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Query: gi|15607174|ref|NP_214546.1| 8-amino-7-oxononanoate synthase BioF2 (Rv0032) [Mycobacterium tuberculosis H37Rv], from M.tuberculosis

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAALLast
1 -98.400[H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes  ali follow..  33  65..............................................................................................................................................................................................................................................................................................................................................................................................LTQKIASEQLGIANPFYRPHQTAAGATTMI-DGRKLINFASYDYLGLNRHAHVLERARETIADFGISASASRLVAGERPQHVELEEKIAQFYGVDAAVCFVSGYLTNVAAISCLMGPKDLVIHDEFIHNSALAGIKLSGATRRFFKHNDTADLEHVLRTVDYRRILVIVEGIYSMDGDVANLPALLKLRAEYGFWLMVDEAHSLGVLGRHGRGLAEHFGADHEVDIWMGTLSKTTSSCGGYIAGSAALAAVLKASAGGFVYSVGLAPVLAASAVASLDILASEPERTAAVRRNGSLFLKLAKEAGLDTGSGGFSVVPVIVGDSLRAVQLSNDLLAAGVNVLPIIHPAVPEGQARLRFFITCDHTEEQIRRTVTLTAERLKDLTDRNFGL 456
2 -91.600[O] KOG1357 Serine palmitoyltransferase  ali follow..  30  62.............................................................................................................................................................................................................................................................................................................................................................................................RIQDCFERPISSAPDAWFDVVERYSNDNNKTTKTSRCLNLGSYNYLGFGSFEYCTPRVIESLKKFSASTCSSRVDAGTTSVHAELEECVTRFVGKPAAVVFGMGYATNSAIIPVLIGKGGLIISDSLNHSSIVNGARGSGATIRVFQHNTPSHLERVLREQPWKKIIVVVEGIYSMEGEICHLPEVVAICKKYKAYVYLDEAHSIGAIGKTGKGICELLGVDADVDVMMGTFTKSFGSCGGYIAGSKELIQYLKHQCPAHLYATSIPTPSAQQIISAIKVILGEAQKLARIRENSNFFRAELQKMGFEVGDNDSPVMPIMLYNPAKIPAFSRECLRQKVAVVVVGFPATPLLLARARICISASHSREDLIRALKVISKVGDLSGIKYFP. 473
3 -86.300[O] KOG1358 Serine palmitoyltransferase  ali follow..  21  101....................................................................................................................................................................................................................................................................................................................................................................................................TDVEKLELKSIPVLESVHLHTKLI-DGRPITNFASFNFLDLAENKHITECAVATLRECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERAIVYAQSFQTISSVIPAFSKRGDILVVDEACNFAIQKGIQISRTTIRYFKHNNMKDLERILQELEDTRRFIITEGISENYGDMVDLTKIVALKKKYKYRLILDETWSFGTCGRTGKGLTEHFGVPTDVEIIIGSLTTSLAGGGGFCAGSELMVEHQRLSGMAYIYSAALPASLAVAAYEAISILSRDGSMLNDLRSKSALFHAKLSRNKFFESDIESPIIHLRFKDKDISHDKQVFLLEEIVELKRVESLERVKVQPSLRICISTGHSAEEIEKLALLIKEKTEIVFDKHKVI 506
4 -85.900[H] KOG1360 5-aminolevulinate synthase  ali follow..  27  149..............................................................................................................................................................................................................................................................................................................................................................................................FRDKIMEKKQDHTYRVFKTVNRWADAFEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLALPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQD. 549
5 -20.900[E] COG2008 Threonine aldolase  ali follow..  18  1.................................................................................................................................................................................................................................................................................................................................................................................................................................MIDLRSDTVTR---SRAMLEAMMAA--PVGDDV-------GDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQAAHNYLFEAAVLGSIQPQPIDAAADGTLPLDKVAMKIKTKLLSLENVLPRE----YLKEAWEFTRERNLALHVDGARIFNAVVAYGCELKE---ITQYCDSFTICLSKGLGTVGSLLVGNRDYIKRAIRWRKMTGGGMRQSGILAAAGIYALK---NNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRV-GEENAAALGEYMKARNVLI---------NASPIVRLVTHLDVSREQLAEVAAHWRAFLAR........ 333
6 -19.700[R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes  ali follow..  14  20...........................................................................................................................................................................................................................................................................................................................................................................................................................................PIQRGGILTEEARKVLLEWGDGYSDICLEGRVDLLDKRFKEEVAEFLGMDEVRFTAGA---RHAKFVAMSGFKGALVVDSLAHYTTYIAAELNGLRVYEVPESYTDVFEKVKEETGDYPAVALLTHADYKYGNLADAKKVAEICRDYGIPLILNTAYTSGIMEVSGRET--------GCDFIVASGHKSWAATAGILATTFEFAERVFKKEVALFGCSPVYGLPLVTLMASFPVVKERVKRWKEEVEKARWFVEEMEKIGVMLLGERPKNHTLMNFETPSFNLIAKKHRRKGYFLYHEL--GVQPGMTRNVKLNVYGLSWEEVERVAEAFKEIAEKYGL..... 386
