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Query: gi|15675951|ref|NP_273069.1| glutamyl-tRNA synthetase (NMB0003) [Neisseria meningitidis MC58], from N.meningitidis

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTVKTRFAPSPTGYLHIGGVRTALFSWAFARHHKGEFLLRIEDTDLARSTAESVNIILDGMKWVGLNYDNADNVVYQTRRFDRYKEVIAELLEKGHAYYCYCSKEELEAMREKAEKEGSATYDRRWRPEVGKTLPEIPSDVQPVVRFKTPLDGVTKWTDLVKGEISIPNEALDDLIIARADGTPTYNFCVVVDDYDMGVTHVIRGDDHVNNTPKQINILKAIDANLPEYGHLPMILNEQGKKISKRSGDTVAITDFGAMGILPEAMLNYLARLGWAHGDDEFFTMEQFIEWFDLKDVSPSPSRMDLKKLYWINGEHIKITPNGKLAELVKPRLALRDIHETEKPALEDVLELVKDRPQDLNTLADECFYFYVKQTPAEADVQKHWDDEAAARMLRFAERLEGLEDWNAEAIHDLFKPFCDEEGIKMGKLGMPLRLAVCGTAKTPSVDAVLALIGKEEVLKRIRALast
1 -129.000[J] KOG1149 Glutamyl-tRNA synthetase (mitochondrial)  ali follow..  31  43LPVRTRFAPSPTGFLHLGSLRTALYNYLLARNTNGQFLLRLEDTDQKRLIEGAEENIYEILKWCNINYDET--PIKQSERKLIYDKYVKILLSSGKAYRCFCSKERLNDLRHSAMELKPASYDRCCAHLGEEEIKSLAQGIPFTVRFKSP-ERYPTFTDLLHGQINFNDKRYDDLILVKSDKLPTYHLANVVDDHLMGITHVIRGEEWLPSTPKHIALYNAFGWACPKFIHIPLLTTVGDKKLSKRKGD-MSISDLKRQGVLPEALINFCALFGWSPPKHECFSMEELETIFNLNGLTKGNAKVDDKKLWFFNKHFLQKRILNELVDDIMPSLESIYTSTISREKVAKILLNCGGSLSRINDFHDEFYYFFEKPKYNDNDAKFLSKNESRHIAHLLKKLGQFQEGTDAQEVESMVETMYYENGFSRKVTYQAMRFALAGCHPGAKIAAMIDILGIKESNKRLSE 526
2 -82.400[J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases  ali follow..  17  27.TVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGN--VRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNPYRDRSVEENLALFEKMRAGGKACLRAKIDASPFIVMRDPVLYRIK---FAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLTISGLRRRGYTAASIREFCKRIGVTKQDNEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQ--VPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEP 506
3 -64.900[J] KOG1148 Glutaminyl-tRNA synthetase  ali follow..  19  262.GVVTRFPPEPNGYLHIGHSKAIAVNFGFARYHNGVCYLRFDDTNPEAEEERYFESIKDLVAWLGFQPYK---ITYSSDYFDKLYELAEELIKRDKAYVCHCTDAEIKKARGGEERGPRYACVHRDRPIEENMRDGKYQPKEAILRMKQDSDGNPQMWDLIAYRVLNSP---HPRTGDKWKIYPTYDFTHCLVDSFENISHSLCTTEFILSRVSYEWLCNALEVYCPAQREYGRL-NVVGTLMSKRKIMKLTLVALRRRGVPPGAILEFVSEVGVTTAVSEVARFENCVRKFLENSVPRLMFLPDPIKVTLENLDDSYREQIEIPFNPKDPSMGSRSAFLTKHIYIDRS-DFREEASSDFFRLTLGQPVGLFRASHPVVAKRVVKNDEG-----EPIEIIAEYDASSSKKPKTFIQWVSRDKESNSPVLIAETRL............................. 706
4 -61.800[J] KOG1147 Glutamyl-tRNA synthetase  ali follow..  17  206.KVVTRFPPEPSGYLHIGHAKAALLNQYFANKYHGKLIVRFDDTNPSKENSEFQDAILEDVALLGIKPDV---VTYTSDYLDTIHQYCVDMIKSGQAYADDTDVETMRHERTEGIPSKRDRPIEESLEILSEMDKGSDVGLKNCIRAKISENPNKAMRDPVIYRCN---LLPHHRTGTKYRAYPTYDFACPIVDSLEGVTHALRTTEYRDRNPLYQWMIKAMNLRKI-HVWEFSRMNFVRTLLSKRKLTEITVRGVRRRGMTIEALQQYIVSQGPSKNI-LTLDWTSFWATNKKIIDPVAPRHTAVESGDVVKATIVNGPAAPYAEDRPRHKKNPE--LGNKKSIFANEILIEQADAQSFKQ...................................................................................................... 573
