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Query: sp|P04424|ARLY_HUMAN Argininosuccinate lyase OS=Homo sapiens GN=ASL PE=1 SV=4, from H.sapiens

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQALast
1 -130.000d1tjva_ a.127.1.1 (A:) Argininosuccinate lyase/delta-crystallin {Domestic duck (Anas platyrhynchos), delta-crystallin [TaxId: 8839]}  ali model 3D-neighbors follow..  70  1................TDPIMEKLNSSIAYDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYDHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAGNPLDIDREMLRSELEFASISLNSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFGFLTLSDAFSTGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKALTPEMLATDLALYLVRKGVPFRQAHTASGKAVHLAETKGITINKLSLEDLKSISPQFSSDVSQVFNFVNSVEQYTALAGTAKSSVTTQIEQLRELMKKQKE 448
2 -100.000d1re5a_ a.127.1.1 (A:) 3-carboxy-cis,cis-muconate cycloisomerase (CMLE) {Pseudomonas putida, strain KT2440 [TaxId: 303]}  ali model 3D-neighbors follow..  19  1.....NQLFDAYFTAPA-------MREIFSDRGRLQGMLDFEAALARAEASAGLVPHSAVAAIEAACQAERYDTGALANAIATAGNSAVKALGKVIATGVPEAERYVHLGATSQDAMDTGLVLQLRDALDLIEADLGKLADTLSQQALKHADTPLVGRTWLQHATPVTLGMKLAGVLGALTRHRQRLQELRPRLLVLQFGGASGSLAALGSKAMPVAEALAEQKLTLPEQPWHTQRDRLVEFASVLGLVAGSLGKFGRDISLLMQTEAGEVFEPAPGKGGSSTMPHKRNPVGAAVLIGAATRVPGLLSTLFAAMPQEHERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGMEVDAARMRRNLDQGLVLAEAVSIVLAQRLGRDRAHHLLEQCCQRAVAEQRHLRAVLGDEPQVSAELSGEELDRLLDPAHYL-------GQARVWVARAVSEHQRFTA.... 448
3 -93.400d1c3ca_ a.127.1.1 (A:) Adenylosuccinate lyase {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  15  1....................VERYMKDLWTEEAKYRRWLEVELAVTRAYEELGMIPKGVTERIRNNAKIDVELFKKIEEKTN---HDVVAFVEG-IGSMIGEDSRFFHYGLTSSDVLDTANSLALVEAGKILLESLKEFCDVLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKISGAVGNYANVPPEEEKALSYLGLK--PEPVSTQVVPRDRHAFYLSTLAIVAAGIERIAVEIRHLQRTEVLEVEEPRKGQRGSSAMPHKKNPITCERLTGLSRMMRAYVDPSLENIALWHERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNIDGLVFSQRVLLKLIEKGLTRKEAYDIVQRNALKTWNSEKHFLEYLLEDEEVKKLVTKEELEELFDISYYL-------KHVDHIFERFEK........... 429
4 -86.000d2j84a_ a.127.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  13........LASRYASPE-------MCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLEN-IDFKMAAEEEKRLRHDVMAHVHT-FGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFEGDDHKVEQLDKMVKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKE-MEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGIERIQVDAYFSPIHSQLDHLLDPSSFT-------GRASQQVQRFLEEEVYPLKPYES 470
5 -84.700d1dofa_ a.127.1.1 (A:) Adenylosuccinate lyase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  15  3......SPFDWRYGSEE-------IRRLFTNEAIINAYLEVERALVCALEELGVAERGCCEKVNKASVSADE-------VYRLERETGHDILSLVLLLEQKSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIRAGAVGTMASWGELGLEVRRRVAERLGLP--HHVITTQVAPRESFAVLASALALMAAVFERLAVEIRELSRPEIGEVVEGG---GGSSAMPHKANPTASERIVSLARYVRALTHVAFENVALWHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITENLQPYILTEFHMNRMIKEGASRAEAYKKAKEVKALTFEYQKWPVERLIEDALSLK............................................... 400
