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Query: gi|15675962|ref|NP_273080.1| 3-deoxy-D-manno-octulosonic-acid transferase (NMB0014) [Neisseria meningitidis MC58], from N.meningitidis

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFQWLYDVLWLLAPIWIRRYLDKRSGSAPAYRAHRDERFGKPYPNPVTGAVWIHAVSVGETRAAQSLIRELRRRFPDAPLLMTQMTPTGRETAQVLFPDAQCRYLPYDKKTWVRQFLREHRPMFGILMETEIWPNLMRECRRAGVPLFLANARLSEKSLNGYLKVRRLIRPAAASLTGCLAQTEADAARLAKLGAASVQVCGNTKYDIIPSEQMKTLAGQFEKRIGGRPVAVCGSTRVYRGEDEAEKLLAAWQQYRGDALLVVVPRHPEHFQTVFETAKRFGFKVQRRSDGLPVEPDTQVWIGDSMGELYAYYLCADVAFVGGSLVDSGCQNIIEPLSCGVPTIFGFSTYNFSEACRHALASGAAVQVESADAWREAVEKTLSSEGGGMQMQARVDGFIAQHRGAGARIAEAVREAVCGYRGRLast
1 -102.000[M] COG1519 3-deoxy-D-manno-octulosonic-acid transferase  ali follow..  32  1MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHLSITFTTFTPTGSERVKATFGDVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSARSAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYEKLNITGNIKYDLNTNDELLRKIDSLRTLWKDRPIWIAASTHNGE-DEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPNENTQVILGDSMGELMLMYGISDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEIFRMLVEVQGVLEVNSADALERAVEALLNSKESRERLGNAGYEVLMENRGALQRLLDLLKPYLERN... 426
2 -18.000[M] COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC  ali follow..  13  182...............................................................................................................TVDALFEQEKISAVIVGTAE----LALMCQRKGAVSICLQHGALMGDEAFIPVFT----------TYQAVFGAYEAEWFIRKGCEQILVTGHPRFDQIFNRTPMDMSIFYRKL-TKKIVLIATQPFSEDFYSGVLQGLSDQKQ-----LQIIIKPHPWEIGK------------KLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTV------GLEAMLFQKPVLI---GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANAESTNALFAELKAKTGVDYRR 468
3 -16.200[S] COG1817 Uncharacterized protein conserved in archaea  ali follow..  14  3..................................................VWIDIMNSPHAHFFKGIIRELEKR--GFEVLVTT---REFDGLTQILDMLGIDYISIGKHGGLSKLIIEEKPDLAIYKNN---PEAPRIAFGLKIPSIGFVDNETAVPQNKL---------MFPFTNRLLYPKPIDAYELLRCGANSLRPVNGIAEIANIYGFKPEDTVLKELGVKKYSYIVMPIKATYFNGDRERSILEDIIPLLPDLPIILFPRTDEQREIFEKF--------------------DNIIIPEKAVDTLTLLFYAKL------MVGAGGTMNREALALGTPAIS--YPGKLLAVTKWLIDLGVLYHSTNPIEVGMKVWEIVRKNSVYRRNIRTVMSSMEN---PVEAIIEEVENLTYPGQFR 349
4 -15.300[R] COG4671 Predicted glycosyl transferase  ali follow..  10  2......................................WPMSPRLNDARILMYDSFGLGHLRRCRTIAHALVEDYRGLNVLIISGATIAGAFDYR--ARVDFVKIP-----IIYHTAESFQPDIFIVDKEPM-EETLAYLKGQGTKLVIGLRDVAPQLLEAEWKRNNVMTKIGQFYDHVWVYGPPDFHDPLTGLDVPQTVRDKMDFVGFLQRSKTQAETVAHRPEGDYLLITTGGGGDGSE-DDVINAYHHDPELTHKALVVLGPYMPAD---------------QRQRFMSSVADIPHIEIIEFDNRMEDLVAGAQAV------VSMGGYNTVEILSFDKPALVVPRTVPREE-ATRASELGLFDMLLNPAKMAEALKALPNRAPPSVNSQNL-------KLDGLENISRRIAEWLPHESEK 398
