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Query: gi|13507743|ref|NP_109692.1| DNA gyrase subunit A MPN004 [Mycoplasma pneumoniae M129], from M.pneumoniae

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAKQQDQIDKIRQELAQSAIKNISLSSELERSFMEYAMSVIVARALPDARDGLKPVHRRVLYGAYTGGMHHDRPFKKSARIVGDVMSKFHPHGDMAIYDTMSRMAQDFSLRYLLIDGHGNFGSIDGDRPAAQRYTEARLSKLAGELLRDIDKDTVDFVANYDGEEQEPTVLPAAFPNLLANGSSGIAVGMSTSIPSHNLSELIQGLILLIDNPDCTINDLLGVIKGPDFPTGANIIYTKGIESYFETGKGNVVIRSKVSIEQLPTRAALVVTEIPYMVNKTSLIEKIVELVKAEEITGIADIRDESSREGIRLVIEVKRDTVPEVLLNQLFKSTRLQVRFPVNMLALVKGAPKLLNMKQALTVYLEHQLDVLIRKTQFNLKKYQERFHILSGLLIAALNIDEVIAIIKKSANNQVAMEALHERFGLDEIQARAVLDMRLRSLSVLEVNKLQTEQQELKALIEFCQQVLADKQLQLKLIKEQLTKINEQFGDPRRSEILYGISEDIDDEDLITQENVVITMSTNGYLKRIGVDAYNLQHRGGVGVKGLTTYTDDSISQLLVCSTHSDLLFFTDKGKVYRIRAHQIPPGFRTNKGIPAVNLIKIDKDEKICALISVNDYQNGYFFFCTKNGTIKRTSLSEFANILSIGKRAILFKENDVLFSVIRTSGQDDIFIGSTAGFVVRFHEDTVRPLSRAAMGVLGINLNQCEFVNGLSTSSNGSLLLSVGQNGIGKLTSIDKYRLTKRNAKGVKTLRVTAKTGPVVTTTTVFGNEDLLMISSAGKIVRISLEQLSEQRKNTSGVKLIKLKEKERLETVTIFKKEEAIKTTTATETDDVGSKQITQLast
1 -62.700PF00521.20; A0A0D1DXS4_USTMA/785-1232; DNA gyrase/topoisomerase IV, subunit A  ali follow..  20  1...........................................RSIPSAIDGLKPGQRKVMYVMFDRKS---NSELKVNTLVGNVLGQAYHHGEAALSMTIVGLAQNFSNNVNLLEPRGQFGTRGGKDAASGRYIFTALPKIARALFPATDDALLDYLED-DGQKVEPHWYIPVVPQVLLNGAEGIGTGWSTSVPNYNPHEIVANLRRRMAGEDVV-------------PMKPWYRGFNGDVEEFGPGRFKISGRV-----TQIDEKTYEITELPIRTWTSNYKELLEERIVDKIPATIKDYKEYHTESTVNFIVELTAKGQAEIADKGVEAFFKLSCQISTTNMVLFDQDKKYTSAEEILEEFYLLRLSYYQKRKEYLVDQLKLMYDKLSNQARFVQMIISRQLVVSNRKRADIVAELRQKDFISADSDFDYLLNMAIYNLTKEKVDKLLKERDHKEEELKILIGRSPQN................................................................................................................................................................................................................................................................................................................................................................................ 441
2 -8.280PF05086.12; O15924_DICDI/5-925; Dictyostelium (Slime Mold) REP protein  ali follow..  14  492..............................KSVIKFIQLCIVMKELLDFMT------RSINYETFK-------------SIISELLG---------MSERVLNLEQDVKKLKDLLLKKSKKSTIDDESELLSRVSNHRVDSITSTLCVEYDSNSIEHKIGFINSRFQPTFTPSNINTVSQQSEEDLKRKYS--LMSSDLSGLLK-VLISFNNNVSGHCKVFSF----DVSNGFSITNLSNLYNRYEEYMGKTRVITAFFFAP------IQLTNFIFQTDKITNDKNISRQIKSIKIYNRSYINIESVKSGFSKVVQINSSSFSSVLINKLNNLSSLVADYYVKSTELLRKADK---LEQLLKKYIEN------------FQKLNTITETEEDIIEAFDFESSAGDDIRNEDEDDE........................................................................................................................................................................................................................................................................................................................................................................................................................................ 911
3 -6.610PF09899.9; V4J3D1_9GAMM/276-1132; Putative amidoligase enzyme (DUF2126 topsan)  ali follow..  17  387......................LDLVANLEASAAETGLRIIIEAVTPDIEVNVHPASSSILYEEARLTRLGTEKFMLDGRHTGTGGGNHVTLGGPTPADSLIQSLITYWQHHPSLS-----GTFIGPTSQAPRVDEAR-----DDSLYELA---IAFQQMPKGQIKQPWIVDRVLRNLLVDGRQGLVEFRAFEMPPHARMSLAQMLLALVARPHFVRQDFGDVIC--DLQRAGYAFESAWFEPFFE---GDLITGNGIRMELRGAIE--VLGEEVTAQGTSRFVDSSVERMQ--KVNGMTGARHALTCNGRRVPLH-PTGRRGEFVAGVRFKAWNPPSGLH----TIASHNPLVFDVVDLCTYYVSHPGGRAEQRFPVNSYEAESRR.................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 825
4 -5.820PF03989.13; GYRA_HAEIN/641-686; DNA gyrase C-terminal domain, beta-propeller  ali follow..  28  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KFVVMATAGGIVKKIALTEFSRPRSNGIIALNLRDEDELIGVDITD.............................................................................................................................................................................. 46
