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Query: 2a0m_A mol:protein length:316 ARGINASE SUPERFAMILY PROTEIN, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAMAARTDDPRLLSLFSAQREEDADIVIIGFPYDEGCVRNGGRAGAKKGPAAFRFFLQRLGSVNNLELNVDASHLKLYDAGDITASTLEEAHEKLESKVFTVLARGAFPFVIGGGNDQSAPNGRAMLRAFPGDVGVINVDSHLDVRPPLQDGRVHSGTPFRQLLEESSFSGKRFVEFACQGSQCGALHAQYVRDHQGHLMWLSEVRKKGAVAALEDAFGLTGKNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTPTVMMMDMSELNPLVEEYRSPRVAVYMFYHFVLGFATRPKPKAENLast
1 -103.0002a0m_A mol:protein length:316 ARGINASE SUPERFAMILY PROTEIN  ali model  100  1MAMAARTDDPRLLSLFSAQREEDADIVIIGFPYDEGCVRNGGRAGAKKGPAAFRFFLQRLGSVNNLELNVDASHLKLYDAGDITASTLEEAHEKLESKVFTVLARGAFPFVIGGGNDQSAPNGRAMLRAFPGDVGVINVDSHLDVRPPLQDGRVHSGTPFRQLLEESSFSGKRFVEFACQGSQCGALHAQYVRDHQGHLMWLSEVRKKGAVAALEDAFGLTGKNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTPTVMMMDMSELNPLVEEYRSPRVAVYMFYHFVLGFATRPKPKAEN 310
2 -85.5001gq6_A mol:protein length:313 PROCLAVAMINATE AMIDINO HYDROLASE  ali model follow..  23  10...PRYAQIPTFMRLPHDPQPRGYDVVVIGAPYDGGT---SYRPGARFGPQAIRSESGLIHGVGIDRGPGTFDLINCVDAGDINLTDMNIAIDTAQSHLSGLLKANAAFLMIGGDHSLTVAALRAVAEQH-GPLAVVHLDAHSDTNPAFYGGRYHHGTPFRHGIDEKLIDPAAMVQIGIRGHNPKPDSLDYARGHGVRVVTADEFGELGVGGTADLIREKVGQPVYVSVDIDVVDPAFAPGTGTPAPGGLLSREVLALLRCV-GDLKPVGFDVMEVSPLYDGGITSILATEIGAELLYQYARAHRTQ... 312
3 -82.8003nio_A mol:protein length:319 Guanidinobutyrase  ali model follow..  20  15...PRFGGIATMMRLPHVAELDALDAAFVGVPLDIGT---SLRSGTRFGPREIRAESVMIRPYNMATGAAPFDSLNVADIGDVAINNLLEAVRIIEQEYDRILGHGILPLTLGGDHTITLPILRAIKKKH-GKVGLVHVDAHADVNDHMFGEKIAHGTTFRRAVEEDLLDCDRVVQIGLRAQGYTAEDFNWSRKQGFRVVQAEECWHKSLEPLMAEVREKVGGPVYLSFDIDGIDPAWAPGTGTPEIGGLTTIQAMEIIRGC-QGLDLIGCDLVEVSPPYDTGNTSLLGANLLYEMLCVLPGVVRR.... 319
4 -82.0003nip_A mol:protein length:326 3-guanidinopropionase  ali model follow..  23  15...PRFAGIPTFMRLPAFTDPAALQVGLIGVPWDGGT---TNRAGARHGPREVRNLSSLMRKVHHVSRIAPYDLVRVGDLGDAPVNDLLDSLRRIEGFYRQVHAAGTLPLSVGGDHLVTLPIFRALGRE--RPLGMVHFDAHSDTNDRYGDNPYTHGTPFRRAIEEGLLDPLRTVQIGIRGSVYSPDDDAFARECGIRVIHMEEFVELGVEATLAEARRVVGGPTYVSFDVDVLDPAFAPGTGTPEIGGMTSLQAQQLVRGL-RGLDLVGADVVEVSPPFDGGATALVGATMMFELLCLLAESAARSALE 320
5 -81.2004dz4_A mol:protein length:324 Agmatinase  ali model follow..  19  27...NTYAGVLSFMRRNYTRDLDGVDVVVSGVPLDLAT---TFRSGARLGPSAVRAASVQLAELNPYPWGFDFDDLAVIDYGDCWFDHPLSIKPAIVEHARTILQSDARMLTLGGDHYITYPLLIAHAQKYGKPLSLIHFDAHCDTWADDAPDSLNHGTMFYKAVKDGLIDPKASVQVGIRTWND--------DYLGINVLDAAWVHEHGARATLERIESIVGGPAYLTFDIDCLDPAFAPGTGTPVAGGLSSAQALAIVRGL-GGVNLIGADVVEVAPAYDSEITAIAAAHVACDLLCLWRQRKAGAR.. 324