5 -15.100[MOI] KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase  ali follow..  11  27..........................................................GVESHIYQLSQCLIER--GHKVIIVTHAYGNRKGIRYLTSGLKVYYLPFHSLPLLRYIFVRERVTII----SAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLLNPEIVSVIPN---------DPTDFTPDPFRRHDSITIVVVSRLVYRKGIDLLSGIIPELCQKYPDLNFIIGGEGPKR-IILEEVRERYQL-------------HDRVRLLGALEDVRNVLVQGHI-FLNTSLTEAFCMAIVEAASCGLQVV-STRVGGIPEVLPE--NLIILCEPSVKSLCEGLEKAIFQLKSGTLPAPENIHNIVKTFRNVAERTEKVYDRVSVEAVLP 387
6 -13.300[S] COG4370 Uncharacterized protein conserved in bacteria  ali follow..  13  2...............................................LPKILLLSNGHGEDAIAVSIGQAWSEMEPGEILVGLPLVGEGNSYRRL-FNNMDARELWRDVQGGLQKWTAQGGKVLAVGDIVPLALAWLGRGDYAFVGTAKSEYYLRSPAGAWLPSTQAWEKMTRKNCVAVFPRDRLTHESLLNQGVA-SYAVGNPMMDGLNPQDYKPQTLQPGQ---SLTITLLPGSRSPEMERLIVESLTSVLAHFADASIFLAAIAPSPLPTLMAELETQGWQPLEDNAVELLTNKVSCLIKGPVQQFADCLHHAQAAIA------MAGTATEQFVGLGKPVISGPQYNPYFARRQTWLLGESLILLNSPDQTGEALQQVLHDVERLEAIACNGRERL-GQAGAARRIAEILREQW...... 422
7 -12.900[M] COG3980 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase  ali follow..  11  12......................................................EKGMGHVVRMKRLAEGLKQRCLITFYTNQDSE----------------------------AFLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDIKIKTETDAKIVLFEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGP-DYLILHPAFQAAREDYTLKKDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK----------------PQYKMIEQTNDMAGLMKQADAAIVA------GGISLYEAICIGVPCLVLSQVEHQTATAKTFADQGAALDLGPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGK--GIIRVTAILQDLYEQE... 338
8 -12.300[M] COG0381 UDP-N-acetylglucosamine 2-epimerase  ali follow..  13  7......................................................MTVVGEIIRLSRVIVACDKHFQ--HILVHTGQNYDYELNEVFFHDLGIRKPDYFLN-AVDQLLEETQPEALLVLGDTNSCLAVLPAKRRKIPTFHMEAGNRCFDMRVPEEINRRIVDHTADINLTYSTIARDYLLAEGLSPDLIIKTGSPMFEVLHFYHEQIKHSKILDKLGLTP-YFVVSAHREESEPHFLDLIHTLNAVAKKYQYPV-IVSTH--------------RTRKRIEELNITFHPLIQLLKPLGFLDYNKLQLMAKAT---LSDSGT----ESSILNFPALN---LRQAHERPEGMEEAAVMLVGLQAERVLQGLAILDEQRRGQERDLRLVADYSMPN--VSAKVIRILLSYTDYVNR. 370
9 -10.900[GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase  ali follow..  8  2................................................RILFVGPPLYGLLYPVLSLAQAFRVNGHEVLIFAQKAAEAGLVVFDGNFSFFSEEMTD-----PLVAFAGQWRPDLIVYPPLGVVGPLI--AAKYDIPVVMQTVGFGHTP----WHIKGVTKSLSNAYRRHGVSAPPRDLAWIDVTPPSMSILQVISMQYVPYNGGAVWEEWWERTPDRKRLLVSLGTPMVDGLDLISWVMDSAGEVDAEIILHLPANARSDLRSLPP----------------------NVRLVDWLPMGVFLNGADGFIHHGGA-------NTLTALHAGIPQIVFGQGADRPVNARAVVERGCGIIPGKSGLTSSMINTFLGNRALREASQEVAAEM--AAQPCPTEVAKKLIAMLQHG... 371
10 -9.800[S] COG2327 Uncharacterized conserved protein  ali follow..  11  13........................................................NRGDSAILRGLLDAINILNPHAEVDVMSRYPVSSSWLLNRPVMGDPLFLQIAIAQGFTDFVRLLS-DAIIQVGGSFFVDLALCTFMAKKPLFMIGHSVGPFQDEQFNQ---LANYVFGHCDALILRESVSFDLMKRSNIAKVEHGVDTAWLVDHHTEDFTASYAVQHWLDVAA-LAPFDKRLGTTQQAYEKAFAGVVNRIEGYQVIALSTCTGIDSY-----NKDDRMVALNLRQHISDPARYHVVMDELNEMGKILGACEL-TVGTRL-----HSAIISMNFATPAIAINYEHKSAGIMQQLGLPEMAIDIRHDGSLQAMVADTLGQ---LPALNARLSEAVSRERQTGMQMVQSVLERIGEVK.. 426
