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Query: sp|Q9H9P8|L2HDH_HUMAN L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens GN=L2HGDH PE=1 SV=3, from H.sapiens

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVPALRYLVGACGRARGLFAGGSPGACGFASGRPRPLCGGSRSASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALLYEYCQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGVPGLRLIQQEDIKKKEPYCRGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGLIKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSIAISGMIADEVQQRFELLast
1 -122.000sp|Q9H9P8|L2HDH_HUMAN L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens GN=L2HGDH PE=1 SV=3  ali  100  1MVPALRYLVGACGRARGLFAGGSPGACGFASGRPRPLCGGSRSASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALLYEYCQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGVPGLRLIQQEDIKKKEPYCRGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGLIKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSIAISGMIADEVQQRFEL 463
2 -37.800sp|Q9UI17|M2GD_HUMAN(removed signalp:1-23) Dimethylglycine dehydrogenase, mitochondrial OS=Homo sapiens GN=DMGDH PE=1 SV=2  ali   17  9..............................REGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMK-DVVLLEKSE-LTAGSTWHAAGLTTY---FHPGINLKKIHYDSIKLYEKLEEETGVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATE-QYLIEPEKIQEMFPLLNMLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDG-----------TWDVETPQGSMRANRIVNAAGFWAREVGKMIGL--EHPLIPVQHQYVVTSTISE--VKALKRELPVLRDLEGSYYLRQERDG-LLFG......................................................................................................................................... 287
3 -36.600sp|Q8NCN5|PDPR_HUMAN Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens GN=PDPR PE=1 SV=2  ali   20  24.............................SARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMGWK-DIVLLEQGR-LAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYYQLEQETGTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIP-SEIISPKKVAELHHLLNVVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQ-----------VTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPVSIPLHACEHFYLLTRPLETPLQSST----PTIVDADGRIYIRNWQGG.............................................................................................................................................. 299
4 -36.400sp|Q9UL12|SARDH_HUMAN Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1  ali   19  49..............................GQGTSVVAQGPSRPLPSTANVVVIGGGSLGCQTLYHLAKLGMS-GAVLLERER-LTSGTTWHTAGLLWQ---LRPSDVEVELLAHTRRVVSRELEELHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVE-SHVLSPAETKTLYPLMNVYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDF------GVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGV--KVPLVAMHHAYVVTER............................................................................................................................................................................. 300
5 -33.800sp|Q96CU9|FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1 OS=Homo sapiens GN=FOXRED1 PE=1 SV=2  ali follow..  14  39.......................KKIKSILPGRSCDLLQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRIRVLVVERDHTYSQASTGLSVGGICQQF---SLPENIQLSLFSASFLRNINEYLALRFNPSGYLLLA-SEKDAAAMESNVKVQRQEGAK-VSLMSPDQLRNKFPWINTEASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAEVHVKMDRSLEYQPVECAIVINAAGAWSAQIAALAGVGEKLPVEPRKRYVYVWHCPQGPGLETPLVADTS------GAYFRREGLGSNYLGGRSPTEQEEPDPANLEVDHDFFQDKV-----------------------------WPHLALRVPAFETLKVQSAWAGYYDYNT--------DQNGVVGPHPLVVNMYFATGFSGHGLQQAPGIGRAVAEMVLK.... 458
6 -29.900sp|Q9P0Z9|SOX_HUMAN Peroxisomal sarcosine oxidase OS=Homo sapiens GN=PIPOX PE=2 SV=2  ali follow..  13  2..........................................AAQKDLWDAIVIGAGIQGCFTAYHLAKH--RKRILLLEQFF--SRGSSHGQSRIIRKAY---LEDFYTRMMHECYQIWAQLEHEAGTQHRQTGLLLLGMKENQ--ELKTIQANLSRQRVE-HQCLSSEELKQRFPNIRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINPGL-------------LVTVKTTSRSYQAKSLVITAGPWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVPHHIYGLPTGEYPGLMK----SYHHGNHADPEERDCPTAR------------------------------------TDIGDVQILSSFVRDHLPDLKP-------EPAVIESCMYTNTPDEQFIL--DRHPKYDNIVIGAGFSGHGFKLAPVVGKILYELSMK.... 367
