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Query: 4ity_A mol:protein length:330 Arginase, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRGSGMAKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYTPHTSSKLLast
1 -89.4004ity_A mol:protein length:330 Arginase  ali model  100  1MRGSGMAKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYTPHTSSKL 324
2 -82.3001wva_A mol:protein length:322 Arginase 1  ali model follow..  41  2...SAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQ------IVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 318
3 -82.2001pq3_A mol:protein length:306 Arginase II, mitochondrial precursor  ali model follow..  37  1.......HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDD-----LYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG........ 306
4 -81.6001d3v_A mol:protein length:323 PROTEIN (ARGINASE)  ali model follow..  38  2...SSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQ------IVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDY 318
5 -80.9001t5f_A mol:protein length:314 Arginase 1  ali model follow..  38  1.......KPIEIIGAPFSKGCPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQ------IVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLAVIWVDAHTDINTPLTTSSGNLAGQPVAFLLKELKGKFPDVFSWVTPAISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSAFGTKREGNHKPETD. 312
6 -79.3006dkt_A mol:protein length:296 Arginase  ali model follow..  30  1.....MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKI-------KNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEG-YAPKIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYL--SACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKL.............. 295
7 -79.2001cev_A mol:protein length:299 PROTEIN (ARGINASE)  ali model follow..  34  2.......KPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERLHYDIEDLGDI--PIGKAERLHEQGDSR--LRNLKAVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHYERLGVIWYDAHGDVNTAETSPSGNIHGMPLAASLGFGHPALTQI-GGYSPKIKPEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYLK-ERTDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDERNKTASVAVALMGSLFGEKL.............. 298
8 -77.3005ynl_A mol:protein length:362 Arginase  ali model follow..  48  45..FLATPRTAGIVGCPFSGGQPKAGVHSGPLQLIESGLLNDIENLGWTVDFAGAD---ALAVSIVSDTPDPDIGLKQPRLVSRVTKDVADRVYAHASKGQLTVTLGGDHSLAMGTVSGTFKAYPEACLIWVDAHADINTPHTTESGRLHGCPVSFLLGLDGTSSEEIFSWIKPCLKPERIVYIGLRDIDAGERKILKDNNIKCFSMFHVDKYGIGKVVEMALDHVNPDRTRPIHLSFDVDALDPSVAPSTGTAVRGGLTFREGHYICEAIAETNLLVSLDIMEINPSLGALASVA-QTVDVGRSLVRCALGETLL......... 356
9 -77.2002eiv_A mol:protein length:291 Arginase  ali model follow..  32  2.......ERVAVVGVPMDLGANRRGVDMGPSALRYARLLEQLEDLGYTVEDLGDVPVSLARASRRRG------RGLAYLEEIRAAALVLKERLAALPEGVFPIVLGGDHSLSMGSVAGAAR-GRRVGVVWVDAHADFNTPETSPSGNVHGMPLAVLSGLGHPRLTEVF----RAVDPKDVVLVGVRSLDPGEKRLLKEAGVRVYTMHEVDRLGVARIAEEVLKHL---QGLPLHVSLDADVLDPTLAPGVGTPVPGGLTYREAHLLMEILAESGRVQSLDLVEVNPILDERNRTAEMLVGLALSLLGKRI.............. 290
10 -74.4004q3p_A mol:protein length:385 Arginase  ali model follow..  31  31.KPKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKTTLRIAERVEELMKQSNKHTVELSGSKSTPVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVL-KTQSSAVHILRACLGHCRSGHLPFKVR. 361
