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Query: 5VMA Entity 1(prereleased), from PDB1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSNKERFLTLYHQIKSDANGYFSPEGIPYHSIETLICEAPDYGHMTTSEAYSYWLWLEVLYGHYTRDWSKLEAAWDNMEKYIIPVNEDGNDEQPHMSAYNPSSPATYASEKPYPDQYPSQLSGARPAGQDPIDGELKSTYGTNETYLMHWLLDVDNWYKYGNLLNPSHKAAYVNTFQRGQQESVWEAIPHPSQDDKSFGKPNEGFMSLFTKENQVPAAQWRYTNATDADARAIQAIYWAKELGYNNSTYLDKAKKMGDFLRYGMYDKYFQTIGSGKQGNPYPGNGKGACHYLMAWYTSWGGGLGDYANWSWRIGASHCHQGYQNPVAAYALSSDKGGLKPSSATGASDWEKTLKRQLEFYVWLQSKEGAIAGGATNSWNGDYSAYPAGRSTFYDMAYEDAPVYHDPPSNNWFGMQAWPMERVAELYYIFVKDGDKTSENVQMAKSCITKWVNYALDYIFIGSRPVSDEEGYFLDDQGRRILGGTNATVATTSAPGEFWLPGNIAWSGQPDTWNGFQSATGNPNLTAVTKDPTQDTGVLGSLVKAFTFFAAATKLETGNYTALGVRAKDAAAQLLEVAWNYNDGVGIVTEEEREDYDRFFKKEVYFPNGWNGTFGQGNQIPGSSTIPSDPQRGGNGVYTSFADLRPNIKQDPAWSSLESKYQSSFNEATGKWENGAPVFTYHRFWSQVDMATAYAEYHRLINLELast
1 -7.770[R] COG2936 Predicted acyl esterases  ali follow..  13  32..........................................................................................................WMPEDAGNDPVPVILE--------------HLPYRKRDGTIFRDQLTHPYFAGHG-RGNGDSEGLMDDEYSEQELQDACDVIAWAVAQPWCMGISWGGFNCLQVAAKQPPALKAVISLCSTVDCLLIENFGWASTMLSYSSRPPDPLIALPLWLSHQHRDAYWKRGSICEDFSAVK-----AVLSIGGWHDGYRNTISNL---------------VSNIEAPVKGIVGPWIHKYPHYAGPQPAIGFLQEALRWWRWLKGTETGVE--------------DDPAYRAYVMDSVRPARWHPERPGRWVAEQQWPSPAIKTRTIELLPKGGRPAIVASPQTCGLAGGE-------------------YFPFTFGPELPGDQRPDDALSVCFDQPELTEAIDIVGAPEVEVRLSSDRPQANIAIRLCDVHPD-GASELISYGVL--LTHRDSHEFPQALVPGETVSARVVLDQCAYRVPAGHSLRIAVSNAYWPMIWPS...................................................................................................... 502
2 -6.510[T] COG3292 Predicted periplasmic ligand-binding sensor domain  ali follow..  11  39..................ETWTSTDGLPHNSINSIAQTRDGY------------LWFATWEGVVRYNGINFQVFDRNPQTGMVDSGTRTLLPMDNNGLL-------VAGARGSITHRQSYGWQSFRSAPSLVNGALIDDAQN-------WLAIEGLGVVVRPYLGNNLYGPDRWLLTDASVYRLVKN------HGVIFAATDKGLYRF----NDWQASAMELPIGRYERINYISISLNQELVVATDQGVWINTEEGFQSLFVPLEKEVVTLAEQDRAGNWWIGTVNRGIARLKNWVGTNAGIMGDYVRTLLPLDDRRVMVGTSRGLSIIEEGLAHSALMPQVGARPSILSLAKADQQGEKVWV----GTVQKGLLLWQNGQLRPVLDENNGLPSSEV--RAIVTDPQDNLWIGTSNGIVKRTPQGVLTTYNKDNSPLPDDYIMALAVDSWVG---------------------SAVGVAYFDAQGKIRPVDLTKQEQAQYVFGFYMESDYVWMATDRGIVRYRLS-SVSLVGRAAGLPIDKFFQMVWLSSNRGVWKLNYDQMLAVADGMSTQLEFEHFDEGD--GMATSQANGGTNSLPNGELLFATAKGVASIKVQRLQQLSELR............................................................................. 644
3 -6.430[D] KOG4775 Uncharacterized protein SFI1 involved in G(2)-M transition  ali follow..  9  19.EDLRRDLEILRLILLRLSHAADDTSPLFNAYESVLRE---NGLNPARHRS-YIRILYRLISSKKLSWN---DEWRNLDLNTPLFPLNNTDMENDPFIVNGDDYRSRSNQQKSSQFASEVAQTIKSQTAMFRRADQYRSQKDKILYFPRWVQKLRNIQSRIYSAGEAYRLILIGQM------NRWRQKTRERLHQKLRFQKNAFLLDVL--------LKWSLTVNWNRKHEYMLKRRVFTNWMSKRRRNESLIQKANVFFQHSVLAHSFKT---KANLSIKNAATLYEKKVVFMSFNRWHANYESHVLDLQKAELFSQKAYYSIALHKWKLRIEELSDLMNKADDLYEWRRKATTYEKIDFWMDGHDVDIVKSAFFKWKNKFIKVDRNFELADTILQNTF-------------LTKWRLAVRVKVVQEKRNKDRLIVTDHRLLTIAWEAWKDNYQRRIKLQKEAQELQLQYLIKWRISLLDIKELSIRAEKLHTTNEIIGVWNQWVVS-EHWRYLRETNMLLRLENKVVDFREVQ--EKLVLRCWNAWVARLLSVSQMLDTAELSTQKVVVRAYEA-WSFR----NHQKEIMSQADQFYNERLM--VFWRYQLRAIKFYFNISDWKRREFNRQT--------LRNAFDA---WHLLMFRVTSLVMQADREQKKNKLLGKYFRKWLQ................. 765