6 -79.8003m1r_A mol:protein length:322 Formimidoylglutamase  ali model follow..  22  18....KDRDVTKMSDLIATDGQDIKGPALIGVPLSKSS---ISHSGASFAPGTIRQALKHSSAYSAELG-EHVVSELLYDLGDIDITDIVKSHHHIFQTMHALLSDHPVPLILGGDNSISYSTIKAIAQTK-GTTAVIQFDAHHDVRNTEDGG-PTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVVQDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDRDMTSRAAAHVLLHALKGMKLSPFK.... 322
7 -79.2003pzl_A mol:protein length:313 Agmatine ureohydrolase  ali model follow..  20  11...DHASELRSIFSLKKVNGYEEAKYVVFGIPFDNTS---SYRRGSKYAPDSIRGAYVNLESYEYSYG-IDLLASGMADLGDMEEEDVEYVIDTVESVVSAVMSDGKIPIMLGGEHSITVGAVRALPK----DVDLVIVDAHSDFRSSYMGNKYNHACVTRRALD--LLGEGRITSIGIRSV--SREEFEDPDFRKVSFISSFDVKKNGIDKYIEEV-DRKSRRVYISVDMDGIDPAYAPAVGTPEPFGLADTDVRRLIERLSY--KAVGFDIVEFSPLYDNGNTSMLAAKLLQVFIASREKYYKEHIEG 307
8 -79.2001wog_A mol:protein length:305 agmatinase  ali model follow..  22  7...LPYGGIPTFARAPLVQPDGQADVAALGVPFDIAL---GFRPGARFAPRALREASLRSVPPFTGLDGKTLQGVTFADAGDVILPEPQLAHDRITEAARQVRGRCRVPVFLGGDHSVSYPLLRAFADV--PDLHVVQLDAHLDFTDTRNDTKWSNSSPFRRACEA-LPNLVHITTVGLRGLRFDPEAVAAARARGHTIIPMDDVTADLAGVLAQLP----GQNVYFSVDVDGFDPAVIPGTSSPEPDGLTYAQGMKILAAAAANNTVVGLDLVELAPNLDTGRSELLMARLVMETLCEVFDHV...... 304
9 -75.6003lhl_A mol:protein length:287 Putative agmatinase  ali model follow..  18  2.................SLNYEESNLIVFGVGFDGTT---SNRPGARFASSSMRKEFYGLETYSPFLD-LDLEDYNICDYGDLEISSTEQVLKEIYQETYKIVRDSKVPFMIGGEHLVTLPAFKAVHEKY-NDIYVIHFDAHTDLREEYNNSKNSHATVIKRIWD--IVGDNKIFQFGIRSG--TKEEFKFATEEKHTYMEIGGI------DTFENIVNMLNKNIYLTIDLDVLDASVFPGTGTPEPGGVNYREFQEIFKIIKSNINIVGCDIVELSPDYDTGVSTVIACKILRELCLIISDKIKE.... 280
10 -71.1001xfk_A mol:protein length:336 Formimidoylglutamase  ali model follow..  20  24...RRVHHIACPIQVGELAN-QEPGVALIGFECDAGVERNKGRTGAKHAPSLIKQALANLAWH---------HPIPIYDLGNIRCDELEQAQQECAQVIQQALPHA-RAIVLGGGHEIAWATFQGLAQHFQPRIGIINFDAHFDLRSELAPVRPSSGTPFNQIHHFCQQQGWHYACLGVSRASNTPALFERADKLGVWYVEDKAFSPLSLKDHLTQLQHFIDDYLYLTIDLDVFPAASAPGVSAPAARGVSLEALAPYFDRILHKNKLMIADIAEYNPSFDDQHTARLAARLCWDIANAMAEQVQSIRH. 335
11 -68.4004rhm_A mol:protein length:351 Arginase  ali model follow..  17  3...SSSSGLVPRGSHM-------FSKFLMNVKGVTPR---GSDWANRLGPVALFGYGAGMPRRAPLLDFDHYAELTIHDKGPIECPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPDDIVIVHFDAHPDVS--------DPRSPLRVLLDKGLLK--GVVSVGNRQV--SSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR----DYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNGI-RGPKVVGIDVYGYNPDLDVGLTAIALSKIIKEGILKAYSISTHTEEE 323
