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Query: sp|P08908|5HT1A_HUMAN 5-hydroxytryptamine receptor 1A OS=Homo sapiens GN=HTR1A PE=1 SV=3, from H.sapiens

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQLast
1 -90.500PF00001.21; HRH2_CANLF/35-288; 7 transmembrane receptor (rhodopsin family)  ali follow..  36  1....................................................GNVVVCLAVGLNRRLRSLTNCFIVSLAITDLLLGLLVLPFSAFYQLSCRWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPVRVAVSLVLIWVISITLSFLSIHLGWNSRNETSSFNCKVQVNLVYGLVDGLVTFYLPLLVMCITYYRIFKIARDQAKRIH--------------------------------------------------------------------------------------------------HMGSWKAATIGEHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDD-AINEAFEAVVLWLGYANSALNPILY...................... 254
2 -59.700PF10320.9; Q18767_CAEEL/20-275; Serpentine type 7TM GPCR chemoreceptor Srsx  ali follow..  16  1..............................................IPVGIFSNVIMIICFFVNPRLRSPFHILLTLTCLADGIHVCGQIIFVFQ--MLTNTYSYQSTCYMLNVLPVIGLTLAAPLLMQIGLDRLLAVSFPIRYRELQFQKLFYTSIHLIFPILYTISILYLGFLERNNEQVKCAIPTALAGISFKVFTL--SSHAIYVSIILAYLMTAILLKFHDTS-------------------------------------------------------------------------------------------------------------SRFKAVFKSIGVTVGIVLFGWAITTVSNTFGLFVTDDMEVYNLIQMYSGITVNIAISSNLIIFYTINPEYQLTVKMLM....... 256
3 -42.900PF10323.9; Q86DM2_CAEEL/15-294; Serpentine type 7TM GPCR chemoreceptor Srv  ali follow..  12  1..........................................FYGMSIVTLPIYFTILICLIHLRCYKTTFYSLLLQHCIADLFSMLGYIALSPAREIPFIRQFEYYIAAATYNIIYVSLYIRCTGIILLSLQRYLVITSPHSKIAIKVQTAANWKIILVYWIPPTLLNIVVLKDTNFHFDGLEDMAIVAEKIQRNTLMALIVVSITCIVSSGAYGALFSFVRKNSS--------------------------------------------------------------------------------------------------------RLSKSLRREVHLAFQVLVLLFAFFLILVFYTFLNYFSRT--QNNGPIFYMRGLYPMANGFLSYINPFCILFLNKELTRKMIKPISC..... 280
4 -41.100PF10324.9; Q7YXG6_CAEEL/40-347; Serpentine type 7TM GPCR chemoreceptor Srw  ali follow..  11  2.........................................HVNEISISSILINLVHFFILTRKPMRTSSINILMAAVAFFDIFTSLLPIEVLFERYKDLDTYGLVLTKALLTVVKDYSRRCSTWLIFFIAFIRTLIIQNPLSSKYEALGKPKASIIVITGICVVTLPISMFKFLENQFVESMPRDSCAPNTKYFYLFNSSISDIIPCILLLIVTILLVWNLFKTSKK---------------------------------------------------------------------------------------------------RTKISSVSNNRNSRGKSGLVLCVAIMFFVVECPYGLSVGSAWIFIHAPGAHNMFGAIFSMLITLNTCTHLIVCLFMSSQYRSTTIQVFSC..... 307
5 -34.300PF13853.6; D3ZCZ7_RAT/34-313; Olfactory receptor  ali follow..  18  1..........................................FCLMYIIIFLGNGTILHVIRTEASLHQPMYLFLAILALAEVGVSASTLPTVLGLFLFDTTEITFEACLLQMFFIHSFSIMESAVLLAMSVDRFVAIYSPLRYTAILTLPRIFRTGAIIGLKSVILMAPLPVLLRRLHNALSHSYCLISINNIYGLFVVTSTFGIDSLLIVVSYGLILHTVLG--------------------------------------------------------------------------------------------------------------TTGDGRKKALNTCGSHICAVLAYYVPMIGLSMVHRFAHHVSPLLQTMMANAYLF--FPPVINPIVYSIKTKEIRRVIIRMLSEK.... 280
