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Query: gi|13507759|ref|NP_109708.1| helicases MPN020 [Mycoplasma pneumoniae M129], from M.pneumoniae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTIAEIRKFAQTTQKFVEAENLFEHGNVVLPKKYLNKARGMAEVLYNSQVIKVSFTAKDGELTCKCSCLANVDNCVHIVAVLLKYHQMLVESKRSFNLAEAFHLDCDQAEMLIENLSLEIIAGGWNFKLGFTINLDKHNPQPSVLRFYCCDATFVYFLHLENDTLHSVELSKFKPEERATLLFFDKLCKQFTVGYDRNSLLFPLAGFLKELQANTEPTIFVFNDDKIDNILFLRISKKHHGLNHVCGFSGKKVFDFVTYKQKEKQIVLRSAYLSKFTDFKFPYTINIYKLQFGEPLFFYFLIQLKRDGFKNFYFQSEDSIVKEKEYLPKLYFKVEYDPVKNKFVSDAFFKYKNHFNKGTTTVYPHRYYMAKKSDRGGFNRLLFYEEAVENFYQDQFDLGYFRKFEHLPIQDKNQIEAFKAALDDLMPVDLAEVSLSDNLLHQKPLHFALSDLEAVAVDDKQIKLSFAPSAVELKLIKRILSAYHKGNVVCIDQESWYDLKQPAAKELIQFWNQFDLRNATSDGNHIYLPKYYLFEVAKIFSQYLDIKNLFDVPTIKKIEDQNNNVFDLSLEHKKITSLRNYQQEGVKWIRGLEENKFGGILADEMGLGKTVQVIFALLDSYLKNHVNLPSLIIVPASLLLNWKSEFEKFAPQIKVKVANIPSKERGELYEKLTNEILIVSFNVLRSDVKLITKQRFHYVVIDEAQGIKNDSSSITKAAKKVKGNFCLALTGTPIENRLLDLWSCFDFVLPSFLGNKKQFTDQFEKEKTDQSFHLLMQRTSPFILRRTKSKVLKELPNKITTDIYVELNPMHQKLYEEERDRGLEEIKQIQDKSSFNILTLILKLRHLCSLPKNSQGILENSAKKEAALEIIHEAIENQRKIILFTQFIDVIDHFKDTFKEQGIEYFIFDGRKSPKSRHSIIEKFNNAKNPCVLLASLKAGGVGINLTAAEVVIHFDVWWNTAVENQATDRAHRIGQKKTVQVYRIIAKNTIEERVCQVQAEKQELVSKTLVEDVNFFESLTNEELLRLFELast
1 -162.000[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  23  2LNFRKLRRDF-SANILQDGKKLFEQGAVIDAKINGETVCISAQVRGLDNIYECEIEVDSDTVDSNCDCSYNYD-CQHIVALLFYLEQYFNEMVVAYARSADLETDHEINEEVKKELKETFVAAATKFQLVLRLPCRSKPFYISNIRTFLEGVLYQEPIVLNGRRFFFTM-QSFNASDRKLIDLLIRYVRYPNHTTEEKLLKSAYLMPPALGVILAKMFEHQLADRNLEEPLCWSLTPAKMKFNLDFFDMPYKALLMTPVILVDDDEVQPEQTSPQIKRAHLRSFSRLRDIAIPEALFGSFRENALPVFQEYAEIANVHNSFVTLPYVDEVRAICDMSYLDGELEAKLHFLYGSLRVPAASLALQYQDVRAFISDEGILARNLVEERKMLEEVFSGFIY-DERDGAFRVKSEKKIVEFMTETIPANQHRITFNCPENQFIYDETIFELSFREGSDINYYEADLKVHGLLKGVPLDLLWDCIS--AKKRFLELPKACILVLDLEKIAPVVQIFNEIGFKVLDDLVQKCPLWSLTGISLDQFEALPVNFSMSERLIEIQKQIRGEIEFDFQDVPQQIQATLRSYQTEGVHWLERLRKMHLNGILADDMGLGKTLQAIIAVTQSKLEKG-SGCSLIVCPTSLVYNWKEEFRKFNPEFRTLVIDGVPSQRRKLTALADRDVAITSYNLLQKDVELYKSFRFDYVVLDEAHHIKNRTTRNAKSVKMIQSDHRLILTGTPIENSLEELWSLFDFLMPGLLSSYDRFVGKYIRTNKADNMVALKKKVSPFILRRMKEDVLKDLPPVSEILYHCHLTESQKELYQSYAASAKQELQEGFERIHIHVLATLTRLKQICCHPAIFAKEPGDSAKYDMLMDLLSSLVDSGHKTVVFSQYTKMLGIIKKDLESRGIPFVYLDGST--KNRLDLVNQFNEDPSLLVFLISLKAGGTGLNLVGADTVIHYDMWWNPAVENQATDRVHRIGQSRSVSSYKLVTLNTIEEKILTLQNRKKSLVKKVINSDDEVVSKLTWEEVLELLQ 1165
2 -95.600[KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)  ali follow..  29  236........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SENNKDRGEFEGKDEWLLPHPSKKGQTFEGGFTIPGDIRPHLFRYQVTCVQWLWELYCQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKFQKPALIVCPATLMKQWVNEFHTWWAPLRVVVLHATGSGQRASREKRRGHILITTYAGLRIYGDLILPREWGYCVLDEGHKIRNPDSEISISCKQIRTVNRIILSGTPIQNNLTELWNLFDFVFPGRLGTLPVFQNQFQVQTAYKCACMLRDLISPYLLRRMKLDVAADLPKKSEQVLFCKLTPLQRKAYQDFLQGSDMQKILN---GKRQMLYGIDILRKICNHPDLVTREYEKSGKLKVIRALLTLWKKQGHRTLLFSQTRQMLDILEIGLKDPDVHYCRMDGSTSIALRQDLVDNFNKNEYFDVFLLTTRVGGLGVNLTGADRVILFDPDWNPSTDAQARERAWRLGQKKDVVVYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQR-RFFKMTDLHDLFT 793
3 -93.700[B] KOG0389 SNF2 family DNA-dependent ATPase  ali follow..  27  277.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VEQPKLLSSQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGFTGFDVLLTTYHIVGEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFKSIEDIKSLFAKKFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITSNEKG--EVHEQRCVVKLLT 818
4 -81.200[L] KOG1002 Nucleotide excision repair protein RAD16  ali follow..  27  98........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ETWEKEQNSWIDEHMSEDVDLDQHNAVIAETAEPPSDLIMPLLRYQKEFLAWATKQEQSVAGGILADEMGMGKTIQAISLVLARREFGEAAGCTLVLCPLVAVSQWLNEIARFTSSTKVLVYHGAKRAK-NIKEFMNYDFVLTTYSTVESEYRRLHSVKWNRIILDEAHYIKERRSNTARAVFALEATYRWALSGTPLQNRVGELYSLIRFLQPNAVRHFCWWNKYVAKPGKRAMILLKHKVLKDILLRRTKLG-DLALPPRIITLRRDTLDVKEFDYYESLYKNSQAEFNTYIENNYAHIFDLLTRLRQAVDHPYLVVYSNSSSTKIEALREEIRFMVERSAKAIVFSQFTSFLDLINYTLGKCGVSCVQLVGSMTMAARDTAINKFKEDPDCRVFLMSLKAGGVALNLTVASHVFMMDPWWNPAVERQAQDRIHRIGQYKPIRVVRFIIENTVEERILRLQKKKELVFEGTVGGSQEAIGKLTEEDMRFLFT 832
5 -31.000[KL] COG4646 DNA methylase  ali follow..  12  238.....................................................................................................................................................................................................................................................................................................TSAADALAVVLNERGHVDRDHIAELLHRDPEDVVTELGSAIFRDPADGSWQMADAYLSGHVREKLKVADAAAGLDPAYERNVSALTAVQPVDLRPSDITARLGAPW---------IPAGDVVAFVKEMMG------------TDIRIHHMPELASWTVEARQLSYLAAGTSEWGTDRRHAGELLSDALNSRVPQIFD-GDSEKRVLNVVDTEAAKEKLHKIKQAFQR-----IWSDPDRTDRLARVYNDRFNNIAPRKFNGDHLKLPGASG----------AFVLYGHQKRGIWRI-----SAGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKA-MQVVPGHCLAQAAREFLALYPTARILVADESKDKRARFAATATWDAIIITHSAFRFDLLTIAEIGVDQIIVDEAQEFRK-DPNGSQRAWDLYVKSRFIASGTPITNTLGEMFSVQRLMGHPALMERDAWASTFGDTTTELELQKPVSRFASFV--VMPADLREYVKTGRRQIVTSKPTQAFKHYQMVLAERIKEEREGPPQPGDDILLSVITDGRHAAIDLRLVDADNEADNKLNNLISNAFNIWKAGAAQMIFSDL-SAYRWIRDELIRLGVPIAFMQDFKKSEAKQRLFGDVRAGSV-RFLIGSSETMGTGVNAQLRLKALHLDVPWLPSQIEQREGRIVRQGQHDEVDIFAYATEGSLDATMWQNNERKARFIAAALSGDTSIGQANQFAMAKAIAS 1093
6 -26.300[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  15  32.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DDRVEKFRIPAMRYRAVVEALQAEDVFFIDEA-----------KQFYPIDLVPSLEMEPYPHQSEA---LAAWKLAGRQGVVVLPTAAGKTYLAQLAMQATPRT------TLIVVPTDLMHQWYAHLVAAFPDAEVGLLGGGSRDKS--------PVLVATYDSAAIHAEALGN-QYALIVFDECHHL--PTDFSKVIAEYAIAPYRLGLSATP--------------------------------ERTDGKHADLNILIGQEVYRKRAEDLAGKLAEHEIVQIKVKLSQQERERYNNLIQIRNDFLRQKVSLGSIQGWQMFVQMRAMLAHREAKEIALGTDSKLRILANLLAK--HYPERVLIFTADNATVYKISQDLLIP-----AITHQTPVKERHEILTKFREGEYN--TLVASHVLNEGVDVPAAAIAIILSGTGSTREYIQRLGRILR-IQNKQAILYEVIAEDTSEENTSARRRGKANLQVVYGSGKGTTAKAAEQIEINYVVD 486
