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Query: 3c8f_A mol:protein length:245 Pyruvate formate-lyase 1-activating enzyme, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst SVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCLDTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGVKPPKKETMERVKGILEQYGHKVMFLast
1 -115.0003c8f_A mol:protein length:245 Pyruvate formate-lyase 1-activating enzyme  ali model  100  1SVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCLDTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGVKPPKKETMERVKGILEQYGHKVMF 245
2 -73.6003can_A mol:protein length:182 Pyruvate-formate lyase-activating enzyme  ali model follow..  31  1..................................................................SNAGGGVTFCGGEPLLHPEFLIDILKRCGQQGIHRAVDTTLLARK--ETVDEVMRNCELLLIDLKSMDSTVHQTFCDVPNELILKNIRRVAEADFPYYIRIPLIEGVNADEKNIKLSAEFLASLRHPEIINLLPYHDIGKGKHAKLGSIYNPKKMQTPSEEVQQQCIQILTDYGLKATI 180
3 -33.7004njg_A mol:protein length:230 7-carboxy-7-deazaguanine synthase  ali model follow..  15  21.........EIFYTLQGEGANAFCRFAGCNLWSGREEDRAQAVCNGGKFKDADALVATIAGLWP-AGEAHRFVVCTGGEPMLQLDQ--PLVDALHAAGFGIAIETNGSLP--------VLESIDWICVSPKADAPLVVTKGNELKVVIPQDNQRLADYAKLDFEYFLVQPMDGPSRDLNTKLAIDWCKRHPQWR---SMQTHKY......................................... 220
4 -28.1005tgs_A mol:protein length:263 7-carboxy-7-deazaguanine synthase  ali model follow..  16  21.....VLEIFGPTI-QGEGKTMFVRTAGCDYSCSWCDSAFTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQ-LDAFIELLKENNIRAALETQGTVY------QDWFTLIDDLTISPKPPSSKMVTNF-----QKLDHILTSLQENDRQHAVSLKVVIF---NDEDLEFAKTVHKRYPGIPFY................................................. 200
5 -27.9006djt_A mol:protein length:331 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase  ali model follow..  16  50..DKNCYKSKFYGIETHRCIQCTPSVIWCQQNCIFCWRVDISQIKEPKWEEPEVVYEKILAMHKRIIMGYAGVLSLSGEPTLYPYLD-ELIKIFHKNGFTTFVVSNGILT---DVIEKIE--PTQLYISLDAYDLDSYRRICGGKKESILNTLDILKEKKRTC-IRTTLIRGYNDDILKFVELYERA----DVHFIELKSYMHVGYSQ--------RLKKEDMLQHDEILKLAKMLDEN...... 297
6 -27.2002yx0_A mol:protein length:342 radical sam enzyme  ali model follow..  11  55..GRFCYKQKFYGIHSHRCLQMTPVLAWCTHNCIFCWRPMENFLGTELPQPWAFIVEESIKAQRKLLIG---AISLSGEPMLYPY-MGDLVEEFHKRGFTTFIVTNGTIPERLEEMIKEDKLPTQLYVSITAPDIETYNSVNIPMIERILRFLELMRDLPTRTVVRLTLVKGENM--HSPEKYAKLILKAR-PMFVEAKAYMFVGYSR--------RLTINNMPSHQDIREFAEALVKHLPGYHI 311
7 -22.9005v1q_A mol:protein length:459 Radical SAM  ali model follow..  16  103NARKHVAKLKKHNILSFPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLS------VSILGGEPTRYFDID-NLLIACEELKIKTTITTNAQL-IKKSTVEILAKSYITPVLSLQTLDSKLNFELMGVRPDRQIKLAKYFNEVGKKCRINAVYT---KQSYEQIIELVDFCIENK-IDRFSVANYSEVT--GYTKIKKKYDLADLRRLNEYVTDYITQ........... 323