6 -27.600PF04789.15; E3LU62_CAERE/638-942; Protein of unknown function (DUF621 topsan)  ali follow..  9...............................DWIYYLVITTFVLFTVLSTLLTGTFLLSSVYFWSSFKAMKFFFLTQLTLSVFILSTLNLVINVPATLFAHLTQDSVFYIAMSYIIDFCHYTILISNLVIAIQRFFVFFFRHLTYRVFDSLIIFGWLLSVWSVSGTVTIIMAYKKTLKHYVLNCQPLKSVVDLPPPKWIQMLELILQFGIPCLILVMYVAVVIKISI-------------------------------------------------------------------------------------------------------MKKTSLNKNEIRVLIQAIIIFILFQTSSCVFLFCQTLEF----NSATAFIIKRLINTIEIFAGAATPCFFFFTSKEIRKLLSTKISAVSSQG 303
7 -26.100PF11710.8; Q6BXX0_DEBHA/37-236; G protein-coupled glucose receptor regulating Gpa2  ali follow..  12  2....................................YTTRLLAIISSTMSIFAGIIGIYFLLAIDYKKVFRHQLIFFLILYDCIKALFLLLYPARVVAKASVYYDLNFCKVVGFFTALSIEGSDIAILSFAIHIALLVFKPNQTVKRGMSYEGGLFRYRYYVYAISILLPILLASNGMGYEPLTNWCYMPTRPLYRLVLSWIPRYLIIISIFVIYGCVYHHVTRQYSNV................................................................................................................................................................................................. 200
8 -25.500PF05462.11; CAR4_DICDI/1-309; Slime mold cyclic AMP receptor  ali follow..  15  9.....................................LTYSILVIADFSSIFGCLLVLIAFKKLKLLRNHITRVIACFCVSSLLKDIISTGLTLSLGPQNEAGSTSFQCYLYAITITYGSLACWLWTLCLAFSIYNLIVK----REPEPEKYEKFYHGVCWTIPLICVIVMLA---KKTIEPVGNWCWISEKYVGY---RFGLFYGPFFAIWIISAVLVGLTSRYTYS---------------------------------------------------------------------------------------------------VIRNSVSDNKDKHMTYQFKLINYIIVFLLCWVFAIVNRILNGL-----YYPTLPNILHTYFSVSHGFFASVTFIYNNPLMWRYWGSKIFLIFAKF 280
9 -23.400PF10328.9; P90819_CAEEL/12-272; Serpentine type 7TM GPCR chemoreceptor Srx  ali follow..  14  1..............................................FFVSLLGNSYFVYKILSTRVAINSFQKLCFVKAFSNAVISLTIIVWAVPLSAFLI-FWRNVNVGISELVASGGYIFGPLCQILMAANRVIIMYFPFWRMKISRFPSTNVAVFVCAFVSLYCSVAGMRGPCVLTYHPDTLAWSPELSTCTDSMDGLQLPIIILLTMVSIIFNFIAAFKLIYDKVAGISDVQKLKRRNKW.................................................................................................................................................................................. 204
10 -19.400PF05296.13; T2R13_HUMAN/1-300; Taste receptor protein (TAS2R)  ali follow..  10  6...................................PSIFTLVIIAEFIIGNLSNGFIVLIWVSKREL-SSVDKLLIILAISRIGLIWEILVSWFLALHYLAIFVSGTGLRIMIFSWIVSNHFNLWLATIFSIFYLLKIAS-FLYLKWRVNKVILMILLGTLVFLFLNLIQINMH-YERNTTWNFSMSDFETFSVSVKFTMTMFSLTPFTVAFISFLLLIFSLQKHLQKM------------------------------------------------------------------------------------------------QLNYKGHRDPRTKVHTNALKIVISFLLFYASFFLCVLISWISE------LYQNTVIYMLCETIGVFSPSSHSFLLILGNAKLRQAFLLVA....... 296
11 -18.600PF02101.15; W5K1T9_ASTMX/5-409; Ocular albinism type 1 protein  ali follow..  10  28.....................................FFGAICIGSAGLSLIFSVLQILPKRYPLPKPASSSRILFIISICDILGCAGIIVRSSVWLGLPGLIGPEVFCVGSAMWIQLFFSASFWWMFCYAVDVFLVVK------RSAGISTIVLYHMITWGLAVLLCVEGVAMLYYPSIS------------LQHAIPHYITTYAPMLLVLLVNPILFTRTVTSVTSLLKGRQGIYTENER-----------------------------------------------------------------------------------------------RLGTEIKIRFFKIMLVFFICWLPNLINEGLLFYLEMQTDIKKNVRNVALITWFIMGILNPLAFHGWTGLDVDLSLQP........ 326