7 -25.700[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  15  313..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FRNDTNNPDINIDLKPAAVLRPYQEKSLRKMFGNGRAR-SGVIVLPCGAGKSLVGVTACC------TVRKRALVLCNSGSVEQWKQQFKMWSDDSMICRFTSEAKDKPM-----GCGILVTTYSMITHTMRWLQEQEWGIMVLDEVHTI--PAKMFRRVLTIVQSHCKLGLTATLLRE--------------------------------DDKIADLNFLIGPKLYEANWLELQKKIARVQCAEVWCPMSPEFYREYLTTKTSKKMLL------------------------------YVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNVFALKHYAIKMNKP-----FIYGPTSQNERIQILQNFKFNSKVNT-IFVSKVADTSFDLPEANVLIQI-HGGSRRQEAQRLGRILRAKKGAI-FFYTLVSQDTMEMSYSRKRQRNQGYSYKVITHLKGMDTD-TQEEQGQLLQ 731
8 -25.400[R] KOG0354 DEAD-box like helicase  ali follow..  14  58................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DESAAQQWVYPINVS--FRDYQFNIVQ--KALFE---NVLVALPTGLGKTF-IAAVVMMNYLRWFPKSYIVFMAPTPLVTQQMEACYKITPKSQTAELSGHVPVTTRNQYYQSRNVFFVTPQTILNDIKICDRTRISCLVIDEAHRSTGNYA--VEVVHLLSLSNKLALSATP--NKLEAIQNVIDSLH-------SRIEIRTENSID----------ISQYVQKKEVDFFPVDLSAEITDIR-YYRIQNAKDITSFTVVQAKQAFLAMSGQNFLNTFDALATFAYP-IEILLRDQSFVGHPKLEHLERIVTEYFEKEQRIMIFVEIRSSAEEILRFLGKFYVRPAIFIGQSSQKLQNETVKQFQKGE----TLIATSIGEEGLDIGEVDMIICYDASASPIRMLQRMGRT---GRKRKGYIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEKFR 589
9 -21.400[L] COG1111 ERCC4-like helicases  ali follow..  18  12..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PEKIE--ARTYQQL----LAADVIRKGNSMIVAPTALGKTV-VAVLVAAERLRKYRGSKVLILSPSKPLAIQHEESFREFMLATCTSLTGSIKPEERKERWIKSQIISATPQTVESDILRYDLRDVSLIVFDECHRAVGSYSYVFLASNYIQNARHLGLTASP--ADEDKIKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELIRELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRISLLASCINVTRAMHLTRRAMMSGVEHPKLDRLMEILKRELKGDERIIVFTQFRDTLEEIYQRCKREGINAVKFYGQNSRKQQRDIIKSFRMGN----VLLSTSVAEEGIDIPSVDLVVMYEP---VPSEIRMIQRRGRTGRKRKGRMVVLITEKTRDEAYYYSSIRKERSMKENLRGGSVNVEV........... 507
10 -21.000[R] COG4889 Predicted helicase  ali follow..  11  2............................................................................................................................................................................................................................................................................................................................................................................................................................STITDAVSALRTLPSQSAQGLAFEKLMVNFIKSDPTLSTEFDEVHRWVDWPYNGGTMDTGID----VAYNKDDDAYTAIQ-LPTTSLAKGQLDSFFEASGRTFETPEGTRSFSNRLVISTTDKWSSNAEKMLENQTIPTNRIGLSAIAEPGSELTINLQLKEPYSPRPHQQTAIE-IEGFQTHDRGKLIM--CGTGKTFTALRLSEEVARLNGNKARILFLVPSQTLKEWTAQKTM---DLRPVAVCSDSKVSKAAEDIAAYDVVFSTYQSLPHAAQEAGAEPFDLVICDEAHTLAGEDPSNFTRISYIKAAKRLYMTATPAADHSAEVSS---------MDDEAIYGPEFHR--------GFGEAVEKGLLTDYK-------------VVVMTVDEQVASALTVLGSTPGEELTLDMTSAIIGAWNGLAKRSGKEQDTKTGFSSSDAAME----------------RAVAFQQIAESFPRVVNAYTTESVACQHVDGSMNALERNSRLTWLKAQSMETKILTNARCLSEGVDVPALDSVIFFNPRNSMVDVVQSVGRVMRKSPGKNIILPVAVPPGVAPSAALNDSRRFKVVWQVL--------NALRAHD...... 645
11 -20.700[A] KOG0335 ATP-dependent RNA helicase  ali follow..  14  258.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGDLGSGKTLPILAHMMHDSRFKELQEPCIIVAPTELVNQIYLEARKFS-CVRAVVIYGGTQLGHSIRQIVQCNILCATMDIIGKEKIGLKQIKY--LVLDEA-------------------------------DRMLDM---------GFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAV--------------------------GQVGGACRDVQQTVLQVGQ--------------FSKREKLVEILRNIGDE--RTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCP--VLVATSVAARGLDIENVQHVINFD------LPSTIDEYVHRIGRTGRCRAISFFDLESAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGS...... 686
12 -19.700[A] KOG0333 U5 snRNP-like RNA helicase subunit  ali follow..  13  290...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SIKGGRVPRPLRNVYQAVKEIGYLEPTPIQRQAIPIGLQNDVGSGKTLPLLVWITSERQEHRDLGPAIIMAPTELAQQIEEETNKFG-GIKTVSVIGGASREDQGMKLRMVEVVIATLDVLENRYLLLNQCTY--VILDEADRMLD---------MGFEPDVQKVLEYMPDTN----------------------------MKKDTDEFDNEEALMKGFSTREKYRQTV---------------------MFTATMSSAIERLARQYLRRPAVV--HIGSAGKPTERVEQVVYMVPEDRKRKKLVEVLESQFQP--PIIIFVNQKKGADMLSKGLTKLGFKPTVLHGGKGQDQREYALQALKEGTSD--ILVATDVAGRGIDVKDVSLVLNYD------MAKSIEDYTHRIGRTGRA--------GKHGKAITFLTPDDTAVYFDLKQVLVESPVSSCPPELANH.. 707
13 -19.700[A] KOG0347 RNA helicase  ali follow..  12  188...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PEFSAWSSMRLHPLL---MKSIYRLDFKEPTKIQKACFNVAAYQDVGSGKTLPILQRLLDEREKVGKLYAALIITPTELALQVTEHLENAAKSVKVVPIVGGMFSEKQERRLKE-EIVVATWELMSAGEKHLVELHLSFFVLDEADRM----------------------------------------VERGHF-------------------RELQSILDLLPVTDKPNEGKTQTVKSNDTVLNVPKKKRQTFVFSATIALSSDFRKKQSSSGEVNSIEVLSERAGMRDNVAIIDLTTTSILKDAYLYYILSV--HGQGRTIVFCTSVTDLRHISGLLKILGLDVCTLFSEMKQRARLKSIDRFRASENG--ILIATDLVARGIDIKNVRTIIHYK------LPHSAEVYVHRCGRTADGCSIALIEPNE-TSKFYTLCKSFSMESVKIFPLDNSYMPAVRKR....... 643
14 -19.500[A] KOG0331 ATP-dependent RNA helicase  ali follow..  16  91...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPVLNFYEANFPANVMDVIAAIQAQG--WPVALSGLDMVGVA--QTGSGKTLPAIVHINHQPFLERGDGPCLVLAPTELAQQVQQVAAEYC-RLKSTCIYGGAPKGPQIRDLERVEICIATIDFLECGKTNLRRTTY--LVLDEA-------------------------------DRMLDM---------GF---------------------------EPQIRK-----IVDQIRP-----------DRQTLMWSATWPKEVRQLAEDFLKDYIHILSANHNILQIV-------DVCHDVEKDEKLIRLMEEIMSEKEKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAP--ILIATDVASRGLDVEDVKFVINYD------YPNSSEDYIHRIGRTKTGTAYTFFTPNNVSDLISVLREANQAINPKLLQLVEDRGSGRSRGR...... 486