5 -55.900[J] COG1384 Lysyl-tRNA synthetase (class I)  ali follow..  13  17.PQRVSTGISPSGPIHVGNMREILTKAITKRGLESDFIYLCDDMDPLRKVYPFLSKDYE--RYVGQPLKNIPAPQGAGKYSDYYLEPFVRVMKEANIPARVIKTSDLYESGMLAQACDIANNREKIKDILETVSGRKIEGDPLCEKCGRISTTHVISYSYPYAEYACKCGHHGFADIRKAEGKMPWRVEWPAKWFALKVTVEPFGKDHGAPGGSRRIAREVFGIEPPVPLMYERIILKGKGAMHSSTGLAIAASEIME--VIPPDLLRYMIAIDFDPGMGILALSDELEKLQDAYFENRASLDEDQAAMVEYSLVNKDRKPYPVDFRHLVTLVQIYRTEDEILRAVKKIEADFRKEIEYARRWLERYAPESVKFRILPVDQKIELSDSDLAILSDFLNGIED-MPWNSESIHDRIYEISQKFKTNPESVFTLFYRVFIGKDRGPRLGYFLFNLGKDFVRERIRN 502
6 -12.600[J] COG0143 Methionyl-tRNA synthetase  ali follow..  12  15........PYANGSIHLGHMLEHIQADVWVRRMRGHEVNFICADDAEQMIGEMSQEHQTDFAGFNISYDN-----HSEENRQLSELIYTRLKENGFIKKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAP-GKYFYVWLDAPIGYMGSF--KDSTAELYHFI-GKDIVY----HSLFWPAMNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNH-FDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLAS-RNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESRE----FGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMKQVEALVEASKE 549
7 -12.100[J] COG0018 Arginyl-tRNA synthetase  ali follow..  13  124.KFQIEFSANPTGDLHLGHARGAAIGDSLANKMAGFDVSR---NDAGNQINNLVLSAEARYF-SEFPEDGYRGSDIIALGKDLAAKYGDKYVNASSVFRVDALAFETGKLRADLEEFR---------DEWFSETSLYEENKVLPALERLRENGYIYEQD---GATWLRTTDFEDRVLIKSDGSYTYDIAYHLNKLERGFDVLI-GADHHGYIPRMRAAIEALGYSPNQLE-VHLFEDGVQVKMSKRTGKSVTMRDLIEE-------------VG------------DATRYFFAMRSSDTHMNFDMSLAKYVQYAHARISSIRSGKEQGLEVSKDANMSLLETEAEYDLLKVLGEFADVVAEAAVKRAPHRIVRYLNDLATAFHRFYNSNKVLDMDNLEVTKARLALIKTAQITLRNGLTLLGVSAPE.................................... 554
8 -11.600[J] KOG0436 Methionyl-tRNA synthetase  ali follow..  14  187..LTEELDDSCSTEPHIGHAYTAVLCDVAHRKHPGAQAQFSIGTDEKQFCDRVSSKFSDLFTDLELSHTN-----TDPAHLEAVQHFWMKIQDNGYIYK-YSITDECFIPEEDVVKKIVEGGAEKLTLKSNGTPVEWIEEENYMFRLSINRENIVVHPSKYKSLALTSLEMSEDLSISRSRGIPVQTIYVWLDALVNYLTQVI-GKDITK----HLYYWPAFGLSLPQKVFIHGHWLIDNVKMSKSLGNVVNPSEAITK-FTAEGLRYFLLKHGNPSYDCS-FNWNSCLQTINSDLVNNVGNLLNSTVEKINKEGMYPKMEIEDIEAEIRENAKKLMEMVEESRGTAEITTWSAEKREKSGK...................................................................................................... 603
9 -11.500[J] KOG1247 Methionyl-tRNA synthetase  ali follow..  14  26........PYVNNVPHLGNIIGCVLS-VYARRLRGYNAIYICGTDEKEICDKYHAIHKEVYDWFGISFDK-----STPEQTEVCQAIFNKLWDNKWLSE-FLADRLVEGSCPFEGCNYDSARGDQCEKCGKQNTPRIRDTDHLFIELPLLKDRLEAYIKKTSVTGSWSQNALRQRCITRDEKYKDKVFYVWFDPENVELYQFM-GKDNVP----HTVMFPSTNWTLMKTISVTEYLNYEDGKFSKSKGVGVFGNDVKDTNIPVEVWRYYLLTNRPEVSDTS-FSWTDLQAKLNGELLSNLGNFVN-RVLSFIAKPD------NAGYGSVIPDAHDAESHSLTKSLAEKVEKFLKQGLKTAMLISSEGNYYLQASQFW--KLYKEDKPLCAVVIRTAAGLVHLLAQLLEPFMPSFSCEVFKQLNLPPQFSLSDERGEVLLASRPWDILPPSHRIGTPQPLKELEN 573
10 -9.030[J] COG0180 Tryptophanyl-tRNA synthetase  ali follow..  12  11.........QPSGELTIGNYMGALRQWVNMQDDYHCIYCAITVRQDAQQLRKATLDTLALYLACGIDPEKS---FVQSH--------VPEHAQLGWALNCYTYFGELSRMTQFKDKSARYA------------------------------------ENINAGLFDYPVLMAADILLYQTNLVPV-------------------GEDQKQHLELSRDIAQRFNGLYGDIFKVPEPFTKKMSKSDDNRNNVIGLLEDPKS--IKRAVTDSDEPPVVRYDVKEKAGVSNLLDILS--AVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEAFLQKVMKDGAEKASARAA...................................................................................................... 318
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.