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Query: gi|13507745|ref|NP_109694.1| thymidylate kinase MPN006 [Mycoplasma pneumoniae M129], from M.pneumoniae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKQGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAMEPLTEAYLFAASRTEHVRQLIQPALQQKQLVIVDRFVWSSYAYQGLIKKVGLDVVKKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVKKQADFNTMRQYYHSLVDNKRVFLLDGQNQTGCLEQFIEQLSQCLTQPTLSLast
1 -85.100[F] COG0125 Thymidylate kinase  ali follow..  33  2..SGLFITFEGPEGAGKTTVLQEIKNILTAE--GLQVMATREPGGIDIAEQIREVILNENMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSPLAYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGS-REKNRLDLEKLDFHKVQEGYQELMFPERFHSVDAGQSKDLVVQDVLKVIDEALKK... 209
2 -54.200[F] KOG3327 Thymidylate kinase/adenylate kinase  ali follow..  16  1......................................MNFPERSSSIGQVINSYLTNSDLPDEVIHLMFSANRWEHINQ-VKEKLLEGTTLVVDRYSFSGVAYSA-AKGLDFDWCYAPER---GLIKPDAVFYLRAPPNDLTHRGQYGK-----ERYEKVE-FQGRVAEVFNRICSGSYFHQFDARQSVEDLHAQIASITEELLPK... 161
3 -37.400[C] KOG3877 NADH:ubiquinone oxidoreductase, NDUFA10/42kDa subunit  ali follow..  14  80.ENSKVICVEGPIAAGKSKFAKELAEELDME--YYPAVDLDLIYINSYGYDMRKLDPQSHDLAAQFQIRMYMLRYSQYIDALQHVLSTGQGVVLERSPYSDFVFMGYLSRGARSVYNELRQNTIGELKPHLVIYLDLPVDAVKKQIKARNVDYEVQSKVFSDAYLSDLEQLYKQQYLKDELLIYDWTAETEVVVEDIERIDFNQFEADIH 317
4 -31.300[F] COG1428 Deoxynucleoside kinases  ali follow..  12  4.VGNKVIVLAGMIGAGKSSYTELIANEL-----GTKAFYESIKDNRILEMFYDDP-FALQIYFLNTRFRSIKAALTDQNNVLDRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEELAYMPKKAPDLLIYLRGSLDTVLSRISLRGRPYEQTFDNPGLLDYKHLHSRYDSWFDKSDTLVINIDENKPSDAKYVMQLIHEKLKR... 214
5 -19.300[F] KOG3079 Uridylate kinase/adenylate kinase  ali follow..  15  32LMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDE-PDSQYGELIEKYIKEGKIVP-----------VEITISLLKREMDQTMAANAQK---NKFLIDGFPRNQ--DNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSS--GRSDDNRESLEKRIQTYLQSTKPGKVKKIDASKSVDEVFDEVVQIFDK....... 226
6 -18.500[F] COG2019 Archaeal adenylate kinase  ali follow..  11  1....MRSVITGVAGVGKTTVLDIVARESGIPVVN-------------YGTLMFEVAKRRGLVENRDQIRLSRETQVDLQKLAGEEIGKMENAIVDTHM-------------PFGYLPGLPEWVLRSINASVFVIIEADPAIIKRRRDNDPTRAGVDSIREHQEMNRYFAAAYSIFSGATVKIVKNEEGKPEQAADEIVRVIK........ 181
7 -16.800[P] COG3709 Uncharacterized component of phosphonate metabolism  ali follow..  13  12LSPGTMIVIVGPSGAGKDTLMDYAAAQLSGRP-----VITRSC---DAGGENHDAVSMHEFNQLEDAGAFAVSWQAHIPAAVYRHLEAGDVVIAN---------------GSRSALPHFGTAFSR-----KVVNIVARPDVLARRLEQRGR-------ESRDDILRRLERSSLAVAGDFDVTTVDNSGAIEDAGKTIMQVLQQSAGSS.. 197
