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Query: 4u0o_B mol:protein length:296 Lipoyl synthase 2, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MALSRPLPSWLRKPLGKASEISTVQRLVRQYGIHTICEEGRCPNRGECYGQKTATFLLLGPTCTRACAFCQVEKGHAPAAVDPEEPTKIAAAVATLGLRYVVLTSVARDDLPDQGAGQFVATMAAIRQRCPGTEIEVLSPDFRMDRGRLSQRDCIAQIVAAQPACYNHNLETVRRLQGPVRRGATYESSLRVLATVKELNPDIPTKSGLMLGLGETEAEIIETLKDLRRVGCDRLTLGQYLPPSLSHLPVVKYWTPEEFNTLGNIARELGFSHVRSGPLVRSSYHAAEGGLast
1 -121.0004u0o_B mol:protein length:296 Lipoyl synthase 2  ali model  100  1MALSRPLPSWLRKPLGKASEISTVQRLVRQYGIHTICEEGRCPNRGECYGQKTATFLLLGPTCTRACAFCQVEKGHAPAAVDPEEPTKIAAAVATLGLRYVVLTSVARDDLPDQGAGQFVATMAAIRQRCPGTEIEVLSPDFRMDRGRLSQRDCIAQIVAAQPACYNHNLETVRRLQGPVRRGATYESSLRVLATVKELNPDIPTKSGLMLGLGETEAEIIETLKDLRRVGCDRLTLGQYLPPSLSHLPVVKYWTPEEFNTLGNIARELGFSHVRSGPLVRSSYHAAEGG 290
2 -95.6005exi_A mol:protein length:331 Lipoyl synthase  ali model follow..  43  34.TPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAE-LDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPD------FNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAG--LVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRL. 312
3 -55.3001r30_A mol:protein length:369 Biotin synthase  ali model follow..  15  14..........YFQGSAHRPRWTLSQVLFEKPLLDLLFEAQQVHRQHFDPRQVSTLLSIKTGACPEDCKYCPQSSRYKERLMEVEQVLESARKAKAAGSTRFCMGAAWKNPHERD-----MPYLEQMVQGVKAMGLEACM------TLGTLSESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVRDAG--IKVCSGGIVGLGETVKDRAGLLLQLANLPPESVPINMLVKVKGTPLADNDDVDAF--DFIRTIAVA---RIMMPTSYVRLS....... 279
4 -48.7003t7v_A mol:protein length:350 methylornithine synthase PylB  ali model follow..  13  4.KMALDEFDSLGDKVIEGYQLTDNDLRTSKEGLERLYSAARKVRDHYFGNRVFLNCFIYSTYCKNQCSFCYYNCRNEINRLTMEEIKETCKTLKGAGFHMVDLTM-GEDPYYYEDPNRFVELVQIVKEE---------LGLPIMISPGLMDNATLLKAREKGANFLALYQETYTELYRKLRVGQSFDGRVNARRFAKQQG--YCVEDGILTGVGNDIESTILSLRGMSTNDPDMVRVMTFLPQEGTPLEGFRDKSNL--SELKIISV---LRLMFPKRLIPAS....... 277
5 -47.8004jy8_A mol:protein length:358 FEFE-HYDROGENASE MATURASE  ali model follow..  17  20..........LERREFTREVLKEALSINDRGFNEALFKLADEIRRKYVGDEVHIRAIIESNVCRKNCLYCGLRRDNKN-RMTPEEIVERARLAVQFGAKTIVLQS---GEDPYYMPDVISDIVKEIKKMGVAVTLSL----------GEWPREYYEKWKEAGADRYLLRHETAPVLHRKLRPDTSFENRLNCLLTLKELG--YETGAGSMVGLGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFT--LTLKMVAL---TRILLPDSNIPAT....... 278
6 -47.8005fep_A mol:protein length:358 [FeFe] hydrogenase maturase subunit HydE  ali model follow..  17  17............LEKLERREFTREVLKEDRGFNEALFKLADEIRRKYVGDEVHIRAIIESNVCRKNCLYCGLRRDNKN-RMTPEEIVERARLAVQFGAKTIVLQS---GEDPYXMPDVISDIVKEIKKMGVAVTLSL----------GEWPREYYEKWKEAGADRYLLRHETAPVLHRKLRPDTSFENRLNCLLTLKELG--YETGAGSMVGLGQTIDDLVDDLLFLKEHDFDMVGIGPFIPHPDTPLANEKKGDFT--LTLKMVAL---TRILLPDSNIPAT....... 278