7 -29.400sp|Q9UL12|SARDH_HUMAN Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1  ali   17  1......................................................................................................................................GGLFIASNRQRLDEYKRLMSLGKAYGVE-SHVLSPAETKTLYPLMNVYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVR------RVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGV--KVPLVAMHHAYVVTERIEG------IQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDL-------------------------DWEVFTQHIEGAINRVPVLEKTGIKSTVCGPES--------FTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIH.... 280
8 -29.300sp|P43304|GPDM_HUMAN(removed signalp:1-23) Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Homo sapiens GN=GPD2 PE=1 SV=3  ali   15  35....................................EAQLLTLQNTSEFDILVIGGGATGSGCALDAVTR--GLKTALVERD-DFSSGTSSRSTKLIHGGVRY--QKAIMKLDIEQYRMVKEALHERANLLEIAPHLS-----APLPIMLPVYKWAGSNCLKSSYVLSKSRALEHFPMLQKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPQTGKVRVSGARCKVLTGQEFDVRAKCVINATGPFTDSVRKMDDKDAAAICQPSAGVHIVMPG............................................................................................................................................................................. 298
9 -24.600sp|Q8NCN5|PDPR_HUMAN Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens GN=PDPR PE=1 SV=2  ali   16  1...............................................................................................................................................................GIP-SEIISPKKVAELHHLLNVVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQ-----------VTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPVSIPLHACEHFYLLTRPLETPLQSS----TPTIVDADGRIYIRNWQGGILSGGKNPKPIFTEGKNQLEIQNLQEDWDHF--------------------------EPLLSSLLRRMPELETLEIMKLVNCPET--------FTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVH.... 255
10 -20.500sp|P43304|GPDM_HUMAN(removed signalp:1-23) Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Homo sapiens GN=GPD2 PE=1 SV=3  ali   10  11...........................................................................................................................................................AGSNCLKSSYVLSKSRALEHFPMLQKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPQTGKVRVSGARCKVLTGQEFDVRAKCVINATGPFTDSVRKMDDKDAAAICQPSAGVHIVMPGYYSPESMGLLDPATSDG-----VIFFLPWQKMTIAGTTDTPTDVTHHPIPSEEDI---------------------------------NFILNEVRNYLVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISESGLITIAGGK---WTTYRSMAEDTINAAVKTHNL 284
11 -20.400sp|Q9UI17|M2GD_HUMAN(removed signalp:1-23) Dimethylglycine dehydrogenase, mitochondrial OS=Homo sapiens GN=DMGDH PE=1 SV=2  ali   13  1................................................................................................................................................................................PLLNMLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDG-----------TWDVETPQGSMRANRIVNAAGFWAREVGKMIGL--EHPLIPVQHQYVVTSTISE--VKALKRELPVLRDLEGSYYLRQERDG-LLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRI-----------------MEHIKAAMEMVPVLKKADIINVVNGPIT--------YSPDILPMVGPHQGVRNYWVAIGF-GYGIIHAGGVGKYLSDWILH.... 244
12 -19.800sp|Q99489|OXDD_HUMAN(removed signalp:1-19) D-aspartate oxidase OS=Homo sapiens GN=DDO PE=2 SV=1  ali follow..  13  1..............................................................VCISKLVP--RCSVTIISDK------FTPDTTSDVAAGMLIPPIHTQKQWFRETFNHLFAIANSADAGVHLVSGWQIFQSTPTEE------VPFWADVVLGFRKMTEAEL----KKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRR------------------------IEDLWELHPSFDIVVNCSGLGSRQLAG------DSKIFPVRGQVLQVQAPWVEHFSGLTYIYPGTSHVTLG--------GTRQKG-----------------------------------------DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQT------LLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVH. 311