7 -19.400[S] COG3146 Uncharacterized protein conserved in bacteria  ali follow..  15  40....VSHAYLSALEESGSTGWLGQHLLMEDADGSLRGALVCYVKSHSQGEYVF--DHGWADAFERAGGRYYPKLQCSVPFTPATGPRLLAAEGSDRQTVGNALAAGLKELTRRHGLSSAHVTFVPVDE----MAALEQAGFLHRMDQQFHFINQGYGSHDDFLATLASRKRKALKRERRAAVENGITIDWLTGSDLTEEIWDQFFA-MDTGGRKWGRPYLTRAFYSLIGERMADDILLVMAKRGGRYIAGAINFIGGDALYGRH-----WGCIEDHPFLHFEVCYHQAIDYAIAKGLKRVEAGAQGEHKLA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 340
8 -19.100[E] KOG1405 4-aminobutyrate aminotransferase  ali follow..  14  54..........................................................................................................................................................................................................................................................................................................................................................................................RSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQ--IG--SHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAGMSQLITMACGSCSNENALKTICPDYSILSFMGAFHGRTMGCLATTHSKAIH---EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHAFRKLRDIARKHGCAFLVDEVQ-TG-GGCTGK-AHEHWGLDDPADVM--TFSKKMM--TGGFFHKEEFRPNAPYRIFN---TWLGDPSKNLLLAEVINIIKRE-DLLNNAAHAGKALLTGLLDLQISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGC-------GDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK...... 500
9 -18.500[H] COG0001 Glutamate-1-semialdehyde aminotransferase  ali follow..  16  22.................................................................................................................................................................................................................................................................................................................................................................................................................FDHVKGAYIWDVDGNQYIDYVGT-ICG--AHPDVIGALHDALEK-GTSFGAP------SFLENVLAEMVIAAVPSIEMVRFNSGTEACMAVLRAFTNREKVIKFEGCYHGH-ADMFLVKAGSTLTAPYNDLEAVKALFEENRDQIAGVILEPVVGNAGFITPLEGLRELTHEHGALLVFDEV--TGFRIAYG-GAQEKFGVTPDL----TTLGKVIG--GGLYGGRRDIMSMIAPAGPVYQAGTSGNPLAMTAGIKTLELLQ-KPGAYEYLERITKKLADGLLQV-FGLFFTSGPVHDAKNSDTAKFGRFHRGMLERGVYLAP---------SQFEAGFTSLAHTDEDIDQTIAIAREVLSSI....... 411
10 -18.400[E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase  ali follow..  16  39.............................................................................................................................................................................................................................................................................................................................................................................................................................QTNDFIKLNTNE---YDPPAQVLAAVAAELPKVRLYPDPVS---------TQLRQAAADLYGVDNQVLAGNGSDDILNIVRTFVDPGETVAFLDLTYSLYETIASVHGAKVQKIATDA--NFDLTGPVICPEAKLIFLASPNPPKGKHLNREFLWQTCAQAEGVVVIDEAYGDFSDEDHWDFLQEFDNV-----IISRTLSKSYSLAGGLAIAAPALIEEMDKVRDSY----NLDRLAQVLGTAALRNQAEFVPLWEKVRHTRTRLMEQLAELDFQVCPSDANFV-FAAPRWMAAADLYQALKEKKILVRYFNHPRITD----LRITVG---TDGEIDQLLLAIASLKGSLG...... 367
11 -17.900[E] KOG1402 Ornithine aminotransferase  ali follow..  13  39..........................................................................................................................................................................................................................................................................................................................................................................................TSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSVNQG--CHPKIVNALKSQVDKLTLTSRA------YNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLA-YKAKIVFAAGNFWGRTLSAISSSTDPTSYIPYNDLPALERALQ--DPNVAAFMVEPIQGEAGVVVPLMGVRELCTRHQVLFIADEIQT---LARTGR-AVDYENVRPDI-----LLGKALSG--SAVLCDDDIMLTIKPGEHGSTYGGN--PLGCRVAIAALEVLEEEIILRNELMKLPSDVVTAVRGKGLLNA------IVIKETKDWDAWKVCLRLRDNGLLA-------KPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF....... 439
12 -17.900[E] KOG1368 Threonine aldolase  ali follow..  17  87...............................................................................................................................................................................................................................................................................................................................................................................................................................MRSVDLRSDTVTR---TDAMREAMCNA--EVDDDV-------GYDPTARRLEEEMAKMMGKEAALFVPSGTMGNISVMVHCDVRGSEVILGDNCHISTIGGVHPKTVKNEEDGTMDLEAIEAAIRDPKPSTRLICLENTHANSGSVEYTEKVGEIAKRHGVKLHIDGARLFNASIALGVPVHK---LVKAADSVQVCLSKGLGAVGSVIVGSQSFIEKAKTVRKTLGGGMRQIGVLCAAALVALQ---ENLPKLQHDHKKAKLLAEGLNQMKVNVAAVETNMDGSRLTAE----KLRKNLEENGILL--------RGNSSRIRIVIHHQITTSDVHYTLSCFQVKRIFI....... 430