7 -41.5004rtb_A mol:protein length:477 HydG protein  ali model follow..  12  35.RNPKEEISQIIQKLQKGERLSLIEAGITEELDQILFWQARKVKEEIYGKRIVLFAPLYSNICINNCSYCSFRRENKELRLSLEEAVDEAKAIREMGHTRILLVMGEEP--EDKTLSYLEEIIPAIYSEVDIRRINV--------NIAPLTLKGYERLKKLKIGTYQLFQESYPEVYREVGPKTNFLWRLNAVERAIEAGI-DDIGIGALFGLGDPLFELLGVIAHADYLGPHTVSVPRLKPALNSVFSNDYKISDH--KFKKIVAL---LRIMLPYTGIILSTREPQHL 326
8 -40.8004wcx_A mol:protein length:480 Biotin and thiamin synthesis associated  ali model follow..  10  31.KATSKDALEIIEKAKNLKGITPEEAAVDEDLLNEMFKVARYIKEEIYGNRIVIFAPLYSNYCVNNCRYCGYRHSNEQQKLTMEEVRREVEILEEMGHKRLAVEAGEDP--VNCPIDYIVDVIKTIYDTKLKNGSIRRVNV----NIAATTVENYKKLKKVGIGTYVLFQETYHEYMHPQGPKHDYDYHLTAMDRAMEAGI-DDVGLGVLYGLYDYKYETVAMLYHANHLGPHTISVPRLRPALNISIDKFPY-IVSDKDFKKLVAV---IRMAVPYTGMILSTREKPKF 326
9 -34.2004r33_A mol:protein length:420 NosL  ali model follow..  9  42.EAATVDTRAVLALAEGEEPAESRAAVADRSIGTAELQAAAEARCGARRPRLHTFVPLTTNYCDSECKMCSMRKGNHR-FSGRKEITEQLEILYHHEGVRGVGFLTGEYEDKHTRLASAFRIGWAIRTALDLGFERVYF------NIGSMEQDEIDVLGEEDPVTMCVFQESYRETYRRFMGKADFDRRVVSFDRWLDAGYR-YVNPGVLVGLHDDSAELVSLVAHGDHLRSRGATADLSVPRMRPAMKSRDTTRVGDDDYLRLMSV---VAFTCPEQRLVLT....... 335
10 -17.3006fd2_B mol:protein length:457 Putative apramycin biosynthetic oxidoreductase 4  ali model follow..  16  197.....................................................ITSINGSFGCPYPCRFYCPYPGRKIRTYPVERIVAEFRQCAELGITAAVF----RDPVFSFHRDRTLELCQALKAADTGVPWWCET------RIDRLDEEVVAALVDAGCVGVEVGVESGDPQATAVRKRLNLDTVRKFHAVARKAG--LKLVFLFLIGLRETRMSIRRTFDFILELGLADTEFNVITPYPGTEL.......................................... 387
11 -16.7005vsl_A mol:protein length:318 Radical S-adenosyl methionine domain-containing protein 2  ali model follow..  10  37...........................................................TRQCNYKCGFCFHTAKTS-FVLPLEEAKRGLLLLKQAGLEKINFS--GGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSN-------GSLIRERWFKDYGEYLDILAISCDSFEQVNALIGRGQGKKNHVENLQKLRRWDYKVAFKINSVINRFNVDEDMNEHIKALSPVRWKVFQC..................................................... 207
12 -16.4005v1q_A mol:protein length:459 Radical SAM  ali model follow..  12  122.....................................................ELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPTRYFD-----IDNLLIACEELKIKTTITT--------NAQLIKKSTVEILAKSKYITPVLSLQTLDSKLNFELMGVRPDRQIKLAKYFNEVGKKCRINA-----TKQSYEQIIELVDFCIENKIDRFSVANYSEVTGYTKIKKKYDLADLRRLNEYV......................... 317