13 -18.500sp|P14920|OXDA_HUMAN(removed signalp:1-16) D-amino-acid oxidase OS=Homo sapiens GN=DAO PE=1 SV=3  ali follow..  13  1..........................................................LCIHERYHSVLQ--PLDIKVYADR---PLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHS-----PNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWF-----TSLILEGKNYLQWLTERLTERGVKFF-QRKVESFE----------------------EVAREGADVIVNCTGVWAGALQR------DPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYN----SPYIIPGTQTVTLGGIFQ-----------------------------------LGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLER------QLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILE. 319
14 -17.000sp|Q16134|ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Homo sapiens GN=ETFDH PE=1 SV=2  ali   12  2LVPLAKLSCLAYQCFHALKIKKTTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQHEKDIRVCLVEKAAQIGAHTL-------------------------------------------SGACLDP------GAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIAQKDGAPKATFERGLELHAKVTIFAEGCHG-HLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWWPL................................................................................................................................................................ 299
15 -15.900sp|Q8N2H3|PYRD2_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=PYROXD2 PE=2 SV=2  ali follow..  14  4.................SGRGLCKAVAASPFPAWRRDNTEARGGLKPEYDAVVIGAGHNGLVAAAYLQRL--GVNTAVFERRHVIGGAAVTEE---IIPGFKFSRAS--AQFSQKDAQVFPKYEEFMHRLALAIDPLLGRILGAQLPRYYEVLTAPITKVLD--QWFESEPLKATTPGSGYVGAWGYVQGGM---GALSDAIASSATTHGASIFTEKTVAKV---------QVNSEGCVQGVVLEDGTEVRSKMVLSNTSPFLERISQLDTRSPVTKI------NVAVDRLPSFLAAPNAPRGQPLPHHQCSIHLNCEMDGLPSHRPVIELCIPSSLDPTLAPPGCHVVSLFTQYMPYTLAGGK------EQERDAYADRVFDCIEVYAPGFKDSDLERIFGLPGGNIFHCAMSLDQLYFARSGYRCPLQGLYLCGSGAHPGGGVMGAAGRNAAHVAFRDLK. 579
16 -15.400sp|Q6NUM9|RETST_HUMAN(removed signalp:1-18) All-trans-retinol 13,14-reductase OS=Homo sapiens GN=RETSAT PE=2 SV=2  ali follow..  13  10........SSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSANQVPEKLDVVVIGSGFGGLAAAAILAKA--GKRVLVLEQHTKAGCHTFGKNGLEFDTGIHYIGRMEEGSI-----RFILDQITEGQLDWAPLSQGLKEKFPQEEAIIDKYIKLVKVQSLAEVQLGASSELQAVTPNNHYMKGGFYPRGG---SSEIAFHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKK------GHELVNIYCPIVVSNAGL-FNTYEHLLPGNARCLPGVKQ----QLGTVRPGLGMTSVFICLRGTKEDLHLNYYVYYDTDMDQAMERYVSMPREEAAEHIPLLFFAFPSAKDPTWWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQLEGQFYLAAPRGACYGADHDLGRLHPCVMASLRAQSPIPN-LYLTGIFTCGLVGALQGALLCSSAILKR... 572
17 -15.200sp|Q14534|ERG1_HUMAN(removed signalp:1-43) Squalene monooxygenase OS=Homo sapiens GN=SQLE PE=2 SV=3  ali follow..  14  38.....AKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRD--GRKVTVIERDLKEPDRI---------VGEFLQPGGYHV--------------------LKDLG-------------LGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNKFIEGVVLQLLEEDDVVMGVQYKDKE------TGDIKELHAPLTVVADGLFS-KFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSP------VLIYQISSSETRVLVDIRGEMPRN--------------------LREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGV----------LLGD----------------AYNMRHPGMTVAFKDIKLWRKLLKGIPDL 398
18 -14.200sp|Q7RTP6|MICA3_HUMAN Protein MICAL-3 OS=Homo sapiens GN=MICAL3 PE=1 SV=2  ali   17  71................................KRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLL--GAKVVVIEKRDAFS------RNNVLHL------------------------------------------WPFTIHDLRGLGAKKFYGKFC------------------------AGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRN-TLEGFRRKE.............................................................................................................................................................................................. 236