13 -17.000[E] COG4992 Ornithine/acetylornithine aminotransferase  ali follow..  16  21..........................................................................................................................................................................................................................................................................................................................................................................................SSPFSTDSFDASVMSTYGRFPLALERGAGCRVWDTQGKEYLDFVAGCTLGHA-HPAMVEAVTRQIQKLHHVSN-------YIPEQGELAQWIIQHSCADRVFFCNSGAEANEAAIKLAIEKPIILTANASFHGRTLATITATGQAKYQVNYNDISAVEAAISELDYRVAAILIEPLQGEGGVRPGFQKLRQICDDTGILLMFDEVQV---MGRSGK-GYEYLGVEPDI-----TSAKGLG--GGIPIGAKKFCDVFQPGEHASTFGGN--PFACGVALAVCQTLERE-NILQNVQDRGEQLRSGLRAIAAKYPHHLTEVLELAADIPLTAADVVKAAINEGLLL-------VPAGPKVVRFVPPLIVTEAEINTALKLLEKALATVT...... 426
14 -16.700[E] KOG1404 Alanine-glyoxylate aminotransferase AGT2  ali follow..  13  58..........................................................................................................................................................................................................................................................................................................................................................................................EVLQKRKKFLGPSLFHYYQKPLNIVEGKMQYLYDESGRRYLDAFAG--CGHC-HPDILNAITEQSKLL-QHATTIYLHHAIGDFAEALAAKMPG--NLKVVYFVNSGSEANELAMMLYTGSLEMISLRNAYHGGSSNTIGLTALNTWKYPLPQYGTSGKVAG--------FIAETIQGVGGAVELLKSVYEIVRNAGGVCIADEVQGFGRTGSHYWGF-QTQDVVPDI-----TMAKGIGN--GAVVTTPEIASVLASKILFNTFGGN--PVCSAGGLAVLNVIDKE-KRQEHCAEVGSHLIQRLKDVGIELVSDRKDKTP----AKAETSVLFEQLRELGILVG-----KGGLHGNVFRIKPPMCFTKDDAGKFLMHWTIPSPGCE...... 445
15 -16.500[E] KOG0633 Histidinol phosphate aminotransferase  ali follow..  17  87.............................................................................................................................................................................................................................................................................................................................................................................................................................KPEDIVKLDANE---YGPPPEATLGNMKFPYVYPDPQS------------RRLRDALAQDSGLEEYILVGCGADELIDLIRCVLDPGEKIIDCPPTFSMYVFDAAVNGAGVIKVPRNNVDRIAEVVEL--EKPKCIFLTSPNNPDGSIISEDDLLKILEM-PILVVLDEAYIEFSGVESRMKWVKKYE------IVLRTFSKRAGLAGGYGAFPLSIIEYLWRAKQPY----NVSVAGEVAALAALSNGKYLEDVRDALVRERERLFGLLKEVPLNPYPSYSNFILCEVTSGMDAKKLKEDLAKMGVMVRHYNSQELKG----VRVSAG---KPEHTDVLMECLKQF........... 414
16 -16.300[E] COG0112 Glycine/serine hydroxymethyltransferase  ali follow..  20  32......................................................................................................................................................................................................................................................................................................................................................................................................................................QRHEIELIASENIVSRAVLEANKYAEGYPGKRYYGGCQIAEALAIERAKKLFGVNFANV--SGSQMNQAVFLALLQPGDTFMGNSGGHLTHGSPVNMSGKWFNVVSYGDMDEVARKAREQ--KPKLIIAGG--TAYSRIWDWKRFREIADEVGAWLMVDMAHIAGLVAGG-----QHPSPFPHCHVATTTTHKSLGPRGGMITNDEEIAKKINSAVFPGLQGGPLMHVIAAKAVALGEALQPSKDYAAQVVKNARTLAETLKANGLDIVSGGTDMLVDLRKKNATGKRAEAALGRAYVTCNKNGIPFDPEKTSGVRLGAPAGFKEAEFKEVGELIVEVLDG........ 397
17 -16.200[E] COG0436 Aspartate/tyrosine/aromatic aminotransferase  ali follow..  10  1............................................................................................................................................................................................................................................................................................................................................................................................MQFAKRLEKIPPYLFAEINRKREALIA------KGVDIINIGVGD--DKPTPAHILQAMREAIDNYPPYEGTQEFREAAVEWMER-RFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYTLIPDPGYPVYRTSTIFAGGEAFSMPNKFLPDLDLIPEEVARKAKMLWINYPNNPTGALATFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKSYNMTGGFAVGNAYAIKGLS-QVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQSRRDIIVKGLQSLGWPIEPPKATLY-VPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASGEGYFRVALTI--SDERLHEAIQRMQDAGIRYA...... 390