8 -22.6003rf9_A mol:protein length:404 Ribosomal RNA large subunit methyltransferase N  ali model follow..  20  103.......RVETVYIPEDDRATLCVSSQGCALECKFCS---TAQQGFNRNLRVSEIIGQVWRAAKIVGAAKTNVVMMGGEPLLNLNNVVPAMEIMLDDF-RVTLSTSGVVP----ALDKLGDMIDVALISLHAPNDEIRDEIVPINKKYNIETFEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPC--KINLIPWNPFPGAPYG------------RSSNSRIDRFSKVLMSYGFTTIV 343
9 -21.1006c8v_A mol:protein length:394 Coenzyme PQQ synthesis protein E  ali model follow..  16  4SSSGLVPRGSHMDVIPAPVGLLAELTHRCPLRCPYCSN-PLELDRRSAELDTQTWLRVLTE---AAGLGVLHVHLSGGEPTARPDIV-EITAKCAELGLYSNLITSGVGGALAKLDALYDVGLDHVQLSVQGVDAANAEKIGGLKNPQKMQFAARVTELGLPLTLNSVI---HRGNIHEVPGFIDLAVKLG-AKRLEVAHTQYYGWAY--------VNRAALMPDKSQVDESIRIVEAA...... 227
10 -21.0006b4c_A mol:protein length:298 Viperin  ali model follow..  14  17........................FSRKCNKECLFCFHTAT----TSHVEKPENAKRGL---TLLKQAGMKKINFAGGEPFLYPKFLGEMIDFCKETLESVSIVTNGSL-VKEQFLQKHGRNIDILAVSCDSFNEATNIKIGGDNVQKLYEIGSWCQKYDIKFKLNTVVNK--FNHLEDMNDHLNALQPF-RWKCFQVLIVTGENDSD..................................... 194
11 -20.1001tv7_A mol:protein length:340 Molybdenum cofactor biosynthesis protein A  ali model follow..  15  10...GRPIRDLRLSVTD------------CNFRCDYCM-PKEVFGDDFVFLPKNELLDEMARIAKVYAELG--IRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNITTILEQIDYATSIGLNVKVNVVIQKGIND--DQIIPMLEYFKDKHEIRFIEFMDVGNDNGWDFSKV................................. 210
12 -19.1005vsl_A mol:protein length:318 Radical S-adenosyl methionine domain-containing protein 2  ali model follow..  14  36........................FTRQCNYKCGFCFHTA----KTSFVLPLEEAKRGLLL---LKQAGLEKINFSGGEPFLQDRGLGKLVRFCKEELASVSIVSNGSL-IRERWFKDYGEYLDILAISCDSFDEQVNALIGRGQGENLQKLRRWCRDYKVAFKINSVINR--FNVDEDMNEHIKALSP........................................................ 199
13 -17.2005wgg_A mol:protein length:453 Radical SAM domain protein  ali model follow..  15  100.....................CLHISHDCNLRCKYCFASTGNFGGQRNMMSLEVGKKAIDFLISESGNRK-EIDFFGGEPMMNFDVVKGIIEYARQKNFRFTLTTNGLL-LNDENIKYINENMQNIVLSIKEVNDRMRIRIDGSGCDDILPKFKYVAESQDNYYVRGTFTR---ENMDFSNDVLHLADEGFRQISVEPVVAAKDSGYDLREEDLPRLFEEYEKLAYEYVKRRKE........... 321
14 -16.5004k36_A mol:protein length:392 Anaerobic sulfatase-maturating enzyme  ali model follow..  15  2.................PPLSLLIKSSGCNLKCTYCFSLSDNRNVKSYGIMRDEVLESMVKRVLNEANGHCSFAFQGGEPTLAGLEFFEKLMELQRKKIYNSLQTNGTL-IDESWAKFLSENKFLVGLSMKEIHNLNRKDCCGLDTSKVERAAELFKKYKVEFNILCVVT---SNTARHVNKVYKYFKEKD-FKFLQFIN............................................. 193
15 -14.6002a5h_A mol:protein length:416 L-lysine 2,3-aminomutase  ali model follow..  15  110.............THRYPDRVLLLITDMCSMYCRHCTRRRFAGQSDDSMPMIDKAIDYIRNTPQVRD-----VLLSGGDALLVSDIIAKLIPHVEIVRIGSRTPVVLPQRITPELVNMLKKYHPVWLN--------THFNHPNEITEESTRACQLLADAGVPLGNQSVLLRGVNDCVHVMKELVNKLVKIR------VRPYY........................................... 288
16 -14.0004m7s_A mol:protein length:269 BtrN  ali model follow..  10  1.............MDKLFSMIEVEVNSQCNRTCWYC--PNSVSKRKETGEMDPALYKTLMEQLSSLDFAGRISFHFYGEPLLCKNLD-LFVGMTTEYIARPIIYTNGDFLTEKRLQTLTELGIQKFIVTQHAGAKHKFRGVYD...................................................................................................... 129