12 -67.6001t5f_A mol:protein length:314 Arginase 1  ali model follow..  24  2........................PIEIIGAPFSKGC----PRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHP-DLAVIWVDAHTDINTPLTTSSGNAGQPVAFLLKELAISAKDIVYIGLRDV--DPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGTPEEVTRTVNTAVALTLSAFGTKREGNHK 308
13 -67.2001d3v_A mol:protein length:323 PROTEIN (ARGINASE)  ali model follow..  23  2...................SSKPKPIEIIGAPFSKG----QPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVH-PDLCVIWVDAHTDINTPLTTSGNLHGQPVAFLLKELCISAKDIVYIGLRDV--DPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGTPEEVTRTVNTAVALTLSCFGTKREGNHK 313
14 -67.0004rhi_A mol:protein length:351 Arginase  ali model follow..  16  3...SSSSGLVPRGSHMFSKFLMNV-KGVTPRGSD---------WANRLGPVALFGYGAGMPRRAPLLDFDHYAELTIHDKGPIECPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPDDIVIVHFSARPSVS--------DPRSPLRVLLDKGLLK--GVVSVGNRQV--SSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR----DYPVFISIDASVLDPAFAPAVDSPVAGGLSTRDLLHIMNGI-RGPKVVGIDVYGYNPDLDVGLTAIALSKIIKEGILKAYSISTHTEEE 323
15 -66.8001pq3_A mol:protein length:306 Arginase II, mitochondrial precursor  ali model follow..  19  2........................SVAVIGAPFSQG----QKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCP-DLCVVWVDAHADINTPLTTSGNLHGQPVSFLLRELCISSASIVYIGLRDV--DPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLASEEEAKTTANLAVDVIASSFGQTRE.... 305
16 -66.3001wva_A mol:protein length:322 Arginase 1  ali model follow..  23  2...................SAKSRTIGIIGAPFSKG----QPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVH-PDLGVIWVDAHTDINTPLTTSGNLHGQPVSFLLKELCISAKDIVYIGLRDV--DPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGTPEEVTRTVNTAVAITLACFGLAREGNHK 313
17 -65.8005ynl_A mol:protein length:362 Arginase  ali model follow..  18  27...SPDLGTDDDDKMSPATLATPRTAGIVGCPFSGG----QPKAGVHSGPLQLIESGLLNDIENDFAGADALAVSIVSDTPDPDIGLVSRVTKDVADRVYAHASKGQLTVTLGGDHSLAMGTVSGTFKAY-PEACLIWVDAHADINTPHTTSGRLHGCPVSFLLGLDCLKPERIVYIGLRDI--DAGERKILKDNNIKCFSMFHVDKYGIGKVVEMALDHVNRPIHLSFDVDALDPSVAPSTGTAVRGGLTFREGHYICEAIAETNLLVSLDIMEINPSLGALASVAQTVDVGRSLVRCALGET...... 354
18 -64.8002eiv_A mol:protein length:291 Arginase  ali model follow..  21  3........................RVAVVGVPMDLGAN----RRGVDMGPSALRYARLLEQLED--------LGYTVEDLGDVPVSLARRAAALVLKERLAALPEGVFPIVLGGDHSLSMGSVAGAARG--RRVGVVWVDAHADFNTPESPSGNVHGMPLAVLSGLGAVDPKDVVLVGVRSL--DPGEKRLLKEAGVRVYTMHEVDRLGVARIAEEVLKHLQGPLHVSLDADVLDPTLAPGVGTPVPGGLTYREAHLLMEILAESGRVQSLDLVEVNPILDRNRTAEMLVGLALSLLG............ 287