6 -84.000d4adma_ a.127.1.0 (A:) automated matches {Mycobacterium tuberculosis [TaxId: 83332]}  ali model 3D-neighbors follow..  16  12VRVPAKALWRAQTQRAVEN-----ISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQCIAGLTANVEHLRRLAESSSIVTPLNSA-----IGYEEAAAVA----KQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE........................... 459
7 -80.600d3bhga_ a.127.1.0 (A:) automated matches {Legionella pneumophila [TaxId: 272624]}  ali model 3D-neighbors follow..  13  10........IDGRYVNKTRA-----LSPYFSEFALTYYRLMVEIKWFESLAANDTIPEVPALDNKARKFLSDLEAEKIKEFEKQTNHDVKAVEYYLENEQLKSCVAFIHFACTSEDINNLAYALMIKQAIAQIQPTIAEIMGSITLLGKQHADVAMLSRTHGQPATPTTMGKELVNFVARLKRPQQQLAEVLIPAKFNGAVGNYNAHVAAYPEVDNFVTSLGLS--FNAYTTQIEPHDGIAEVSQIMVRINNILLDYTQDIWSYISLGY-FKQKTIAEEVGSSTMPHKVNPIDFENAEGNLGLSNALFIHFANKLTQSRMQRDLSDSTVLRNLGVAFSYSLIAYHSVAKGNDKLQINKSALQKDLSENWEVLAEAIQTVMRRYNEPNAYEQLKELTRGQMIDAENLKKFIKTLSIPEEAK---AELMKLTPETYT-------GLATQLVKAF............. 453
8 -73.700d1jswa_ a.127.1.1 (A:) L-aspartate ammonia lyase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  14  15REVPADAYY-GVHTLRAIENFYISNNKISDIPEFVRGMVMVKKAAAMANKELQTIPKSVANAIIAACDEVLNNGKNMNTNEVLANIGLELMGHQKGEYQYLNPNDHVNKCQSTNDAYPTGFRIAVYSSLIKLVDAINQLREGFERKAVEFQDILKMGRTQLQDAVPMTLGQEFRAFSILLKEEVKNIQRTAELLLEVNLGATAIGTGLSPLAVKKLAEVTGFPCVPAEDIEATSDCGAYVMVHGALKRLAVKMSKICNDLRLLSSGPRAGLNEINELQAGSSIMPAKVNPVVPEVVNQVCFKVIGNDTTVTMAAEAGQLQLNVMEPVIGQAMFESVHILTNACYNLLKCINGITANKEVCEGYVYNSGIVTYLNPFI---------GHHNGDIVGKICAETGKSVREVVLERGL----LTEAELDDIFS................................... 458
9 -5.850d5c05a2 a.128.1.0 (A:269-596) automated matches {Thymus vulgaris [TaxId: 49992]}  ali model 3D-neighbors follow..  11  1..........................................................................................................................................MNPIIYELGKIDFHIIQE--TQLQEVQEVSQWWTNTNLAEKLPFVRDRIVECY--------ALGLFEPHEYGYQRKMAAIIITFVTIIDDVYDVYDTLDELQLFTDAIR-SISTLPYYMQVCYLAVFTYASELAYDILKDQGFNSISYLQRPTLAEYLE-NAKVSISSPTIISQVYFTLPNSTERTVVENVFGYHNILYLSGMILRLADDL--------GTTQFELKRGDVQKAIQCYMNDNNATEEEGTEHVKYLLREAWQE---MNSAMADPDCPLSEDLVFAAANLGRTSQFIYLDGDGHGVQHSEIHNQMGGL......... 322
10 -5.780d2e1ba2 d.67.1.2 (A:88-216) AlaX-M trans-editing enzyme, C-terminal domain {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  16  12.....................................................................................HTGLHLLEHVLNEVLGEVGSGMSVEKGRYDIAYPENLNKYKEQIISLFNKYVDEGGEVKIWWEGDREVIPCGGTHVKDIKEI--GHIKKLKRSSIGRGKQRLEMWLE................................................................................................................................................................................................................................................................................ 129
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.