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Query: 4q3p_A mol:protein length:385 Arginase, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHMMLKSVATPYYPIQDEKPKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKHTVELSGSKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQTKQLast
1 -91.3004q3p_A mol:protein length:385 Arginase  ali model  100  1MGSSSSGLVPRGSHMMLKSVATPYYPIQDEKPKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKHTVELSGSKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQTKQ 379
2 -80.4001pq3_A mol:protein length:306 Arginase II, mitochondrial precursor  ali model follow..  41  1....................................HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNL------------IVNPRSVGLANQELAEVVSRAVSDGYSC-VTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEATTANLAVDVIASSFGQTREG......................... 306
3 -79.9001d3v_A mol:protein length:323 PROTEIN (ARGINASE)  ali model follow..  39  2................................SSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSP-------------FQIVKNPRSVGKANEQLAAVVAETQKNGTIS-VVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVRTVNTAVALTLSCFGTKREGNHKPETDYLKPPK............ 323
4 -79.9001wva_A mol:protein length:322 Arginase 1  ali model follow..  40  2................................SAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDS-------------PFQIVKNPRSVGKASEQLAGKVAEVKKNGRIS-LVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVRTVNTAVAITLACFGLAREGNHKP..................... 314
5 -79.4005ynl_A mol:protein length:362 Arginase  ali model follow..  34  18.AKFERQHMDSPDLGTDDDDKMSP---ATSPFLATPRTAGIVGCPFSGGQPKAGVHSGPLQLIESGLLNDIENLGWTVDFAGADAL---------AVSIVSDTPDPDIGRLKQPRLVSRVTKDVADRVYAHASKGQLT-VTLGGDHSLAMGTVSGTFKAYPEACLIWVDAHADINTPHTTESGRLHGCPVSFLLGLDGTSSEEIPEFSWIKPCLKPERIVYIGLRDIDAGERKILKDNNIKCFSMFHVDKYGIGKVVEMALDHVNPDRTRPIHLSFDVDALDPSVAPSTGTAVRGGLTFREGHYICEAIAETNLLVSLDIMEINPSLGALASVAQTVDVGRSLVRCALGETL........................... 355
6 -79.1001t5f_A mol:protein length:314 Arginase 1  ali model follow..  38  1....................................KPIEIIGAPFSKGCPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDS-------------PFQIVKNPRSVGKANEQLAAVVAETQKNGTIS-VVLGGDHSMAIGSISGHARVHPDLAVIWVDAHTDINTPLTTSSGNLAGQPVAFLLKELKGKFPDVPGFSWVTPAISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVRTVNTAVALTLSAFGTKREGNHKPE.................... 310
7 -76.6006dkt_A mol:protein length:296 Arginase  ali model follow..  33  2...................................DKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINR--------------EKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFP-LVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHES---LVNLEGYAPKIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYL--SACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKN---KTGKTAVELVESLLGKK............................ 294
8 -76.5001cev_A mol:protein length:299 PROTEIN (ARGINASE)  ali model follow..  32  2....................................KPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERLHYDIEDLGDIPIGKAERLHEQGDSRL-----------RNLKAVAEANEKLAAAVDQVVQRGRFP-LVLGGDHSIAIGTLAGVAKHYERLGVIWYDAHGDVNTAETSPSGNIHGMPLAASLGFGHPA---LTQIGGYSPKIKPEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYLKER-TDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDERN---KTASVAVALMGSLFGEKL........................... 298
9 -74.4004ity_A mol:protein length:330 Arginase  ali model follow..  31  2..............................RGSGMAKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRI-------GRVKRPRLTAECTEKIYKCVRRVAEQGRFP-LTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPEC--FSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVDTISVGCAIARCMMGETLLYTPHTSSK.................. 323