19 -14.200sp|O94851|MICA2_HUMAN Protein MICAL-2 OS=Homo sapiens GN=MICAL2 PE=1 SV=1  ali   18  71................................KRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYL--GAKVVVVEKRDSFS------RNNVLHL------------------------------------------WPFTIHDLRGLGAKKFYGKFC------------------------AGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRN-TLEGFRRKE.............................................................................................................................................................................................. 236
20 -13.900sp|Q9Y2Z2|MTO1_HUMAN Protein MTO1 homolog, mitochondrial OS=Homo sapiens GN=MTO1 PE=1 SV=2  ali   12  13........................VSFTKQQFPLARLSSDSAAPRTPHFDVIVIGGGHAGTEAATAAARC--GSRTLLLTHRVDTIGQMSCNPS---------------------------------------FGGIGKGHLMREVDALDGLCSRICDQSGVHYKVLNRRKGPAVW-----------GLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEPEHTGKCRVSGVVLVDGS--TVYAESVILTTGTFL........................................................................................................................................................................................................ 197
21 -13.500sp|P21397|AOFA_HUMAN Amine oxidase [flavin-containing] A OS=Homo sapiens GN=MAOA PE=1 SV=1  ali follow..  9  1...................................MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEY--GVSVLVLEARDRVGGRTYTEHVDYVDVG---------GAYVGPTQNRILRLSKELGIETYKVERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNL--RTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNIVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDKLNHPVTHVDQSSDNIIIETLNHEHYE--------CKYVINAIPPTLTA--KIHFRPELPARLPMGAVIKCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHIMTQYGRVIRQPVGRI---FFAGTETATKWSGYME--GAVEAGERAAREVLNGLGKVTEKDI.. 471
22 -13.300sp|P27338|AOFB_HUMAN Amine oxidase [flavin-containing] B OS=Homo sapiens GN=MAOB PE=1 SV=3  ali follow..  9  1............................................MSNKCDVVVVGGGISGMAAAKLLHDS--GLNVVVLEARDRVGGRTRNQKVKYVDLG---------GSYVGPTQNRILRLAKELGLETYKVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNF--RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDKLERPVIYIDQTRENVLVETLNHEMYE--------AKYVISAIPPTLGM---IHFNPPLPTRVPLGSVIKCMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHILTQYGRVLRQPVDRI---YFAGTETATHWSGYME--GAVEAGERAAREILHAMGKIPEDEI.. 462
23 -13.200sp|Q6QHF9|PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3  ali   14  1...................................MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGIRSERCFGGVVEVGAHWIHGPSRGN--------VFQLAAEYGLLGEKEENQLVETGGHVGLPSVSYASSGTSVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGE............................................................................................................................................................................................................................................................................. 157
24 -13.000sp|Q9Y6N5|SQRD_HUMAN Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1  ali follow..  13  17.....................ACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERVGAGAKQLSSSVIPSGVEWIKARVNCIHTDDDEKISYRY-------------LIIALGQLDYEKIKGLPEGFAHPKIGKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDK-------PGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDRTIS........................................................................................................................................... 361
25 -12.700sp|Q6QHF9|PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3  ali   12  2...............................................VPSVGEYLKKEIGQHVARLCGHSAFP-HLRVLEATARAGIRSERCFGGVVEVGAHWIHGPSRGN--------VFQLAAEYGLLGEKEENQLVETGGHVGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYQGLTNCMMAALPED--TVVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPL.......................................................................................................................................................................................................... 277
