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Query: sp|Q8WXG1|RSAD2_HUMAN(removed signalp:1-15) Radical S-adenosyl methionine domain-containing protein 2 OS=Homo sapiens GN=RSAD2 PE=1 SV=1, from H.sapiens

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VFRQPLSSLWRSLVPLFCWLRATFWLLATKRRKQQLVLRGPDETKEEEEDPPLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGMEKINFSGGEPFLQDRGEYLGKLVRFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISCDSFDEEVNVLIGRGQGKKNHVENLQKLRRWCRDYRVAFKINSVINRFNVEEDMTEQIKALNPVRWKVFQCLLIEGENCGEDALREAERFVIGDEEFERFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYIWSKADLKLDWLast
1 -56.300[H] COG2896 Molybdenum cofactor biosynthesis enzyme  ali follow..  16  13.............................................TEPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAEHPKKDLLTLEELDRLCSVFIEKGVRKLRLTGGEPLVRKNIMHLIGNLSRHLKSGALDELTLTTNGSQLARFAGELADCGVRRINVSLDTLNPEKFRTITRWGDLSRVLEGIDAAQKA----GIHVKINAVALKDFNDAEIPELIRWAHGRG---MDVTLIETMPMGEIEFDRTDQY-LPLSQVRADLASQFTLAD-IPYRTGGPARYVTISETGGRFITPMTYNFCESCNRVRLTCTGMLYMCLGQNDDADLRKALRESESDEHLSQ. 309
2 -56.300[H] KOG2876 Molybdenum cofactor biosynthesis pathway protein  ali follow..  15  40...........................SQEVSRRRQFLREHAAPFSAFLTDSFGRQHSYLRISLTEKCNLRCQYCMPEEGKANLLTTEEILTLARLFVKEGIDKIRLTGGEPLIRPDVVDIVAQLQRLE---GLRTIGVTTNGINLARLLPQLQKAGLSAINISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYN---PVKVNCVVMRGLNEDELLDFAALTEGLP---LDVRFIEYMPFDGNKWNFKK--MVSYKEMLDTVRQQWPELEKVPEEESSTAKAFKIPGFQGQFITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLRDHLRAGASEQELLR. 353
3 -47.100[R] COG0535 Predicted Fe-S oxidoreductases  ali follow..  13  6......................................................RGPTHVDFNLTNGCNLACSHCHSASGPDNELKTEEILQTIDALHIIGALKIAFAGGEPFIRRDIFNILSHACSLP-----WGISVITNGFYLNSLTVEKLKAPNLSINISVDGSTPAGYSTLRKQLNRQPLFERVLSGIDNVVRSGMSNSVNFTITKATLHDATYELVDRIGADNMVAIKFFPGGY------GKEHLDLYEIPYDMWDEHFVALTRAKLGGKLEGDVAGISELCISSDGEVYPSVGEKTMSCGNLREHSLQRIWQES......................... 324
4 -44.700[R] COG2100 Predicted Fe-S oxidoreductase  ali follow..  12  108..................................................GLIDRGTNLIQVRGSTGCNMRCIFCSVDEGVVDIDYLLKWFDWVAKEKGKGLEAHLDAQGEPLLYPF---IVELVQALREHPHVSVISMQSNGVLLNDKLVEELEAGLDRVNLSIHSLDPEKAKMLMGIKDYD--LNHVLEMAEALVNAGIDVLIAPVIMFGVNDDEAEAFIEFARRIGAGKPALGFQNYIPYKFGRNPVIAKPVPFKEFYRWLRELEEKTGMKPLILKPHHFGMYPRPFIPLAFKRG-------EVVKAEVILPGRIEGEMIAKARNRLIQVINSNAKVGDRIK. 403
5 -42.600[R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme  ali follow..  11  34......................................................VRGEKLVLFVTGVCPRNCFYCPLSPWRANERPVRSEKDIIEEAKIQDARGAGITGGDPLARLSTVEYIRLLKEEFGKK--FHIHLYTTGILASEEALEKLYDGLDEIRFHPDLFQPN-----------SKFFEREIENMKKAFDFGWDVGGEVPAVPGFEDRWFASLLDKLGAKFLNINELEFSETN......................................................................................................... 217
