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Query: 4if6_A mol:protein length:281 NAD-dependent protein deacetylase sirtuin-1, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst GPHMRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEILast
1 -112.0004if6_A mol:protein length:281 NAD-dependent protein deacetylase sirtuin-1  ali model  100  1GPHMRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEI 281
2 -105.0004i5i_A mol:protein length:287 NAD-dependent protein deacetylase sirtuin-1  ali model follow..  99  2.........ALNTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEI 273
3 -98.8004zzh_A mol:protein length:356 NAD-dependent protein deacetylase sirtuin-1  ali model follow..  97  49.PPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVGGGSG 328
4 -96.2005btr_A mol:protein length:397 NAD-dependent protein deacetylase sirtuin-1  ali model follow..  97  91.PPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEI 370
5 -94.3005d7n_A mol:protein length:281 NAD-dependent protein deacetylase sirtuin-3, mitochondrial  ali model follow..  39  2....HMSDKGKLSLQDVAELIRACQRVVVMVGAGISTPSGIPDFRSPGGLYSNLQQ--YDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGISKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCT-----GVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLARDVAQLGDVVHGVESLVELLGWEMRDLVQRETGKLD. 281
6 -94.1004y6l_A mol:protein length:293 NAD-dependent protein deacetylase sirtuin-2  ali model follow..  41  2..SQKERLLDELTLEGVARYMQRCRRVICLVGAGISTSAGIPDFRSPSGLYDNLEK--YHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEDLVEAHGTFYTSHCVSASCRYPLSWMKEKIFSEVTPKCEDCQ-----SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGGGGRDVAWLGECDQGCLALAELLGWELEDLVRREHASID. 290
7 -92.9005ol0_A mol:protein length:324 Putative silent information regulator 2,Putative silent information regulator 2  ali model follow..  39  9.APHQEHVLGEPTLEGLAHYIRNVRRILVLVGAGASVAAGIPDFRSPDGIYANLGK--YNLEDPTDAFSLTLLREKPEIFYSIARELNPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSRCSTCG-----GIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLRDVLFRGDCQENVVTLAEYLGLALAKRMRLSDAAPA. 315
8 -92.1003glr_A mol:protein length:285 NAD-dependent deacetylase sirtuin-3, mitochondrial  ali model follow..  39  1...SNASDKGKLSLQDVAELIRACQRVVVMVGAGISTPSGIPDFRSPGGLYSNLQQ--YDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGISKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCT-----GVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLARDVAQLGDVVHGVESLVELLGWEMRDLVQRETGKLD. 281
9 -91.0005bwn_A mol:protein length:309 NAD-dependent protein deacetylase sirtuin-3, mitochondrial  ali model follow..  39  17.LYFQGSDKGKLSLQDVAELIRACQRVVVMVGAGISTPSGIPDFRSPGGLYSNLQQ--YDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGISKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCT-----GVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLARDVAQLGDVVHGVESLVELLGWEMRDLVQRETGKLD. 299
10 -91.0002od2_A mol:protein length:308 NAD-dependent deacetylase HST2  ali model follow..  36  7ASMSVSTASTEMSVRKIAAHMKPNAKVIFMVGAGISTSCGIPDFRSPGGLYHNLAR--LKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNFDTLERQAGVDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKC--DVCGELVKPAIVFFGEDLPDSFSETWLNDHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKTDLIVHQYSDEFAEQLVEELGWQED............ 294
11 -90.9004o8z_A mol:protein length:303 NAD-dependent protein deacetylase sirtuin-3, mitochondrial  ali model follow..  39  12..FQGSSDKGKLSLQDVAELIRACQRVVVMVGAGISTPSGIPDFRSPGGLYSNLQQ--YDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGISKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCT-----GVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLARDVAQLGDVVHGVESLVELLGWEMRDLVQRETGKLD. 293