13 -16.3001tv7_A mol:protein length:340 Molybdenum cofactor biosynthesis protein A  ali model follow..  13  16......................................................LRLSVTDRCNFRCDYCMPKEVFKNELLTFDEMARIAKVYAELGVKKIRIT--GGEPLMRRDLDVLIAKLNQIDGIEDIG-----------TTNGLLLKKHGQKLYDAGLRRINVSLDAIDTLFQSINNRNKATTILEQIDYATSIGLNVKVNVVIQKGIND--DQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEM............................... 216
14 -15.9005l7j_A mol:protein length:459 ELP3 family  ali model follow..  12  22.............................................................PCPGKCIYCPTFAATPQSYTPESPAVLRADMGHPTDKVELIIMGGTFLSADITYQYGFIKDCYDALNGVVAGSLEECVGLCIETRPDICGKAEIQRMIDFGTTRVELGVQMLDDIYKLVERGHRVSDVAEATCLLREYGLKVHY---WMPGLGSSPEKDLALSRMVFEFCPDGLKLYPTMVVEGTILKEGRYTPYPNGTMTGLIADIKAL-----PPYVRISRVLRDIP 283
15 -15.4005l7l_A mol:protein length:446 ELP3 family, ELP3 family  ali model follow..  12  22.............................................................PCPGKCIYCPTFAATPQSYTPESPAVLRADMGHPTDKVELIIMGGTFLSADITYQYGFIKDCYDALNGVVAGSLEECVGLCIETRPDICGKAEIQRMIDFGTTRVELGVQMLDDIYKLVERGHRVSDVAEATCLLREYGLKVHY---WMPGLGSSPEKDLALSRMVFEFCPDGLKLYPTMVVEGTILKEGRYTPYPNGTMTGLIADIKAL-----PPYVRISRVLRDIP 283
16 -15.4006b4c_A mol:protein length:298 Viperin  ali model follow..  7  18...........................................................SRKCNKECLFCFHTATTS-HVEKPENAKRGLTLLKQAGMKKINFA----GGEPFLYPKFLGEMIDFCKETLQLESVSIVTN-------GSLVKEQFLQKHGRNIDILAVSCDSFNEATNIKIGRGSVQKLYEIGSWCQKYDIKFKLNT--VVNKFNHLEDMNDHLNALQPFRWKCFQVLIVTGENDSDKTLRNTISDDEFDRFCERHSSQTCLVPEPNRLMAKSY...... 235
17 -15.1004jc0_A mol:protein length:438 Ribosomal protein S12 methylthiotransferase RimO  ali model follow..  14  140.....................................................AYVKISDG-CDRGCTFCSISFKGSLRSRSIEDITREVEDLLKEGKKEIILVAQDTTSIDLYRKQALPDLLRRLNSLNGEFWIRVMYL---------LTEEIISAMLELDKVVKYFDVHGSDKILKLMGRTKSSEELKKMLSSIRERFPDAVLRTSIIVGFGETEEDFEELKQFVEEIQFDKLGAFVYSDEEGTVAFNLKEKVDPEMAKRRQEEL....................... 354
18 -14.1006c8v_A mol:protein length:394 Coenzyme PQQ synthesis protein E  ali model follow..  13  23.....................................................GLLAELTHRCPLRCPYCSNPLERRSAELDTQTWLRVLTEAAGLGVLHVHLSGGEPTARPD-----IVEITAKCAELGLYSNLIT--------SGVGGALAKLDALYDVGLDHVQLSVQGVDAANAEKIGKNAQPQKMQFAARVTELGLPLTLNSVIH----GNIHEVPGFIDLAVKLGAKRLEVAHTQY-YGWAYVNRAALMPDKSQVDESIRI....................... 223
19 -13.9001olt_A mol:protein length:457 OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE  ali model follow..  15  62..............................................................CHKLCYFCGCNKIVTRQQHKADEIVHRAPLFAGRHVSQLHWGGGTPTYLNKAQISRLMKLLRENFQFNADAEISIEVD-------REIELDVLDHLRAEGFNRLSMGVQDFKEVQRLVNREQDEEFIFALLNHAREIGFT-STNIDLIYGLKQTPESFAFTLKRVAELNPDRLSVFNYAHLPTIFAAQRPQQKLDILQETIAFLTQSGYQFARPDDELAVAQREGV.. 305