6 -35.800[R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)  ali follow..  16  3..........................................................ITAKPTSYQCNLKCDYCFYLSKHKGWMTEETLETFIERYISASGHDVYFTGGEPTMA-GLDFFEKAIQYQNRYKGTKKIALQTNGILLDDAWCLFLRENHFLVGVSIDG-PKELHDRYRVTRSGKGSFDKVMAGIEQLKKHQVEFNTLTVINRINVKYEVYRTLKSIGAKHIQFIELLETTEPNSNQKSTFELIEFTVPAVDYGHFMAEVFKENGHTSCVFQKSCKNNFVMESNGDIYECDHYPEYKIGNIYHDKLDSLASDKLSAQKE................... 308
7 -35.100[R] COG1964 Predicted Fe-S oxidoreductases  ali follow..  17  93..................................................NNHKSHTALLNIVLTNRCDLACWYCFFYAREPTIEQIREMVRKAKNMKPIGCNAVQLTGGEPTLRDDLIDIIRMIK----EEGYDHIQLNTNGIRLAEDALRVRVAGVNTVYLSFDGVDEKTN---------PKNHHEIPKILENCRRAQLGLVLVPTVIKGVNDHQLGDIIRFAAENIDIVRGVNFQPVSLVGSMPRKEREQFRITIPDCIKAIEEQTN............................................................................ 308
8 -34.800[R] COG5014 Predicted Fe-S oxidoreductase  ali follow..  18  76..........................................................GIVTADTVGCKFLCAYCWNYFRAGDFLSPEEVERLLEISKKRKCDLFRISGAEPILGRRAEHVRKVIELVNNT-----FILETNGLMFDPSLVDLFVNLNVLIRVSVKGWDEESFEKITGASG-----EYFRYQLKALEHLHGKVHFWVAVVYLFREKGLKELEKRLPIPC..................................................................................................................... 247
9 -27.800[C] COG0731 Fe-S oxidoreductases  ali follow..  10  87...........................................................LQMTPTLICNQRCLFCWRPTPGEWDSPEKIVEESIACQRKL-NNVAISLSGEPTFYPYLPELIEEYEKRGF-----TTFLVTNGTV--PSMLAKVNP--SQLYMSLDAPDLKTYLRVCQPKS-PALWDRINESLDIMKDKCSRTVIRTTLVKGENIFNPKGYAELIKRASPDFVEIKAYMHLGFSRLRLDRSA--MPTHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDG...................................................... 333
10 -25.100[R] COG2516 Biotin synthase-related enzyme  ali follow..  11  28..........................................................YLMTYYEGRCINDCKFCAQARSSRAVWPAFELETVLKNFSKGNFKRICLTIDYPNMLSDVFSLLEELSKLNVPIS------LSITPVPRSELEEFSTLGVDYIGVGLDAASERVYKDVKISR---YSWDDMWKFFDDVLSVFGKGRAVVIVGLGETDKEIVETIGEVYKKG-SLFAFTPIKGTQMENFSPPPLERYRKIQVAHYLIKTGEAELEDFEFDEFGNLIG.............................................................. 257
11 -21.800[R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins  ali follow..  12  126................................................................FSGCNFRCVFCISQFRIGVEYLPEYMAIKIEKAFQLGARNVNFVGGEPTPN-----LPFILETLRYVRVPIPIVWNSNM-YMSEEAMKLLDGVVDIYLGDFKYGNDRCAMKYSKVPRYWEVVTRNFLLAK--EHFRAEFLIRHLVMPNHLDCCTKPILRWIAENLGREIRVNVMFQRPEYKAIEYDEIARTLTLDEMREAEKITKKL........................................................................... 329
12 -21.800[O] COG1180 Pyruvate-formate lyase-activating enzyme  ali follow..  10  79................................................................TYGCNWMCMYCQNSQRRKAEGVELSPEEIVELAMGYDVDGMTYTYNEPAIF--SEFAHDVGIVAKRYG--LFNTMVSNG-YWTPNLVDYVKDFLDAVTIDFKGNGEQKFLRRY---TGATSAEPIIETASELSKKGIHVEITDLIIPQDDLQAAKQLLTKLYDQLGADIPIHFLRFHPDYKLNYIPWTPVETLERHYKLAKELGFKFVYVGNVPGHPYENTY............................................................ 297