15 -19.200[A] KOG0339 ATP-dependent RNA helicase  ali follow..  14  254...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RVGGLKPPRPVCSLMEAIRKSEYEQPTPIQAMAIPSALSGDVGSGKTWPAIVHIMDQPDLKAGEGPAVIVVPTELAIQVFQEAKKFC-NINPICAYGGGSKWEQSNELQNAEMVVCTIDLVKMGATNFLRTTF--LVFDEA-------------------------------DRMFDM---------GF----------------EAQVKSISDHVRP---------------------------DRQCLMFSATFKQKVERLARDALVDPVRIVEANADIEQK------VFVMQNQDVKLHWLIRNLVEFASLG-KVLIFVTKKLDSEDVAKKLKMKDFDIVLLHGDMLQAERNENLLKFRKKSQ---ILVATDVAARGLDISEIRTVINFD------MARDIDTHVHRIGRTHKGTAYTLVTEKDVGHLVKNLESVSQEVPKPLMD................... 642
16 -18.700[A] KOG0336 ATP-dependent RNA helicase  ali follow..  14  210...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGEKRLIPKPTCRLLKSIIRVGIVKPTPIQSQAWPIILQDLIVVAQT-KTLSYLMQPISREQRNGPMLVLTPTELALHVEAECSKYSKGLKSICIYGGRNRNGQIEDISKVDIIIATNDLQMNNSVNLRSITY--LVIDEA-------------------------------DKMLDM---------EF---------------------------EPQIRK-----ILLDVRP-----------DRQTVMTSATWPDTVRQLALSYLKDPMIVLVAVNTVKQNI-------IVTTEKEKRALTQEFVENMSPND-KVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIK--ILITTDIVSRGLDLNDVTHVYNYD------FPRNIDVYVHRVGYIKTGTSVTLITQRDAGELIKILDRANQSVPEDLVVMAEQYKLNQQKRH...... 612
17 -18.300[A] KOG0350 DEAD-box ATP-dependent RNA helicase  ali follow..  15  123...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTTVEFSSLNISSKLVERL---QKQNITRGFAVQAAVLPLLLQDDVGSGKTLSVIPIVQCLSHRTVPRLRCVVIVPTELTVQVAKTFEYYMSGLQVCAWTGQKSLRHETYQLNGIDVLVSTPGRLVDHIRNDESFSLQYMVIDEADRLLDQS----------------------FQDWVDTVMMEIS-----------------KCLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQKLVFSATLTRDPSKIASLKLHNPRLVLVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYSVSSEKPILLYHLIHS--KNLTNILCFVKSNEAAARLHRLLENQSFSCGLFTSSLSRDERKKIISRFATGDLN--LLVCSDLMARGIDVANTQNVINYD------PPLSVRSYVHRIGRTREGFAWTLVQSHEGHLPIKRIKIEFSHISEEFVVAYDKALEALRVE....... 590
18 -18.300[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  12  435.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EELLEMLGSEPQKQNQWFADNPGMSELGLRYYQEDAVRAVEKAIVKG--ILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLVDRRSLGEQALGAFEDTRINGDTFNSIFDIKGLTDKFPEDSTKIHVATVQSLVKRTEPMPVARYDCIVVDEAH--RGYILDKEQTEGELQFRSQ-----LDYVSAYRRILDHFDAVKIALTATPA--LHTVQIFGEPVYRYTYRTAVIDGFLIDQDPPIQIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVADFN--------RGL------------IPAFNRAVCNELTNYLDPTGKTLVFCVTNAHADMVVEELRAAFKKKYKITGDADARKVQTMITRFNKERLPNI-VVTVDLLTTGVDIPSICNIVFLRKVRSRILYEQMKGRATRLCPEVNKTSFKIFSVDTMRPVVVRPKVELQTLVNEITDSETYKITEADGRSFAEHSH 914
19 -18.300[A] KOG0343 RNA Helicase  ali follow..  15  19............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDEYIENLKTKIDEYDPKITKAKFFKDLPISDPT---LKGLRESSFIKLTEIQADSIPVSLQGDVGSGKTVPVIEKLYREKWTEFDGLGALIISPTELAMQIYEVLTKIGSSFSAGLVIGGKDVKFELERISRINILIGTPGRILQHLDQLNTSNLQMLVLDEAD--------------------RCLDMG---------------------------FKKTLDA-------------------------IVSTLSPS-----------RQTLLFSATQSQSVADLARLSLTDYKTV-STPETLQQ------------PLADKLDILFSFIKS--HLKCKMIVFLSSSKQVHFVYETFRKPGISLMHLHGRQKQRARTETLDKFNRAQQV--CLFATDVVARGIDFPAVDWVVQVD------CPEDVDTYIHRVGRCKKGKSLIMLTPQEQEAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLF... 438
20 -18.000[A] KOG0332 ATP-dependent RNA helicase  ali follow..  14  181......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FIQKEVKMMKDVVVDVQRQDPKSPLYSISSFRELRLKPEV---LKALDTMNFQFPTRIQETALPLLLMEPSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTL-IGEVVEKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQIVIGTPGIT-QKYKCIDPSKIRCLVLDEAD----------------------------------------VMIYHQGFTD----------------------------ISTTIYNMVEDASDSVQSM-----------LFSATYDEPVINFATKIIKNAIVV-QALPNIKQ------FYVQCACRDSKYAAIVNLYS--GLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFK--VLITTNVFARGIDVAQVSVVINYDP--DGFTQPDCETYLHRIGRTKTGIAINLIDS---EDSMNMINVLENHFQMKIARMDPSNLVELEAIEM..... 612
21 -17.700[A] KOG0338 ATP-dependent RNA helicase  ali follow..  14  192........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KDRKKKKKKGQEAGGFFEDASQYDENLSFQDMNLSRPL---LKAITAMGFKQPTPIQKACIPVGLLGDIGTGKTLPVLERLIYKPRQAPVTR-VLVLVPTELGIQVHSVTRQLAQNITTCLAVGGLDVKSQEAALRA-DILIATPGRL-HNCPSFHLSSIEVLILDEADRM----------------------------------------LDEYFEEQ---------------------------------KEIIRMCSHH-----------RQTMLFSATMTDEVKDLASVSLKNPVRI-DVAPFLRQ------IRIRPNREGDREAIVAALLTR--TFTDHVMLFTQTKKQAHRMHILLGLMGLQVGELHGNLSQTQRLEALRRFKDEQID--ILVATDVAARGLDIEGVKTVINFT------MPNTIKHYVHRVGRTRAGRSVSLVGED--ERKMLKEIVKKAPVKARILPQDVILKFRDKIEKMEKDVY 611
22 -16.800[A] KOG0341 DEAD-box protein abstrakt  ali follow..  16  135...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IVNGDDIPPPIKNVLDTLKEKGIVQPTPIQVQGLPVILAGDMGSGKTLVFVLPMIMIALQEEMMMPGLIVCPSELARQTYEVVEQFVPPLRSLLCIGGIDMRSQLEVVKRVHIVVATKDMLAKKKMSLDACRY--LTLDEAD--------------------RLVDLG---------------------------FEDDIRE-------------------------VFDHFKS-----------QRQTLLFSATMPTKIQIFARSALVKPVTV--NVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQK---TSPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDREYAISSFKAGKKD--VLVATDVASKGLDFPDIQHVINYD------MPAEIENYVHRIGRTKTGIATTFINKNQLLDLKHLLQEAKQRIPPVLAELNDPMEEAETIAN...... 543
23 -16.600[A] KOG0348 ATP-dependent RNA helicase  ali follow..  15  23............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGLFASCSFSSLGLDTKLSDQLK--ERMGFEAPTLVQAQAIPVILSGDVGTGKTAPLIHHLQGHSPKVDRSHGALVIVPTELCLQVYETLEKLLHRFHGYVMGGEKKAKEKARLRKGISILIATPGRL-KNTASFVHKNLRWVIFDEAD--------------------SILELG--YGKEIEQIIKLLG--------------SGQNEQGEEDDIVPKGIQKQNLLLSATLNDKVNDL-AKLSLDDPVMIGLDNTKLQQNLSIESPAAPDSDAEDMVIHVNKSANPLSEDYGIPSQLVQR-PCGARLVALLSVLKNLFERSQKVVVFFSTRDAVDFHYSLLSELKCKTFRLHGSMEQEDRRSAFGTFKTEKQA--VLLSTDVAARGLDFPKVRCIIQYD------CPGEATEYVHRVGRTARI--------GEKGEALLFLQPIEIDYLKEL..................... 464