26 -12.400sp|Q96RQ9|OXLA_HUMAN(removed signalp:1-21) L-amino-acid oxidase OS=Homo sapiens GN=IL4I1 PE=1 SV=1  ali follow..  10  26...................................KVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDA--GHKVTILEADNRIGGRIFTYRDQ--NTGWIGELGAMRM----SSHRILHKLCQGLGLNLTKFQALKDLKALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFYLSFAEALGWDLLPRALLSSL---SGLVLLNAPVVAMTQGPHDVHVQIETSP-----PARNLKVLKADVVLLTASGPAEALRRLHYVPATKVFLSFRRPFWREEHNTDRPSRMIFYPPPREGALLLASYTW---------SDAAAAFAGLSREEALRLALDDVAALHG-------PVVRQLWDGTGVVKRWAEDQHSQGGFVVQP-----------PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVE--TAVKSALRAAIKINSRK.......... 487
27 -12.400sp|O15229|KMO_HUMAN Kynurenine 3-monooxygenase OS=Homo sapiens GN=KMO PE=1 SV=2  ali follow..  15  2.........................................DSSVIQRKKVAVIGGGLVGSLQACFLAKR--NFQIDVYEAREDTRVATFTRGRSI---NLALSHRGRQA--------------------LKAVG-------------EDQIVSQGIPMRARMIHSLSGKKSAIPYGT-------KSQYILSVSRENLNKDLLTAAEKYNVKMHFNHRLLKCNPEEGMITVLGSD---------KVPKDVTCDLIVGCDGAYS........................................................................................................................................................................................................ 171
28 -12.200sp|Q9UHG3|PCYOX_HUMAN(removed signalp:1-27) Prenylcysteine oxidase 1 OS=Homo sapiens GN=PCYOX1 PE=1 SV=3  ali follow..  11  1.........................................AELRAPPDKIAIIGAGIGGTSAAYYLRQKFKDVKIDLFERE-----EVGGRLATMMVQGQEYEAG---GSVIHPLNLHMKRFVKDLGLAFSSVEKLLHALGGDDFLGMETLQKAGFSEKFLN-QSTDINAFVGAVSLSCSDSGLWAVEGGN---KLVCSGLLQAS---KSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIILHD----YLN---------------------------GIECAASAMEMSAIAAHNAALLAYHRWNGHTD. 463
29 -12.200sp|P50336|PPOX_HUMAN Protoporphyrinogen oxidase OS=Homo sapiens GN=PPOX PE=1 SV=1  ali follow..  14  4.................................................TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGRSVRGPNGAIFELG----PRGIRPA---ALGARTLLLVSELGLD----SEVLPVRGDHPAAQNRFLYVGGALHALPT-RRLGPEVASLADSLCRGVFAQWSLRGGL---EMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEAVISAIPASVLSELLPAEAAPLARALSAIVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDFPEQDGSPPGLRVTVMLGGSW---ASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAG--ASYEGVAVNDCIESGRQAAVSVLGTEPNS.................................... 477
30 -12.100sp|Q8TDZ2|MICA1_HUMAN NEDD9-interacting protein with calponin homology and LIM domains OS=Homo sapiens GN=MICAL1 PE=1 SV=2  ali   14  69................................KRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALL--GARVVLVEKRTK----FSRHNVLHLWP-----------------------------------------------FTIHDLRALGAKKFYGRF----------------------TGTLDHISIRQLQLLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPN---PPAQLANYEFDVLISAAGGKF-VPEGFKVRE.............................................................................................................................................................................................. 231
31 -11.700sp|Q8IWF2|FXRD2_HUMAN(removed signalp:1-26) FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=FOXRED2 PE=1 SV=1  ali   13  1............................................VPPRRDYCVLGAGPAGLQMAYFLQRA--GRDYAVFERAPRPG-------------SFFTR--------------------------YPRHRKLISINKRYTGKANAEFNLR------------DWNSLLSHDPRLRHYSRAYFPDAR-----DMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGH-----FILTDQKGQVHQCSVLFVATGLSVPNQVDFPGSEY------AEGYESVSVDPEDFVGQNVLI-----GRGNSAFETAENILGVT............................................................................................................................................ 210
