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Query: gi|13507742|ref|NP_109691.1| DNA gyrase subunit B MPN003 [Mycoplasma pneumoniae M129], from M.pneumoniae

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEDNNKTQAYDSSSIKILEGLEAVRKRPGMYIGSTGEEGLHHMIWEIIDNSIDEAMGGFASTVKLTLKDNFVTIVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSGGLHGVGASVVNALSSSFKVWVAREHQQYFLAFHNGGEVIGDLVNEGKCDKEHGTKVEFVPDFTVMEKSDYKQTVIASRLQQLAFLNKGIQIDFVDERRQNPQSFSWKYDGGLVQYIHHLNNEKEPLFEDIIFGEKTDTVKSVSRDESYTIKVEVAFQYNKTYNQSIFSFCNNINTTEGGTHVEGFRNALVKIINRFAVENKFLKETDEKITRDDICEGLTAIISIKHPNPQYEGQTKKKLGNTEVRPLVNSIVSEIFERFMLENPQEANAIIRKTLLAQEARRRSQEARELTRRKSPFDSGSLPGKLADCTTRDPSISELYIVEGDSAGGTAKTGRDRYFQAILPLRGKILNVEKSHFEQIFNNVEISALVMAVGCGIKPDFELEKLRYNKIIIMTDADVDGAHIRTLLLTFFFRFMYPLVEQGNIYIAQPPLYKVSYSNKDLYMQTDVQLEEWKQQHPNLKYNLQRYKGLGEMDAIQLWETTMDPKVRTLLKVTVEDASIADKAFSLLMGDEVPPRREFIEQNARNVKNIDILast
1 -102.000sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   24  4....................................................................................................................................................................................................................................................................................SEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKK---NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNW----VKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS............................................................................. 300
2 -98.300sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   25  1...........................................................................................................................................................................................................................................................DETGVALKVIHELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK---NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNW----VKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK.................................................................................................. 300
3 -84.500sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   27  2..........................................................................................................................................................................................................................................................................................................................................................................................................................KYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPED-DAAITLAFSKKKIDDRKEWLTNFMEDRRQRRL 248
4 -83.000sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   30  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................NSTECTLILTEGDSAKTLAVSGLGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNKKWKVKYYKGLGTSTSKEAKEYFADMKRH-RIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKL 227
5 -80.600sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   18  1......................................................................................HKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNG------KKLPVNGFRSYVDLYVKDKLDETGVALK----------VIHELANERWDVCL-TLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK---NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCG-----IVESILNWVKFKAQTQLNKKCSS................................................................................................................................................................................................................................................ 300
6 -72.600sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   18  1...........................................................................................................YDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAEYKKMFKQTWMDNMGRAGEMELKP-FNGEDYTCITFQPDLSKFKMQSLDKDIVARRAYDIAGSTKDVKVFLNGNK---------LPVKGFRSYVDMYLKDKLDETGNSLK----------VIHEQVNHRWEVCLTMSEKG-FQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKK---NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKG-------IPKLDDANDAGGR......................................................................................................................................................................................................................... 300
7 -70.400sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   20  21.NEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMEKPFNGEDYTCITFQPDLSKFKMQSLDKDIVARRAYDIAGSTKDVKVFL-NGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQV------------------NHRWEVC.......................................................................................................................................................................................................................................................................................................................................................................................... 300
8 -67.200sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   21  42.KNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEVPGLYKIFDEILVNAADNKQRDKNMTCIKVSPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKKHSFKQTWMNNMMKTSEAKIKH-FDGEDYTCITFQPDLSKFKMEKLDKDIMTRRAYDLAGSCRGVKVMFNGKK---------LPVNGFRSYVDLYVKDK.......................................................................................................................................................................................................................................................................................................................................................................................................................... 299
9 -14.200sp|Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta OS=Homo sapiens GN=TOP2B PE=1 SV=3  ali   22  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASKNKQELSFYSIPEFDEWKKHIENKAWKIKYYKGLGTSTAKEAKEYFMERHRILFRYAGPEDDAAITLAFSK---KKIDDRKEWLTNFMEDRRQ... 95
10 -13.000sp|Q86VD1|MORC1_HUMAN MORC family CW-type zinc finger protein 1 OS=Homo sapiens GN=MORC1 PE=2 SV=2  ali   18  1MDDRYPALQRAQLRLDFIHAN------------STTHSFLFGALAELLDNARDAG----AERLDVFSQGGFMLCFLDDGCGM-----------SPEEASDIIYFGRSKKRLSTLKFIGQYGNGLKSGSMIGKDFILFTKKEETMTCVFFS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 130