24 -16.500[A] KOG0337 ATP-dependent RNA helicase  ali follow..  14  69........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSLDNDAGTSDRGADILKSKSKKNKSGGFQSMGLGFEL---IKGITKRGYKVPTPIQRKTIPLILEGDVGSGKTACLIPLFEKLQRREPTKGAALILSPTELAVQTYKFIKELGRELKSILVLGGDSMDSQFSAIHT-DVIVATPGRFLCVEMDLKLNSIEYVVFDEA-------------------------------DRLFEM---------GFGEQ---------------------------------NETLHRLPSS-----------RQTVMFSATLPKLLVEFARAGLNDPVLI--RLDVESKLPDALALKFLYCRPDDRYTALVVLLKYVIPVQSQTVVFAGTQHHVELISYILTEAGISNASVYSSLDPAARKINTAKFVNKKVS--VLIVTDVAARGIDIPSLDFVVNLH------FPGKPKLFVHRVGRCRTGTAYSIVS----TDDTAHLLDLHLFLNRPFNIHDSSALGTIPQDLLEEEHL 481
25 -16.500[A] KOG0342 ATP-dependent RNA helicase pitchoune  ali follow..  13  63........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EELDNENEDERVQKSVNLNASSTSDIEKFSDLQLSENI---QKAIKEMGFETMTEIQKRSIPPLLAGDVGSGKTIPTIEMLYALKFKPRNGTGVIIISPTR-IFGVAKELLKYHHQTFGIVIGGANRRAEADKLVKGVNLLVATPGRL-QNTKGFVFRNLRSLVIDEADRILE---------IGFEDEMRQIMKILPSENRQTLLFS-------------------------------------------------ATQTTKVEDLARISLKPGPLYV--NVDSGKPTSTVEGLEQGYVVV---------------------DSDKRFLLLFSFLKR--NLKKKVIVFMSSCASVKYMAELLNYIDLPVLDLHGKQKQQRRTNTFFEFCNAEKG--ILLCTNVAARGLDIPAVDWIVQYD------PPDDPRDYIHRVGRTSELGFLRYLKT-NVQSQLEKLVSKNYYLQQSAKDGYRSYLQAYASYSLKSIFD 511
26 -15.700[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  14  407...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AQLNSSQSNAVS--HVLQR-----LIQGPPGTGKTVTSATIVYHLSKIHK--DRILVCAPSNVAVD-AKSREDVESSVSNLALHNLVGRGAKGELLNKADVVCCT---CVGAGDKRLDTKFRTVLIDESTQASEPEC----LIPIVKGAKQVILVGDHQQ------------LGPVILERKAA-----DAGLKQSLFERLISL-VPIRLERMNPYLS-EFPSN--------------MFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEISANGTSIEAMNCERIITKLFRDGEQIGVITPYEGQRAYILQYMQMNG-----LDKDLYIKVEVASVDAFQGREKDYIILSCVRAQAIGF-LRDPRRL-------NVGLT-----RAKYLGNP------RSLARNTLWNHLLIHFREKGCLVEGTLDNLQLCTVQLVRPQPRK... 856
27 -15.500[R] COG1202 Superfamily II helicase, archaea-specific  ali follow..  15  196....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDEVDIPESFKNV---LKLEGITELLPVQVLAI--LVVSATASGKTIGELAGIPKALEGKK----MLFLVPLVALANFKRRYSKL--GLKVAIRVGMSRIKTRVDTGIDADIIVGTVDYLLRSGKKIGNV--GTVVIDEIHMIDDEE------------------RGPRLD----------------------------------------------GLIARLRK-----------------LYPKAQFIGLSATVGNPQELARSLGMKLVLYDERPVDLERHLIIARNESEKWRIIAKLCKAEVMRKSSKGFKGQTIVFTYSRKRCHELASFLTGKGLKAKPYHSGLPYKQRKITEMEFQAQM----VVVTTAALGAGVDFPASQVIFMGNKWLSVREFHQMLGRAGRPLYHEKGKV--YLIVEPGKKYSAQMDETEDEVALKLLTS-EPVIVEWSDEIEE.... 588
28 -15.500[LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)  ali follow..  13  438................................................................................................................................................................................................................................................................................................................................................................................................................EQSLPVAIIGEANLLGKRIQQRSRDKRKTINPDTLVRNLAELKIGQPVVHLDHGVGRYGGLVTLDTGGIKAEYLLL-------------NYANESKLYVPVTSLHLISRYVGGSDESAPLHKLGNEAWAKSRQKAAEKIRDVAAELLDVYAQREAKKGFAKYDREEFQQFSATFPFEETYDQEMAINAVIS-QPKAMDRLVCGDVGFGKTEVAMRAAFLAVMNHKQ---VAVLVPTTLLANFKDRFANLPVNVEVLSRFKTAKEQKQILEEGKVDILIGTHKLIQSDVKF---NDLGLLIIDEEHRF---GVGQKEKIKQLRAN--LTLTATPIPRTL-------NMAMNG--------------------------------IRDLS--IISTPPARRLSIKTFVRQNDDLVVREAILREILRGGQVYYLHNDVASIENTAKLTALV--PEARVIVGHGQMRERELERVMSDFYHQRYNVLVCSTIIET-TIIIERADHFGLAQLHLRGRVDAERRLDALENLDNGAGFILATHDLEIRGAG-ELLGNEESIGFSLY-DAAVKALKEGREPSLEELTQQQAIELRVPALLPDDYLGDVNMRLSFYKRIAAAESKAELDELKVELIDRF. 1052
29 -15.400[LKJ] COG0513 Superfamily II DNA and RNA helicases  ali follow..  14  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTTFAELGLSPKV---IAAVEAAGYTAPTPIQAGAIPPALERDVGTGKTLPMLTLLEKGRARARMPR-TLILEPTELAAQVEENFVKYGIRLNVALLIGGVSFEEQERKLERADVLIATPGRMHFERGKLLLTGVEILVIDEAD----------------------------------------RMLDMGFIPDIER--------------------------------ICKLIPFT-----------RQTLFFSATMPPEITKLTEQFLHSPVRIEVAKASSTAKTVTQRLVKSGKKDWDKRAVLRDLIQSEGDSLKNAIIFCNRKKDVSELFRSLTRHEFDAGALHGDMDQRARMAMLSSFKDGKLR--LLVASDVAARGLDIPDVSHVFNFD------VPIHAEDYVHRIGRTGRAGRSGKAFTIVTSSDTKYLAAIESMIGEKI..................... 370
30 -15.300[A] KOG0344 ATP-dependent RNA helicase  ali follow..  13  42...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HVQGTDLPDPIATLLQNILDAGFQMPTPIQMQAIPVMLHGELGSGKTLASIPILMQLKQPANKGFRALIISPTELASQIHRELIKISEGFRIHMIHKAAVAAKKFGPSKKFDILVTTIYLLKQDPPGIDLASVEWLVVDESD-------------------------------------KLFEDGKTGF-------------------------------------------DQLASIFLACTSHKVRRAMFSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELL---GSETGKLLAMRELVKKGFNP--PVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIW--VLICTALLARGIDFKGVNLVINYD------FPTSSVEYIHRIGRTNKGKAITFFTEDDLRSVANVIQQAGCPVPEYIKG................... 436
31 -15.000[A] KOG0345 ATP-dependent RNA helicase  ali follow..  12  4........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SANINKALTETRFSDLEPPLS-GDIIEALNQSDFEFCTPVQAATIPLLCSYDVGSGKTLAFVVPLVEILRRSTSFPPGVIISPTR-IYNVAQPFVSTLANVNSVLLVGGREVKADMKIIEECNVLIGTPGRLSERMEILDFRNLEILILDEAD--------------------RLLEMG---------------------------FQRQVNY-------------------------IISRLPKQ-----------RRTGLFSATQTEGVEELAKAGLRNPVRV-ESSQQLTNSKTPSGLHLEY-EADKKSSQLVDLLIK--NSDKKLIVFFMTCASVDYWGLVLSKKSISLIPIHGDMKQNARDKALASFTKASSGALLCTDVAA---GLDIPGIDYVVQYDPPQDPNMFNHRAGRTARLGRQGRAIVFLLPKESDVIPIIRSAAMKDRAVMEKGLKAFVSFVRAYKEHHCSFIFR 451
32 -14.900[L] COG4581 Superfamily II RNA helicase  ali follow..  13  272........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EMALDFPFELDNFQKEAIYHL----EMGDSVFVAAHTSAGKTVYAIALAQKHMTK------AIYTSPIKALSN--QKFRDFKHKFDVGILTGDVQVNPEGS------LLMTT-SMLYRGADLIRDVEF--VIFDEVHYVNDLERGVVEVIIMLPPHVTLILSATPLEHYLQNMFKIVDFLMDGYKSANDALKKPDKPVIAKDNKNS-KQNLLPFVFSKKRCEEYVDTLTNRDLN-----HQEKSEVHVVIEKAVARLKKEDRLLPQIGRMREMLS-RGLAVH---------HGGLLPIIKEIVEILFQRGLVKVLFATETFAMGV---NMPAKSVVFSGTQKHDGRNFRDLLPGEYTQ--------CSGRAGRRGLDVTGTVIILSRSELPDTASPSSKLISQFRLTYNMILNLLRV-IEDMIKRSFSENVEEKIKSFEEKLSALKKEMSDVDLKEIKSCLL 797