20 -13.8004m7s_A mol:protein length:269 BtrN  ali model follow..  10  7.....................................................MIEVEVNSQCNRTCWYCPNSKRKETGEMDPALYKTLMEQLSSLDFAGRISFHFYGEPLLC---KNLDLFVGMTTEYIPRARPIIYT------NGDFLTEKRLQTLTELGIQKFIVTQHAGKHKFRGVYDQLAGADKEKVVYLDHSDLVLVVTVLGNVL-MGNIGEQHIDKFTSFRKM............................................................ 220
21 -13.7004m7t_A mol:protein length:270 BtrN  ali model follow..  10  21.....................................................MIEVEVNSQCNRTCWYCPNSKRKETGEMDPALYKTLMEQLSSLDFAGRISFHFYGEPLLC---KNLDLFVGMTTEYIPRARPIIYT------NGDFLTEKRLQTLTELGIQKFIVTQHAGKHKFRGVYDQLAGADKEKVVYLDHSDLVLVVTVLGNVL-MGNIGEQHIDKFTSFRK............................................................. 233
22 -13.3002yx0_A mol:protein length:342 radical sam enzyme  ali model follow..  11  72.....................................................LQMTPVLAWCTHNCIFCFLGTELPQPWDDPAFIVEESIKAEAWNPTHAAISLSGEPMLYPY----MGDLVEEFHKRGFTTFIVT--------NGTIPERLEEMIKEDKLPTQLYVSITAPDI-VNIPMIPDGWERILRFLELMRDLPTRTVVRLTLVKGE--NMHSPEKYAKLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHQDIREFA......................... 299
23 -13.2005wgg_A mol:protein length:453 Radical SAM domain protein  ali model follow..  10  63..................EALREIESLEAEGLLFSEDPYKEYVSSMDRKSVVKALCLHISHDCNLRCKYCFASTGGQRNMMSLEVGKKAIDFLISENRKNLEIDFFGGEPM---NFDVVKGIIEYARQKEKEHNKNFRFTLTTNGL--LLNDENIKYINENMQNI---SIDGRKEVNDRMRISGCYDDILPKFKYVAESRNQDNY--YVRGTFTRENMDFSNDVLHLADEGFRQISVEPVVAAKDSGYDLREEDLPRLFEEYEKLA........................ 312
24 -13.0003c8f_A mol:protein length:245 Pyruvate formate-lyase 1-activating enzyme  ali model follow..  10  20...................................................IRFITFFQG--CLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFM--VTASGGEAILQ--AEFVRDWFRACKKEGIHTCLDT-------NGFVRRYDPVIDELLEV-TDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGIELLPYHELGKHKWVAMGEEKPPKKETMERVKGILEQYGHKVMF............... 245
25 -12.9006djt_A mol:protein length:331 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase  ali model follow..  12  66....................................................CIQCTPSVIWCQQNCIFCDISQIKEPKWEEPEVVYEKILAMEALEPKHVAISLSGEPTLYPY----LDELIKIFHKNGFTTFVVS-------------NGILTDVIEKIEPTQLYISLDYDLDSYRRICKKEYWESILNTLDILKEKKRTCIRTT-----IRGYNDDILKFVELYERADVHFIELKSYMHVGYSQKRLKKEDMLEILKLAKMLDENSSYKLIDDSEDSRVALLQNEN. 318