18 -16.200[E] KOG1401 Acetylornithine aminotransferase  ali follow..  13  35..........................................................................................................................................................................................................................................................................................................................................................................................TSCNIIKKEGANIISVYARYPVVAAKGEGSYLFDKEGRKYIDFTSGTSLGHA-HPEVARLAADQCSK---------LVHSSNLFYNEPAIELSNVIGPTKIFFANCGTEANETALKFAEGKSQIVYFNNSFHGRSLGSLSITANPKYKVVQAVYNDPASIEQFVNDKTAAVIVEPVQGEGGICPALIALRKACDKVGASLIYDEIQC---LGRSGD-AHSIVKDVASPDII--TVAKPLAN--GATIVSSKIAAEIHPGEHGSTFGGN--PVACRVGTFCVNELGSS-KILQNVRKQHKALTSRFDDFVAKYPNLIRGYRGLLLG-TEPPAKFIELARQQGLLL-------LPGGNNNTRVLPSLNVKDEVIAKGLDIMESTLKALS...... 440
19 -16.100[E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases  ali follow..  16  1..............................................................................................................................................................................................................................................................................................................................................................................................MRKEMLLPNLSISYSDPIKFVRGDGVWLIDNRGRAYLDCFNN-HLG--AHPEVVEAIARQAAILNTNTR-------LHDTIVSYAERLTATLGLTVASFACSGSEANSLALRTHSGQRDALVLDWAYHGTTQELIDLSPYKYKRKGGESIAEQIEKMKAQGRAPAFFIAESIPSVAGQVFLLREVYAMVRAAGGVCIADEVQGFGRVGSHWWAF-EMQGVVPDI-----TMGKPIGN--SAVVTTREVADSFNNGME-YFNTFGGNPVSCAAGLAVLDVIEHN-DLRRNALEIGNYLIAGFRSMGIELVMDRKTKEP----ATAIARKINDGARERGILMG-----TEGPFDNVLKMRPPMIFTRANADHLLSVLEDSFAAA....... 421
20 -16.100[E] COG3033 Tryptophanase  ali follow..  14  20.......................................................................................................................................................................................................................................................................................................................................................................................................................RRTTRSYREEAILKAGMNPFLLDSEDVFIDLLTDSGTGAVTQEMQAAMLRGDEAY-HALANAVKEIFGYEYTIPTHQGRGAEQIYIPVLIKKREQEKGLDRSKMVVFSNSQINGATVRNVYTKDLEKLEQGIQEVGAENPYIVCTITCNSAGSLANMRAMYEIAKKYDIPVVMDSAENAYFIQQREPGYKEW-ESYKYADALAMSAKKDAMVMGGLLCFKDKSMEDVYNECRGFPTYGGLEGGAMERLAVGLRDGMRQDWLAYRI-NQIEYLVNGLEAIGVVCQQPGGHAAFVDAGKLLPHIPACELYKVAGIRAVEIGSFLLGRDPKTLRLTIPATYTQTHMDFIIEAFKQVKEN........ 445
21 -15.500[E] COG0520 Selenocysteine lyase  ali follow..  16  37.........................................................................................................................................................................................................................................................................................................................................................................................................................................FFDGPGGTQVPGSVLDAISDYLVRSNANATSARTDALIIAARTAIADFLGCHDEVVFGANMTTLTFTLSRTLQPGDEIIVTRLDHANVSSWEALAEQGAVIRY--DINDLEQQINS---RTKLVAVSYASNAVGTINDIATIVKLAHSVGALVFVDAVHYAPHGPINVHAL--------GCDFLACSAYKFFAPHVGILYGKREHLANLQPNEVPSRWETGTLNEGLAGVVAAVNYLAKDQELVSALIEADKEGIPGLTLYGITDPERFAWRTPTVA-QGKSPESIARTLGDRGIFSWHTEKLGVESNGGLLRLGLVHYNSVEEIIQLLQALKEIGLD........ 464
22 -15.200[E] COG3844 Kynureninase  ali follow..  17  32.........................................................................................................................................................................................................................................................................................................................................................................................................................................YLDGNSLGARPHAALARAQQVGEGLIRSWNQAGWFELPRRLGNKLAPLIGARDEVVITDTTSINLFKVLAAAERRIIVSEAHNFPTDLYIAEGLADLLRDGYKLRLIDAPDALETALGDDVAVTMLTHVNYKSGHMYDMAAVSALAHRHGALAVWDLAHSAGAV----------VDLHTGADYAIGCTYKYLGPGSAFVWASPALRERFWQPLSGW-FLCGTQPITMAMVECGLDIFAQ-TALRAKSLALTDLFIELVEARPLTLATPRDH--SHVSYAHPDGFAVMQALIARGVIGDY-------REPSIMRFGFTPLYRFVDVWDAVDVLREVLET........ 402
23 -15.100[J] KOG3843 Predicted serine hydroxymethyltransferase SLA/LP (autoimmune hepatitis marker in humans)  ali follow..  11  2......................................................................................................................................................................................................................................................................................................................................................................................................................................STSYGCFWRRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDLEELAVICANYDIPHIVNNAY--GVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPGAIIGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEANERLLHTPHNPISLAMHRDKAVTQLGSMLFTKQVSGARVVPLGSMQPCAYLNAASAIGMKMQDVDLFINRLDRCLKAVR...... 383