11 -71.1004g3h_A mol:protein length:330 Arginase (RocF)  ali model follow..  22  1.........MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIK---------GMQTITQERCVLYKEFRYAKNFEDYYLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKKIGILYLDAHADIHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMLEKGGLEIDPKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIRE-NMQEVVQKTKESL--KAVDIIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLESDRLKAVEVTEYNPTVSIKHNNE--EEKQVLEILDLIINSCKIKDKKHS... 317
12 -69.4003mmr_A mol:protein length:413 Arginase  ali model follow..  30  13..SHMASKNVSIIGSPLAAGQPLGGVQLACDDLRKLGLHNVIDVLGWKYEDIGNIDYGNYEENNVISTNDKYKNIRNIKEIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMYQNLRVIWIDAHGDINIPETSPSGNYHGMTLAHTLGLFKKKVPYFWSENLTYLKPENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDPNSNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDEVDKKVHGDSKLCLELIARVLGYDIV......... 407
13 -65.8003lhl_A mol:protein length:287 Putative agmatinase  ali model follow..  20  1MSLNYEESNLIVFGVGFDGTTSRPGARFASSSMRKEFYGLETYSPFLDLD---------LEDYNICDYGDLEISVGSTE---QVLKEIYQETYKIVRDSKVPFMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNN-SKNSHATVIKRIWD---------------IVGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGI------DTFENIVNML---NGKNIYLTIDLDVLDASVFPGTGTPEPGGVNYREFQEIFKIIKNSNNIVGCDIVELSPDYDTTGVSTVIACKILRELCLIISDKIKEG........ 281
14 -65.3003nio_A mol:protein length:319 Guanidinobutyrase  ali model follow..  24  33..AELDALDAAFVGVPLDIGTSRSGTRFGPREIRAESVMIRPYNMATGA--------APFDSLNVADIGDVAINTFN---LLEAVRIIEQEYDRILGHGILPLTLGGDHTITLPILRAIKKKHGKVGLVHVDAHADVNDHMFG-EKIAHGTTFRRAVEED-------------LLDCDRVVQIGLRAQTAEDFNWSRKQGFRVVQAEECWHKSLEPLMAEVREKV---GGGPVYLSFDIDGIDPAWAPGTGTPEIGGLTTIQAMEIIRGC-QGLDLIGCDLVEVSPPYDTTGNTSLLGANLLYEMLCVLPGVVRR......... 319
15 -65.0003nip_A mol:protein length:326 3-guanidinopropionase  ali model follow..  22  30..TDPAALQVGLIGVPWDGGTTRAGARHGPREVRNLSSLMRKVHHVSRI--------APYDLVRVGDLGDAPVNPID---LLDSLRRIEGFYRQVHAAGTLPLSVGGDHLVTLPIFRALGR-ERPLGMVHFDAHSDTNDRYFGDNPYTHGTPFRRAIEEG-------------LLDPLRTVQIGIRGSSPDDDAFARECGIRVIHMEEFVELGVEATLAEARRVV---GAGPTYVSFDVDVLDPAFAPGTGTPEIGGMTSLQAQQLVRGL-RGLDLVGADVVEVSPPFDVGGATALVGATMMFELLCLLAESAARSALE..... 320
16 -64.8001gq6_A mol:protein length:313 PROCLAVAMINATE AMIDINO HYDROLASE  ali model follow..  21  25..PQPRGYDVVVIGAPYDGGTSRPGARFGPQAIRSESGLIHGVGIDRGP--------GTFDLINCVDAGDINLTPFD---MNIAIDTAQSHLSGLLKANAAFLMIGGDHSLTVAALRAVAEQHGPLAVVHLDAHSDTNPAFYG-GRYHHGTPFRHGIDEK-------------LIDPAAMVQIGIRGHKPDSLDYARGHGVRVVTADEFGELGVGGTADLIREKV---GQRPVYVSVDIDVVDPAFAPGTGTPAPGGLLSREVLALLRCV-GDLKPVGFDVMEVSPLYDHGGITSILATEIGAELLYQYARAHRTQ........ 312
17 -64.6003m1r_A mol:protein length:322 Formimidoylglutamase  ali model follow..  19  33..DGQDIKGPALIGVPLSKSSIHSGASFAPGTIRQALKHSSAYSAELGEH---------VVSELLYDLGDIDIHVTD---IVKSHHHIFQTMHALLSDHPVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTEDG--GPTNGTPFRRLLDEE-------------IIEGQHLIQLGIREFSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVVQ-DKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK......... 322
