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Query: 5Z4P Entity 6(prereleased), from PDB1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELSESCTWFPESYVIYPTNLKTPVAPAQNGIRHLINNTRTDEREVFLAAYNRRREGREGNVWIAKSSAGAKGEGILISSEASELLDFIDEQGQVHVIQKYLEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSANFQDKTCHLTNHCIQKEYSKNYGRYEEGNEMFFEEFNQYLMDALNTTLENSILLQIKHIIRSCLMCIEPAISTKHLHYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDVAISSVFPLADTGQKTSQPTSIFIKLLast
1 -66.800[O] KOG2158 Tubulin-tyrosine ligase-related protein  ali follow..  18  143..ETKSTICVSNSRYAMIGKISKTLGYKLVKESK-MWNILWSDSFPGVELF--KNMKRFQQINHFPGMIEICRKDLLSRNLNRMLKI------FPQDYKIFPKTWMLPADYGDAMNYA----------------------LNHKRTFILKPDSGAQGRGIWLTNDLKTI-----GPHERLICQTYIHRPLLID--GYKFDLRVYTLITSPLRIFVYNEGLARFATNKYTPGNANDLYMHLTNYSVNKRNSHYELCDNDGSKRKLSAINNWMRRHNYDV--EEFWSNVDDVIIKTVLSAWPVLKHNYHAQACFEILGFDILVDWKLKPYILEVNHSPSFHEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRK.... 491
2 -64.500[O] KOG2157 Predicted tubulin-tyrosine ligase  ali follow..  22  213..KLKITYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVHMKLD--IVRNLAPYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGM-----KHFDIVPQTFVLPIESRDLVVAH----------------------NKHRGPWIVKPAASSRGRGIFIVNSPDQI-----PQDEQAVVSKYIVDPLCID--GHKCDLRVYVLVTSPLIIYLYEEGIVRLATVKYDADNLWNPCMHLCNYSINKYHSDYIRSSDAGHKWTLSALLRHLKLQSCDT--RQLMLNIEDLIIKAVLACAQSIISACRMFNCFELYGFDILIDNALKPWLLEINLSPSMGSPLDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQK.... 562
3 -12.600[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  15  194...................................................................................................................................................IVKPLQGSGGKNVFKIGSSKEQIFEAVSLEGYLIAQAYLPA--------KEGDVRFFMMNGRPLMRDGQYAALRRVPAKGDLRSNI---------------------------------------HANGTAEAVKVTDEIVELAEMMRPKLVED----------MFLVGLDIVGDK-----ILEVNFSPGGLSNILELTNVDFSDTIIEAVETKVSMQAASGGALS..... 364
4 -10.700[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  13  123......................................................................................................................................VPQTSLRPLDCKFIIKPRTACAGEGIGFSDEVPD----------GHIAQEFIE--------GINLSVSLAV--------------------------GEDVKCLSVNEQIINN---------------------RYAGAVVPARISDEVKREVVEEAVRAVECVEGLNG----------YVGVDIVYSDQ--PYVIEIN--ARLTTPFSRAYGASVADLLAGGEVKHVRRQMVRKSKSAEKPYV 291
5 -10.100[R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)  ali follow..  8  169...................................................................................................................................................KLPHAKKRLERGFFTAASYKEFKEKSEKDLAKARIERYII--------GPVFNFDFFYPIDGEIELLGIDW------RFETSLDGHVRLPAAQQLTLPEWQFEPEYTVCGHASS----------------TLRESLLEKVFDMAEKYVEATKKYYPPG--------IIGLQTAVDKDLNFYIYDVAPR-STGRRIALEIKRAIELDELEKIV................... 379
6 -9.820[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  12  134...................................................................................................................................................VVKPNQEGSTIGLTVAETEEELLQGIERHDDTILIEEFIAGTEVVLGNKGEERSLPVVEIVPKNKLYDYESKYAPGMSEHIVPARISE----------------------------------------------EHTAYVQQAAVRAHQAL-----------GCDVYSRVDFIVPND-DPVILKVNTLPGMTPT--EEMIQTFVNLSLK...................... 304
7 -9.300[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali follow..  13  100.....................................................................................................NSRVDHVEDKYRLYRRIRNSYPTPETHLISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFRE----------GDGEFLLQEYIE--------GVPVSASVLSTGEDAITV------------------------------LTSRQIIDRGVPGFEGQFVYAGNMTPGPSG------------EIEDLASDLILD--------------LSLRGSDLIMRDS-ELYVIEVNPRIQGTFECAEASLGNMVDAHIRACM................... 286
8 -7.870[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  7  187.............................................................INSLHSIYQFQDKPWVFSHLLQLQR-----RLGRDGFPLIEQTFMLHLQHVAIICIPDPVTPPHYRSTRRETFFLSVHLQFQFTKFVLKAGHCHGGVATARLENQSALQDAANDSHCYCTIEPYIDA---------KFSVHI---------------------------QKIGNNYKAFMRKSIT-------------GNWKTNQGSAMLEQITLTEKYKSWVDEISELF------------------GGMEVCGLSVVVAKDGREYIISACDSTF-TQEEDRRQIADLVSGRMQNVCRPSMAQTGPGK........ 466
9 -7.160[S] COG3332 Uncharacterized conserved protein  ali follow..  9  16........................................................................................................LVVAANRDEFYDRPAAPLAWWSDAPHVLAGRDLAQVVGHAGTWM---GMTRDGRFAALTNYRAPSERRPDARSRGELVANFLAAE-QLKARNGVYN---YNLLTATRDELWW------TSNRAEAPRQLAPGVYGLSNALLDTPWFKVRHRV--------AAFAEALAADTGRHGNAIDVARYLDLLAETREAPLGALPATGVAPEWEKLYG--LRIRHDGCFDVTERRFDAQ......................................... 251
10 -6.710[I] COG0439 Biotin carboxylase  ali follow..  15  155...................................................................................................................................................LLKASAGGGGRGQKVIRTQEELQKGFNQADPAIIMEKFLEEF-------RHIEVQVM--------------------------GDGQGHVIHIRDCSIQRRNQKLIEEAPS-----------------------TLPESLRQEILAAGVRLAQFVN--------YAGAGLEFIMDRDGNYYFMEMNTRIQVEHCVSEMISSDLVRLQIEIA.................... 314
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.