26 -12.9004k36_A mol:protein length:392 Anaerobic sulfatase-maturating enzyme  ali model follow..  6  3..................................................PLSLLIKPASSGCNLKCTYCDNRNVKSYGIMRDEVLESMVKRVLNEANGHCSFAFQGGEPTGLEFFEKLMELQRKHNYKNLKIYNSLQTN--------LIDESWAKFLSENKFLV---SMDGPKEIHNLNRKDCTFSKVERAAELFKKYKVEFNILC-------NTARHVNKVYKYFKEKDFKFLQF..................................................... 191
27 -12.7004fhc_A mol:protein length:368 Spore photoproduct lyase  ali model follow..  10  104......................................................AIPLATG-CMGHCHYCYLQTTLGSKYVNLDDIFAQAQKYINERAPEITRFEAACTS--DHLTHSLKKAIEFIGATDYGRLRFVTKYEHVDHLLDARHNGKTRFRFSINSRYVINHFEP---------GTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGWERGYFELFQELAR............................................................. 276
28 -12.7005ul2_A mol:protein length:744 OxsB protein  ali model follow..  12  248..........LIKMLKKELKLDEVNGIS--NFKEEVPTPSLDILGEISKFRGALTLETSRG-CDSRCTFCPRDHLRSWRPLSVEQTLKQLDDILRAGKHFMADEEFIGELPNGTEAQRIIDICEGLLKREEKIRADSVYEPKRTKEWNVERLKMWHYCALAGADRIFIGVESSNQQLKRYGKGTTSEQNIIALRLVSALGINLRI-GFIMFDQMKGLDNLKENLDFLERTDALMKPID-IGDMTYEEL.......................................... 513
29 -12.0002a5h_A mol:protein length:416 L-lysine 2,3-aminomutase  ali model follow..  13  116.....................................................RVLLLITDMCSMYCRHCTRRRGQSDDSMPMERIDKAIDYIRNTQVRDVLLSGGDALLVSDETLEYIIAKLREIPHV-EIVRIGSRTPVVLPQRITPELVNMLKKYHPVWLNTFNHPNEITEES-------------TRACQLLADAGVPLGNQSVLLRGVNDCVHVMKELVNKLVKIRVR--PYYIYQCDLSLGLEHFRTPVSKGIEIIEGLRGHTS--YCVPTFVVDAPGGGGK.. 337
30 -9.5505tgs_A mol:protein length:263 7-carboxy-7-deazaguanine synthase  ali model follow..  8  40......................................................TMFVRTAGCDYSCSWCDSSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISG------NPALLKQLDAFIELLKENNIRAALE---------TQGTVYQDWFTLI-----DDLTISPKPPSSKMVT-----NFQKLDHILTSLQENDRQHAVSLKVVIFNDEDLEFAKTVHKRYPGIPLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVAVDAELNLVRVL................ 243
31 -9.3503rf9_A mol:protein length:404 Ribosomal RNA large subunit methyltransferase N  ali model follow..  10  57FDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSAIAVGDQRVETVYIPEDDRATLCVSSQVG-CALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKRPITNVVMMGMG------EPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVV--PALDKLGDMIDVALAISLDEIRDEIVPINKKYNIETFLAAVRRSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCK-INLIPWNPFPGAPY---GRSSNSRIDRFSKVLMSYGFTTI-----VRKTRGDDIDA 353
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.