32 -11.500sp|P00390|GSHR_HUMAN Glutathione reductase, mitochondrial OS=Homo sapiens GN=GSR PE=1 SV=2  ali follow..  14  31..............PEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAEL--GARAAVVESHK---LGGTCVNVGCVPKGFPSCEGKFRDAYVSRLNAIYQNNLTKSHIEFTSDPKPTIEVSGKKYTAPHILIATGGM-QIPGASGITSDGFFQLEPGIVGAGYIAVEMAGILSASMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPG--RLPVMTMIPDVDCLLWAIGRVPN--TKDLSLNKLGIQTDDKG-HIIVDEFQNTNVK--------------GIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTE-----------DEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVG--IHMQGLGCDEMLQGFAVAVKMGATKAD.... 503
33 -11.400sp|P31040|DHSA_HUMAN(removed signalp:1-19) Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens GN=SDHA PE=1 SV=2  ali   13  24.............................ASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEA--GFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFTVKGSDWLGD---------QDAIHYMTEQAPAAVVELENY--SRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTG----HSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECR-----GVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHT------STGDGTAMITRAGLPCQDLEF--PT-GIYGAGCLITEGCRGE............................................................................................................................................. 295
34 -11.400sp|Q9Y2Z9|COQ6_HUMAN Ubiquinone biosynthesis monooxygenase COQ6 OS=Homo sapiens GN=COQ6 PE=1 SV=2  ali follow..  11  18..............................SGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYHFHDKKILLLEAGPKKVLEKLSETYS------------------------------------------VSSISPGSATLLSSFICNMRYRAFRRMQVWDACSEALIMFDKDNLDDM------IVENDVIMHALTKQLEAVSDRVTVLYR-SKAIRYTWPCPFPMADSSPWVHITLGDGSTFQTKLLIGADGHNS-GVRQAVG------IQNVSWNY-----------SAVVATLHLSEATENNVAWQRFLPS----GPIALLPLSDTLSSSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTKVSARQ-----LPPSVARVDAKSRVLFPLGGHAAEYVRPRVALIGDAAPGFGDISSLAHHLSTAAFNGKDL 403
35 -11.000sp|P26374|RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens GN=CHML PE=1 SV=2  ali   16  2.........................................ADNLPTEFDVVIIGTGLPESILAAACSRS--GQRVLHIDSRSYYGGNWASFS.................................................................................................................................................................................................................................................................................................................................................................................. 51
36 -10.900sp|O60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A OS=Homo sapiens GN=KDM1A PE=1 SV=2  ali   14  118.....................................KRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF--GMDVTLLEARDRVGVATFRKGNYVADLGAMVVTGL---------GNPMAVVSKQVNMEYEANGQAV---PKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSL............................................................................................................................................................................................................................................................................................ 258
37 -10.900sp|Q8NE62|CHDH_HUMAN(removed signalp:1-15) Choline dehydrogenase, mitochondrial OS=Homo sapiens GN=CHDH PE=2 SV=2  ali follow..  17  18........................................AGSESRDEYSYVVVGAGSAGCVLAGRLTED-PAERVLLLEAGPKDVLAGSKRLSWKIHMPAALVSSSLNAMVYVRGHAEDYERWQRQGLPYFR-GPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGF--RWSAACAYLHPALSAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKE---------------VILSGGAINSPQLLMLSGIGNADDLKKLGIPVVCHL-PGVGEWLWKFTTAHLETGGFIRSQPGVPHPDIQFHFLGTSVGWLKL-PQPNYLSTETDIEDFRLCVKLTREIFAQEALAPFRGKELQPGSHIQSDKEIDAFVRAKADSAY----------HPSCTCKMGQPSDPTAVVD---PQTRVLGVENLRVVDASIMPSMVSTIMIAEKAADIIKGQPAL 562