4 -6.050[T] KOG4658 Apoptotic ATPase  ali follow..  8  24KSYIRTLEKNLRALQREMEDLRAIQ----HEVQNKVARDEARHQRRLEAVQV---WLDRVNSVDIECKDLLSVTPVELQKLCLCGLCSKYVCSSYKYGKKVFLLLEEVKKLNSEGNFDEERPTQPTIGQEDMLEKAWNRLMEDGVGIM-------GLHGMGGVGKTTLFKKIHNKFAEIGGT-IWIVV----------------------------SKGVMISKLQEDIAEKLHLCD-----LWKNKNESDKATDIHRVLKGKMLDDIWEKVDLEAIGIPYPSEVNKCKVAFLEPEDAWGDNTLSSDPVIVELAREVAQKCRGLPLALNVIGETM-----SSKTMVQEWEHAIHVFNTSAAEFSDMQNKILPILKYSYDSLGDEHIKSCFLYCALFPEDGEIYNEKLIDYWICEGFIGLGTLTRANLLTKVGTYYCVMHD-----VVREMALWIASDFGKQKENFVVQAGVGLHEIPKVKD--GAVRKMSLMDNDIEEITCESKC----------------SELTTLFLQSNKLKNLPGAFIRYMQKLVVLDLSYNRDFNKLPEQISGLVS.................................................................................................................................... 582
5 -5.960[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  8 1252.QNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVI-WLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISK--ESFLSRFPSKTLGIVSLNCGFHARALATAPYAALESDYRVLQEIYAG--------IDDPDEIEAVSLNFHDYSFDQQLLLHENSGTLSCYEIIIQKDPENKK---AKIGLLNSMLQEASWRSLSIKCLSKSNLEGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDI-RRRLSQVAPYGKFKHQILSYLEI-NGQFQEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEVNEQSERFLSGELVTRIINEFGRSLYYGTNH----ESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSM----KIPQYFFLVALSQ-------------MISRVCHPNNKV-LEHIIANVVASYPGET----ATIKSTSQKRSLRGKSILNVLHSRK-----LSMSSKVDIKALSQSAILITE................................................................................................ 1984
6 -5.900[G] KOG0602 Neutral trehalase  ali follow..  12  302.....RFNELY-------DSYMMALGLLEANVEHFIFEINHYGKILNANRSYYLTEMALVVFKKLGGRSNPDAVDLLKRAF---TASPRLDPETGLSRYHPNPPETESDHFDTVLLPYASKHGVTEFKQLYNDGKIKEPKLDEFFLHDRGVRE-HDTTYRFEGVCAYLATIDLNSLLYKYEIDIADFIKE-------------CDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMW---------------DESGFFFDYNTKIK-----------------HRTSYESATTFWALWAGLA--------------------------------------TKEQAQKMVEKALPKLEMLGGLAACTERSRGPISISRPIRQWDYP----------------------FGWAPHQILAWEGLRSYGY------------LTVTNRLAYRWLFMMTKAFVDYNGIVVEK----YDVTRGTDPHRVEAEYGNQGADFKGAATEGFGWVN.................................................................................................................................................................................................... 710