13 -20.900[S] COG1856 Uncharacterized homolog of biotin synthetase  ali follow..  15  3.VFGVIQELDVELNEKLVEKLIEGFEIRKKNFGDKVFFYSPGFKHYEVEDFSVNSPPKFVDISVTGRCELMCDHCASKWHMIPATTPEELVKVGEDLKKKGIEGVLISGGSDKNFVPLWDFFDAMKYLKEE---LGFLLTCHVGLVDEDYVEKLKENVDAVLLDIIGDNETIAQVYKLPH---KSVEDYDRSLRLLKEAGLRIVPHVIIGKIKGEYNAIDMIAKYEPDALVLVVVMPYYGKAKFQ..................................................................................................... 249
14 -19.700[E] COG1509 Lysine 2,3-aminomutase  ali follow..  13  114......................................................RYKDKVLLLATDRCPVYCRFCTRSLKKKVSPFQSRWDTILAYLRV-VIADVVVSGGDCFRLKP-SRLLAIGMGLLSIPSIRRIRFATKGLAVLPMKITSDHKWTDAL-VNISDAGRDQGVEITHFNHPREITDYTIAAAELLFKRGIRMRNQSVLMAGVNDDQLVKKLSDLHIQPYYVYTCDLVDGIEHMRCSVRLACQIE........................................................................................... 331
15 -19.200[R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif  ali follow..  11  18......................................................RCISLLKILLTNFCIYDCAYCSSSNVERARFTAEEVVWLTLEFYRRNIEGLFLSSGII--DHTMEEMVRVARELRVTHGFRGYIHLKSIPEASPRLIEEAGLYADRLSINIELPTDSGVSRFAPEKQPANIRRSMADIRLKIEEAPAGQSTQMIVDDSTILSTSARLYGSYGLRRVYYSAFSPIPDSSKNLPLIKPPLMREHRLYQADWLYRFY.............................................................................. 255
16 -18.900[O] COG0602 Organic radical activating enzymes  ali follow..  13  31...................................................................CPVGCAWCTKESDKWGAASSEDLLAVINRQ-GYTARHVVITGGEPCIHDLMPLTDLLEKS-------FSCQIETSGTHEVR------CTPNTWVTVSPKVNMRGGYDVLSQALERAN-------------------EIKHPVGRVRDIEALDELLATLSDDKPRVIALQPISQK......................................................................................................... 194
17 -18.100[H] COG0502 Biotin synthase and related enzymes  ali follow..  12  1MLAEKLQINSITPHPSVEYWSVCKVEALFETPFLELVYRATQVHRKHFNPRAI----STLMSIKTGGCPEDCSYCPQSARYHTLLDVDEIVAKAKIAKARGAGRFCMGAARGPKPKDIEKVTEIIKAVKSLGLETCGTF---GLLQDGMAEDLKEAGLDYYNHNLDTAPEHYAEVIGT-----RRFDDRLSTLGKVRKAGLKVCCGGIVGMNETRKERAGLIASLA........................................................................................................................ 223
18 -17.700[HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes  ali follow..  15  7AEITDYLNEKITKKDALELFSLPIHAVGRIADEIR-----------KVKCGDLVTFVNDTNINYTNICLSKCRFCFYAREKGYVLSHEEILRKVGYAVKMGATQIMLQGGM---DLGLEWFEELFRKIKARFSSVHIHSLSPRSSIREVLDRLKAAGLDSLPGG--GAEILVDSVRRKISPNKCSSDEWLRVMETAHSLNMPTTATMMFGHVESDGDIVEKIRELQEKTGGFTAFIPWTFQPGNTELYAEIKRPVSPLRYLQVLA................................................................................. 271
19 -17.200[H] COG0320 Lipoate synthase  ali follow..  90...............................................................LGAICTRRCPFCDVAHGRPVTPDANEPEKLAQTIQDMGLRYVVITDRDDLRDGGAQHFADCISAIRAKNPTIKIETLV-RGRMDRALDILTATPPDVFNHNLENV-PRVYRQVRPGANYDWSLKLLERFKE--AHPDIPTKSGLMVGLGETNAEIVEVMHDLRRHGVTMLTLGQYLQPSRHHLPVQR----YVSPAEFDEMKAEAMAMGFTHAACGPFVRSSY............................................................ 309