38 -10.800sp|P31150|GDIA_HUMAN Rab GDP dissociation inhibitor alpha OS=Homo sapiens GN=GDI1 PE=1 SV=2  ali follow..  10  1............................................MDEEYDVIVLGTGLTECILSGIMSVN--GKKVLHMDRNPYYGGESSSITPL-LIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKI-VPSTETEALASNLMGMFEKRRFRKFLVFVCLETVNRIKLYSESLAPYLYPLYGL---GELPQGFARLSAIYGGTYMLNKPVDDIIMENG-----------KVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHP-----IKNTNDANSCQIIIPQNQVNRKSIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESTHFETTCNDIKDIYKRMAGTA---------ENMKRKQNDVFGE............................................. 444
39 -10.800sp|Q8NBM8|PCYXL_HUMAN(removed signalp:1-22) Prenylcysteine oxidase-like OS=Homo sapiens GN=PCYOX1L PE=1 SV=2  ali follow..  11  6.................................................KIAVVGAGIGGSAVAHFLQQHFPRVQIDVYEKGTVGGRLATISVNKHYESG---------AASFHSLSLHMQDFVKLLGLAFSGVEELLYSLGESTFVNMHSVAESLLQVGVTQ-QSAAMPAFAGAMSLAGAQGSLWSVEGGN---KLVCSGLLKLT---KANVIHATVTSVTLHSTEGKALYQVAYE-----NEVGNSSDFYDIVVIATPLHDNSSSNLTFAGFHPPIDDVQGSFPTVVSLVHGYLNSSYFGFPDPKLFPFANILTTDFPSFFCTLDNICPVNISASFRRKQPQEAAVWRVQSPKPLFRTQLKTLFRSYYSVQTAEWQAHPLYGSRPTLPRFALHD----YLN---------------------------ALEWAASSVEVMAVAAKNVALLAYNRWYQDLD. 457
40 -10.600sp|Q9BRQ8|AIFM2_HUMAN Apoptosis-inducing factor 2 OS=Homo sapiens GN=AIFM2 PE=2 SV=1  ali follow..  15  3.......................................SQVSVESGALHVVIVGGGFGGIAAASQLQAL--NVPFMLVDMKDSVAALRASVETGFAKKTFISYSVTFKDNF-IDLKNQMVLLQGGEALPFSH---LILATQQAAIQAYEDMVRQVQRGGSAGVEMAA--EIKTEYPEKEVT--LIHSQVALADKESVRQEVKEILLRKGVQLLLSERVSNLEELP------LNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLA----SSGALRVNEHLQVEGHSNVYAIGD.............................................................................................................................................................. 285
41 -10.500sp|P50395|GDIB_HUMAN Rab GDP dissociation inhibitor beta OS=Homo sapiens GN=GDI2 PE=1 SV=2  ali follow..  10  1............................................MNEEYDVIVLGTGLTECILSGIMSVN--GKKVLHMDRNPYYGGESASITPL-LIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIKVPSTEAEALASSLMGLFEKRRFRKFLVYVCYETINRIKLYSESLAPYLYPLYGL---GELPQGFARLSAIYGGTYMLNKPIEEIIVQNG-----------KVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICIL----SHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESTHFETTCDDIKNIYKRMTGSEFD-----FEEMKRKKNDIYGED............................................. 445
42 -10.300sp|Q9UJX0|OSGI1_HUMAN Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=2 SV=2  ali follow..  10  76........................PAPSPPPAMSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKTEAPGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHVVLGRNLPGGAGSMVILSQGQWMGL-PDLEVKDWMQKKRRGLATAGDIAHYYRDYVVKKGLGFVSGAVVTAVEWGTPDPSSCGAQDSSPTRNQAQQPFSLWARNVVLATGTFDSARLGIPGEALPFIHHELSALEAATRVGAVTPASDPVLII------GAGLSAADAVLYARHYNIPVIHAFRRAVDDPG----------LVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRSLPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLFTYQSTRQEGLYAMGPLAGDNFVGALAVASSLLRKETRK... 558
43 -10.200sp|Q8NB78|KDM1B_HUMAN Lysine-specific histone demethylase 1B OS=Homo sapiens GN=KDM1B PE=1 SV=3  ali   16  70...................................GADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNF--GIKVTVLEAKDRIGWDDKSFKGVTVGRGAQIVNGC---------NNPVALMCEQLGISIQEGGRITDPTIDKRMDFH.......................................................................................................................................................................................................................................................................................................................... 186
44 -10.000sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   14  38.........................................SAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDAYGIEVLTEAQVVTVDVRTKKVVFK--KTLSCKGKEVENVFTIRTPEDANRVVRLARNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGE-RVGRALMKMFENNRVKFYMQTEVSELRGQEGKLK----------EVVLKSSKVVRADVCVVGIGA.......................................................................................................................................................................................................... 279
