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Query: sp|Q9Y2Z9|COQ6_HUMAN Ubiquinone biosynthesis monooxygenase COQ6 OS=Homo sapiens GN=COQ6 PE=1 SV=2, from H.sapiens

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYDIHFHDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLRTWGLQATNAVSPLKEQIMAFASKLast
1 -127.000sp|Q9Y2Z9|COQ6_HUMAN Ubiquinone biosynthesis monooxygenase COQ6 OS=Homo sapiens GN=COQ6 PE=1 SV=2  ali  100  1MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYDIHFHDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLRTWGLQATNAVSPLKEQIMAFASK 468
2 -50.700sp|Q14534|ERG1_HUMAN(removed signalp:1-43) Squalene monooxygenase OS=Homo sapiens GN=SQLE PE=2 SV=3  ali follow..  16  47.KEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSR----DGRKVTVIERDL-------KEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPENNQVQSGRAFHHGRFIMSLRKAAMAEP-NAKFIEGVVLQLLEEDDVVMGVQYKDKET---GDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFL--MKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEAT---------------------------------DNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLS. 467
3 -38.200sp|O15229|KMO_HUMAN Kynurenine 3-monooxygenase OS=Homo sapiens GN=KMO PE=1 SV=2  ali follow..  16  2............................DSSVIQRKKVAVIGGGLVGSLQACFLAK----RNFQIDVYEAREDTRVATFTRGRSINL-ALSHRGRQALKAVGLEDQIVSQGI-PMRARMIHSLSGKKSAIPYGTKSQYI-LSVSRENLNKDLLTAAEKYP-NVKMHFNHRLLKCN--------PEEGMITVLGSDKVDVTCDLIVGCDGAYSTVRSHL-MKKPRFDYSQQYILTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPM--------------------------ISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSND------SLCLPVFSRLRIPDDHAISDLS......................................... 360
4 -19.900sp|Q16134|ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Homo sapiens GN=ETFDH PE=1 SV=2  ali   12  21...........................................................................................................................................NYIVRLGHLVSWMGEQAEALG--VEVYPGYAAAEVLFHDDGSVKQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEIGLKELWVIDEKNWKPGRVDHTVTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHH---------------PSIRPTLEGGKRIAYGARALN----------------GFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSEN---QSKTIGLHVTE..................................................... 284
5 -19.300sp|O94851|MICA2_HUMAN Protein MICAL-2 OS=Homo sapiens GN=MICAL2 PE=1 SV=1  ali   15  71...................KRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAY----LGAKVVVVEKRDSFS----------RNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHI-----------------------SIRQLQLILFKVALMLG--VEIHVNVEFVKVEPPEDQENQKIGWRAEFLPTDHSEFEFDVIIGADGRRNTLEGFRRKEFRGKLA--IAITANFINRNSTAEAKV-EEISGVAFIFNQKFFQDLKEET...................................................................................................................................................................................................... 282
6 -19.200sp|Q8TDZ2|MICA1_HUMAN NEDD9-interacting protein with calponin homology and LIM domains OS=Homo sapiens GN=MICAL1 PE=1 SV=2  ali   11  69...................KRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELAL----LGARVVLVEKRTKFS--------RHNVLHLWPFTIHDLRALGAKKFYGRFCTGTL-------------------------DHISIRQLQLLLLKVALLLG--VEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGITANFVNGRTVEETQ----PEISGVARIYNQSFFQSLLKAT...................................................................................................................................................................................................... 277
7 -18.600sp|Q16134|ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Homo sapiens GN=ETFDH PE=1 SV=2  ali   15  56......................RWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLAHEKDIRVCLVEKAAQIGAHTLSGA------CLDPGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGL-NHGNYIVRLGHLVSWMGEQAEALG--VEVYPGYAAAEVLFHDDGSVKQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGILKELWVIDEKNWKPGRVDHT-----PLD............................................................................................................................................................................................................. 300
8 -18.100sp|Q7RTP6|MICA3_HUMAN Protein MICAL-3 OS=Homo sapiens GN=MICAL3 PE=1 SV=2  ali   11  71...................KRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSL----LGAKVVVIEKRDAF----------SRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHI-----------------------SIRQLQLILLKVALILG--IEIHVNVEFQGLIQPPEDQENERIGRALVHPKTHSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAK----EEISGVAFIFNQKFFQELREAT...................................................................................................................................................................................................... 282