7 -5.900[G] COG1626 Neutral trehalase  ali follow..  12  302.....RFNELY-------DSYMMALGLLEANVEHFIFEINHYGKILNANRSYYLTEMALVVFKKLGGRSNPDAVDLLKRAF---TASPRLDPETGLSRYHPNPPETESDHFDTVLLPYASKHGVTEFKQLYNDGKIKEPKLDEFFLHDRGVRE-HDTTYRFEGVCAYLATIDLNSLLYKYEIDIADFIKE-------------CDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMW---------------DESGFFFDYNTKIK-----------------HRTSYESATTFWALWAGLA--------------------------------------TKEQAQKMVEKALPKLEMLGGLAACTERSRGPISISRPIRQWDYP----------------------FGWAPHQILAWEGLRSYGY------------LTVTNRLAYRWLFMMTKAFVDYNGIVVEK----YDVTRGTDPHRVEAEYGNQGADFKGAATEGFGWVN.................................................................................................................................................................................................... 710
8 -5.590[S] COG1615 Uncharacterized conserved protein  ali follow..  11  421...........DRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDPNQN-----GGYPQFLVNVVGNGTVVSEGPARLDQPRVYFGPVISNTSADYAIVGKNGDDREYDYETNTDTKRYTYAGSGGVPIGSWLSRSVFAAKFAERNFLF-----------SSVIGSNSKI-LFNRDPAQRVEAVAPWLTTDSSVYPAIVNKIIDGYTTLDNYPYSERTSLSSATAD-------------STEVAFNRLAPDKRVAYIRNSTVDAYDGAVTLYQQDEYDP--------VLKVWMKVFPGTVRPKGDITPEL---AEHLRYPEDL--------------------------FKVQRMLLAKYHVNDPGTFFNTSDFWDDPNPTASSYQPPYYIVAKNILKNDRSASYQLTSAMNRFKQDFLAAYISASSDPETGNVNGPKLANNAITT------------DPAVSQDLGVIGRDNQNRIRWGNLLTLPVAQGGLLYVEPVYAS--------GVSDAASSYPRLIRVAMMYNDKIGYGPTVGDALGLFGPGAASAATGIEPTEAVPPKSPAGSSTPPIAVVPSAPDGSVALSAAKAAALQEIQAVIGAAREAQKKGDFVAYGSALQR............................................................................ 971
9 -5.500[I] COG1657 Squalene cyclase  ali follow..  11  246.............................AAEKWIIERQEATGDWGGIIPAMLNSMLALRSLGYDTNDPIVERGLQALDNFAIETVDCYRVQPCVSPVWDTAWVIRALIDSGIAPDHPAIVKAGEWLLQKQILDYGDWNVKNRQGKPGAWAFEFEN--FYPDVDDTAVVVMALHAAKLPNEQLKQKACDRALQWVASMQCKPGGWAAFDLDNDQDWLNSVPYGNTADVTARVIEML--GACNLSIDSHNLERALT---YLL-----------------NEQEAEG--------CWFGRWG-----------------VNYIYGTSGVLSAL----------ALINPQKYQRHIQQGATWLVGCQNPDGGWGETCFSYNDPSLKGQGDSTPS----------------------QTAWALIGLIAAGEATGNFAHDA----------IERGINHLVSTQQPDGSW............................................................................................................................................................................................................................................... 598
10 -5.460[J] COG0525 Valyl-tRNA synthetase  ali follow..  10  10.RFTPSAVEQALYKHWEESGYFKPSEDTSKPSYSIAIPPPNMGHAFQQTLMDILIRFNRMEGHNTLWQTGTDHAGIATQMVV----ERKIAAEEGKTRHDYGREAFIDKIWDWKAYSGGTISQQMRLGNSAVKEVFVRLHEEGLIYLVNWISDLE--YPLANGAKTADGKDYLVVATTRPETMLGDTAVHPEDERYQSLIGKTVVLPLANRDREFGTGVVKITPAHDFNDYEV-----GKRHQLPMVNVMTLNADIRAEAEIIGSDGKILESYTALIPTKYQGMERFAARKQIVADFEELGLLDEIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLAEVAVKAVEDGEIQFQYENLYFSWMRDIQD-----SRQLWWGHYVARDEAEVRAKHNLPADLALKQDED-DTWFSSGLWTFSTLGKMFHSTD----------ITGFDIIFFWVARMIHFVKDENGKPQVPFKTVYVTGLIRDEQGQKMSKSKGNVIDPLDMIDGIDLESLLEKRTGNMMQPQLAEKIAKATIKAFPEGIAEHGTDAL--FTLTALATNGRDINWDMKRLEGYRNFCNKLWN............................................................................................................................ 653
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.