5 -5.530PF09606.10; MED15_DROME/12-749; ARC105 or Med15 subunit of Mediator complex non-fungal  ali follow..  13  444.RNIRQQSPSASINTPGQVTGNSPFNPQEEALYRE---------KYKQLTKYIEPLKRML--AKISNDGTNVEKMTKMSKLL-EILCN--PTQRVPL-ETLLK-------------------------------CEKALEKMDLISYSGQQFGKSS----------NPLL-------------EVINTTLQSPVANHTLYR--------------TFRPTLELLFGTDITA------RPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLD--TTSQINNKAIRLICCL-DDKRLPSVPPVS-------VSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLLDTW-----EMAVRQAPQSKPRAVCELSTLLGV.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 738
6 -5.480PF03033.20; U80A2_ARATH/195-339; Glycosyltransferase family 28 N-terminal domain  ali follow..  13  1................................................................................IVMLIVGT---RGDVQPFVAIVRLATHANFK-EFVLTAGEFYPLGGDPKVLAGYMVPIQRNQMKDIIYSLLPACKEPDPDSGISFKADAIIPPAYGHTHVAEALKIPIHVFFTMP.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 137
7 -5.470PF17663.1; A0A096NMS8_PAPAN/1-1038; Family of unknown function (DUF5525 topsan)  ali follow..  10  735.PAPAPVAGPAPASTSAPGDSPEQHFTGLHASLCDAISGSVAHSPPEKLREWLETAGTKLLSQLQRFDRTHRCPF---------------PH--------VVRAGAIF---VPILVKERLFPRLPPDHVLQEHRVELRPTTLSEEALRELALPGC-------TSRMLKLLLPDIYPDLL-------------GLQWRDVRRQLGD-----FDTEAGAVSSSEPTLARDEPESLALARKSPAPKVRKPGRKPPTPGPEKGEAAAGEESCAASPAACASPPGPTLKARFRSLLETAWLNGLA--KSRPDRPDSQS.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 1035
8 -5.200PF02689.14; HELI_EHV2/2-789; Helicase  ali follow..  16  4..............................................................................................................................GAGFILNMTSDSKVRAIVGRIRGLAAKTVPFDSQFDPEDAEGPFLP--FSTFLITGTAG--AGKSTSI--SALYQSLNCLIT--GATAVAAQNLSNGLKT------PTIYSAFGFKSRHINILPRHGRNAPADMEGIQRNELCVISDILGEFTKEHLTGAAFGALAKMGTPTLWTVIDEAGSHILTAVVLYKSGAVPCVVVGSPTQTDAIQSTYNLTFLMKHEAVSRYVDLNHNWALFINNKRCTLLKTLEYNLDISPRMVDYIDRFVVPKSKILS-TRLFVSHREVKAYLTALHETLSLNQGGATAEADARLFTCPVVCEVFTDT----------------FNEYREAVNLPGLTVTEWLQKNLCRLSNYSQFIDQDLSAVHIETGEESTKVTYLVKYVKNSYVSLNGKTKKCICGFMG..................................................................................................................................................................................................................................................................................................... 460
9 -5.190PF15449.6; F7B3J9_HORSE/1-1249; Retinal protein  ali follow..  14  2...................................................GCTPSHSEIVNSVAKSGI---QFFKKP--------------------KAILPGCQGDSEKCSIPLLAQSSACSDSGRGLSQGQRPAEDQPSSRWTQTRAEDPTTGKKKDVEGLIPETRTSPLQLNKSKSHMAKDISFKTQTH-------ESQGAAFSGEESEESNSQETSKWERKPDFP--------EPLVKAHQ--------HAYTYLHSCLCKYEAVLHITHQATQTQELLQPMVSFL---CFDEVNQLLGEISKDGEVLLQEVKGEPQGQ-LLQQLLQYTKLQAVASLTGSFLEGSSSYLHTTASHLGKKLSTKRGADERRALGQLESLASDHSDPGVQGLPLCSEDSGI-----GADNDSVL...................................................................................................................................................................................................................................................................................................................................................................................................................................... 358
10 -5.120PF17508.2; A0A1J6ZK55_SALHO/1-103; Microcin V bacteriocin  ali follow..  20  15..................................................................................GQDYGREIAQGAGAAAGTFVA---------------GGGGAIVGPIVAGMVYDWA------------------------SNKTPDSALSPSGLGSTLKKKPEGLAEGRMCNWSPNNLNDVC............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 103
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.