12 -17.400PF03402.14; VR105_RAT/39-303; Vomeronasal organ pheromone receptor family, V1R  ali follow..  10  2............................................................LICGQRSR-LTDLPIGLLSLINLLM-LLMTAFIATDTFISWRGWDDIICKSLLYLYRTFRGLSLCTSCLLSVLQAIILSPRSSC-KHKPSHHISCAILSLSVLYMFISSHLLVSIIATPNLTTNDFCSILPMSYLMQSMFSTLLAIRISLMVLSTWYMVALLCRHRKQTR------------------------------------------------------------------------------------------------HLQGTSLSPKASPEQRATRSILMLMSLFVL----MSVFDSIVCSSRTMYLNDPISYSYQLFMVHIYATVSPFVFIVTEKHIVNSLRS......... 265
13 -16.500PF10316.9; P91077_CAEEL/14-286; Serpentine type 7TM GPCR chemoreceptor Srbc  ali follow..  12  1....................................MNLSAVVITSIGVLSSFLTIFMNIYFIKKITKTRNKMILF-RIFLDVAYGAIACSYMAFCILYDRFKEQQVFIVYLGFPLQTTAAIRMTIAVAISIERVLAVFTPITFHNYRHLCPTVIVLILAISLG-TLENLVLFQSCTLNLSNIPKNCGVL--FSYWASDRSAMFALNFIFSGLLSIKLIFFNKPQHGNGHKEHSKIN......................................................................................................................................................................................... 211
14 -16.200PF10321.9; Q9N526_CAEEL/3-311; Serpentine type 7TM GPCR chemoreceptor Srt  ali follow..  12  32...................................RIFLGVILIIFGIIVEILYVPCLGAIYKKKLLQHSCYKIMFLLGITDMLTTCTATILSGYLLTV-----GAVFCTVAGCFALGGWVSSCAWTLLLVINRISDMIAPRISDFLFSGNRTWALIPIPYTLSVMFFTPAIIFNSTVMAWIGDPLIYEERAQDYYNPIQNLNNVVFISGTIVLYGAYCFFMAKKTMG----------------------------------------------------------------------------------------------------------YKVSAGKNVFIQSTLICSINCSSALVYSSMMFHK--------PNEYIVLFGELAWSFVHGCPAIIYLTMNKTVRQEVLRWIRRKNPA. 306
15 -15.600PF10317.9; Q19419_CAEEL/15-306; Serpentine type 7TM GPCR chemoreceptor Srd  ali follow..  11  1......................................INIYFHFYLVSGLFFQCILMILIIRKNSLND--KLFLYNTAFCQIANILSAY--TLAVLANG--KFGPEVCFGTYHVYLGISSSVALSISTTVMFRYSLIKNW-----RLSRTSLRGLIICGHIAPFIATAIPFTTQWDFDVVRAQSV-DTRSFQFLFVTAAIAIGAYFVPLMSVFVIRKIMIVTKAHSKMSENTK-------------------------------------------------------------------------------------------------------RHTRMLMKGLACQVLLPLISYFPIITLYLVTQMTAEEFLITEHLLNIMTCF----ALVDPFISFYFIVPYRVALLK......... 292
16 -15.200PF02118.21; A8XR42_CAEBR/21-293; Srg family chemoreceptor  ali follow..  10  2........................................YYQFLYLFPATCLNYRILWTIWVSHRQFYSTQSFY-NLYSIDCLASILAMSFEILFTLSGIVGNSPIFMRIYYCSISYFKAIKPVVHIFVAINRMSCVMFPVTYSQN--SNKMCIMVFIIFAAPFLVIWNTLISRNYLGYLNGGFVITYEREVKWASLSLMQFTLVILTVLITMITTFITFHKLRNMK-------------------------------------------------------------------------------------------------------------KRIKASERSLCIAAGLISMLFLFEAVTESLFAFFKDAPWLIDIMVYIMWSTWDFLIVGSPLVLLFVSSQFRYHV........... 273
17 -14.200PF10319.9; O17354_CAEEL/1-310; Serpentine type 7TM GPCR chemoreceptor Srj  ali follow..  11  6.....................................AHYCVPKFNGFCSFLVNLFIYLIFDDTKLMLGNYRWLLLFFAIFNMTCSVLVPVCVAVFISGGPFENYSELNQLLLAVRCGFIGTTYGILHAHFAYRFLVLFRNKQLSNYFIPYGLLITIFYCLFHLSFWTITCYFYIGADLERKIYMQDPIMDIYDTGIIANTILSVASVLIYTIIGFLIIRKLRSNTLLMSKKTKRL-------------------------------------------------------------------------------------------------------QDQLMRALIVSVIPSFVSFAPTMASWYEPIIGFHLGRAVYYTASVLVST----PFFDPTAIIFFIPSFRAKC........... 310