17 -13.8004m7t_A mol:protein length:270 BtrN  ali model follow..  11  30............................CNRTCWYC--PNSVSKRKETGEMDPALYKTLMEQLSSLDFAGRISFHFYGEPLLCKNLD-LFVGMTTEYIARPIIYTNGDFLTEKRLQTLTELGIQKFIVTQHAGAKHKFRGVYD...................................................................................................... 143
18 -13.0006fd2_B mol:protein length:457 Putative apramycin biosynthetic oxidoreductase 4  ali model follow..  11  197...................ITSINGSFGCPYPCRFYCPYPLSEGRKIRTYPVERIVAEFRQCAELGITA---AVFRDPVFSFHRDRTLELCQALKAADTGVPWWCETRIDRLDEEVVAALVDAGCVGVEVGVESGDPDMQATAVRKRLNLDTVRKFHAVARKAGLKL-LIGLPRETRMSIRRTFDFILELGEFNLSVITPYKGWIDGSQNAFTSHNAVMHTDELSIGDLERASRFVDEL...... 431
19 -13.0004u0o_B mol:protein length:296 Lipoyl synthase 2  ali model follow..  10  52...................KTATFLLLGCTRACAFCQVEKGHAPAAVDPEEPTKIAAAVATLGLRY------LTSVARDDLPDAGQFVATMAAIRQRCPGTEIEVDRGRLSQRDCIAQIVAAPACYNHNLETVRRLQGPVRRGATYESSLRVLATVKELNPDIPTKSGLMLGLGETEAEIIETLKDLRRVG----CDRLTLGQYLPPSLSHLPVV------KYWTPEEFNTLGNIARELGFSHVR 275
20 -12.9004fhc_A mol:protein length:368 Spore photoproduct lyase  ali model follow..  13  108.........................ATGCMGHCHYCYLQTTLGSKP--YVNLDDIFAQAQKYINERAPEITRFEAACTSDIVGIDHLTHSLKKAATDYGRLRFVT------KYEHVDHLLDARHRFRFSINSRYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVPIYRHEGWERGYFELFQELARQLEG..................................................... 280
21 -12.4005fep_A mol:protein length:358 [FeFe] hydrogenase maturase subunit HydE  ali model follow..  17  44ALFKLADEIRRKYVGDEVHIRAIIEFSNCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARL---AVQFGAKTIVLQSGEPYXMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEA---ADRYLLRHETANPVLHRKLPDTSFENRLNCLLTLKELG--YETGAGSMVGLPG--QTIDDLVDDLLFLKEHD-FDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRI............. 268
22 -12.2004jy8_A mol:protein length:358 FEFE-HYDROGENASE MATURASE  ali model follow..  17  44ALFKLADEIRRKYVGDEVHIRAIIEFSNCRKNCLYCGLRRDNKNLKRYRMTPEEIVERARL---AVQFGAKTIVLQSGEPYYMPDVISDIVKEIKKMGVAVTLSLGEWPREYYEKWKEA---ADRYLLRHETANPVLHRKLPDTSFENRLNCLLTLKELGYETGA---SMVGLPG--QTIDDLVDDLLFLKEHD-FDMVGIGPFIPHPDTPLANEKKGDFTLTLKMVALTRI............. 268
23 -11.1005l7j_A mol:protein length:459 ELP3 family  ali model follow..  13  10..................GVTPVAVMTPCPGKCIYCPTPAVLRAKSCEYQAYKQVALRLRIIQDMGHPTD--LIIMGGTFLADITYQYGFIKDCYDRCVGLCIETR----CGKAEIQRMIDFTTRVELGVQMLDDDIYKLVEGHRVSDVAEATCLLREYGLKVHYHWMPLPG--SSPEKDLALSRMVFEDPRF-CPDGLKLYPTMVVEGTILEQWWKEGRYTPYPNGTMTGLIADIKAL...... 268
24 -11.1005exi_A mol:protein length:331 Lipoyl synthase  ali model follow..  11  86.....................ATFLIGGCTRRCDFCQIDTGKPAE--EPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYA-ATVRAIKELNPSTGVELLIPDFNGEPTRLAEVFES---PEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAG--LVTKSNLILGLGETSDEVRTALGDLRDAG----CDIVTITQYLRPSARHHPVE------RWVKPEEFVQFARFAEGLGFAGVL 298