12 -89.1001yc5_A mol:protein length:246 NAD-dependent deacetylase  ali model follow..  33  2............KMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKY---------SQNVFDIDFFYSHPEEFYRFAKEGIFLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCN-----SLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVSGGKLVIVNLGETPFDDATLKYNMDVVEFARRVMEEGGIS.............. 246
13 -89.0005y5n_A mol:protein length:336 NAD-dependent protein deacetylase sirtuin-2  ali model follow..  41  21.GSQKERLLDELTLEGVARYMQRCRRVICLVGAGISTSAGIPDFRSPSGLYDNLEK--YHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEDLVEAHGTFYTSHCVSASCRHPLSWMKEKIFSEVTPKCEDCQ-----SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDRDVAWLGECDQGCLALAELLGWELEDLVRREHASID. 333
14 -87.2004iao_A mol:protein length:492 NAD-dependent histone deacetylase SIR2  ali model follow..  43  156.LCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKH--LGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGIDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNF 465
15 -86.7005fyq_A mol:protein length:360 NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2  ali model follow..  41  56.GSQKERLLDELTLEGVARYMQRCRRVICLVGAGISTSAGIPDFRSPSGLYDNLEK--YHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEDLVEAHGTFYTSHCVSASCRHPLSWMKEKIFSEVTPKCEDCQ-----SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDRDVAWLGECDQGCLALAELLGWELEDLVRREHASID. 357
16 -86.3001q14_A mol:protein length:361 HST2 protein  ali model follow..  35  3ASMSVSTASTEMSVRKIAAHMKPNAKVIFMVGAGISTSCGIPDFRSPGGLYHNLAR--LKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKC--DVCGELVKPAIVFFGEDLPDSFSETWLNDSPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKTDLIVHQYSDEFAEQLVEELGWDFEKILTAQGGMGD. 303
17 -85.3001ma3_A mol:protein length:253 Transcriptional regulatory protein, Sir2 family  ali model follow..  31  3...........DEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKY--------DPEEVASISGFKRNPRAFWEFSMEMKDKFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCG----SYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKAGAKMIIVNAEPTMADPFDVKIIGKAGEVLPKIVEEVKRLRSE........... 252
18 -83.3001ici_A mol:protein length:256 TRANSCRIPTIONAL REGULATORY PROTEIN, SIR2 FAMILY  ali model follow..  29  2........SGSHMDEKLLKTIAESKYLVALTGAGVSAESGIPTFRGKDGLWNRY--------RPEELANPQAFAKDPEKVWKWYAWRMEKNAQPNKAHQAFAELERLGVLKCLITQNVDDLHERAGSRNVIHLHGSLRVVRCTSCNNSFEVESAPK---IPPLPKCDKCG-----SLLRPGVVWFGEMLPPDVLDRAMREVERADVIIVAGTSAVVQPAASLPLIVKRGGAIIEINPDETPLTPADYSLRGKAGEVMDELVRHVRKALS............ 250
19 -82.4001m2g_A mol:protein length:249 Silent Information Regulator 2  ali model follow..  29  2.............DEKLLKTIAESKYLVALTGAGVSAESGIPTFRGKDGLWNRY--------RPEELANPQAFAKDPEKVWKWYAWRMEKNAQPNKAHQAFAELERLGVLKCLITQNVDDLHERAGSRNVIHLHGSLRVVRCTSCNNSFEVESAPK---IPPLPKCDKCG-----SLLRPGVVWFGEMLPPDVLDRAMREVERADVIIVAGTSAVVQPAASLPLIVKRGGAIIEINPDETPLTPADYSLRGKAGEVMDELVRHVRKALS............ 245
20 -82.1001m2n_A mol:protein length:249 Silent Information Regulator 2  ali model follow..  29  2.............DEKLLKTIAESKYLVALTGAGVSAESGIPTFRGKDGLWNRY--------RPEELANPQAFAKDPEKVWKWYAWRMEKNAQPNKAHQAFAELERLGVLKCLITQNVDGLHERAGSRNVIHLHGSLRVVRCTSCNNSFEVESAPK---IPPLPKCDKCG-----SLLRPGVVWAGEMLPPDVLDAAMREVERADVIIVAGTSAVVQPAASLPLIVKRGGAIIEINPDETPLTPADYSLRGKAGEVMDELVRHVRKALS............ 245
21 -80.6006fky_A mol:protein length:284 NAD-dependent protein deacylase sirtuin-5, mitochondrial  ali model follow..  25  3.DPFTKMTRPSSDLTAFREHFAKAKHIAIITGAGVSAESGVPTFRGPGGFWRKW--------QAQDLATPEAFSRDPSLVWEFYHYRRERSKMPNPAHLAIAECEQQGRSVVIITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCGEVKANHKSEARIPVELLPRCERK---SCNGLLRPHVVWFGETLDSDILTAVERELEKCDLCLVVGTSSIVYPAAMFAPQVARGVPVAEFNMECTPATQFKYHFEGPCGSTLPPALERHESE.............. 282
22 -80.6005oj7_A mol:protein length:286 NAD-dependent protein deacylase  ali model follow..  22  4...PACPPPNPHQVEQLQDFVSQSQRLFVMTGAGISTESGIPDYRSEGGLYSRTE------RRPIQHSEFVQSQAARRRYWARNFVGWPSSHEPNSAHVNLCKWERAGRLHWLVTQNVDALHTKAGQCRLSELHGCTHRVICLGCQTVTKRSELQERFLNLNVPACTKCG-----GILKPQVTFFGDTVNRGFVFSIYEQMKQADAMLIVGSSLQVYSGYRFALNAELHLPIAILNIGPTRADHAKVKVSARCGDVLPHILLQD................. 285
