=1  ali follow..  8  2.........GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR----SVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALP----------TGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCF---------PSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAIVVNLQYQGAHLPVQGFGHLVPSSEGVLGIVYDSVAFPEQDGSPPGLRVTVMLGSGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHR--PLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS........ 477
35 -10.800sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens GN=DPYD PE=1 SV=2  ali   13  33................................................................................................................................................................................................................................GVVIVLGAGDTAFDCATSALRCGARRVFI---VFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAM-ETGKHLKADVVISAFGSVLSDPKVKEASPIKFNRWGLPEVDETMQTSEAWVFAGGDVVGLANTTV----------ESVNDGKQASWYI.............................................................................................................. 203
36 -10.300sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens GN=DPYD PE=1 SV=2  ali   13  31...KMSEAYSAKIALFGAGPASISCASFLARLGYS-DITIFEKQELSTSEIPQFRLPYDVVNFEI------ELMKDLGVKIICGKSL-----SVNEMTLSTLKEKGYKAAFIGIGLKDAIFQGLTQDQGFYTSKDFLPLVAKGSKARGVVIVLGAGDTAFDCATSALRCRVFIVFRKGF------NIRAVPEEMELAKEEKCEFLPFLSPRKVIVKG--------------GRIVAMQFVRT------------------------------------------------EQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEA........................................................................................................................................................................... 300
37 -10.100sp|Q6QHF9|PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3  ali   8  2.........VPSVGEYLKKEIGQHVARLCGHSAFP-HLRVLEATA------------------------------------RAGGRIRSERCFGGVVEV---------------GAH--IHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGASVQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPL-------------------GFLREHLDTFFDPPL................................................................................................................................................... 292
38 -10.100sp|Q6QHF9|PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3  ali   12  1MESTGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATA------------------------------------RAGGRIRSERCFGGVVEV---------------GAH--IHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGTSVQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVARLCGHSAFPHLRVLEATARAGGRIRSERCFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQ-ENQLVETGGHVGLPSVSYASSGASVSLQMATLFYGLIDQTR................................................................................................................................................................................ 280
39 -10.000sp|Q9UHG3|PCYOX_HUMAN(removed signalp:1-27) Prenylcysteine oxidase 1 OS=Homo sapiens GN=PCYOX1 PE=1 SV=3  ali follow..  12  1...AELRAPPDKIAIIGAGIGGTSAAYYLRQKGKDVKIDLFEREEV--------RLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLSAVQASGGLLGIYNGETLVFEKLVWRYGFQS------------LRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGD--------------FLGMLNRTLLETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIG--------TETRSDFYDIVLVATPLNRKMSNITFLN.......................................................................................................................................................................... 301
40 -9.880sp|Q9Y2Z2|MTO1_HUMAN Protein MTO1 homolog, mitochondrial OS=Homo sapiens GN=MTO1 PE=1 SV=2  ali   21  27SDSAAPRTPHFDVIVIGGGHAGTEAATAAARCG--SRTLLLTHRVDTRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEVVLVDGSTVYAESVILTTGT................................................................................................................................................................................................................................................................................................................................................................................................ 195
41 -9.720sp|O60774|FMO6_HUMAN(removed signalp:1-17) Putative dimethylaniline monooxygenase [N-oxide-forming] 6 OS=Homo sapiens GN=FMO6P PE=5 SV=1  ali follow..  11  20...............VGGTEEGRASIYQSVFTNSSKEMMCFPDFPYIHHSKLQEYIKTYAQKKDLLRY------------IQFETLVSGIKKCPVTEKDGKQESTIFDAVMICSGVYPNLPTDSFPGLDQFRGLHSRDYKNPEAFKGKRVLVIGLGNSGSDIAVELSRLATQV----------IISTRSASWVMSRVWDDGWDMMYVTRFASFLRNVLPSFISDWLYVQKMNTWFKHENYGLMPLNGSLRKEPVFNDELPSRILC-------------------TLSIKPSVKEFTETSAVFEDGTMFAIDSVIFATGYDYSYPFLDETIMKSRNNEVTLFKGIFPLMEKPTLAVIG-----------VQSLGAAIPTADLQAWWAAKVFANSCTLPTTNEMMDDTDEKMGKKLKCMFSSFFMFGQSQTLQTDYITYVDELGSFNIPWLFLTDPRLALEVYFGPCSPYQ-----LMGPGKWDGARNAILTQWNRTVK... 485
42 -9.330sp|Q9NWM0|SMOX_HUMAN Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1  ali follow..  10  15LSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFT-DVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVSLGVRPGLPTEKVAAIHRLGI--GTTDKIFLEFEEP-GWICGEEALVMEKCDD--------EAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGSTTHGALLSG-QREAARLIEMYRDLFQQGT................. 555
43 -9.140sp|P21397|AOFA_HUMAN Amine oxidase [flavin-containing] A OS=Homo sapiens GN=MAOA PE=1 SV=1  ali follow..  11  1MENQSIAGHMFDVVVIGGGISGLSAAKLLTEYG---SVLVLEARD---------RVGGRTYTIRNEHVDYVDVGGA------VGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADK------------DKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCG---------GTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQ-----------VKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIHFRPELPAERNQLIQRLPMGAVIKCDDTKPDGSLPAFILARKADRLAKLHKEIRKKKICELYAK-GSQEALHPVHYEEKNWCEEQYSGGCYTAYFP---------GIMTQ-RQPVGRIFFAGTETATKWS------GYMEGAVEAGERAAREVLNGL.......................... 463
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;