18 -13.900PF02175.16; Q20962_CAEEL/17-252; Serpentine type 7TM GPCR chemoreceptor Srb  ali follow..  7.....................................IAQFWSFFVSLLAMPSLIFFMVEKVFKLPFHGNLKFLLVSYFIGTFLFASIICFTFGYHFFV-DLIINATLFKYGHMIALIFMTIPMILPTAFTVERFVALKMAHSYEHVRTLLGPVLVLVVIAIDSMFL----YDIYGQEKFDKPFINFILVPATSALQFNSFLWYMLYLKITNFICNLILLFIHKILHQRYRRKNVSLSVK...................................................................................................................................................................................... 212
19 -13.100PF10326.9; Q18441_CAEEL/8-309; Serpentine type 7TM GPCR chemoreceptor Str  ali follow..  3........................................TFTKCGFPTVSIINFLIFLTVFHIRRIFGTYKQMLIVIAIMGILFSAIARPFVIFFSLNTWLGADQLVLQIALAIYASFYLLMMSFISVQFLFRYYTLTNI-RVTKRFENGGVILWMLYPFICGAFYGVPLFLFGLPDEYGDEYFGEQLLVSYGLAIITGSIVMAVQYTIIIYCGIRMHLVMTREFKNSSVPNKKL-------------------------------------------------------------------------------------------------------QKQFFKALVVTIVPTFIFVCPAAFVLLCPFLNLEMNYQTGWIYAALSLY----PPLDSLVLMILVSEYRKAIK.......... 302
20 -12.200PF02117.16; SRA9_CAEEL/1-330; Serpentine type 7TM GPCR chemoreceptor Sra  ali follow..  22.....................................IAQYIDLLCIVITFVTTYPAIQLVLNKSLFQWSTKMLILESLFFANLYQIFYG-IEAITILYKHHFMTSDFCNIMQKVILGTTGGMIFAQTGLMIERTCATFLASYRKRKSEIIGFSITIIVFFCSSITG----KLFIWDDPLDGMVLGCFILPKNSYKRYNTYFTVCTVLPLFNLGISILLKIYNTKLEY-------------------------------------------------------------------------------------------------SSRFEVSARFQKREVIDSTGTVCFLAFSLFILLFIYSVGVGALRHLLHENIISQEDFNLCVVWLYT-AMLLPLLLIYRIRRTRSNRIEML....... 309
21 -12.000PF10327.9; O17171_CAEEL/5-308; Serpentine type 7TM GPCR chemoreceptor Sri  ali follow..  14  10.....................................HMIYHFYTTGTIAVCLNILVIYLILFHSGKLDSFRFYLLAFTSSDVNIAFLIQPVGLF--ICGGYGYGIL---TLMTLFTLFISIQIQVLTICFLRKHEAIMNLKSTVKSNNYWIYILTYIFCLSFSCLISFSIFIADATKEDQYKELQEHYNWRMKVFFVLTGFATLKTTVMVSFLVLRMFNALSAVKSRL-------------------------------------------------------------------------------------------------------SKNTIAKHKITLRSLVMFMVTPISYVPAFMLLVVTLFP-----EYSQQISWYSMMIATMHSILNSLVVITTYPEFRKTL........... 304
22 -11.800PF10292.9; Q9GZD4_CAEEL/4-331; Serpentine type 7TM GPCR receptor class ab chemoreceptor  ali follow..  10  18.....................................TSLGMTTLLCILCVPCTIYSFLAIQKATKLHFNSKCIFHTLTIFAFIHMIVRIILHGKDLLN---IFPSRSRCELRKLYKISAFVVEVTPFVLTAERFVATFRARHYENRYKWCGVLLNIFHISLALFLF----TIQSSEKVGGDIIYYCWMSSTGNRYMLNLPIFVIVFSQLITIPALLYLLRKNEKFRE----------------------------------------------------------------------------------------------ASLQKRSTLSQRYQLSQNLQTLTKFRIVSTVTWIYVTYNAAATFGVHFFLKSMSSAGAIIEIVHCLPLYYLIL-IFLMVKEDKKPHRQFSIKV....... 305
23 -11.000PF00002.24; GLP1R_RAT/141-398; 7 transmembrane receptor (Secretin family)  ali follow..  12  1..........................................LLSLYIIYTVGYALSFSALVIARHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYS---DSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVF----SEQRIFKLYLSIGWGVPLLF----VIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKST.................................................................................................................................................................................. 213