24 -15.100[H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase  ali follow..  14  33................................................................................................................................................................................................................................................................................................................................................................................................................VITGGDGIYVVDDEGKRYIEGLAGLFCAGLGFQRLVEAATRQLKTMPFYHSFAHK---STEPGIRLAEKLLSIAPVPMSKVFGSGSEANDTAIKLI-EKKKIISRRKAYHGVTVATASLTGLPFNHRDFDLANNLEAIILEEGPETAAFFAEPVMVSGGVITPFEKVQAVLRKYDILLIADEV--CG-FGRTGN-GSETYGLKPDMISCAKQLSAAYMPISALMINAKIADALVDQSRKIGTFSHGFTPVAAAVALEALTIYEEI-DIVGHVRSVAPAFQDRVRKLGLEFVKDKATRENF--PAWQVANQAGKFATARGVLTRGL--------GDMVSLCPAMIIDDEQIDDLMTRMGLALDDT....... 450
25 -14.800[E] KOG0257 Kynurenine aminotransferase, glutamine transaminase K  ali follow..  15  43..........................................................................................................................................................................................................................................................................................................................................................................................................................TLAAETKAVNLGQ-GFPDSPAPKFVTDLLENLSKH--TAAHQYTRGYGHPMLVDILAKMYSHFYNVQEVLVTVGAYLSLYYAFLGWVNKGDEVLIIEPAYDCYYPQVKFAGGVPVPVVMNDFADMESKINE---KTKMLVINNPHNPTGKLHELEKLAEIAKKHNLIVIADEVYEFHVWDKNDMVRFASLPGMYERTISIGSAGKAFSVTGGWAVGPKQLLEPLKAIHQNCVFTCSTP--TQMAIAEAFRLDWPKTGLSGELRAKRDKLAKMLEEGNFRPIIPDAGYFMLA-EEDPDDFVFSRWLCREKKLA------VIPKNSNMVRLCYFK--KDETLDAAEEILKKLGKQ........ 441
26 -14.800[E] COG1982 Arginine/lysine/ornithine decarboxylases  ali follow..  11  181....................................................................................................................................................................................................................................................................................................................................................................................................................................................................SISVTELGSLLLEAEEYIARTFGAEQSYIVTNGTSTNKIVGMYAAPSGSTLLIDRNCHKSLAHLLMMNDVVPVWLKPTRREFTRDSIEEKVAAVHAVITNSTY--DGLLYNTDWIKQTLDVPS--IHFDSAWVPYT---QGKSGMSGERVAGKVIFETQSTHKMLAALASLIHIKGEYDEEAFNEAFMMHTTTSPSYPIVASVETAAAMLRGNKRLINRSVERALHFRKEVQRLRVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVE--------TGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSYD...... 561
27 -14.000[M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis  ali follow..  16  5..............................................................................................................................................................................................................................................................................................................................................................................................................................................NAPPVVGTELDYMQS----AMGSGKLCGDGGFTRRCQQWLEQRFGSAKVLLTPSCTASEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDNIDETLIEAAITD---KTRVIVPVHYA---GVACEMDTIMALAKKHNLFVVEDAAQGVMSLGTIGHIGCFSFHETKNYT--------AGGEGGATLINDKALIERAEIIRE---SSYLMSDLQAAYLWAQLEAADRINQQRLALWQNYYDALAPLAKAG-DGCVQNAHMFYIKLRDIDDRSALINFLKEAEIMAVFHYIPTTKESERLLRLPLFYNLSPVNQRTVIATLLNYFS......... 376
28 -13.800[E] KOG2467 Glycine/serine hydroxymethyltransferase  ali follow..  14  36......................................................................................................................................................................................................................................................................................................................................................................................................................................QKESIALIASENFTSRAVMDANKYSEGYPGARYYGGNEQAERLCQTRALEAFHLDGEKWGVSGSPANLQAYQAVMKPHDRLMGPHGGHLSHGFSTPQKAISAVSTYFSDYDSLEKAAIQF--RPKVIVAGASAYA-----DYKRMRKITEMCNAYLLCDMAHISGLVAAG-----VIPSPFEYADIVTTTTHKSLGPRGAMIFYRKGLEDKINFSVFPGHQGGPHNHTITALAVALGQAKTEFYQYQKDVLSNAKAMANAFITRGYKLGTDTHLVLVDLTDKGVDGARVERILELVNISANKNTVPGDKSIPRGLRLGTPAC-DEKDFERVVELIDEVVS......... 421
29 -13.800[E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases  ali follow..  13  97........................................................................................................................................................................................................................................................................................................................................................................................................................................................PDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPANTILKRMGVDVEYYDPEIGADIAKLMRP---NTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFR----------LDFGVDISIHAATKYPSGLFGTISTNEKCWPQLLETHG--TMGLCAGPDDTYQILRRLRTMG----RLEHHRKSALEIARWLEEIWKRDFSGSSGIFSFVLGEHAQASAFLNALYSWGGYQSLALEVKLGDRTVSIRLQIGLEDVPDLIADLERGFAAI........... 442