18 -63.9001wog_A mol:protein length:305 agmatinase  ali model follow..  21  25...GDWQADVAALGVPFDIALGRPGARFAPRALREASLRSVPPFTGLDGK-------TRLQGVTFADAGDVILPSLEPQ---LAHDRITEAARQVRGRCRVPVFLGGDHSVSYPLLRAFAD-VPDLHVVQLDAHLDFTDTRND-TKWSNSSPFRRACEAL--------------PNLVHITTVGLRGLDPEAVAAARARGHTIIPMDDVTADLAGVLAQLP-------RGQNVYFSVDVDGFDPAVIPGTSSPEPDGLTYAQGMKILAAAAANNTVVGLDLVELAPNLDPTGRSELLMARLVMETLCEVFDHVL.......... 305
19 -62.9004dz4_A mol:protein length:324 Agmatinase  ali model follow..  22  42..RDLDGVDVVVSGVPLDLATTRSGARLGPSAVRAASVQLAELNPYPW-------GFDPFDDLAVIDYGDCWFDAHHPL---SIKPAIVEHARTILQSDARMLTLGGDHYITYPLLIAHAQKYGPLSLIHFDAHCDTWADDAP-DSLNHGTMFYKAVKDG-------------LIDPKASVQVGIRTWNDDY------LGINVLDAAWVHEHGARATLERIESIV---GGRPAYLTFDIDCLDPAFAPGTGTPVAGGLSSAQALAIVRGL-GGVNLIGADVVEVAPAYDQSEITAIAAAHVACDLLCLWRQRKAGAR....... 324
20 -61.8003pzl_A mol:protein length:313 Agmatine ureohydrolase  ali model follow..  24  28AVNGYEEAKYVVFGIPFDNTSSRRGSKYAPDSIRGAYVNLESYEYSYGID---------LLASGMADLGDMEES----EDVEYVIDTVESVVSAVMSDGKIPIMLGGEHSITVGAVRAL---PKDVDLVIVDAHSDFRSSYMG-NKYNHACVTRRALD---------------LLGEGRITSIGIRSVSREEFEDPDFRKVSFISSFDVKKNGIDKYIEEVDR-----KSRRVYISVDMDGIDPAYAPAVGTPEPFGLADTDVRRLIERL--SYKAVGFDIVEFSPLYD-NGNTSMLAAKLLQVFIASREKYYK.......... 302
21 -60.9004rhm_A mol:protein length:351 Arginase  ali model follow..  19  15......MFSKFLMNVKGVTPRGDWANRLGPVALFGYGAGMPRRAPLLDFFLQSPRDCDHYAELTIHDKGPIECPPETVMTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPDIVIVHFDAHPDVSD---------PRSPLRVLLDKGL---------------LKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR-------NDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNGI-RGPKVVGIDVYGYNPDLDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMER. 327
22 -59.9002a0m_A mol:protein length:316 ARGINASE SUPERFAMILY PROTEIN  ali model follow..  18  19..QREEDADIVIIGFPYDEGCVRAGAKKGPAAFRFFLQRLGSVN--------NLELNVDASHLKLYDAGDIT-----ASTLEEAHEKLESKVFTVLARGAFPFVIGGGNDQSAPNGRAMLRAFGDVGVINVDSHLDVRPPLQD-GRVHSGTPFRQLLEES-------------SFSGKRFVEFACQGSGALHAQYVRDHQGHLMWLSEVRKKGAVAALEDAFGLTG----KNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTPTVMMMDMSELNPLVE-EYRSPRVAVYMFYHFVLGFATRPKPKAEN..... 310
23 -58.9004rhi_A mol:protein length:351 Arginase  ali model follow..  18  17..SKFLMNVKGVTPRGSD-----WANRLGPVALFGYGAGMPRRAPLLDFFLQSPRDCDHYAELTIHDKGPIECPPETVMTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPDIVIVHFSARPSVSD---------PRSPLRVLLDKGL---------------LKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR-------NDYPVFISIDASVLDPAFAPAVDSPVAGGLSTRDLLHIMNGI-RGPKVVGIDVYGYNPDLDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMER. 327
24 -55.1001xfk_A mol:protein length:336 Formimidoylglutamase  ali model follow..  13  37.ELANQEPGVALIGFECDAGVERTGAKHAPSLIKQALANLAWH-----------------HPIPIYDLGNIRCEGDE---LEQAQQECAQVIQQALPHA-RAIVLGGGHEIAWATFQGLAQHFPRIGIINFDAHFDLRTFESELAPVSSGTPFNQIHHFCQQQ------------WDFHYACLGVSRATPALFERADKLGVWYVEDKAFSPLSLKDHLTQLQHFI--DDCDYLYLTIDLDVFPAASAPGVSAPAARGVSLEALAPYFDRILHKNKLMIADIAEYNPSFDIDQHTARLAARLCWDIANAMAEQVQSIRHP..... 336
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Liu T, Rojas A, Ye Y, Godzik A. Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 2003 Sep;12(9):1872-81.