10 -74.4002eiv_A mol:protein length:291 Arginase  ali model follow..  29  2....................................ERVAVVGVPMDLGANRRGVDMGPSALRYARLLEQLEDLGYTVEDLGDVPVSLARASR-------------RRGRGLAYLEEIRAAALVLKERLAALPEGVFP-IVLGGDHSLSMGSVAGAAR-GRRVGVVWVDAHADFNTPETSPSGNVHGMPLAVLSGLGHPRLTEV------FRAVDPKDVVLVGVRSLDPGEKRLLKEAGVRVYTMHEVDRLGVARIAEEVLKHL---QGLPLHVSLDADVLDPTLAPGVGTPVPGGLTYREAHLLMEILAESGRVQSLDLVEVNPILDERN---RTAEMLVGLALSLLGKR............................ 289
11 -68.3004g3h_A mol:protein length:330 Arginase (RocF)  ali model follow..  18  1......................................MILVGLEAELGASKRGTDKGVRRLREALSATHGDV----IKGMQTITQERCVLYKEFRYA------------KNFEDYYLFCKENLIPCMKEVFEKKEFP-LILSSEHANMFGIFQAFRSVHKKIGILYLDAHADIHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSELEKGGLEIDPKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIRE-NMQEVVQKTKESL--KAVDIIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLESDRLKAVEVTEYNPTVSIKHNNE-EEKQVLEILDLIINSCKIKDKKHSFAR................. 320
12 -67.0003mmr_A mol:protein length:413 Arginase  ali model follow..  28  9...........................VPRGSHMASKNVSIIGSPLAAGQPLGGVQLACDDLRKLGLHNVIDVLGWKYEDIGNIDNGDNEMKQEKKTNNYINNNDNYYDNIRNIKEIGIFSKNLFDTMSNELRKKNFV-LNIGGDHGVAFSSILSSLQMYQNLRVIWIDAHGDINIPETSPSGNYHGMTLAHTLGLFKKKVPYF-EWSENLTYLKPENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDPNSNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDEVDKKVKTGKLCLELIARVLGYD............................ 405
13 -65.5003nip_A mol:protein length:326 3-guanidinopropionase  ali model follow..  19  2...SNDHPQPLDAAEIPRFAGIPTFMRLPAFTDPAALQVGLIGVPWDGGTNRAGARHGPREVRNLSSLMRKVHHVSRIAPYDLVRVGDLGDAPVNPI------------------DLLDSLRRIEGFYRQVHAAGTLP-LSVGGDHLVTLPIFRALGR-ERPLGMVHFDAHSDTNDRYFGDNPYTHGTPFRRAIEEG---------------LLDPLRTVQIGIRGSSPDDDAFARECGIRVIHMEEFVELGVEATLAEARRVV---GAGPTYVSFDVDVLDPAFAPGTGTPEIGGMTSLQAQQLVRGLRGL-DLVGADVVEVSPPFDVGG---ATALVGATMMFELLCLLAESAARSALE.................. 320
14 -65.4001gq6_A mol:protein length:313 PROCLAVAMINATE AMIDINO HYDROLASE  ali model follow..  22  1.......MERIDSHVSPRYAQIPTFMRLPHDPQPRGYDVVVIGAPYDGGSYRPGARFGPQAIRSESGLIHGVGIDRGPGTFDLINCVDAGDINLTPF------------------DMNIAIDTAQSHLSGLLKANAAF-LMIGGDHSLTVAALRAVAEQHGPLAVVHLDAHSDTNPAFYG-GRYHHGTPFRHGIDEK---------------LIDPAAMVQIGIRGHKPDSLDYARGHGVRVVTADEFGELGVGGTADLIREKV---GQRPVYVSVDIDVVDPAFAPGTGTPAPGGLLSREVLALLRCVGDL-KPVGFDVMEVSPLYDHGG---ITSILATEIGAELLYQYARAHRTQ..................... 312
15 -65.3003nio_A mol:protein length:319 Guanidinobutyrase  ali model follow..  21  16...........RFGGIATMMRLPH---VQSPAELDALDAAFVGVPLDIGSLRSGTRFGPREIRAESVMIRPYNMATGAAPFDSLNVADIGDVAINTF------------------NLLEAVRIIEQEYDRILGHGILP-LTLGGDHTITLPILRAIKKKHGKVGLVHVDAHADVNDHMFG-EKIAHGTTFRRAVEED---------------LLDCDRVVQIGLRAQTAEDFNWSRKQGFRVVQAEECWHKSLEPLMAEVREKV---GGGPVYLSFDIDGIDPAWAPGTGTPEIGGLTTIQAMEIIRGCQGL-DLIGCDLVEVSPPYDTTG---NTSLLGANLLYEMLCVLPGVVRR...................... 319
16 -63.1003pzl_A mol:protein length:313 Agmatine ureohydrolase  ali model follow..  20  1MSLGGNGREKDHASELRSIFSLKKIA--DAVNGYEEAKYVVFGIPFDNTSYRRGSKYAPDSIRGAYVNLESYEYSYGI-DLLASGMADLGDMEES-------------------EDVEYVIDTVESVVSAVMSDGKIP-IMLGGEHSITVGAVRAL---PKDVDLVIVDAHSDFRSSYMG-NKYNHACVTRRALD-----------------LLGEGRITSIGIRSVSREEFEDPDFRKVSFISSFDVKKNGIDKYIEEVDR-----KSRRVYISVDMDGIDPAYAPAVGTPEPFGLADTDVRRLIERLSY--KAVGFDIVEFSPLYDNG----NTSMLAAKLLQVFIASREKYYKEHI.................... 305
17 -62.4001wog_A mol:protein length:305 agmatinase  ali model follow..  21  2.....SGPAHLPYGGIPTFARAPLV----QPDGDWQADVAALGVPFDIAGFRPGARFAPRALREASLRSVPPFTGLDGKTLQGVTFADAGDVILPSL------------------EPQLAHDRITEAARQVRGRCRVP-VFLGGDHSVSYPLLRAFAD-VPDLHVVQLDAHLDFTDTRND-TKWSNSSPFRRACEAL----------------PNLVHITTVGLRGLDPEAVAAARARGHTIIPMDDVTADLAGVLAQLP-------RGQNVYFSVDVDGFDPAVIPGTSSPEPDGLTYAQGMKILAAAAANNTVVGLDLVELAPNLDPTG---RSELLMARLVMETLCEVFDHVL....................... 305