33 -14.700[A] KOG0340 ATP-dependent RNA helicase  ali follow..  14  55...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TSATNFEGLGLAEWA---VETCKELGMRKPTPVQTHCVPKILAGDVGSGKTAAFALPILHRLAEDPYGVFALVVTPTELAFQLAEQFKALGSCLNLVIVGGMDMLTQTMSLVSRPHIVITTPGRINNPDVPPVFSRTKFLVLDEADRV----------------------------------------LDVGFQDE---------------------------------RTIFQCLPKS-----------RQTLLFSATMTSNLQALLEHSSNKAYFY-KTVDTLTQQFI-------FEDKDAKELYLVHILSQMEDKGRSAMIFVSTCRTCQRLSLMLDELEVENIAMHSLNSQSMRLSALSKFKSGKVP--ILLATDVASRGLDIPTVDLVINYD------IPRDPRDYVHRVGRTRGGLAVSIITETDVKEEEVGKKMEPYNK......................... 430
34 -14.600[A] KOG0346 RNA helicase  ali follow..  14  7...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IREESSEKTFSDFNLDPRL---QRAIHKCEFEKPTSVQSETIPLALEGDLGSGKTIPILELLLKQKQIDENQRGALLLVPTELAQQVYNVLEKLTAHIRFINVATNSSDTVQRPLLLD-DIVIATPSRCVVHVASLPLDKLKFLVIDEADLMLS-NEDMKTLSRSLPRGTQSFLMSATLSKNIASLQKLV--------------------------------CRNPFILAVKDKEASGKL---------------------------TQYVVKCSEQDKFLLAYILLKLRLI------------------------------KGKILIFVNEINRCYRLKLFLEQFGLKSLVLNSELPVNSRLHILEQYNKGLYQ--IIIATDESGMMGEIEELENNVDFV---EEEVISTDQPTLDKMKDQEN--------ADVNDESILAAAKDKSKKKKRV-DKEYGVARGLDFENVACVLN 400
35 -14.500[R] COG1201 Lhr-like helicases  ali follow..  14  24...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TRPTEPQERAFPHILD----GKHTLLIAPTGSGKTLPVFNAILKKKPEKRSGISALYITPRALNRDMLSRIEVMGKLLKVQVRHGDTPQSERQRQSRN-DLLITTQAMFSGSRLRKNMETVTHVVVDEIHELASSK------------------RGAQLAIGLERL---------------VEISGEFQRIG-------LSATVGN-------WEIAKFLAGANRDFTVIEVALLKL---------------------EFDVISPQVSGEAEDREVMEIARTVGCEPEFASHLSLIRKIVEESQSTLIFVNTRQSAEALAAGFRKLGASIGVHHGSLSFEARVEAEEAFKAGALRGL--ICTSSMELGIDIGNVDRVVQYGSPRQVSRLLQRVGRAHRLHEVSRGTVLKAALEGRVED--ISPHVNSLDVVANQIAGMVMDFGEVGIEKIFRILR 431
36 -14.500[A] KOG1804 RNA helicase  ali follow..  11  306.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTV-TIIEAVLQVHFALPDSRILVCAPSNSAADLVCL-SKVLQPATMVRVNATCRFEEIVIDASRFRIIITTCSSSGLFYQIVRVGHFTHVFVDEAGQASEPECLIP-LGLMSDISGQIVLAGDPMQ--LGPV-SFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNY------RSHEALL-MLPSRL--------------FYH-------RELEVCADPTVVTSLLGWEKLPK----PLIFHGVRGSEAEAVQVLRYCCLLAHSISSQVVITPYRKQVEKIRILLRNVDLMDIKV----------GSVEEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLSNS-FNVAI-TRPKALLIVLGNPH------VLVRDPCFGALLEYSITNGVYMGCDLPPALQSLQNCGEG....... 754
37 -14.100[A] KOG0326 ATP-dependent RNA helicase  ali follow..  14  94..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RELLMGIFEMGWEKPSPIQEESIPIALSGDIGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTR-VSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDVHVVIATLDLIKKGVAKVDHVQM--IVLDEADKLLS---------QDFVQIMEDIILTLPKNRQI----LLYSATFP----------------------LSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQ---------------------------------------------------KVHCLNTLFSR--LQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCR--NLVCTDLFTRGIDIQAVNVVINFD------FPKLAETYLHRIGRSHLGLAINLITYDD-RFNLKSIEEQLGTEIKPI..................... 449
38 -14.000[A] KOG0330 ATP-dependent RNA helicase  ali follow..  14  43...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAPKTFKELGVIDEL---CEACEKLGFKTPTPIQQEAIPVVLNKDVGSGKTAAFALPVIQELWNNPSPFFAVVLAPTELAYQISEQFEAIGGSIGVVIVGGMDMVTQAVALSKKPHVLVCTPGRLMDHLENTKGFSLKYLIMDEADRLLDMD-----------------------------------------------FGPIIDK-------------------------ILKIIPHE-----------RRTLLFSATMTSKVEKLQRASLHQPVRV-STVDTLIQRYL-------FFPFKHKDTYLVYLVNE--LAGNSIIIFARTVNDTQRLAILLRTLGFSAIPLHGQLSQSNRLGALNKFKSGARS--TLVATDVAARGLDIPLVDVVINYD------IPTDSKAYIHRVGRTRAGKSIALVTQYDLEEATIGKKMQEYEI......................... 413
39 -13.800[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  10  8.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RQVADSVAAF--RAAFPLNSPLFNGENNDNVSMLEQFLAQ------------------ETLLKGPYLSAQLPFRKSDLPLNFFPN---------------LTLPFPPHAHQARAFQRLGSDAPQPTLVATGTGSGKTFPLLNHCAGASQAG----KAIIIYPMNALAT--DQASRFAKKVTVGLFVGDSEIKHTLRESPP-DILLTNYKMLDGDQPLWRYNQLRYLVVDELHTFDGAQSDLACLVRRLKHH-ACVGTSATVGDELGQL-TIFD-VIREDRYTAAEYLQNYAIAYSQYPGPEVASALDPQSYATPVAYLNGQIPLWFPDSDLQLPDDLESDDGREKRIALGSLLRRHSVMHVLLLQGGILSERECLLQVMLAESADHARRVLQSILALIAQARLEVPETEHDARPVLPFVQLRSQLWLREMRRLVASVAKTPRLVFADDVAVEDREHYLPVIHCRDCHATGWARHGQSVQLETDL---PYCNSKQGISILGSRAASLSAV---MIHQLYGSKLITFSDSVQDAAHRASFFTARTWPLMIRGQIASVLS 673
40 -13.400[R] COG1203 Predicted helicases  ali follow..  12  13................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SPYEYQKE----MDNLLEGKS--IIRAPTGAGKTEASLIPFIYGLNDYLPPQ-LIYSLPTRTLVE-GERAIKYASKLRVAIHHGKKATSSLFEE----DIIVTTIDQTAGAY-FVGGIASALTVFDEVHTLDEKGLQTAAAIAMQSAKLGIIMSAT----------------LPDVF----------------------------------IERVKERIEKNGGKVEIMDVKNESEIKSRR--------------NRKVELIN---------------------RPDEMLTADTVLKEAENCRKLVVVVNTVERAQNLYLDLRKKDYPIFLLHSRYLEKDRAEFEKVFGKNGKGECIFISTQVIEVGMDISSPIILSEVAPI-------QRAGRCARWGGNGEFHVFGLARDS--SNPYAPYLKELIESTITEIRSKGD--FPLDWQTELQLVN 390
41 -13.100[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  11  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MNSINQQKIKRRKKMANNKTLFDWVEDRKSTLEEIEQTDFFALPENLKYPFFEWQKSALENFVIFDRAS----MA--TGAGKTMMMAALILYYFEKG---RHFLFFVNQNNIVD--KTENNFIDPAHAKFLFTERKVEMFSPHSDGIEIKFTSIQKLYNDIHTERENQ--VMLGDEAHHLNAQTKGKKNKNGNPGQNVLLEFTATLPENA----FGLKEFLQKGYTKEINLVSSTLNKKERVLHALLFAANFKPVMLFRSKTIDESKADYSAFLNWAENVQADDFEFLDTFSGSLNNSDNANEQGKTR----------------QALKFMQDNKFGFAHLANWVKQNYQKHNVIITNSETNKNKT------------------EKTDSETEKLLNNLEAADNPIRAIFTVDRLTEGWDVLNLFDIVRLYE--ATVSEKQLIGRGVRY-MQHELRILEELFYYTHDEQSRYISELKNELRKDGYLPEKDDDKVLATFKLKSEFA 588