11 -9.490[M] COG0763 Lipid A disaccharide synthetase  ali follow..  12  11.......................................................LVAGETSGGAGLIRALKERVPNARFV-PRMQAEGCEAWYEMEELAVMGIVELHIRADLTKRFGELKPDVFVGIDAPDF-ILEGNLKKQGIKTI---------SPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNSARDVLGIPYDAHCLALLPGSRGAEVEMLSLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAAVA---------------PDLSVHLLDGMGREAMVASDAALL------ASGTAALECMLAKCPMVV-PNLLAGRELVKELLQEEC-----EPQKLAAALLPLLANGKTSHAMHDTFRELHQQRCNADEQAAQAVLELAQ..... 382
12 -9.390[M] COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase  ali follow..  17  2.............................................KNKKLLVMAGGTGGHVFPAIAVAQTLQKQEWDICWL------TKDRMEAQLVPKYGIPIRFIQISGLAKKIIQEEKPDAVLGMGGYVSGPAGVAAKLCGVPIILHEQNA----------IAGLTNKLLGKIATCVLQAFPTAFP-------HAEVVGNVREDLF---EMPNPDIRFSDREEKLRVLVVGGS---QGARVLNHTLPKVVAQLADKLEFRHQVGKGAVEEVSQLYGENLE---------------QVKITEFIDNMAEAYAWADVV-----ICRSGALTVCEIAAVGAAAIF-QHKDRQQYLAKYLSDVGAAKIIEQADLTPEILVNYLKNRENLLQMALKAKTMSMPN--AAQRVAEVIKQYSN..... 351
13 -9.370[S] COG4641 Uncharacterized protein conserved in bacteria  ali follow..  10  42................................................................................................................SLMKIEAFQPDFTLMMVDRVPHDWLTWLKGKDIPVYV----LTEDPFY------DISLQVIKLADAILTIEQNAALYYQELGYQNVYYV---------------------------PIPVNHRLFK-----------MGTEHSYHSNLLIIGYPYPNRVQLMKEAVHLPGKEWGKYLPKKVLKQPHIDVVSTWVPQAVHYYNGADIVI--RIKNASFNNRTFDIAACERFQLTD---------LPAAHPFSSIISYHGMNDFKEKAAFYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLA..... 315
14 -9.220[M] KOG0853 Glycosyltransferase  ali follow..  9  460..................................................................................................................HFSCQFTADLIAMNNADFIITSTYQEIAGTKNTVGQYESHGAFTLPGLYRVVHGIDVFDPKFNIVSPGADMTIYFPYSEETRRLTALHGSIEEMLYSPDQTDEHVGTLSDRSKPILFSMARLDKVKNISGLVEMYSKNTKLRELVNLVVIREEIVEIEKMHNLMKNYKLDGQFRWITAQTNRA-------RNGELYRYIADTRGAFAQPAFYEAFGLTVVEAMTCGLPTF----ATCHGGPAEIIEHGLSGFHIDPGNIMADFFERCKEDPNHWKKVSDAGLQRIYERKIYSERLMTLAGVYGFWKYVS 777
15 -9.010[O] KOG2941 Beta-1,4-mannosyltransferase  ali follow..  10  12......................................LGDLGRSPR---MQYHALSLARQASFQVDIVAYGGSIPHEAVLIHIHTMAQPRFIQYFPKILYPVTLLLKAFIQFTMLLWFLAPDIFLVQNPPSVPAFVVDWHNFGYTLLMATGSLCVTKAMQ-EERHELFCRVRKDLCHPIGVYDFISRELENQELNETLFTTKFNADISLKQNRPALVVSSTSWTPDENAVMYDRRVAARSKGSETAEISEEQHHYPNLLFIITGKGPEK-EMYEEKIKRLNL-------------RHVAFRTMWLADYPLLLGSADLGVC-SSSGLDLPMKVVDMFGCGLPVC----SVSYSCIQELVKDGKNGLLFSSSSELADQLLILFKGFPGNCDALMSLKAGAMETGSSATEWEDCAKPLITQVVSQ 461
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.