11 -12.800sp|Q9UHC1|MLH3_HUMAN DNA mismatch repair protein Mlh3 OS=Homo sapiens GN=MLH3 PE=1 SV=3  ali   15  2..............IKCLSVEVQAKLRSGLAI-----SSLGQCVEELALNSIDAE----AKCVAVRVNMETQVQVIDNGFGMGSD-----------EKVGNRYFTSKCQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYPVRRKCMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSM................................................................................................................................................................................................................................................................................................................................................................................................................................................ 197
12 -12.500sp|Q9Y6X9|MORC2_HUMAN MORC family CW-type zinc finger protein 2 OS=Homo sapiens GN=MORC2 PE=1 SV=2  ali   15  2.............AFTNYSSLNRAQLTFE-YLHTNSTTHLFGALAELVDNARDAD----ATRIDIYAERREDLCFLDDGAGM-----------DPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMIGKDFILFTKKEDTM.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 125
13 -11.600sp|P54278|PMS2_HUMAN Mismatch repair endonuclease PMS2 OS=Homo sapiens GN=PMS2 PE=1 SV=2  ali   18  1MERAESSSTEPAKAIKPIDRKSVHQICSGQVV-----LSLSTAVKELVENSLDAG----ATNIDLKLKDYGLIEVSDNGCGVEEE---------FEGLTLKHHTSQEFADLTQVETFGFRGEALSSLCALSDTISTCHASAKVGTRLMFDHNGKIIQKTPY----PRPRGTTVSVQ--KEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQ.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 212
14 -11.500sp|A6NHR9|SMHD1_HUMAN Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens GN=SMCHD1 PE=1 SV=2  ali   17  102.SVNQLLLTATKERIDFLPHYDTLVKSG-EYYASEGQNPLPFALAELIDNSLSATSRN-VRRIQIKLQGKPAVAVIDNGRGM-----------TSKQLNNWAVYRLSKFTRQGDFESSYFGVGGKQAVFVGQSARMISKPADSQ.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 260
15 -11.400sp|Q8TE76|MORC4_HUMAN MORC family CW-type zinc finger protein 4 OS=Homo sapiens GN=MORC4 PE=1 SV=2  ali   16  11.PGAPGCGLARPGGGPQAFGIRLSTMSPR-YLQSNSSSHPFSAIAELLDNAVDPD----VSARTVFIDVEEVLTFTDDGCGM-----------TPHKLHRMLSFGFTDKVIKKSQCPGVFGNGFKSGSMLGKDALVFTKNGGTLTVGLLS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 152
16 -10.700sp|P03950|ANGI_HUMAN(removed signalp:1-24) Angiogenin OS=Homo sapiens GN=ANG PE=1 SV=1  ali follow..  10  1...............QDNSRYTHFLTQ---HYDAKPQGRDDRYCESIMRR---RGLTSPCKDINTFIHGRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 122
17 -10.700sp|Q14149|MORC3_HUMAN MORC family CW-type zinc finger protein 3 OS=Homo sapiens GN=MORC3 PE=1 SV=3  ali   16  1MAAQPP------------RGIRLSALCPK-FLHTNSTSHPFSAVAELIDNAYDPD----VNAKQIWIDKTVILTFTDNGNGM-----------TSDKLHKMLSFGFSDKVTMNGHVPGLYGNGFKSGSMLGKDAIVFTKNGESM.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 125
18 -10.200sp|P40692|MLH1_HUMAN DNA mismatch repair protein Mlh1 OS=Homo sapiens GN=MLH1 PE=1 SV=1  ali   13  1MSFVAGVIRRLDETVVNRIAAGEVIQRPA------------NAIKEMIENCLDAK----STSIQVIVKEGGLIQIQDNGTGIRKE------------IVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVETRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGE................................................................................................................................................................................................................................................................................................................................................................................................................................................... 199
19 -10.100sp|O95744|PM2L2_HUMAN Putative postmeiotic segregation increased 2-like protein 2 OS=Homo sapiens GN=PMS2L2 PE=5 SV=1  ali follow..  17  63LPVQPAKLTEPAKAIKPIDRKSVHQICSGPVV-----LSLSTAVKKIVGNSLDAG----ATNIDLKLKDYGLIEVSGNGCGVEEENFEGLSLSALKHHTSKI---REFADLTRVETFGFQGKALSSLCALSDTISTCHVSAKVGTRLVFDHDGKIIKKTPY----PHPRGTTVSVK---QLFSTLPVRHKEFQRNIKK.................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 244
20 -9.900sp|P54277|PMS1_HUMAN PMS1 protein homolog 1 OS=Homo sapiens GN=PMS1 PE=1 SV=1  ali   16  24..........................................VVKELIENSLDAG----ATSVDVKLENYGKIEVRDNGEGIKAV---------APVMAMKYYTSNSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQYVLDG---SGHILSQKPSHLGQGTTVTALPVRKQFKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKA................................................................................................................................................................................................................................................................................................................................................................................................................................................... 195
21 -9.700sp|P11388|TOP2A_HUMAN DNA topoisomerase 2-alpha OS=Homo sapiens GN=TOP2A PE=1 SV=3  ali   20  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STPNHKKWKVKYYKGLGTSTSKEAKEYFMKRHRIQFKYSGPEDDAAISLAFSK---KQIDDRKEWLTNFMEDRRQ... 74
22 -9.240sp|Q13400|PM2L8_HUMAN Postmeiotic segregation increased 2-like protein 8 OS=Homo sapiens GN=PMS2L8 PE=3 SV=1  ali follow..  16  149LERAENSSTEPAKAIKPIDRKSVHQICSGPVVPSLRPN----AVKELVENSLDAG----ATNVDLKLKDYGLIEVSGNGCGVEEE---------FEGFTLKHHTCQEFADLTQVETFGFRGEALSSLCALSD---VTISTCRVSAKVGTRLVFDHYGKIIQKTPYPRPRGMTVSVK---QLFSTLPVHHKEFQRNIKKKRAC................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 332
23 -9.220sp|O95746|PM2LG_HUMAN Postmeiotic segregation increased 2-like protein 16 OS=Homo sapiens GN=PMS2L16 PE=2 SV=1  ali follow..  21  2..HFYLLGTEPAKAIKPIDRKSVHQICSGPVV-----LSLSTAVKKIVGNSLDAG----ATNIDLKLKDYGLIEVSGNGCGVEEE..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 77
24 -9.000sp|Q15118|PDK1_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial OS=Homo sapiens GN=PDK1 PE=1 SV=1  ali follow..  16  273.......................................LYHMVFELFKNAMRATMEHHANRIQVHVTLGNTVKMSDRGGGVPLR--------KIDRLFNYMYSRPRVETSRAVPLAGF-GYGLPISRLYAQYF.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 369
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 5 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.