42 -13.000[LK] COG1200 RecG-like helicase  ali follow..  14  183..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPNEFNPHQYSLKEALRLLHRPPPDISLEMPAQQRLIFEELLAHNLAMQKVRLGTQQFSALPHYQTDLKQRFLATLPFQPTNAQKRVVSDIELIKDYPMMRLVQGDVGSGKTLVAALAALTAIDNG----QVALMAPTEILAHANNFRRWFKPGIEVGWLAGKVKGKSR-IKTGAVQMVVGTHALFQEEVEF---SDLALVIIDEQHRVHQRLMLREKGEKAGFYPHQLIMTATPIPRTLATVYADLDT------------------------------------------SIIDELPPGRTPITTVVVSEERREIVMRVKNACVNEKRQAY----------------VC--TLIDESEVLEAQAAEAIWEDLTKALPM-------------------------LNIGLVHGRMKPQEKQDVMMRFKNAELD--LLVATTVIEVGVDVPNASLMIIEN------AERLGLSQLHRVGRGCTASFCVLMYKPPLGKVSQKRLQVLRDSQDGF---------VISEKDLE.... 628
43 -12.800[A] KOG0349 Putative DEAD-box RNA helicase DDX1  ali follow..  16  278..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TQTKFLPNAPKALIVEPSELAEQTLNNIKQFKPKLRELLIIGGVAARDQLSVLENVDIVVGTDDLVSTGKLNLSQVRF--LVLDEADGLLSQG---SDFINRMHNQIPQVTSDGKRLQVI-----VCSATLHS---------------------FDVKKLSEKIMHFPTWVDLKGEVPDTVHHVV-VPVNPKTDRLWERLGKSVHAKDNTRPGANSPEMWSEAIKI------------------KGEYAVRAIKE--HKMDQAIIFCRTKIDCDNLEQYFIQQGFSCVCLHGDRKPHERKQNLERFKKGDVR--FLICTDVAARGIDIHGVPYVINVT------LPDEKQNYVHRIGRVRMGLAISLVATE--KEKVWYCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIE 663
44 -12.800[A] KOG0329 ATP-dependent RNA helicase  ali follow..  12  54..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PELLRAIVDCGFEHPSEVQHECIPQAILGDVGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTELAFQISKEYERFSPNVKVAVFFGGLSIKKDEEVLKK-HIVVGTPGRILARNKSLNLKHIKHFILDEC------------------------------DKMLEQL----------------DMRRDVQE-------------------------IFRMTPHE-----------KQVMMFSATLSKEIRPVCRKFMQDPMEIFLTLHGLQQYYV-------KLKDNEKNRKLFDLLDVL--EFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRR--ILVATNLFGRGMDIERVNIAFNYD------MPEDSDTYLHRVARATKGLAITFVSDENDAKILNDVQDRFEVNISEL..................... 414
45 -12.400[A] KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily  ali follow..  11  59.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLEKAELLKILNKFTQRREIKSLCNENGL-----DDYLQQQAFGSFRRFCIEAENLPVDLHITFSDITQGAGHIDDIFPYFLRHAKT----------------VFPHLD-LKKISDLRQPANWYSNARAITRKILLA--------TEVYNKAERGTPCDLVTGEERKFGISESLPANHVACT--------VEMTSNTPYEVAVIDEIQQIRDPQR--TRAFLGLIAD-EVHVCGEP--------------------------------------------GALDLL-----QKICETTGETVEVRLYDRLTELT------------------VENTALGSLDNI----------------------------------VPGDCIVCFSK--HDIYTVSREIEARGKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAIGMGLNLSIRRIIFYPS---SVSSALQIAGRAGRFRTQWEHGYVTAFKSEDLQTLQRILARTPEPIKQAGLHPTADQIELYAY........ 462
46 -12.400[V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  13  1..........................................................................................................................................................................................................................................................................................................................................................................................MAEAKFEAALIKKLETEGWTYREDLS---NVSIKKLEEHWRDILNETNAHKLNGVPLSEIEFGLILQELQRIRTP-EDDVAGGRSRYEIVNQVRFDNLSEGLTTKRIIDVALLING-HIEEKDEHLQNQWRAFEQLKGYHGDGLYKGL-FAFVQVQVIMSQHSRDENNKDITDAFEFIHQVMSIPALHRLDASNDNIMVMRSYQIQATR-LQRMKEMKEGGYIWHTTGSGKTVTSFKVAQLLASAPRIKNVLFIVDRIDLIDQTLENFKSFAYAHFKNRIKKVNGRERELKRKGSSQILLISVQGLTKAVKKGLENDDWNVIIDEAH--RSASGESVKLIKKLKKTTWFGFTGTPNFYS-----EINDVKTTREISTHDIFGKRLHTYTIKDAIGD--GNVLGFDVTYFKPHWVVEHPQEDFSEKDYEKEVYQSD-----------------VYRQEVVKDILDNWTKTSSG--ALIAGKREENAFQAMFNIFKSKGSHLNVAMTFSDYTEKFNVPSILDAKDPARAYMLDITKRLARKRPYNQGKEKDRLDLVIVSDQ--------LTGFDSVIYMDKMLKEGMLIQAISRTNRTLNSKP-KVRFYRQGDEMREFV-ALRIYTRGGNDTLQEAEEETKNQLPKENDDILAK 731
47 -12.300[L] KOG1803 DNA helicase  ali follow..  11  233...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GNLPETLNPSQVAAVS--AAMNTQRNLLCIQGPPGTGKTRVIAEIVHQLMKKKK---KVLVCAPTHVAVR-LSTMSTSDPLYKKMSYEYYLIRNSIFRSFYPKLAVFSTLGTSSIQKLPEYHWNADVMIVDEAAQCTEPAT----PVLTTPSCKKLILVGDQKQ------------LPAVVLSKLSLMEKLAEEFSSNNINILLNEQY------RMNKKIM-NWSNE--------------VFYEN-------QLTAHSTVSDITLRDICPNLPED--NPIMMINMENNTDELNLVTEYVNRLVVDPKAIAVISPYYAQIEKLRRSIPFR---------------DVNTVDAFQGHERQVVIFCLVRDGQIGLNV--------------------AVTRARRIGNG------RMMKGNKHLLKLYKHLQSEKVIFGPSILETFNDLEEAALPRSDKF.. 693
48 -11.900[J] KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases  ali follow..  12  29...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EIVDSFDDMNLSESL---LRGIYAYGFEKPSAIQQRAILPCIKGQSGTGKTATFAISILQQIELDLKATQALVLAPTELAQQIQKVVMALGDGASCHACIGGTNVRAEVQKLQMPHIIVGTPGRVMLNRRYLSPKYIKMFVLDEAD----------------------------------------EMLSRGFKDQ---------------------------------YDIFQKLNSNTQVV-----------LLSATMPSDVLEVTKKFMRDPIRILLTLEGIRQ------FYINVEREEWKLDTLCDLYET--LTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSR--VLITTDLLARGIDVQQVSLVINYD------LPTNRENYIHRIGRGRKGVAINMVTEEDIETFYTSIEEMPLNVADLI..................... 406
49 -11.900[J] KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily  ali follow..  13  20............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDVEVIPTFNAMNLKEEL---LRGIYAYGFEKPSAIQQRSITPIVKGQSGTGKTATFSISILQSLDTTLRETQVLCLSPTELAVQIQKVILALGDMMNVVCIGGTNLGEDIRKLDYGQHIVSGTPGRVMIKRRVLRTRAIKMLVLDEAD----------------------------------------EMLNKGFKEQ---------------------------------YDVYRYLPPATQVV-----------LISATLPHEILEMTSKFMTDPIRILLTLEGIKQ------FFVAVEREEWKFDTLCDLYDT--LTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERDEIMKEFRAGQSR--VLITTDVWARGIDVQQVSLVINYD------LPNNRELYIHRIGRSGRFGRKGVAINFVKSDDIRILRDIEQYYSTQI..................... 388