23 -79.2003u31_A mol:protein length:290 Transcriptional regulatory protein sir2 homologue  ali model follow..  24  23.ISFLKKDTQSITLEELAKIIKKCKHVVALTGSGTSAESNIPSFRGSNSIWSKY--------DPRIYGTIWGFWKYPEKIWEVIRDISSDEIEINNGHVALSTLESLGYLKSVVTQNVDGLHEASGNTKVISLHGNVFEAVCCTCNKIVKLNKIKTSHFMHQLPPECPCG-----GIFKPNIILFGEVVSSDLLKEAEEEIAKCDLLLVIGTSSTVSTATNLCHFACKKKKKVEINISKTYITNSDYHVCAKFSELT-KVANILKGSSE............ 284
24 -79.2005bwl_A mol:protein length:290 NAD-dependent protein deacylase sirtuin-5, mitochondrial  ali model follow..  25  10.PRGSHMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKW--------QAQDLATPLAFAHNPSRVWEFYHYRREGSKEPNAGHRAIAECETQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSDASIPVEKLPRCEEA---GCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAAGVPVAEFNTETTPATNFRFHFQGPCGTTLPEALA................... 284
25 -78.9005xhs_A mol:protein length:288 NAD-dependent protein deacylase sirtuin-5, mitochondrial  ali model follow..  24  8.YFQGASARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKW--------QAQDLATPLAFAHNPSRVWEFYHYRREGSKEPNAGHRAIAECETQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSDASIPVEKLPRCEEA---GCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVARGVPVAEFNTETTPATNFRFHFQGPCGTTLPEALA................... 282
26 -77.6004hda_A mol:protein length:275 NAD-dependent protein deacylase sirtuin-5, mitochondrial  ali model follow..  25  3...DPFTARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKW--------QAQDLATPLAFAHNPSRVWEFYHYRREGSKEPNAGHRAIAECETQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSDASIPVEKLPRCEEA---GCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAAGVPVAEFNTETTPATNFRFHFQGPCGTTLPEALA................... 275
27 -75.1001s5p_A mol:protein length:235 NAD-dependent deacetylase  ali model follow..  26  2........................PRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAFYNARRRPEIQPNAAHLALAKLQDAGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD---WTGDVTPEDKCHCCQFP-----APLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKHGAHTVELNLEPSQVGNFAEKYYGPASQVVPEFVEKLLKGLK............ 235
28 -74.1003zg6_A mol:protein length:296 NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6  ali model follow..  21  32...........RKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEER--GLAPKFDTTFE---------------------SARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKKARGLRACR-----GELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRVIVNLQPTKHDRADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERAL 286
29 -73.2005mf6_A mol:protein length:302 NAD-dependent protein deacetylase sirtuin-6  ali model follow..  21  26...........RKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEER--GLAPKFDTTFE---------------------SARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATRGLRACR-----GELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRVIVNLQPTKHDRADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERAL 280
30 -70.6003pki_A mol:protein length:355 NAD-dependent deacetylase sirtuin-6  ali model follow..  22  32...........RKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEER--GLAPKFDTTFE---------------------SARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKAARGLRACR-----GELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVINLQPTKHDRADLRIHGYVDEVMTRLMEHLGLEIP............ 274
31 -51.0005a3a_A mol:protein length:303 SIR2 FAMILY PROTEIN  ali model follow..  16  14........KNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQF--LDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEETKDYHIITTNADNAFWVAGYHNIFHIQGEYGLWQCSQH-RQMIAEQKNMKVPGQLIPHCPECE-----APFEINKRNEEKGMVEDYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFSENPNALFVTLNHKHYRIRRQSLELTEHIAQLISATKTIYQ................ 295
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.