8 -16.300[V] COG3896 Chloramphenicol 3-O-phosphotransferase  ali follow..  16  20MPEGKLILLNGGSSAGKTSLALAFQDLAAECHIGIDLFWFALPPEQLDLARVRPEYYTWDSAVEADGL-ILDLAMHSRYRAIRAYLDNGMNVIADDVIWTREWLVDALRVFEGCRV--------------WMVGVHVSDEEGARRELERGDRHPGWNRGSARAAHADAEYDF----------ELDTTAPVHELARELHESYQA....... 209
9 -16.000[R] COG0645 Predicted kinase  ali follow..  14  2....FLAVTHGVSAVGKSQVAMRLVEALGAVRLR--------------SDIERKRLFGEQPEHDRGQFIYSSQASEHLHQLAAKILQAGYPVVID------------AAYLKQNQRQAACHIAEETGVPFLILDCQAPEAVIAGWLAQR-QAEGKDPSDATLDVIRTQQATREPLTAAETVQSKRVDTHDAASLDGLVDGIRQRLP.... 183
10 -15.500[R] COG3911 Predicted ATPase  ali follow..  18  9......FVLTGGPGSGKTTLIAALRRA----------------GFATSVVAGRGIVRDQTALPWSDRTLFAELMLSWEMRSYQNAVEQKGPVFFDRGVPETLGYLRLSGLPVADHVST----AAKRFRYNPRVFIAPPWPDIFAQDEERKQT-----PDEAKCTYHALAEIYTELG---ELVPLPLAPVETRLRFVLADA.......... 180
11 -14.500[R] COG4639 Predicted kinase  ali follow..  14  5IPELSLVVLIGASGAGKSTFARKHFQPFEVISS----------------DFCRGLVSNDENSQSASRDAF-----DVLHYITTKRLAAGKLTVID------------ATNVQPEDRKTLLQMAKQYHCFTVAIVFDLPEELCHERNQQRSDRQFGSHVVRRHTQMLREKEGF------RYVYTLKSPEEIANVAIELQPLWNNKKHEH.. 179
12 -14.300[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  12  11......VAILGGESSGKSTLVNKLANIF---------------NTTSAWEYGRDYVGDEIALQYSDYDKIALGHAQYIDFAVK---YANKVAFIDTDFVTTQAFCKKYEGREHPFVQAL----IDEYRFDLVILLENNTP-------VADGLRSLGSSVDRKEFQNLLVEMLEENNIE--FVRVEEEDYDSRF-LRCVELVREMMGEQ.. 186
13 -14.200[F] COG4088 Predicted nucleotide kinase  ali follow..  11  3.....LIIVSGYPSSGKTTRSNELKKALEDRIHQNIDN----------TKDYRVIIINDESLNIEKETYRESKNEKAARSAVQRELSKSTFVICD----ALNYIKGF---------YQLYCESKSMYTTHCVIHVAVPQDLCRKFNSNKEQPYPDDVLEQLMFRYEEIDDIWSVLIHNKNVKPNQATMVKPPAEVNYLYELDKTTQDVIM 211
14 -14.100[F] KOG3078 Adenylate kinase  ali follow..  14  13.PKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATDMLRAMVASGSELGKKLKATMDAGKLVS------------EMVVELIEKNLETPL-------CKNGFLLDGFPRTVRQAEMLD-DLMEKRKEKLDSVIEFSIPDSLLIRRITGR-GEPLIRRSDDNEKALKIRLQAYHTQTTPGIHSAIDASQTPDVVFASILAAFSKATS.... 232
15 -13.800[F] COG0563 Adenylate kinase and related kinases  ali follow..  13  3......LILMGLPGAGKGTQAEKIIEKYGIPHISTDMFRAAMKNETELGLKAKSYMDAGELVP------------EVTIGIVRDRLSQDD-------CQNGFLLDGFPRTVAQAEALE-DILASLDKKLDYVINIDVPEQLLMDRLTGRRGSELIQRDDDKPETVKKRLEVNQKQAQPGYLQNINGDQDISRVFEDINELLKGL...... 215
16 -13.800[F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)  ali follow..  13  1....MLIAITGTPGVGKTTVAKLLAKKLNYEYVSLKDFALEKGCGRRVNDEV-------------------EVEIDELAYFIERELKGKNAVLDGHLSH---------------------------MPVDLVVVLRAHPKLIGERLRERGYDREKIGENVEAELVDAVLIEAIEEHENV-IEVDTTNKSPEDVVEEIVSLINSGIKKR.. 158
