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Query: gi|15675969|ref|NP_273095.1| glycerate dehydrogenase (NMB0029) [Neisseria meningitidis MC58], from N.meningitidis

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNHKKIVVLDADTLPGRVFHFDFPHELAVYGTTGADETAERVRDAHIVITNKVMISADIIAANPQLELIAVSATGVNNVDIGAAKAAGVAVCNVRAYGNESVAEHAFMLMIALMRNLPAYQRDVAAGLWEKSPFFCHYGAPIRDLNGKTLAVFGRGNIGRTLAGYAQAFGMGVVFAEHKHASAVREGYVSFEDAVRAADVLSLHCPLNAQTENMIGENELRQMKPGAVLINCGRGGLVDENALLAALKYGQIGGAGVDVLTNEPPKNGNPLLNARLPNLIVTPHTAWASREALDRLFDILLANIHAFVKGEAQNRVVLast
1 -84.600[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  30  27FTMAKVLVSDSIDQVGIDILKQVA-QVDVKTGLSEAEIIDIVPEYDAIMRSATKVTEKIIQAGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWERKQFIG------TEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQEIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQEPLG-ESRLR--EFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAV 338
2 -84.500[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  21  1...MRCVVFNLREEEAPYVQSHPGVVVDTYEEPLTAKNKELLKGYEGLVMQFLAMEDEVYDGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQK-----PILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPTVYARLV--AHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEI 329
3 -82.200[K] KOG0067 Transcription factor CtBP  ali follow..  27  33..RPLVALLDGRDCTEMPILKDLATVAFCDAQSTQEIHEKVLNEAVAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSAQGPLK--DAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLR 354
4 -80.100[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  28  80LPKPRILVTEKLGEAGVNLLREFG-DVDCSYDLSPEDLKKKVAESDALIRSGTKVTREVFEAAKRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGKWERSKYVG------VSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADLGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPSKDSRLI--QHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAV 393
5 -68.000[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  28  308..............................PPKNRPEILEKIRGAHAVIGGRDILNAEILDAAPQLKAVSTMSSGINNVDVPELKKRGIPLGSTPAMLTVAVADLTVGLLIAAARRFQEGRRKIDSDKWDKDHLNWMLG---QDIRDSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTQDIEERFNAKKVDFETLLAESDFLIIASPLTKETLGLFNATVFNKMKETAVLVNVGRGKIVNQDDLYEALKSNRIFAAGLDVMDPEPLPSNDKLL--TLDNVVVTPHVGYATRRTRVDAANLASRNVLKGLAGEPMLSPA 597
6 -12.400[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  12  77..........STQDHAAAAIAKAGISASTGIPVLPLPRLACLEGRNRRGVPVTGDLTNLIHSEYSRGISKETTIGVHNLKMMVNGILKVPAIDVNDSATKSKFDNLYGCGIKQATDVM--------------------------IAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALGYEVTTMDEACQEGDVFVT----TTGCVDIILGQHFEQTKDDTIVCNTGYFDVMDVKWLNKNTVEKVNVKLQVDPYRLKNGRGIILLAEGRLVNLACAMGHPSFVRSNSFTSQVMAQIKLWT........... 355
7 -12.100[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  19  198...................................................................VTEETTTGVHRLHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRATDML--------------------MGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEALQALMDGYSVVTVDEAIEDADIVIT----ATGNKDIISFEQMLKMKDHALLGNIG.................................................................................... 345
8 -9.440[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  13  35................................................................................................................................................LKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPRATENGFKVGTYEELIPTADLVVNLTP--DKQHSKVVADVMPLMKKDSAFGYSH----------FNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAAT......... 198
9 -9.390[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  17  3.....................................................................................................................................................LGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMSLRELSQRLSAPRVVWVMVPAGNITTAVIEE--ANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGT.......................................................... 121
10 -9.170[E] COG0686 Alanine dehydrogenase  ali follow..  11  59...................................PTAADVFAKAEMIVKVKEPQAIERAMLKEGQILFTYLHLAPDFPQTEELIKSKAVCIAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEK--SRGGSGLLLGGVPGVAPAKVVVLGGGVVGANAARMAIGLRADVTILDRNIDTLRKLDEEAIEKYVLEADLV-IGAVLIPGAA-LVTQQHIKRMKPGSAVVDVA----IDQGGCFETSHPTTH---------AEPTYIVDDVVHYCVANM---P--GAVARTSTFALNNATLPYIVKLANKG...... 328
11 -9.050[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  18  6...................................................................................................................................................PSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIGAVPSTADQAVKDADIVFLAVPLHK-------RSVNPATLEGKIVIDTMNDPRSTSEIIAEFFAGSTMVKS.............................................................. 130
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.