50 -11.700[L] COG1110 Reverse gyrase  ali follow..  13  31..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVRATGFRWVKRILRGKSFSIIAPT-GMGKSTFGAFISIYFAIKGK---RSYIVVPTTPLVVQTVKMERAGVNVRLVYYHGNLKKKEKRIKDGDFDILVTSSQFLATRFDELRDKRFDLIFVDDVDAF-----KASKNIDRS-----LLLLGFT-QEVINRAWEVIKL--------KKQLAKLLQAQGKEKEVEELNKEI-----EKIEREIERYRRENNIGILIVASATGSAR---GDRIKLYRELLG------FEVGSGRSVLRNI------VDTYIIPERSIEEVENLLRKLGKGG---LIFVP-IEFAEELTNYLKSKGFK-----VELVSAKNKRGLELFERGEVDYLVGVATYYGTIGLDLPHL-FAVFAG----PKFRFSM-----DLEQPTIYRVLGLMSE---------LPQEKREEGEKLYARLRRLIRNIPQYELMKIEE 489
51 -11.500[U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)  ali follow..  14  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MLGFAKKLFGSSNERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDI-LNEAFAVVMRHFDVQ------------VGGMVLHEMGEGKTL--VATLPTYLNALEGKGVHVITVNDYLAADWMGQVYNFL-GLSYGVIVNGLSQGER-QRAYRSDITYGTFDYLRDNLDEMVQRGHNFAIVDEVDSI--------------EARTPLIISGPTEDRS--SFYKTIDVLVKELILDKSMFDHDEKQKQQALRANILYTRDKDYIVKGGEVVLIDELHQAIEAKEGADIQPENQTLASVTIQNYFRLYKKGTASTEAQEFDDIYKMSVSEIPTN----YRTEREKNEAILKQIADCHVRGQPILVLSKLLSTFSFEKDGKKVKGIPHQVLNARFHEQEAVIVA---DAGVPGAVTIATNMAGGTDIQLAGGLFVLGTERHESRRIDNQLRGRTGRQGDPGRSKFFLSCEDDLLRERLDAIMRTTHKWLNNAIATAQKRVEQRNYEIRKNLLK 659
52 -11.100[R] COG1204 Superfamily II helicase  ali follow..  9 1360.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PNFKFFNKIQTQVFNSVYKTNNGSGKTCAELALLHHWSQEDYGT--AVYIAPIQEI-EWYGKFSDLGDGKVLVKLTGERSQDLK--LIQVADLIFCT-SLSKRWRSMRSIQKVDFYICDELQLLGGFYSRIRYMAVQLEKNIRVVGLSVSVAN-ARDLGEWLGTSPQCIF----NFSPKDR-------------------------------PNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKSTIVFTPDRKVAKQLAFDLVTFSMADEDEYLFSLMENEAFNKVEDAAL-------------QQSLKHGIAYIS--EITSSNDQNIVQYLYRHGLIKVLIASRDVI--YSLKAKSNAVIVMGTQYYDGKEHRQMLGFTASMTVTTKKEYYKKFLNEPMESHLQVHDAFVSEISTQTIESKQDAVDWLTWSYM..... 1795
53 -10.500[A] KOG0923 mRNA splicing factor ATP-dependent RNA helicase  ali follow..  14  228............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQV----------------IIEGETGSGKTTQVPQYLV---EAGFTKDKKMIVAAMSV-------AARVAEEMGVKL--GYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIRPELKLLISSATLD---AEKFSAFFDDAPIFRIPGRRYDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELI-----------IPVYANLPSDMQ---------------------AKIFEPTPPNARKVILATN------IAETSLTIDNIIYVIDPGFAKQN------------------NFNSRTGMESLMVV-------------PISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNEIQRINLGNAVLM-----LKALGINDLIHF.. 631
54 -10.500[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  12  90............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KWRGQLTPFQEKVSEGLLQVVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGA---VCLASPRDVCLELYKRLQQDFS-CGIALLHGESEPYFRTP------VVATTHQLLK--------QAFDLLIVDEVDAFDNPMLYHAVKNSVKENGLRIFLTATSTNE----------------------------------------------LDKKVRLGELKRL-----------------------------NLPRRFHGNPLIIPKPIWLSD--------FNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQEQFPNEKIGFVSSVTEDRLEQVQAFRDGELT--ILISTTILERGVTFPCVDVFVV-HRLFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLNIKKAIKEIQMMNK........................... 428
55 -10.300[L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits  ali follow..  12  637............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IIYCRWLESAYAAAEKELNRLYRFYLKVDRERIGLRGANVIGMTTTGLNKYRDILERINPKICFIEEAADVLEGPIIPA----VFPSLEQLVLIGD--HKQLRPGCSTYALRQDPFNLSISMFERLVENDMEYTRLT-MQRRMHP------------------------QIRRLVSSVY--------EDLSDYEITKYWPSIPGMGEIRRFFLTHSRIEDNDGFASKAQMLVQFAVYLINNGQKITCLTFYAAQKDLIERLLSES-------LNREKHFIKVATVDGYQ-GEENDVVLLSLDRTEVGF-LSSPHRV------------CVSLSRARRFGNAQL-----VAESNPLWWDAINTLMNDETIQG....................... 967
56 -10.300[V] COG3587 Restriction endonuclease  ali follow..  15  5............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NYEKNQ-PHQMRAVSAVLGV----FDGAYANNIGTGKTYTYTQTMFELHRWLGVFK-FIVVVPTLSIKAGTQQFDYEGVRLKTYVVESAKKNKGKAENKKEIHVLLINAGMVNSSVDALAAVR--FMIVDEPHKFPTRDSAKTGNIKRLKPQYILRYGATFNDEYYNLLYRLVDAFNDGLVKGVRVFQEEMQGGMDAAVKLVSSDGKEAKFELNEKDKKQTFKLAKGEDLAQIH-TVQDAMMQRAVAEHFKLELAERAPQPKIKPLT-LFFIDDI-------AGYRSGNELSGSLKDKFESWIRAEAARRL-PFYRDYLQKTLDDVSACHGGYFSKDNTDSDDRIEQEINKLLSLDNPRRFIFSLREG-----------------WDNPNVKLQEVGRGLRL-VRDVPYKLNYFVDSSEKDFVKQLVGEIND.......................... 575
57 -10.100[A] KOG0925 mRNA splicing factor ATP-dependent RNA helicase  ali follow..  13  63........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QNYFKILETRRELPVYQQREEFLKIYHENQI----------------VFVGETGSGKTTQIPQFVLYDELPHLTNTQIACTQPRRVAA--MSVAKRVADEMDVDL--GYNIRFEDCSGPNTLLKYMTDGMLLREAMTDHMLSRYSCIILDEAHERTLATDILMGLMKRLRPDLKIIVMSATLD---AKKFQKYFFDAPLLAVPGRTYEIYYTQEPERDYLEAALRTVLQIHVEEGPGDILVFLTGEEEIEDACRK-----------ITLEADDLVREGAAGPLKVYPLYGSLPP---QQRIFEPTPEDTKS------------GYGRKVVISTN------IAETSLTIDGIVYVVDPGFSK-------QKIYNPRIRVESLLVS------------------------PISKASAQQRAGRAGRTRPGKCFRLYTEEAFRKELIEQEILRSNLSSTVLE-----LKKLGIDDLVHF.. 462
58 -10.000[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  14  289..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAKQELQEVVEFLKNPQK----------------FTILG-------GKLPKGILLVGPPGTGKT------LLARAVAGEADVPFYYASGSEFD--------------EMFVGVGASRIRNLFREAKANAPCV--------------------IFIDELDSVGGKRIESPMHPYS--------------RQTINQLLAEMD----GFKPNEGVI-----------GATNFPEALDNALIRRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLAALKAAVD--SKDKILMGPERRSVEIDNKNKTITAYHESGHAIIYYTKDAMPINKATIMPRGPTLGHVS---LLPENDR------WNETRAQLLAQMDVSMGG-----VAEELIFGTDHITTGASSDNATKIAKRMGMSEKLGVMTY-TQSAIEQEIRILLRDSYERAKHILKTHAKEHETLDAKEIQIVLE 709