18 -62.2003m1r_A mol:protein length:322 Formimidoylglutamase  ali model follow..  20  24......................KMSDLIATWDGQDIKGPALIGVPLSKSISHSGASFAPGTIRQALKHSSAYSAELGE-HVVSELLYDLGDIDIHV------------------TDIVKSHHHIFQTMHALLSDHPWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTEDG--GPTNGTPFRRLLDEE---------------IIEGQHLIQLGIREFSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVVQDK-TDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDFRD---MTSRAAAHVLLHALKGMKLSPFK...................... 322
19 -62.0004dz4_A mol:protein length:324 Agmatinase  ali model follow..  21  25........IENTYAGVLSFMRRNY------TRDLDGVDVVVSGVPLDLATFRSGARLGPSAVRAASVQLAELNPYPWGFDFDDLAVIDYGDCWFDAH------------------HPLSIKPAIVEHARTILQSDARM-LTLGGDHYITYPLLIAHAQKYGPLSLIHFDAHCDTWADDAP-DSLNHGTMFYKAVKDG---------------LIDPKASVQVGIRTWNDDYL------GINVLDAAWVHEHGARATLERIESIV---GGRPAYLTFDIDCLDPAFAPGTGTPVAGGLSSAQALAIVRGLGGV-NLIGADVVEVAPAYDQSE---ITAIAAAHVACDLLCLWRQRKAGAR.................... 324
20 -61.8003lhl_A mol:protein length:287 Putative agmatinase  ali model follow..  20  2..............................SLNYEESNLIVFGVGFDGTSNRPGARFASSSMRKEFYGLETYSPFLDL-DLEDYNICDYGDLEISV------------------GSTEQVLKEIYQETYKIVRDSKVP-FMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNN-SKNSHATVIKRIWD-----------------IVGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGID------TFENIVNML---NGKNIYLTIDLDVLDASVFPGTGTPEPGGVNYREFQEIFKIIKNSNNIVGCDIVELSPDYDTTG---VSTVIACKILRELCLIISDKIKE...................... 280
21 -61.1004rhm_A mol:protein length:351 Arginase  ali model follow..  17  1........MGSSSSGLVPRGSHMF-------------SKFLMNVKGVTPGSDWANRLGPVALFGYGAGMPRRAAELTIHDKGPIECPPETVMFMP---VLNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVP-VSVGGDGSATLSMVEAYKRLFPDIVIVHFDAHPDVSD---------PRSPLRVLLDKGL-----------------LKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR-------NDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGP-KVVGIDVYGYNPDLDRKDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQRQGTVSENP 341
22 -60.2002a0m_A mol:protein length:316 ARGINASE SUPERFAMILY PROTEIN  ali model follow..  17  4................AARTDDPRLLSLFSAQREEDADIVIIGFPYDEGGGRAGAKKGPAAFRFFLQRLGSVNNLELNVDASHLKLYDAGDIT--------------------ASTLEEAHEKLESKVFTVLARGAFP-FVIGGGNDQSAPNGRAMLRAFGDVGVINVDSHLDVRPPLQD-GRVHSGTPFRQLLEES---------------SFSGKRFVEFACQGSGALHAQYVRDHQGHLMWLSEVRKKGAVAALEDAFGLT----GKNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTPTVMMMDMSELNPLVEEY----RSPRVAVYMFYHFVLGFATRPKPKAEN.................. 310
23 -59.3004rhi_A mol:protein length:351 Arginase  ali model follow..  15  1........MGSSSSGLVPRGSHMF-------SKFLMNVKGVTPRGSD-----WANRLGPVALFGYGAGMPRRAAELTIHDKGPIECPPETVMFM---PVLNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVP-VSVGGDGSATLSMVEAYKRLFPDIVIVHFSARPSVSD---------PRSPLRVLLDKG------------------LKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR-------NDYPVFISIDASVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGP-KVVGIDVYGYNPDLDRKDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQRQGTVSENP 341
24 -53.8001xfk_A mol:protein length:336 Formimidoylglutamase  ali model follow..  15  26............VHHIACPIQVG-------ELANQEPGVALIGFECDAGKGRTGAKHAPSLIKQALANLAWHH-PIPIYDLGNIRCEG--------------------------DELEQAQQECAQVIQQALPHAR--AIVLGGGHEIAWATFQGLAQHFPRIGIINFDAHFDLRTFESELAPVSSGTPFNQIHHFCQQQ--------------WDFHYACLGVSRATPALFERADKLGVWYVEDKAFSPLSLKDHLTQLQHFIDD--CDYLYLTIDLDVFPAASAPGVSAPAARGVSLEALAPYFDRILHKNKLMIADIAEYNPSFDIDQ---HTARLAARLCWDIANAMAEQVQSIRH................... 335
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.