45 -9.940sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens GN=TXNRD1 PE=1 SV=3  ali   15  2.....................................NGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQY--GKKVMVLDFVTPTPLGTRWG------GGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVMIEAVQNHIGSLNWGYRKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFS-QDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLR---VAQSTNSEEIIEGEYNTVMLAIG........................................................................................................................................................................................................... 292
46 -9.830sp|P24386|RAE1_HUMAN Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens GN=CHM PE=1 SV=3  ali   14  2.........................................ADTLPSEFDVIVIGTGLPESIIAAACSRS--GRRVLHVDSRSYYGGNWASFS.................................................................................................................................................................................................................................................................................................................................................................................. 51
47 -9.750sp|Q9NWM0|SMOX_HUMAN Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1  ali follow..  12  6.............................SSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFT-DVTVLEASSHIGVQSVKLGHATFELGATWIHGS--------HGNPIYHLAEANGLLLTNHGRRIPKDVVEEFSSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGVIQLGKPVRCIHWDQASARPRGPE-----IEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPAD--------HVIVTVS------LGV---LKRQYTSFFRPGL-PTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFYGHVLSGWICGEEALVM----EKCDDEAVAEICTEMLRQFTGNPNIPKPGSYSYTQVG............. 488
48 -9.670sp|Q9NNW7|TRXR2_HUMAN Thioredoxin reductase 2, mitochondrial OS=Homo sapiens GN=TXNRD2 PE=1 SV=3  ali follow..  12  12....................GGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQL--GRKVAVVDYVEPSPQGTRWG------GGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVMAEAVQNHVKSLNWGHRV-QDRKVKYFNGITSDDIFWLKPGVVGASYVALECAGFLTGQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDS-----TTGKEDTGTFDTVLWAIGRVPD--TRSLNLEKAGVDTSPDTQKILVDSREATSVPH-IYAIGD-------------VEGRPELTPIAI------------MAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQ.... 489
49 -9.460sp|Q86VQ6|TRXR3_HUMAN Thioredoxin reductase 3 (Fragment) OS=Homo sapiens GN=TXNRD3 PE=1 SV=3  ali   14  39.........................................QEDLAYDYDLIIIGGGSGGLSCAKEAAIL--GKKVMVLDFVVPSPQGTSWG------GGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVMTKAIQNHISSLNWGYRKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFS-QEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKL...................................................................................................................................................................................................................................... 300
50 -9.360sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens GN=TXNRD1 PE=1 SV=3  ali   19  151....................................MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQY--GKKVMVLDFVTPTPLGTRWG------GGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVMIEAVQNHIGSLNWGYRV-REKKVVYEQFIGPHRIK.................................................................................................................................................................................................................................................................................................. 291
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;