17 -13.200[F] COG0572 Uridine kinase  ali follow..  10  6.HQCVIIGIAGASASGKSLIASTLYRELREQVGDQHIGVI----------PEDGYYKDQSHLSMEERVKTNYDHPSAMDHNLLQALKAGKPVELPLY------YTEHTRKKETVHLEPKKVIILEGIL-NFSIFVDTPLDICLMRRMKRDVNERGRSMDSVMAQYQKVRPMFLQFIEPSK-IIVPRGGKNRIAIDILKAKISQFFE.... 213
18 -13.200[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  14  6......ILLTGTPGVGKTTLGKELASKS-----GLKYI--------NVGDLAREEQLYDGYDEEYDCPI---LDEDRVVDELDNQMREGGVIVDYHGCDFFPERW------------------------HIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLP-SNKPEELENNVDQILKWI...... 163
19 -13.200[C] COG3954 Phosphoribulokinase  ali follow..  10  3.AKHPVIAVTGSSGAGTTTTSLAFRKIFAQLNLHAAEVEGDSFHRYTRPEMDMAIRKARDAGRHISYFGPEANDFSLLEHTFI-EYGQTGKGQSRKYLHTYDEAVPWNQVPGTPLPEPTDVLFYEGLHGDLLVGVVPIVNLEWIQKLIRDTSERGHSREAVMDSVVRSMDDYINYITPQF-INFQRVPTVDTSNPFAAKGIPSLDES... 228
20 -13.100[G] COG2074 2-phosphoglycerate kinase  ali follow..  10  88CKEPLIILIGGASGVGTSSIAFEVANRLGIRNMISTDMIREVMRKIVSRELLPSILRIPPPPELDEVLIGFRDHVESVEAVIERALTEGISIVIE------------GVHIVPGFIREDLVNKENVA---MFVLTVSDENVHKGRFYSRCRRRPLKRYISYFWAIRRIHRYIENQARKHGVPVIDVVTTIDSIIKSLTKTTVKGGEKG.. 301
21 -12.900[H] KOG3220 Similar to bacterial dephospho-CoA kinase  ali follow..  11  2....FIVAVTGGIATGKSTISKVFERQIDADKIAREIVEPGQPCWRQIREVFGDEVLLPS-AVLGKMIFEDKELRGKLNKITHPTIHR-------KIFWQVCKLLVTGHAWIVLDLPLLFETGVLMDFIHKIVCVTCDSDKQLERLIARNELSESERVDSQMPLDKKCEKS----------FVIDNNGSVEEAESSAMSIYNLMRDSK.. 200
22 -12.900[F] COG0194 Guanylate kinase  ali follow..  14  43.ERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSPREGEVNDEFEQMIADNKLLEWAEYVYYGTPVDY-----VEQTLQDGKDVFLE------IEVQGALQ--------------VRNAFPEGLFIFLAPPSLSENRIVTRGT-------ETDALIENRMKAAKAEIEMMDAYDYVVENDNVETACDKIKAIVLA....... 225
23 -12.200[S] COG4185 Uncharacterized protein conserved in bacteria  ali follow..  15  9LEQPVFLIVAGPNGSGKSS----VYANADLELEGRSVWIVN-------PDLLAGRISEVENKPLPEA---NLVAVQRIEAWIQSSISVHKTIGVETVLSTD------------KYRRLVEAAEAVGFAIWLFYTVLDSPERSIERIKLRVAKGGHD--DKVRARYARSLDQLPWFLE-DRAWIWDNSGATPKLIGEKQD........... 183
24 -12.000[H] COG0237 Dephospho-CoA kinase  ali follow..  9  3....LVIGLTGGIASGKSTVANMLIEKIDADIIAKQAVEKGMPAYRQIIDEFGEDILLSN-KKLGALVFTNEQKRLALNAIVHPAVRQ-------EMLNRRDEAVANREAFVVLDIPLLFESKLESLV-DKIIVVSVTKELQLERLMKRNQLTEEERIRSQMPLEEKTARA----------QVIDNSGTLEETKRQLDEIMNSW...... 196
25 -12.000[F] COG1102 Cytidylate kinase  ali follow..  14  3.KGCLVITVSGLAGSGTTTLCRNLAKHYGFKHVYAGLIFRQ---AKERGMSLEEFQKYAELHPEID---------REVDRRQVEAAKECNVVIEGRLAGWMVK------------------------NADLKIWLDAPIRVRAERVAKREGISVEEAFMKIAEREMQNRKRYLNLYGID--LIIDTSKSPEGVFAIVKAAIDHLYEK... 180