25 -11.0004rtb_A mol:protein length:477 HydG protein  ali model follow..  9  73ILFWQARKVKEEIYGKRIVLFAPLYLSNCINNCSYCSFRRENKELSRVRLSLEEAVDEAKA---IREMGHTRILLVMGEEDKTLSYLEEIIPAIYSEVDIRRINVN-IAPLTLKGYERLKKLIGTYQLFQESYNPEVYREVPKTNFLWRLNAVERAIEAGI-DDIGIGALFGLGDPLFELLGVIAHADYLKKKFGPHTVSVPRLKPAL------NSVFSNDYKISDHKFKKIVALLR........ 308
26 -10.6005l7l_A mol:protein length:446 ELP3 family, ELP3 family  ali model follow..  13  2..........KKLSRTISGVTPVAVMTPCPGKCIYCPTPESPAVLRAKSCEYQAYKQVALRLRIIQDMGHPTLIIMGGTFLADITYQYGFIKDCYDRCVGLCIETR----CGKAEIQRMIDFTTRVELGVQMLDDDIYKLVEGHRVSDVAEATCLLREYGLKVHYHWMPLPG--SSPEKDLALSRMVFEDPRF-CPDGLKLYPTMVVEGTILEQWWKEGRYTPYPNGTMTGLIADIKAL...... 268
27 -10.4001r30_A mol:protein length:369 Biotin synthase  ali model follow..  11  70............................CPEDCKYCSSRYKTGLEAERLMEVEQVLESARK-----AKAAGSTRFAAWKNPHERPYLEQMVQGVKAMGLEACMTLGTLSESQAQRLANA---LDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVRDAG--IKVCSGGIVGLGETVKDRAGLLLQLANLP--TPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARI............. 269
28 -10.1004jc0_A mol:protein length:438 Ribosomal protein S12 methylthiotransferase RimO  ali model follow..  10  141.....................YVKISDGCDRGCTFCSIPSFKGSLRSRSIETREVEDLLKEGKKEIILVAQDTTSYGIDLYRKQALPDLLRRLNSLNGEFWIRVMYLHPDHLTEEIISAMLELDKVVVPVQHGSDKILKLMGTKSSEELKKMLSSIRERFPDAVLRTSIIVGFGETEEDFEELKQFVEEI-QFDKLGAFVYSDEEGTVAFNLKEKVDPEMAKRRQEELLLLQAEISNSRLDRFV. 370
29 -9.9703t7v_A mol:protein length:350 methylornithine synthase PylB  ali model follow..  11  42RLYSAARKVRDHYFGNRVFLNCFIYFSTCKNQCSFCYYNCRNEIN-RYRLTMEEIKETCKT---LKGAGFHMVDLTMGE--EDPNRFVELVQIVKEELGLPIMISPG--LMDNATLLKAREKANFLALYQETYDTELYRKLVGQSFDGRVNARRFAKQQGYCVED---ILTGVGNDIESTILSLRGMSTN----DPDMVRVMTFLPQEGTPLEGFRDKSNLSELKIISVLRL--MFPKRLIPA.. 276
30 -9.2705ul2_A mol:protein length:744 OxsB protein  ali model follow..  11  303..................GALTLETSRGCDYRCTFCPRDHKLRS---RPLSVEQTLKQLDDDEEFIGELPNGTEAQ--EGLLKREEKIKFDFAARADSVYEPKRTKEWNVERLKMWHYCALAADRIFIGVESGSNQQLKRYGGTTSEQNIIALRLVSALGINLRIGFIMFDQLMKGLDNLKENLDFLERTDLMKPIDIGDM---YEELYDKL................................. 517
31 -9.2301olt_A mol:protein length:457 OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE  ali model follow..  8  43.........QAVARYPERPLSLYVHIPFCHKLCYFC---GCNKIVTRQQHKADQYLDALEQEIVHRAPLFAGLHWGGGTPYLNKAQISRLMKLLREADAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHAREIGFTSTNIDLIYGLKQTPESFAFTLKRVAELNP-DRLSVFNYAHLPTIFAAQRKIKDADLPSPQQKLDILQETIAFLTQSGYQ... 283
32 -9.0804r33_A mol:protein length:420 NosL  ali model follow..  13  80AELQAAAEARCGARRPRLHTFVPLYTTNCDSECKMCSMRKGNHRLDRKFSGRKEITEQLEI--LYHHEGVRGVGFLTGE-LASAFRIGWAIRTALDLGFERVYFNIG--SMEQDEIDVLGEWPVTMCVFQESYDRETYRRFMGKTSDRRVVSFDRWLDAGYR--VNPGVLVGLHDDSAELVSLVAHGDHLRS..................................................... 287
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.