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Query: gi|13507756|ref|NP_109705.1| 5,10-methylene-tetrahydrofolate dehydrogenase MPN017 [Mycoplasma pneumoniae M129], from M.pneumoniae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSFDGKQLAHEILLTYKNRDWSQVKLVILQTNNDVSSDAFIRQKMNACNTLGAQSELIKYHESVTEKELLEKIQQLNTDPEVTGIILQLPVYPHLKQNKLLKAIDPYKDVDYLTGNCPLPIRSCVVEAVLILKEHFHHDFTNKQIVVVGLGVTGGGPIFHYLKETGHQVVGCDKHTPNTMELIKTADVVITAIGKPHFFKTTNFKPGVILYDVGVSRNVLNKLCGDIDPNGIEKVAKWWSPTPGGVGPFTVLAIMKNLWVLYEAHQRRILast
1 -102.000[H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase  ali follow..  29  5.IISGTELSKQIKANLADKIKRAPGLAVILVGADPASQIYVGNKRKSCEEVGILSKSYDLPETTTQNELLAIIDQLNADKNIDGILVQLPLPKQINAEAIIERIDPKKDVDGFHPYNVGRLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAGATVTVTHRFTKNLENHVRQADILVVAVGKPNLISGDWIKESAVVIDVGINRV-DGKLVGDVEFDKAAEKAAYITPVPGGVGPMTVAMLMSNTLYAYEHNK... 282
2 -94.000[H] KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase  ali follow..  29  32VVISGRKLAQQIKQEVRQEVNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGATVTISHRYTEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR.. 327
3 -80.800[H] KOG4230 C1-tetrahydrofolate synthase  ali follow..  30  3LLLEGTSLARKVREELREQIYFNVSLKIIQVGGREDSNVYVRMKTRAANEAGISCEHVNFPEDITEYDLLLAIKGFNEDPTVHGIIVQLPLPAHINEQIITEAVAPEKDVDGFCETNLGKLTACTPKGIMCILKHYGINVQGKHAVVIGRSNIVGRPMSILLEKANATVTLCHSKTESIADIVRTADIVVAAIGIPHFVKADWLKKGVVAIDVGINSIPDARLTGDIDFENAKEVASAITPVPGSVGPMTVAMLLQNVVESAVRFRKM. 293
4 -12.100[R] COG5322 Predicted dehydrogenase  ali follow..  13  67.............................................................................QGAVCEGILHYMPLTAE--AQRVVDAVESLKDQ-GAQVVGLGGFTAAAYRNVLESMDRLGVEPADTEVAVVGYPGSIALVIAKLLAGHGCRLCLVHRGSNDIEHCYEHVQFYVAATSTGGLIDPYRLRPGSVVVDAALPR----------DVKPYRKDRNDILIIDGGL....................... 279
5 -9.330[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  10  10.............................VFGNPINHSKSPFIHTLFARQTQQSMIYTAQ--CVPVDGFTEAAKHFFA-QGGRGCNVTVPFKEEA-ADRLTERARLAGAVNTLKKLDDGEILGDNTEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRKAQAFEQLKQSYDVIINSTGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQ--------WARQHGCAQAIDGLG-----MLVGQAAESFM...... 254
6 -7.950[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  17  184...................................................................................................................................IKQATDVMIAGKVAVVAGYGD-KGKSCAQALRGFRASVIITKTEVTTMDEACQEGDVFVTTTGCVDIILGQQTKDDTIVCNTGYFDV-------EMDVKWLNKNTVEKVNVKLQVDPYRL.................. 311
7 -7.860[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  16  200..............................................................................EETTTGVLYHFAEEGVLPFPAMNVNDAVTKSK-------FDNKYGTRHSLIDGINRATDMLMGGKNVLVCGYGD-VGKGCAEAFDGQGARVKVTEASVVTVDEAIEDADIVITATGNKDIISFEKMKDHALLGNIGHFDN-------EIDMHSLLHRDD................................ 361
8 -7.810[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  15  1....................................................................................................................................MSTMKVAVYGLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPATDNDAEAASEAEIAVLFTPFGKKTFENHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAA........................ 150
9 -7.070[GQ] KOG2741 Dimeric dihydrodiol dehydrogenase  ali follow..  9  10....GLLSCTNKVRKLSRAINLSPNATISAI----ATTSSIEEAKSFAKSNNFP----------PNTKLHSSYESLLEDPDVD--AVYFPIPTRLHVEWATLAAIKGKHI----------------------LLDKPVALNVAEF-----DQIVEACEVNGVQFMDGTQWMHSPRTDKIKEFVNDLESF----GQIKSVYSCFLDGLGALGDAGWYTIQAILLVNNFKLPKTVTALSGSVLNDAGIVLSCGALF............... 230
10 -6.940[E] KOG3007 Mu-crystallin  ali follow..  11  158..............................................................................................................................................RSVRIWNHRFESAKSLASRASKELPSIQIDAVPIQNLENAVKCSDIISSATSKKPIIVGSWINPGTHIDLVGGFTIQISNVFVDTRKGALHEAGDLLTPIKEGL....................... 272
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 5 1 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205