59 -9.870[S] KOG2340 Uncharacterized conserved protein  ali follow..  10  159...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEIKNIDDLGLKQRILDSYKSMQIELAKAMFN----------QDVFFTNMSLHALNHVFKTRDQGYTRPKVLILLPTNSAFEFINLLISYSGTNQVYLFSGNRKTVKLFSQFYNSDIIVASPLGLRRDLDYLSSIEI--AMVDQAHALVMQNWEHIECIFDE-------LNGLPKEAHGCDF-----------------------------------SRVRPWYLDQQARYMRQTI------LFSQYNNLDINSFFSHYMSNIAGKVK---SLLHGVLNRLGYKVTQTFVRISVDSIIKVPDARFSYFTGSILVQLKKYSGILVYIPSYFDFVRVRNYMDEEGINYSAISEYSSVSDMTRARNLFYQGRTNIMLYTERAHHFRRFDFRGVKAVVMYGP---P---TNPQFYVELVRMPMRTISEGNLDSDAAKCRIMYTKFDSICL-EGIVGYQRVSNMCHGKHEVFEFL. 652
60 -9.830[L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase  ali follow..  12  163......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGLEYQAVDQKKVKTQSWYEVDHAQLEGVEISTRAKKKLELRDYLLSHPESASLASLLESYSREQVNFFVDQGAVTIVQKEVQR--------SAAYFEGIEASRPLELNPEQRQARDAVVSSIGSSQPPFLLQGIGSGKTLQIIQGALDKGKTAILLVPEISLTPQMT----ERFIARFGDKVAILLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNL-----GVMIIDEEHEAAYKQDSNPRYHAREVAILRAQYNQATL---------VLGSATPSL-------ESRARAGKGVYQHLRLTQRANP----------LATIPEVQVIDFRDYIGQNETSNFTP---PLLEAIQDRLVKKEQVVL--MLNRRRECCDISLTLHMDTKTMNCHYCGFSKDIPQVKSRSIRYYGTGTQKAY-LAELFPQARILRMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDVGVLNADTALNLPDF---SSERQVAGRSGRAEKAGQVLIYEGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILR 729
61 -9.820[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  14  296..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RGIFNIGKATITRADKHSKNKIYFKDVAGCDEAKQEIMEF--VHFLKNPKK-------YEDLG-------AKIPKGALLVGPPGTGKT------LLAKATAGESGVPFLSISGSDFM--------------EMFVGVGPSRVRHLFQEARQAAPSI--------------------IFIDEIDAIGRARGRGGLGGNDER------------ESTLNQLLVEMD----GFGTTAGVVVLAGTNRPD---------ILDKALLRRFDRQITIDKPDIKGRDQIFKIYLKKIKLDHEPSYYSQRALTPGFAGADIANVAALIAARH--AIDRVIGGLEKKNRVISKLERRTVAYHESGHAVVGWAEPLLKVTIVPR--TAALGFAQYVPNENLLMTKEQLFDM-----------TCMTLGG-----RAAEQVLIGKISTGAQNDEKVTKMTYAQGFSDKVGLLSF-TGAIIDEEVRDWVAKAYERTVELVEEHKVKVAELHQDDLLKILG 756
62 -9.660[Q] COG3321 Polyketide synthase modules and related proteins  ali follow..  11  61...........................................................................................................................................................................................................................................................................................................................................................................................RSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETSWEAIEQGGLDPASLAGS-LNNSVASGRISHTLGLHGPAMTFDTACSSGLMAVHLACRSLHDGESD--LALAGGCAVLLEPHASVAASAQ-TGRCKSFAADADGFVRSEGCAMVLLKRLPDA---LRDGNRIFAMILATNQDGGTETLMMPSE-VAVYQALAVAGVE-IGVVEAHGTGTPIGDPI-LGSAKSNMGHSTASAGTVGLIKAILSLVPPLLHFDWPVGVSSFAPSEACAPDVPETSPGTGDATVGRQLFMLSSIAALRETARQLATW-----VEEHQDSVVLSDLAYTLARGRAHRPVRTAVVAADLPELVEGLCEIADWVFSGLLANEPVFAATITK-----LEPVIAAESSFSVTEAITAPETVTGIDKVQPSVFAVQVALATTMEQTYGVRPGAVIGHSMGESAAAVVAGALSLRVICRRSKLMNRVAGSGAMGSVELDDVVISVVASPQSTVIGGATETVRDLIAQWEQRDVMAREV--AVDVASHSSQVDPILDDLAAALADIAPMTPKVPYYSATLFDPRVCNGYWNTVQFAAAVQAAMEDGYRVFAEL---LLTHAVEQTARNLDMSVAALAG--MRREQSMPYGLRGL-LADLH. 851
63 -9.640[O] KOG0740 AAA+-type ATPase  ali follow..  16  375..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVPDIFTGLRGPPK---------------GILLFGPPGTGKT------LIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRAL---------------------------FAVARC----------AVIFIDEIDSLLSQRGDGHESSRRIKTEFLVQLDGA--------------------------------TTSSEDRILVVGATNRPQEIRRLVKRLYIPLPEASARKQIVIMSKEQCCLSEEEIEQIVQQS-DAFSGADMTQLASLGPIRSL-------------------QTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDL-----------ELYENWNKTFGCGK...................................................................................................... 674
64 -9.630[L] COG1643 HrpA-like helicases  ali follow..  13  65........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAARPSITYPQNLPVSQKKQDILEAIRDHQV----------------IVAGETGSGKTTQLPKICMELGRGIK-TQPRRLAART---------ANRIAEELQTEPCIGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAH-----------------------------ERSLN-----IDFLL-GYL-----------------------------------KELLPRRPDLKVIITSATIDPE--------------RFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGRESP-ILIFMSGEREIRDTADALNKLHTEVLPLYARLSNSEQNRV---FQSHSGRRI-VLATNVAETSLTVPGIKYVI--DP--EPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRFTDPEILRTNLASVILQ-----MTALGLGDIAAF.. 451
65 -9.400[L] COG0514 Superfamily II DNA helicase  ali follow..  15  18......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSALFATPERVLHEV---GYQQFRVGQQEVIEAALAGRTGGGKSLQIPALVL--------EGVTLVISPISLMKDQVDQLKANAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLTAIERLSHLPLAMIAVDEAHCISQ--------------------------------WG-------------HDFRPEYAS------LGQLKQRFPPVMADATRHDIMQRLQLNEPHQYLGSFDR-----------------------------------------PNIRYMLVEKHKPVSQVIRYLET--QRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQ--IVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLRMLDEKPDGAQKQVESHKLTAMGA....................... 385
66 -9.310[M] COG5498 Predicted glycosyl hydrolase  ali follow..  10  75..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TDSLSSPIETN-------------KFFDNN-------LLGSMGGICIAHTDDNQRVMDTDDTIPSYCSLGFGASGITSNTDPIVDEIDQSMQLTLTEGMA----TTAVYTNAIPQIFS-AVQKYRVTMSDNHVWLIYIYGDSLTLTESTSQMLVGSNTFNGYIQIAKTGISISGYVED-FTPLFFLLPHQVDTAVSGTKVTSIVLASLVSGDMNAAANSITFAEAIPQDIGFLPWSPTGGQIGYSEEALEIIAEVAGTELGEDFSANSNLNSMY--KVLAKYAMLCV---TINDILGDETSSEQCIQKLEAAFAQQIYPLTYNTWKGVVSV-NSYYNDHHFHYGYFTAAVIGHIDPDWINTGNNKEWVNFLVRDV------ANPSSNDPYFMIDIYWASGLDEESTSED--YNFFFGMKLWGQVIGDSMEDRANIILGIERNALNKLYADGNVQPTSMQPNYVAGIT. 633
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Godzik A. NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1. Trends Biochem Sci. 2004 Mar;29(3):106-10.