26 -11.900[R] KOG3062 RNA polymerase II elongator associated protein  ali follow..  11  3.....LVVITGLPASGKSTRARQLRDHFVERGRKVHLISE---------NEAVPKAGFGKNSHTGDSQKEKVVRSD-LKSEASRHLNQEDLVILD----AGNYIKGY---------YELYCMSKVSRTTQCTVFTCIPQEEAWTFNSQRTAPDELPGDSERVQPVDNSDVPYTRETFDALCQRYEEPQSNNRWDSPLVVVLPK....... 178
27 -11.700[G] KOG3354 Gluconate kinase  ali follow..  12  12.PYKYVFVVIGPAGSGKTTMAKAVSEKLGFEYIEGDDLIEKMSQGHPLNDNDRW---------------WLHNCGGACAMELDKESIKGVVLTCS--------------ALKRSYRDILRSSLEHRPAILRFIYLAASRETLIKRTTSRK-----NHYMKADMVESQLAILEAPTADEKDVITISVENGKEQSEEECLDIVHKMVNEN.. 190
28 -11.700[L] KOG2134 Polynucleotide kinase 3` phosphatase  ali follow..  11  12.AKQIVVLLIGPPGSGKSTFCDTAM----------------RSSHRPWSRICQDIVNNGKAGTKAQCL-----------KMATDSLREGKSVFIDR-------------NLDREQRSEFIKLGGPEF-EVHAVVLELPAQVCISRSVKRTGHEGNLQGGRAAAVVNKMLQSKELPKVNEGFSRIMFCYSDADVDNAV............. 167
29 -11.400[FH] KOG2702 Predicted panthothenate kinase/uridine kinase-related protein  ali follow..  12  125.NLKRLVGLAGPPGAGKSTVANEVVRRVNKLWPQKAASFDAEVNPPDVAIVL-RSQLDAMEDPKPALLLNCLKKLKNEGSVYVPSFDHG---VGDPVEDDIVIVEGNYILLEEGSWKDISDMF------DEKWFIDVNLDTAMQRVENRHISTGKPP--------DVAKWRVDYNDRPNAELIIKSKTNADLL................. 327
30 -11.100[S] COG2326 Uncharacterized conserved protein  ali follow..  13  57.GARIVIVFEGRDAAGKGGVIKRITERVSPR--VFRVVALPAPTDREKTQ-------------------------IYMQRYIQQFPAAGEVVIFDRSWYNRPGVERVMGFCSLEIAPRFEAAMIESGIVLLKYFLDVSEEEQDRRFRQRINDPLRQKLSPMDVESYRRWWDYTRAYDEAPWWIVPSDNKKQARVNCIAHILSSI...... 249
31 -11.000[G] COG3265 Gluconate kinase  ali follow..  17  6......IIVMGVSGTGKSCVGQALALALGAKFIDGDDLHPRAAAGQPLNDQDRAPWLER------------------LSDVAYSLQQKNEVGF-----------------LVCSALKKQYRDRLREGNEGIRFLLTGDYDLVLHRMQQRA-----GHFMPESLLKSQFATLEAPGSDEPDVIPIDISSSIADVVEHCIAALSL....... 168
32 -10.900[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  13  1MKRPLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAAITNDIYTKEDARILLNTSVLPADRIAGVETGGCPHTAIREDASMNFAAIEE---MCDKHPDLQLLFLESGGDNLSATFSPDLVDFSI--------YIIDVAQGEKIPRKGGQGMINKVDLAPYVGANVEVMKADTLKSRGNKDFFVTNLDEGLKSVADWIEKRLQLALLEE.. 206
33 -10.700[R] KOG4622 Predicted nucleotide kinase  ali follow..  13  20.....LCVLCGLPAAGKSTFARALAHRLQQEQGWAIGVVAYDD--PSQWKLLRQELLKYTCLKDQDLIFSAAFEAQSCYLLTKTAVSRPLFLVLD----DNFYYQSM---------YEVYQLARKYSLGFCQLFLDCPLETCLQRNGQRPQALPPETIHLMGRKLEKPNPE------EHNSLTIPSPACASEASLEVTDLLLTALENPVK 252
34 -10.500[H] COG1072 Panthothenate kinase  ali follow..  9  78.RIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQVLKE-LMKKKGFPESHRLVKFVSDLKSGVPNVTPVYSQPDILI----LEGLNVLQSGMDYPHDPHHVFVSDFV------DFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNAMTLWKEINWLNLKQNILPTRERASL................. 291