24 -10.600PF10318.9; Q9TXK5_CAEEL/9-315; Serpentine type 7TM GPCR chemoreceptor Srh  ali follow..  5.....................................GFSTLHIISTSISVPIYIVAFWILIFKVHFSKYRNYLVFSGLLLELHMGTIWKVTIIL--IPIMCSNSPL---QLLFVCFVYTGISAQQLFLYRMEAVVIFQNENSRLKKLVTITKFGFYIGALLITLFAILIYPDLKYQKSYKMDNCFFMNFDSNIFKIFYLICGIGTVMCFSSSFSAFTATIRYLNSVK-----------------------------------------------------------------------------------------------------IKLSVKTAALHRNFLHSLILITVHIICILCPVLIF-LGAISVVVELSQFPYIPYILLMIIQEHGAASTVTMFLTNNLLRQTIRKMLP...... 306
25 -10.100PF14362.6; C7PMA2_CHIPD/18-306; Domain of unknown function (DUF4407 topsan)  ali follow..  11  1..........................................................................MLKRAPSE--IGATIFFTGLLAAFSGGYALWTVFSSPWGAV----VFGIVWGLMIFNLDRYIVSGMKKRSRFMQEFGMALPRLVLAILIAVVISKP--------------------------------------LELKVFEKEINQELIVMEQQVFKTQEDKVKDRFQQQVNTLNAEIAQLNEGIRQQAIKVDTLQLIAQQEADGTGGSRKQNLGPIYKAKKADADSAAALLQRVTTQNGALIAQKRQQLASIDSTRQSTVGTLDRSHIDGLAS---------------LDALGHLTDRSEPVKWANWFIMLLFITIE--TAPVFVKLISP--RGPYDDLL....... 285
26 -9.950PF03125.18; Q9XUK3_CAEEL/1-363; C. elegans Sre G protein-coupled chemoreceptor  ali follow..  11  32.....................................IYLIVYGIFHLLIMYFVLKCAYICLKIRVFHWNLTCLIFSCSVQ-FIGSLMILPYESGYWILGE-PNFFNLFFLGSFLKFHYILSMGTTGLLLAVERTFACYYLTDYEKKPRIHLVVILIIGHQTFNFISAILHFFQ-------------------ILQNLVYIVLIALIPNVVSSVIFAVTENYNQKVTKTIENFANPNNYT-------------------------------------------------------------------------------------------AARYQAKENVKCFAMIKKVIFAGIGMIF-ISCSSILLIYFDVFPNHVDLLNFVFEASLNVGPSFIGPTLIHSVDAWRNYELCPF....... 320
27 -9.250PF14079.6; D2QK55_SPILD/2-113; Domain of unknown function (DUF4260 topsan)  ali follow..  20  2..............................................TLLKSEELIQFLAAIYLFSRLSFAWWWFPALLLLPDIMVGYLINP-AVLYNIAHHKGLGIVIGLIGLALSNYLMLAGVILFAHSSMDR--VAGYGLKYADSFKHTSL............................................................................................................................................................................................................................................................................. 110
28 -9.140PF11600.8; H2VC85_TAKRU/240-396; Chromatin assembly factor 1 complex p150 subunit, N-terminal  ali follow..  33..............................................................................................................................................................................................................................KKKEEARKIKEERQREKREKKEKEERERREKKEKDEKEKAERLKAKEDLKKSKLEAKQEEKRKKEEEKRMKEEEKRLKEEKDRLKAEKAEITRFLQKSKIQQAPKTLAAACGKFAPFEIKENVYL........................................................................... 157

FFAS is supported by the NIH grant R01-GM087218-01
1 3 6 9 2 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A,Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15;393(Pt 2):503-11.