30 -13.200[E] KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases  ali follow..  13  115..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................GNPTTENVEVVINEIEGGAGSLLYNSGLAAISAVFLEFLSSGAHMIVMNPIYSGINETLARFGVEITSVDVEKEKDFAGAVEKARPNTKMIYFESIANPTMAVPDILGTIEVAKKYKILTCLDATFSSPYNIQ----------LKLGADISLHSCSKYIGGAGVVTVSSYDNWKKLKLQQL--TTGSSLSPYDAALLTRGLKTLG----RVDRISENAQKTAEFLEQYAKQVMKQFAGMIAFDVGTAENAIKLVEAI-SLGGTESLIEHPLSMSAPGLLRFSVGIENVEDIIGDLNDALEKL........... 444
31 -13.100[E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase  ali follow..  12  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................LLMIPGPVQLHERIIRAMARQMIGHRTADFS----AIMEFCVEKLREIFGTKGDICLGSGTAGMEAAIASFSRVKKIATLENGKFGERLGDIAERYTQVERVKVPELDAVKEALDNGCEAVAFVHNE---TSTGILNPAKEIAKLAKEYDALVIMDAITSAG---------GDYVKMDEGVDVAIVGSQKCLGAPPGAVAVSEKAWDYYNERCPYYLTPYTPAVPLFFALAEALKIIDEEENRIQRHRILSAAVRKWAVEAGLELSSYSNTVTAIKMPEGVSDSELRGTLKKEGILVSG------ELKGKIFRIGTMGNVGKFETVSTLAALEDVLMRKNAIKPAL 361
32 -13.000[P] COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance  ali follow..  11  33..................................................................................................................................................................................................................................................................................................................................................................................................................................SERNEWRVLQSYRKHKVSDTHFTPSTGYGYDDIGRDTL-------ESIYADVFGGEAGLVRPQIISGTHAISIALFGVLRPGDELLYITGKPYDTLEQIGYNAVDLTKDGKIDYDAVAAAINP---KTKVIGIQRSKGYANRISEIKEMIRFVKEENLIVFVDNCYGEFVE--------ELEPCHVGADLMAGSLIKNPGGTGGYLVGKAKWIEACSYTSPGIGREAGASLYSLQEMYQGFFLA---PHVVSQSLKGAVFTARFLEKLGFTSNPKTDLIQSVEFSDGEKMIAFCQAIQMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKNAICSA.. 411
33 -12.400[E] COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase  ali follow..  15  1..................................................................................................................................................................................................................................................................................................................................................................................................MTFSLFGDKFTRHSGITRLMEDLNDGLRTPGAIMLGGGN---PAMQDYFQTLLTDMVESGKAADALCNYPQGKTALLNALAVLLRETLGWDQNIALTNGSQSAFFYLFNLFADGSTKKVLFPLAPEYIGYADSGLEDDL--EGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITLMKLDRLANQHNIPLVIDNAYGVPFPGIIFSEARP---LWNPNIILCMSLSK-LGLPGGIIIANDKTITAIANMNGIILAPGGMGPAMMCEMIKRNDLLRLKPFYYQRVQQTIAIIRRYLSEERCLIHKPEGAIF--FKDLPITTELLYQRLKARGVLMVP-LDKPWPHTHQCMRMNYVP--EPDKIEAGVKILAEEIERA....... 412
34 -12.200[E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins  ali follow..  10  76.....................................................................................................................................................................................................................................................................................................................................................................................................................................................ARQLMADTFDKNMIDKDEYPQTAEIELRCVNILSRLWNAPAS---ATGCSTIGSSEAAMLGDRPNLVMGINVQVCWEKFCRYWEVEPRFVPMEGDRSPEEAVKLIDENTIGVIGILGSTFDGSYEPIEALNDALETLQVPLHIDAASGGFIAPFLDPDLRWDFRLPWVKSINTSGYGLVYPGVGWIIWRDKEELNYLGGDLPNFALNFSRPGNQVVAQYYNFLRLGKERKIQQTCRDTALYLSGKIAQLGPFELLTDGGDIPVFANTCYTLYDMADKLRERGWLVPAYRMPKNREDLVVQRIVVKEGFSRDMADLLLADMERAIAYF....... 450
35 -12.200[E] KOG2040 Glycine dehydrogenase (decarboxylating)  ali follow..  16  512...............................................................................................................................................................................................................................................................................................................................................................................................................................RYMKKLENKDMIPLGSCTMKLNSTTEMMPCSFRHFTDVEQAQGFHQMFKELEHDLCEITGYDRISF-AQGEYAGLRAIRSYHEHRNICLIPISAHSAQMAGMKVEPIRILSNGSIDMAHLRAKAEEHAHELSCLMITY--STMGVFEEVADICTLIHKHGGQVYLDGANMNAQVGLCRPG---DYG----SDVSHLNLHKTFCGGGGPIGVKAHLAPYLSFGVVSAAPFGSSAILPISWSYIKLMGSRGLKRATQVAILNANYMSKRLEQHYKTLYKAPNSIRDLKKSANIEAVDVAKRLMDYGFHAPTMSWPV----AGTLMIEPTESEDKEELDRFCDAMISIREEIAEIEAG. 912