35 -10.400[P] KOG0635 Adenosine 5`-phosphosulfate kinase  ali follow..  16  113.QKGCVVWITGLSGSGKSTVACALSKALFERGKLTYTL----------GDNVRHGL-------NRDLTFKAEHRTENIRRIVAKLFADVGVICIASLISPYRRDRDACRSLLPD-------------------FVEVFMDVPLHVCESRDPKGLYKLARAGKIGFTGIDDPYEAPVNCEVVLKHTGDDESCSPRQMAENIISYLQNKGY. 290
36 -10.400[P] COG0529 Adenylylsulfate kinase and related kinases  ali follow..  13  1.QKPAVLWFTGLSASGKSTIANRLEQRLHALGKHTYLL----------GDNVRHGL-------NSDLGFSDADRVENIRRVVARLMADAGLITPVSFISPFREERDQVRARLPEG------------------FIEIFIDTPIEECMARDPKGLYAQALRGEIAFTGIDSPYEPPVAPE-LRLNTAGRTVDELIAEVENYLAE....... 171
37 -10.400[F] KOG0707 Guanylate kinase  ali follow..  13  135.NAEKPIVISGPSGVGKGTLISMLMKEFPSMFGFSVSHTTRSPRSMEMDKVMEKEIKDGKFLEFASV-LYGTSI-----ESVEAVTDSGKRCILD---------------IDVQGARSVRA-----SSLDAIFIFVCPP--SMKELEDRLRARGTETEEQIQKRLRNAEAEIKEGISSGIFGLILYNDNLEECYKKLKVNHLLLIAQNV. 326
38 -9.470[F] COG0283 Cytidylate kinase  ali follow..  12  1MNRQKVIAIDGPGASGKGTVAARVAAALGYDYLDTGALAQKQGVGWHDEENVSELAKKLPAVFSDSRILLGGERTEAIGMGASAVAQRASLLQRQRDFLTEKGLVADGRDTGSVVFPQA----------ELKIFLTAESKIRAERIGIPCEGLAFERIDIEARDEADRNRKVAPLKQQPDALLLDTSRTIEETVKKVLDWYRKV...... 218
39 -9.330[V] COG1131 ABC-type multidrug transport system, ATPase component  ali follow..  12  28IQRGEIFALLGPNGAGKTTLISIVCGIVNRSTDGHDIGKDYRAARSLIGLVPQELTIDAFESVWATVNYSRGPNHGFVEKVLR------DLSLWDKKDAKAITLSGGMK-------RRLMIAKALSHEPRI-LFLD-EPTAGVDVELRQDMWEMVRRLREDGVTI--LTTHYIEEAEADRVGVINRGE...................... 211
40 -9.280[F] KOG3308 Uncharacterized protein of the uridine kinase family  ali follow..  12  3.RKTIIVGVSGASCSGKSTLCQLLHAIFEG-----SSLVHEDQESLNLDAFLENLLRNRENKNVAPEALIEYADIIKEFKAPAIPTLEQHLVFVDGFM------------YVNEDLINA----------DIRLMLVTDFDTLKRRREARTGYITLEGFWQDPPHYFEVWPGYVHGHSHNGDVTGKLLDKRIQLSPSSKMSVRDNVQWAIN 223
41 -9.260[E] COG0703 Shikimate kinase  ali follow..  13  74......IFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTG-----ADVGWVFDLEGEEGFRDR-----------EKVINELTEKQGIVLA----------TGGGSVKSRETRNRLSARG-------VVVYLETTIEKQLARTQRDKKRPLLHVETPPREVLEALANERNPLYEEIADVTIRTDQSAKVVANQIIHMLES....... 239
42 -9.140[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  13  52.GNTLRLGVTGTPGAGKSTFLEAFGMLLIREGLKVAVIAV-DPGGSILGDKTR-----NDLARAEAAFIRPVPSSGHLGGASQRARE--LMLLCEAAGYDVVIVETVGVGQSETEVARMVDCFISLQIAGG--LMEVADLIVINKDDGDNHTNVAIARHMYESALHILRRKYDEWQPRVLTCSALEKRGIDEIWHAIIDFKTALTAS... 263
43 -9.010[R] COG4619 ABC-type uncharacterized transport system, ATPase component  ali follow..  11  30LRAGEFKLITGPSGCGKSTLLKIVAS-LISPTSGTLLFEGEDVSTLKPEIYRQQVTLFGDTVYDNLIFPWQIRNRQPDPAIFLDFLER--FALPDSILTKNIAELSGGEKQRISLIRNL-------FMPKV-LLLDEITSALDESNKHNVNEMIHRYVREQNIAVLWVTHDKDEINHADKVITLQPHA...................... 214
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.