20 -16.400[H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases  ali follow..  16  7.......................................................PPLSLYIHIP--CVQKCPYCFNSHAQKGHIPEQDYIAHLDSIQDRSLHSIFIGGGTPSL-EGIHTLLSGVAQCLPFQPDIEITLEANGTAEAERFKGYVQAGVTRISMGIQSFNDDKLVRLGRIHNAQEAKSAVGFAKLSGLK-SFNLDLMHGLPNQTLEEALSDLAIALEPPHLSWYQLTIEPNTMFAYRPPVLPDDDALWD........................................................................................ 225
21 -16.200[H] KOG2672 Lipoate synthase  ali follow..  13  127...............................................................MGDTCTRGCRFCVKTSRRPGPLDPNEPENTAEAIKQWNLGYIVLTDRDDLTDLGANHIAKTIQKIKEKAPHILVEALTPDFSGRMDLVEIVKSGLDVFAHNVETVEELTPFVRDRRATYRQSLSVLKHVKKT--CPHLITKTSIMLGLGETDAEILTTLKDLLEHNVDVVQYMRPTKRHLKVQEYVHPKKFEYWKEVAEKL.................................................................................. 332
22 -15.900[H] KOG2900 Biotin synthase  ali follow..  10  6.IRQQIRRSSALSLV--NNWTREEIQKIYDTPLIDLIFRAASIHRKFHDPKKV----CTLLSIKTGGCTEDCKYCAQSSRYNTLMKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNRTFKNILEIIKEVRSMDMEVCVTLGMLNEQQAKELKDAGLTAYNHNLDTSREYYSKIIST-----RTYDERLNTIDNLRKAGLKVCSGGILGLGEKKHDRVGLIHSLATMPTHPESVPFNLLVPIPGTPVGDAVKERLPIHPFLRSIA................................................................................ 268
23 -15.100[R] COG1242 Predicted Fe-S oxidoreductase  ali follow..  11  20.............................................NYCLREEFGQKTYKVALDGGFDCPNRCTFCAAGSGDFAGNRALDLKVQFQQVRDK--KCIAYFQAFTNTHAPVAELREKFETVLNEPGVVGLSIATRPDCLPDDVVEYLAETYLWLELGLQSAHDETGRLINRAHD----YDCYLEGVRKLQKHNIRICTHIINETPEMMMETAQKVVESGVDGIKIHLLHLLKGTPMVEDYKKGDLEFLTRDGYVNLVADQLEILPPEM....................................................................... 268
24 -15.000[C] COG1032 Fe-S oxidoreductase  ali follow..  10  246.............................................................VEVMRGCGVGCDFCEVTLRPLRYMPLNMIVDEIKINVAGGVDNAWLHKHGHFFEPNEEALSELFSTVMSVPGVKTSNPTHGRIAGYPEMMEKLSKILKAIQTGLETGSEELAKKHMPNKTLPLRIDIVWQGVFVETRNYWRSAFTIQVQEGETPEDLWETIALINKLS-FEFTVTPLVNVPLGRIKSKKLNTSMLDVNGLAVYYASYRHLAKMAARD.................................................................... 494
25 -14.500[R] COG1244 Predicted Fe-S oxidoreductase  ali follow..  13  23................................................................TIGCYRYCYMCSYPAQAPKKTSQERILSHFLEAVHK--SIRIFTSGSFFDSAEVDTRIRIFREISKLDNVYEVVVETRSEIIREDWVRELAEMVEEVAIGLESANDDI---ADVSINKGSTFNDFVRASEIIHNAGAKVKTYLLLK-LSERDAIEDVKFSIE........................................................................................................................ 200
26 -14.300[R] COG0820 Predicted Fe-S-cluster redox enzyme  ali follow..  14  70.....................YVSEAQHSADGTIKWAMRVGDQDVETVYIPEDDRATLCVSSQV---CALECKFCSTQQGFNRNLRVSEIIGQVWRAAREPITNVVMMGGEPLL--NMKNLIPALEIMLDDLGFRRVTVSTSG--VVSGLEQMIGQIDVALAISLHAPNDKLRSEINDRWNIEAFLEVVRRYIASSNANRGKVTVEYVLLDHVNDEHAHELAELLKGTPCKI-NLIPFNPYPGSPYKKPSNSRIDRFQKTLMQ................................................................................... 325
