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Query: sp|P04424|ARLY_HUMAN Argininosuccinate lyase OS=Homo sapiens GN=ASL PE=1 SV=4, from H.sapiens

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQALast
1 -67.300PF00206.20; FUMC2_BRADU/22-352; Lyase  ali follow..  20  3IEVPSDRYWGAQTERSRQNF----IGTDRMPISLVHALGIVKLAAAQSNRELGLLDQRRASAIIRAAREVIDGSLDDHFPLVVWQTGSGTQTNMNLNEVIAHPNDHVNMSQSSNDSFPTAMHIAAASRTADLVPALGELLRALRKKEKEFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVESGIARLKVAVKELYPLAQGGTAGLNAKPRFARLFAKHVAGITKLAANKFEALASNDAYVLAHGAISSVATGLFKIANDIRLLGSGPRSGLGE-PENEPGSSIMPGKVNPTQCEAMTMVCCQVFG............................................................................................................................................................... 331
2 -26.400PF14698.6; E1ZPB2_CHLVA/384-450; Argininosuccinate lyase C-terminal  ali follow..  56  1...............................................................................................................................................................................................................................................................................................................................................................................MLATDLAEYLVRKGVPFRETHHISGAAVKLAEDRGCELSALTVADLQGIHPLFAEDVVEVWDFNRSA.............................. 67
3 -15.800PF10397.9; C7JHA0_ACEP3/358-441; Adenylosuccinate lyase C-terminus  ali follow..  6  3...............................................................................................................................................................................................................................................................................................................................................................................VHSGEVLLALAKAGLSREDAYRIVQRNAMETWTECKTFRENLDADPEISGRISPDVLDAAMDSRQHL-------KALDTQYEKI............. 84
4 -12.400PF08328.11; A4SZU3_POLAQ/333-447; Adenylosuccinate lyase C-terminal  ali follow..  11  1..............................................................................................................................................................................................................................................................................................................................SRWQRDLTDSLRNLGPAFGHSVLAYDSALRGLGKLEVNHAAIAADLDECVLAEPVQTVMRRYGIE--NPYEQLKELTRGKGINQADLQNFIRG---LKIPEDAKARLLEMTPSSYL.............................. 115
5 -5.850PF07747.11; U6EBT0_9EURY/6-75; MTH865-like family  ali follow..  17  3........................................................................................................................................................................................................................................................................................................................................HAQIVGALAGASFPLTTPEELLSAFPDGAETTCKYGDFELKAGDAGTVLTPDDFPFKSAKEVADVIV..................................................................... 69
6 -5.220PF10415.9; A9WU82_RENSM/421-479; Fumarase C C-terminus  ali follow..  12  10..................................................................................................................................................................................................................................................................................................................................................................................................GYENAAKIAKKAVAEGLTVREAVIALYLERGELTEEQLDKALDVLSMTR............................. 59
7 -5.210PF06127.11; A4VMB1_PSEU5/9-103; Protein of unknown function (DUF962 topsan)  ali follow..  15  2.....................................................................................TRFADFYPFYLAEHSNPTCRRLHFVGSLLVLAILGYALISQQWLWLLAMPVAGYGFAWV------------GHFVFEKNRPATFQYPLYSLLGDWVMFKDMLT.................................................................................................................................................................................................................................................................................... 92
8 -5.120PF06160.12; R7G8R1_9FIRM/22-573; Septation ring formation regulator, EzrA  ali follow..  9  97....................ARRRLNELSDDLALCETDVNKIHTVLDDILEQENEQRVHINALKETFRKVKKTIHENRTAYSQSYEYLETEIIA-IEKMFSKFEEWMFAS----EFNKAADQQKIKESITRLNEIVEALPSLYERAKGILPRAIDEVGYNYARAKNKGVLLEHLEVSKNLDVISDMLKNDLNRLHSGTPENVKEDLDDLEVRIAQLAEQIRLEEEAFDEVNDGLTFDSIREVNCEFDDIKSLYARVYERFGFLQDTQTRLDVLNDMQRRLDKIVLDKQVPIAYKELAQSNAGFSKEVELMKEKLNNACSDEERKGEDMMHDVRDILEHSPLDVTQLNAKLREAIDFIYTLYNNVNNLVGMAIMVENTIVFGNRYRSSCPEIDSELTRCELRDGQYTKALKIGIQCIEKMHPGAYEKLVN................................... 552
9 -4.940PF03936.16; B9RHX4_RICCO/278-543; Terpene synthase family, metal binding domain  ali follow..  10  1...............................................................................................................................................LEFAKLDYNRVQL--LHQQELCQFSKWWKDLNLASDIPYARDRMAEIF--------AVAMYFEPDYAHTRMIIAKVVLLISLIDDTIDAYATMEETHILAEAVA-CLEKLPDYMKVIYKLLLNTFSEFEKELTAEGKSYSVKYGREPSFDDYLY-NGSMTTGLPLVSTASFMGVQEITGLNEFQWLETNPKLSYASGAFIRLVNDLTSH--------VTEQQRGHVASCIDCYMNQHGVSKDEAVKILQKMATDCWKE............................................................... 266
10 -4.710PF16368.5; A0A1D5R0L8_MACMU/1-307; Cytoplasmic polyadenylation element-binding protein 1 N-terminus  ali follow..  26  274...........................................................................................................................................................................................................................................................SIEREAR----------QAAAVNEATCTWSGQLPPRKNP.............................................................................................................................................................................. 307
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.