9 -15.100sp|Q9Y2Z2|MTO1_HUMAN Protein MTO1 homolog, mitochondrial OS=Homo sapiens GN=MTO1 PE=1 SV=2  ali   16  2FYFRGCGRWVAVSFTKQQFPLARLSSDSAAPRTPHFDVIVIGGGHAGTEAATAAAR----CGSRTLLLTHRV-----------DTIGQMSCNPSFGGIGKGHLMREVDALDGLCSRICDQSGVHYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLT--VQEGAVEDLILTEPEPEHTGKCRVSVVLVDGSTVYAESVILTTGTFLRGMIVIGLETHP-DQPSIGLAQTLE-----KLGFVVGRLKTGTPPRI-----AKESINFSILNKH............................................................................................................................................................................................... 256
10 -13.100sp|Q9P0Z9|SOX_HUMAN Peroxisomal sarcosine oxidase OS=Homo sapiens GN=PIPOX PE=2 SV=2  ali follow..  12  2.............................AAQKDLWDAIVIGAGIQGCFTAYHLAK----HRKRILLLEQFFLPHSRGSSHG-QSRIIRKAYLEDFYTECYQIWAQLEHEAGTQL---------QTGLLLLGMKENQELKTIQANLSRQRVEHQCLEELKQRFPNIRLPRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINPGLLVTVKTTSRSYQAKSLVITA----------PWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVSQAFPCFLWL-HHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSSFVRDHLP-IESCMYTNTPDEQFILDRHPKYDNIVIGAGFS-GFKLAPVVGKILYELSMKLTPSYDLAPISRFPSLGKAH................................................. 389
11 -12.900sp|Q96CU9|FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1 OS=Homo sapiens GN=FOXRED1 PE=1 SV=2  ali follow..  13  56...........................TSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGIRVLVVERDHTYSQASTGLS-LPENIQLSLFSASFLRNIGYLLLASEKDAAAMESVKVQRQEGAKVSLMSPDQLRNKFPWINTEGVALASYGRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEYQPVECAIVINAAGAWSQIAALAGVGE-----GPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLETPLVADTSGAYFTEQEEPDPANLEVDHDFFQDKVWPHLALRV-------------------------------PAFETLKVQSAWAGYYDYN-----TFDQNGVVGPHPLVVN-FSGHGLQQAPGIGRAVAEMVLKGRFQTIDLSPFL-FTRFYLGEKIQENNII............................................ 486
12 -11.400sp|Q9H9P8|L2HDH_HUMAN L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens GN=L2HGDH PE=1 SV=3  ali follow..  11  31.................SGRPRPLCGGSRSASTSSFDIVIVGGGIVGLASARALIL--RHPSLSIGVLEKEKDLAVHQTGHNSG--IVAVEQEEIPRLQAL-----YEKGLQNGVPGLRLIQQEDIKKKEPYCRGLMAI--IVDYRQVALSFAQDFQEAGGSVLTNFEKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSRISELSGIVPFRGDY--KGNIYPVPDSRFPFLGVHFTPRMDGGPNAVLAFKREGYR---PFDFSATDVMDIIINSGLIKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILVRAQALDRDGNLVEDFVFD-AGVGDIGNRILHVRNAPS----P--------AATSSIAISGMIADEVQQRFEL................................................................. 463
13 -11.300sp|Q9UI17|M2GD_HUMAN(removed signalp:1-23) Dimethylglycine dehydrogenase, mitochondrial OS=Homo sapiens GN=DMGDH PE=1 SV=2  ali   13  4............RSVCGREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMK---DVVLLEKSELTAGSTWHAA-GINLKKIHYDSIKLYEKLSIRLATTPVRVDEFKYMTRTGWHATEQYLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMKCGALLKYPAPVTSLKARSDGTWDVETPQGSMRANRIVNAAGFWARVGKMIGLEHPLIPVQHQYVVTS......................................................................................................................................................................................................................................... 253
14 -10.900sp|Q8N2H3|PYRD2_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=PYROXD2 PE=2 SV=2  ali follow..  11  1.MAASGRGLCKAVAASPFPAWRRDNTEARGGLKPEYDAVVIGAGHNGLVAAAYLQR----LGVNTAVFERRHVIGGAAVTEEFSRASYLLSLLRPQIYTDLELKKH-MAENQKQIAQFSQKDAQVFPKYRYYEVLTAPITKVLDQGALSDAIASSATTHGASIFT--EKTVAKVQVNSEGCVQ-------VVLEDGTEVRSKMVLSNTSPQITFLKLTP-RISQLDTRSPVTKINVAVDRLPS-EDAMDGLPSHRPVIELCIPSSLDP---TLAPPGCHVVSLFTQYMPYTLAGGKAWDEQERDAYADRVFDCIEVYAPGFKDSVVGRDILTPPDLERIFGLPGG-PVPLHSGYRCPLQGLYLCGSGAH---P--GGGVM-GRNAAHVAFRDLKS......................................................................... 580
15 -10.700sp|Q9NWM0|SMOX_HUMAN Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1  ali follow..  15  3.............SCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFT---DVTVLEAS---------SHIGGRVQSVKLGHATF--ELGAW--IHGSHGNPIYHLAEANGLLEETTDGERSVLTNHGRRIPKDVVEERVVELLAEGIPAHVIQLGKPVRCIHWDQGRWDEDEQWSVVVECEDCELIPADHVIVT-GIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGS--NPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLGQREAARLIEMYRDLFQQGT................................................................... 555
16 -10.600sp|P21397|AOFA_HUMAN Amine oxidase [flavin-containing] A OS=Homo sapiens GN=MAOA PE=1 SV=1  ali follow..  12  2.......................ENQEKASIAGHMFDVVVIGGGISGLSAAKLLTE----YGVSVLVLEAR---------DRVGGRTYTIRNEHVDYVDVGGAYKEIPTDAPWEAQHADKWDKMTNINVTSEPHEVSALWFL--SGQVSERIMDLLGD-----QVKLNHPVTHVD--------QSSDNIIIETLNHEHYECKYVINA-TLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIITKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMT-QYGRVIRQPVG----------RIFFAGTETATKWSMEG-AVEAGERAAREVLNGLGKVTEK..................................................................... 469