36 -11.900[T] KOG0256 1-aminocyclopropane-1-carboxylate synthase, and related proteins  ali follow..  12  19............................................................................................................................................................................................................................................................................................................................................................................................SRVAVSDTHGEDSPYFAGWKAYDENPYDESHNPSGVIQMGLAENQVS-LEKKNPEGSMWGSKGAPGFRENALFQDYHGLKTFRQAMASFMEQIRGDPDRIVLTAGATAANELLTILADPNDALLVPTPYYPGFDRDLRWRTGVKIVPIH-TPEALESAYQTARDRVRGVLITNPSNPLGATVQLEDLLDFCVRKNIHLVSDEIYSGSVFHAS----IDDVSVKERVHIVYS-LSKDLGLPGGTIYSYNDNVVRTARRMSSFTLVSSQTQHMLASMLSDEEFTEK-RINRERLRRRYDTIVEGLKKAGIECLKGNAGLFCWM-TKDGELQLWDVILKELNLNISP------CSEVGWFRVCF-ANMSENTLEIALKRIHEFMDRRR...... 445
37 -11.900[E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain  ali follow..  15  40...............................................................................................................................................................................................................................................................................................................................................................................................................................RYMRRLADRDIPLGSCTMKLNATAEMLPITWPEFSEIADQALGYQHLIEDLSQKLCAITGYDAISM-AQGEYAGLLAIRAYHIANDVCLIPTSAHGTNPASAQMAGMKVVVVKEIDMDDFRAKAEQYADTLSCCMITY--STHGVFEEVREVCEVVHKHGGQVYLDGANMNAMVGLSRPG---------GSDVSHLNLHKTFCGGGGPIGVKSHLAPFLHEGAVSAAPFGSASILPISWSYCLMMGGEGLTQATKVAILNANYVAARLKGAGRVAHECIIDTRPLAESAGVTVDDVAKRLIDCGFHAPTMSWPV----AGTLMIEPTESETKAELDRFCDAMLAIREEA....... 427
38 -11.800[E] KOG0258 Alanine aminotransferase  ali follow..  13  2.....................................................................................................................................................................................................................................................................................................................................................................................SLKALDYESLNENVKNCQYAVRGELYLRASELQK------EGKKIIFTNVGNVVSLCQAPFLLDRAKHYLSLTSGGLGAYSDSRGLPGVRKEVAEFIERRDGYPELIFLTDGASKGVMQICVIRGQKDGILVPVPQYPLYSATISLLGGTLVPYY--DVNNLRQSVAQARSTVRAMVIINPGNPTGQCLSIREILRFCCDERLVLLGDEVYQQNIYQDERPFISSKKVLMD---ISFHTVSKGYGECGGYFEMTNIPPRTVEEIYK--VASIALSPNVSAQIFMGLMVSPPKPGILESLRRRARMMTDGFNSCNVVCNFTEGAMIKLPSKAIQAAKQAGKLLEATGISTVPGSGFGQKEGVFHLRTTILP--AEEEMPEIMDSFKKFNDEF....... 468
39 -11.200[E] COG2873 O-acetylhomoserine sulfhydrylase  ali follow..  16  38....................................................................................................................................................................................................................................................................................................................................................................................................................................................DDADHAASLFGLKAFGNIYTRIMNPTQAVLEERVAALEGGTAALAVASGHAAQVIVFHNLMQPGDNFVAATRLYGGSINQFGHAFKNYWEVRWADTNDLSTFESQIDDRTKAIFIESLANPGGTFVDIEKIGDIARKHGLPLIVDNTLASPYLIR----------IEHGADIVVHSLTKFIGGIGGVIVDGGTFDWSKSGKYPML-LGPAISPFNAFLILTGLETLP----RMQRHCDNAVTVAGWLSNHGLPSPLGAGAVFTFGLGGYEAGVKFVEALENVGDTKSLVIHPASTTGPDTVRLSIGIEDVTDIVADLEQALAKV........... 426
40 -11.000[E] COG1448 Aspartate/tyrosine/aromatic aminotransferase  ali follow..  16  1..............................................................................................................................................................................................................................................................................................................................................................................................MFENITAAPADPILGLADLFRADERP--------GKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYIDGIPEFGRCTQELLFGKGSALAQTPGGTGALRIAADFLAKNTSVKRVWVSNPNHKSVFNSADLEVREYAYYDAEDFDALINSLNEAQAGDVVLFHGCCHNPTGTLEQWQTLAQLSVEKGWLPLFDFAYGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGLYNGACTLVAADSETVDRAFSQMKANYSNPPAHGASVVATIIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEGVYAVA-------------RVNV-AGMTPDNMAPLCEAIVAV........... 395
41 -10.900[E] COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]  ali follow..  13  102................................................................................................................................................................................................................................................................................................................................................................................................................................................EAAVEAVAQAMRSP-VTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVERIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLVHTSNYSIQGKAIDEAELVALGKELDVPVVTDLGSGS-LVDLSQYGLPKEPMPQELISLVSFSGDKLLGPQAGIIVGKKEMIARLQS--HPLKRALRADKMTLAALEATLRLYLHPEASAEVIQIQAQRLQAPLAAHSGSLPVDRLPSAALTFTPHDGRGSHLESLAAR---------VPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK............. 463