27 -14.000[KB] COG1243 Histone acetyltransferase  ali follow..  13  26...................................................................CHGKCVFCIENDYDPFHQVQSRLRQYVENGHTPSKVELIIMGGTFLSPSFVYLEDAQVKNEKAEVRCVGMTIETKPDWAKEWHADQMLRGATKVELGVQTVYDDILKFTNRGHT----VKDSIESTRILKDSGFKVVYHVMLDPDKDLEAFKTIFSNFRPDMLKIYPTLVVETAPLANLWRRGLYKPYGTETLIELISEMYRYIPKWV....................................................................... 285
28 -13.500[BK] KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase  ali follow..  12  28LLKAHEAKKDVNLNRMKSLVASKYGLDSSPRLVD--IIAAVPQDAKKILLPKLRAKPIRTASGIA--TGNICVYCIRSRYDPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMCLPSANVAEAVRYSEKSRTKCIGITIETRPDYCLKRHISDMLSGCTRLEIGVQSVYEDVARDTNRGHT----VRAVCESFQLGKDAGYKIVTHMMLPNVDFERDIEQFNPAFRSDGLKIYPTLVIRGTGLYELWKTGRYKSYPPSMLVDLVAK................................................................................ 353
29 -13.500[J] COG0621 2-methylthioadenine synthetase  ali follow..  13  115.........................IVDKETSGLSQVDISFPEIEKFDHLPPARVEGGAAFVSIMEGCSKYCSFCVYTRGEEFSRPLNDVLTEIANLAQQGVKEINLLGRGEMDDGEICDFATLLRIVHEIPGIERMRFTTS---FTDSIIECYRDLVSHLHLPIQSGSDRVLSAMKRGYTALEYKSIIRKLRAIRPDLCLSSDF-IVGFPGETEREFEQTLKLVKDIAFLSFVFIYSPRPGTPAANLPDDTPHEEKVRRLEALNEVIEAETARINQTMVGTVQRCLVEGISKK.................................................... 395
30 -12.100[T] KOG2492 CDK5 activator-binding protein  ali follow..  11  187......................RLVAVAAGGSNGINVQLSLDETYADVQPIRVDSASKTAFISIMRGCDNMCTYCVFTRGRERSRPIESIVEEVQRLRDQGYKQVTLLGRDMT-KSGGLTFTTLLEKVADAAPDIRFRFTSP---FPMQLIELIASRCKQLHLPAQSGDDETLERMERGYTRDLYLRLVDDIRHVLPSVSLTSDF-IAGFCGETEQAHQNTLSLIRAVRYSFCFVFPYSMRGKTRAHHRLTDDVDVKARRHLDLTTVFREEALKLNQALIGSEQTVLLEGKSKR.................................................... 495
31 -12.100[R] KOG4355 Predicted Fe-S oxidoreductase  ali follow..  12  197..................................................PKIRKNPLIEIISISTGCLNACTYCKTKHARGNLASIDELVDRAKQSFQEGVCEIWLTSGRD-IGTNLPTLLWKL--VEVIPEGAMLRLMTNPPYILEHLEEMAKRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDI-ICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYS.......................................................................... 428
32 -11.900[C] COG1031 Uncharacterized Fe-S oxidoreductase  ali follow..  15  174.........................................................VICEIEVSRGCERRCSFCTEPHGRLKSRDVQAILKEIESLYRAGCRAFRFGRAANILAEILEELYSGTREVAPHLEVLHTDNANPSYLVTYETIVRYNTPGDVFSFGVESFDENVLKKNNVQGSPEEFLKAIAVVNEIGGVRKLLPGVNLIF-PGETEETLKKNYSYLKRRRINIRKLLAYPGTPVYEYLKNKKHR--IKSYLHDQWKRRIRE............................................................................ 422
33 -11.700[L] COG1533 DNA repair photolyase  ali follow..  11  11..RSAGINPSGRFEPVSRHVFDDGWSSLEELPPFKTEVQVE-KPRTIITRNESPDISFDRSINPYRGCEHGCVYCFARPETKLFAKPDAARLLDKELSKEGYQPRTIAIGDPYIEKQYRIMREILEVLEARG--HPVGIVTKSALVTRDLSRMAERGLAKVALSVTTLDRMLARTM---EPRASTPTKRLEAIRQLSDAGIPTSVMVAIIPGLTDQEMERILDSAYAAGAREAGYVVLR........................................................................................................... 263

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sikora S, Godzik A. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein Sci. 2004 Mar;13(3):786-96. Epub 2004 Feb 06.