17 -10.600sp|Q96RQ9|OXLA_HUMAN(removed signalp:1-21) L-amino-acid oxidase OS=Homo sapiens GN=IL4I1 PE=1 SV=1  ali follow..  13  24....................LLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSD----AGHKVTILEAD---------NRIGGRIFTYRDQNTGWIGELGA-PSSHRILHKLCQGLGL-KALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFYLSFAEALR----AHSCLSDRLQYSRIVGGWDLLPRAL--LSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVPLPRHMQEALWREEHDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQ-TEKDDWTVPYG----------RIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHG................................................... 511
18 -10.400sp|Q8NCN5|PDPR_HUMAN Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens GN=PDPR PE=1 SV=2  ali   15  2MFYRLLSIVGRQRASPGWQNWSSARNSTSMALPTQAQVVICGGGITGTSVAYHLSKMGWK---DIVLLEQGRLAAGSTRFCA-LTIEQKMADYSNKLYYQLSIFLAQTQDRLISLKRNAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYLSNEEPVSIPLHACEHFYLLTR......................................................................................................................................................................................................................................... 271
19 -10.400sp|Q9Y6N5|SQRD_HUMAN Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1  ali follow..  10  9SGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKR--KVGAENVAIVEPSERHFYQ-----------------------------------------------------------PIWTLVGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKN----------CIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFK--CAGAPQKIMYLSEARSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDKPGETQVISYEMLHVTPPMSPPVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVA---AQSGILDRTISVIMK...................................................................... 365
20 -10.000sp|Q16134|ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Homo sapiens GN=ETFDH PE=1 SV=2  ali   10  5..............................................................................................................................................................................................................................................................GGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHH-----------------------------------PSIRPTLEGGKRIAYEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSEN---QSKTIGLHVTE..................................................... 134
21 -9.900sp|P26374|RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens GN=CHML PE=1 SV=2  ali   25  2............................ADNLPTEFDVVIIGTGLPESILAAACSR----SGQRVLHIDSRS............................................................................................................................................................................................................................................................................................................................................................................................................ 41
22 -9.820sp|Q9UL12|SARDH_HUMAN Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1  ali   14  59...........................PSRPLPSTANVVVIGGGSLGCQTLYHLAKLGMS---GAVLLERERLTSGTTWHTA-SDVEVELLAHTRRVVEETGLFIASNRQRLDEYKRMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVARAASARGAQVIENCPVTGIRVWTDDFGVRRVAG--VETQHGS-IQTPCVVNCAGVWASVGRMAGVKVPLVAMHHAYVVTE......................................................................................................................................................................................................................................... 299
23 -9.670sp|P24386|RAE1_HUMAN Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens GN=CHM PE=1 SV=3  ali   22  2............................ADTLPSEFDVIVIGTGLPESIIAAACSR----SGRRVLHVDSRS----------YGGNWASFSFSG...................................................................................................................................................................................................................................................................................................................................................................................... 54
24 -9.540sp|P27338|AOFB_HUMAN Amine oxidase [flavin-containing] B OS=Homo sapiens GN=MAOB PE=1 SV=3  ali follow..  10  2................................SNKCDVVVVGGGISGMAAAKLLHD----SGLNVVVLEAR---------DRVGGRTYTLRNQKVKYVDLGGSYREIPSDAPWKAPLAEEWDNMTNLCVTAETHEVSALWFL--SGQVSERIMDLLGD-----RVKLERPVIYID--------QTRENVLVETLNHEMYEAKYVISA-TLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIITKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILT-----------QYGRVLRQPVDRIYFAGTETATHWSMEG-AVEAGERAAREILHAMGKIPED..................................................................... 460
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;