42 -10.800[HE] COG1932 Phosphoserine aminotransferase  ali follow..  2...............................................................................................................................................................................................................................................................................................................................................................................................................................AQVFNFSS----GPAMPAEVLKLAQQELCDWHGLGTSVMEIS--IQVAEEAEQDFRDLLNIPSLFCHGGGRGQFAGVPLNLLGDKTTAWAASAIKEAKKYCAPQIIDAKITVDGKRAVKPMREWQLSDNAAYLHYCPN--TIDG----IAIDETPDFGPEVVVTADFSSTILSA-------------VSRYGVIYAGAQKNIGPAGTLVIVREDLLGKAHESCPSIL-SMFNTPPTFALSGLVFKWLKAQAAMHKINQQKAELLYGVIDNSDFAQANRSRMNVPFQLADNTLDKVFLEESFAAGLHALK-------RVVGGMRASIYNAMPIEGVKALTDFMIDFERRHG...... 362
43 -10.800[E] KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2  ali follow..  13  78.......................................................................................................................................................................................................................................................................................................................................................................................................................PSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVTV------------------QTISGTGALRIGASFLQRFFKFSRDVFLPKGNHTPIFRDAGMQLQGYRYYDPKDFTGAVEDISKIPEQSVLLLHACAHNPTGRPEQWKEIATVVKKRNLFAFFDMAYASGDGDKDAWAVRHFIEQGINV-CLCQSYAKNMGLYGGAFTMVCKDADEAKRVESQLK-MYSNPPLNGARIAAAIQWLQEVKVMADRIIGMRTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKESIYMTK-------------RISV-AGVTSSNVGYLAHAIHQVTK......... 430
44 -10.600[E] KOG0634 Aromatic amino acid aminotransferase and related proteins  ali follow..  12  12..............................................................................................................................................................................................................................................................................................................................................................................................LSLESASREYGPFQMLGRIQSDSDIKMLSFAGGEPNPSKFPIHKLSVSFPEVNSWEKDTNKDQYGQC-------QGIPELVKFIKDHVGQIHMKDWDIKITNGNTIGLEYCRLLVNRGDCILIEKYTYPAAITAMRPLGVKFIPIDMDEPESFEKVMETWDSSHVLYTIPTGQNPTGSTLTLEKFLTLAKKYDIIIVEDEPYYFLQMEKYDANWKPHLDTDGRV-LRVDSFSKLIGLRLGWITGNSLFIDRITRYAEV-ESPSGVSQVVLYAILNRWGFLEWLQDLQNSYTMRRNALLLAADKLWVELDKNRLICSNMDKSISEIEMEIFVELVNNGVKPVCFMGEPNSADKIFFRFAYSLA-DLSTFEAGLERFTSTIQKY....... 467
45 -10.200[E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes  ali follow..  17  11.........................................................................................................................................................................................................................................................................................................................................................................................................................................YLDYAATTPVDPRVAEKMMQY-FGNPASRSHKFGWQAEEAVDNDVAALVGADREIVFTSG-LAIKGAANFYQKKGKHIITCKTEHKAVLDGFEVTYLAPQPNGIIDLKQLEATMRE---DTILVSIMHVNNEIGVVQDIAEIGEMCRSRGIIFHVDATQSVGVYGPMGIGAL----VRRKPRIRIEAQQHGGGHERGMRSGTLPV------------------HQIVGMGEAYRIAKEEMESEAARLRSLRLRLWNGIKDIEVYLNGSLENGAP--VEGESLIMALKDLAVSSG-YVLRALGMNDELAHSSIRFSLGRFTTEEEIDYAIALVHKSIGRLR...... 386
46 -9.350[E] KOG0629 Glutamate decarboxylase and related proteins  ali follow..  15  103.....................................................................................................................................................................................................................................................................................................................................................................................................................................GQLDPFGLAGA--VTEAMNGSTYTYEVAPVFSLI-------ETEVIATICKLAGYKEGIFAPGGSTSNMYGMVLARYK--VLFTSDESHYSFVKAANWLGLGSYNCVQMLLDDLEAKIAEAKARGGFVNCTAGTTVLGAFDDINGAADVTERHGLWLHVDACLGGALLSAKNRSLIAGLERANSFSW---TIGAPLQCSLFLTRESGRLLERCNSTEAHYLFQQDKFYDVCGRKIDAFKFYGKYGLMVDHAIHIARLLEGKLRQRGFRLVIPEHEYSNVCF--YTVAPKIKEQMAHSGLMIGYSPLKAKNLGNFFRMVFTCFPILKKELDFILDEIERLGEKIVL..... 510

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Pio F, Pawlowski K, Godzik A. Saturated BLAST: an automated multiple intermediate sequence search used to detect distant homology. Bioinformatics. 2000 Dec;16(12):1105-10.