19 -61.7001cev_A mol:protein length:299 PROTEIN (ARGINASE)  ali model follow..  23  3........................PISIIGVPMDLGQT----RRGVDMGPSAMRYAGVIERLERLHYDIEDLGDIRLHEQGDSRLKAVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHY-ERLGVIWYDAHGDVNTAESPSGNIHGMPLAASLGFGKIKPEHVVLIGVRSL--DEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYLKDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDRNKTASVAVALMGSLFGEKL......... 298
20 -61.7006dkt_A mol:protein length:296 Arginase  ali model follow..  21  2......................DKTISVIGMPMDLGQA----RRGVDMGPSAIRYAHLIERLSD--------MGYTVEDLGDIPINSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHY-DNLGVIWYDAHGDLNTLESPSGNIHGMPLAVSLGIGKIKPENVVIIGARSL--DEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDKNKTGKTAVELVESLLGKKL......... 295
21 -60.3004g3h_A mol:protein length:330 Arginase (RocF)  ali model follow..  14  1.........................MILVGLEAELGA----SKRGTDKGVRRLREALSATHGDKGMQTITQERCVLYKEFRYAKNDYYLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKKKIGILYLDAHADIHTAYDSSKHIHGMPLGMVLNRVEIDPKCLVYFGVRST--EQSERDVIRELQIPLFSVDAIRE-NMQEVVQKTKESLKDIIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLESDRLKAVEVTEYNPTVSIKEEEKQVLEILDLIINSCKIKDKKHS.. 317
22 -60.3004q3p_A mol:protein length:385 Arginase  ali model follow..  17  17...LKSVATPYYPIQDEKPKLLYTSANFLGIPTNRG----QPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEAERVEELMKQSNKHTVELSGSKSTPVIVGGDHSMATGTILGHAEAK-PDLCVLWIDAHGDINTPLNSSGNMHGMPLSFLVKELCLNASNIAYIGLRDL--DAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQKTQSSAVHILRACLGHCRSGHLPFKVR 361
23 -59.9004ity_A mol:protein length:330 Arginase  ali model follow..  18  3..................GSGMAKKMSIVLAPFSGGQP----HSGVELGPDYLLKQGLQQDMEKRVFDGKVVEARKASDNGDRIPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVH-PDAGVIWVDAHADINTMSGTSGNLHGCPLSILLGLDVLKPNKIAYIGLRAV--DDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLATESHVNDTISVGCAIARCMMGETLLYTPH 319
24 -53.2003mmr_A mol:protein length:413 Arginase  ali model follow..  14  82.....................INNNDNNNDNNNDNNNDN---NNNCYIPNGVIKEKKHDLSNNKNHNFYGNYEENNVISTNDKYIKEIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMY-QNLRVIWIDAHGDINIPESPSGNYHGMTLAHTLNLTYLKPENTAIIGIRDI--DAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDVDKKVHGDSLPILDNATKTGK........ 392
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A., Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11;117(6):699-711. Review.