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Query: PF00290.20; TRPA_MAIZE/94-347; Tryptophan synthase alpha chain, from PfamA32U

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAALMAKGKTAFIPYITAGDPDLATTAEALRLLDGCGADVIELGVPCSDPYIDGPIIQASVARALASGTTMDAVLEMLREVTPELSCPVVLLSYYKPIMSRSLAEMKEAGVHGLIVPDLPYVAAHSLWSEAKNNNLELVLLTTPAIPEDRMKEITKASEGFVYLVSVNGVTGPRANVNPRVESLIQEVKKVTNKPVAVGFGISKPEHVKQIAQWGADGVIIGSAMVRQLGEAASPKQGLRRLEEYARGMKNALPLast
1 -87.000[E] COG0159 Tryptophan synthase alpha chain  ali follow..  39  19FDELKQKKEGALIGYVMAGDPSAEATFGIVKALVNGGADIIELGFPFSDPVADGPTIQAAGQRALAAGMDIEHYFELVRGLGVE--VPLVCMTYYNPVFRYGVDKFADAGISGLIIPDIPVEEAADLKSSCEKYGLDLIFLVAPTTTDARIRKILERGSGFIYLVSRLGVTGARADVSGSTKELLSRVK--TDIPKAVGFGISTGKQAAEVRKAGADAVIVGSVFVRIIEEG---NGVNEKLEALARELKSGIL 269
2 -85.700[E] KOG4175 Tryptophan synthase alpha chain  ali follow..  34  9FANAKKENRNALVTFMTAGYPTVKDTVPILKGFQDGGVDIIELGMPFSDPIADGPTIQLSNTVALQNGVTLPQTLEMVSQARNEVTVPIILMGYYNPILNYGEERFAKAGANGFIIVDLPPEEALKVRNYINDNGLSLIPLVAPSTTDERLELLSHIADSFVYVVSRMGTTGVQSSVASDLDELISRVKYTKDTPLAVGFGVSTREHFQSVGSV-ADGVVIGSKIVTLCGDAPE-GKRYDVAKEYVQGILNGAK 266
3 -36.500[R] COG0434 Predicted TIM-barrel enzyme  ali follow..  14  3......FNNKPLIGVVLPGSPGYKGELDEVIDRAISDAAKYQ------EAGFDAIILENYGDFPYSKTVGKETVSAFANEVKREIALPLGINVLRNDCYSIKADFIRVNVLTGVAFTDQGIVEGCARELAELRTRLPSRIDVLADVHVKHATHFALLDTIERGGADAVIVTGSRTGSEVDI-QELITAKRISPVPVLVGSGV-NPRNIKLFWRY-SDGFIVGTWVKEGGRTINEVSI--ERATKLAKLVKSLRE 258
4 -35.800[R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold  ali follow..  16  13....ILRERKIHLTLIDPEEQTPEEAVEIARAAIRGGTDGIMLGGSTTDSSELDNTARA---------------------LRENIDVPIILFPGNTTGVSRYADAILLNSTNPYWIIGAQALGAATVKKVEPGGTVGWVGDTKPVPRNKPDIAAAYAMAAEFLGMRLFYLEAGSGAPEHVPEEMIALVKRCTDQILIVGGGIRSGEDAARVAGAGADVVVTGTVVEN-------SDNVEDKIREIVEGMGS... 247
5 -15.100[G] COG3010 Putative N-acetylmannosamine-6-phosphate epimerase  ali follow..  13  5........................SHPQVLEQIKYG---IASCQPVDNGPMDSPEIVAAMAQASVIGGAAGLRIEENLKATRNVVNVPIIGIVVRISPFLQDIEELAAAGADIIAFDGTDRVRPTTREAIIKRIKELGCLAMADCSNFEEGMYCHNLGVEII--STMSGYTGGEIPAEPDY-QLVKDLNA-AGCRVMAEGRYNTPELAKTAIEIGAYSVTVGSALTRLEHIVSWFADAVKSAK........... 228
6 -12.900[G] COG0036 Pentose-5-phosphate-3-epimerase  ali follow..  18  2.......KQYLIAPSILSA--DFARLGEDTAKALAAGADVVHFDV------MDNHYVPNLT----------PMVLKSLRNYGITAPIDVHLMV------DRIVPDFAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGG--QSFIPQTLDKLREVRRRFDIRLEVDGGVK-VNNIGEIAAAGADMFVAGSAIFD----QPDYKKVIDEMRSELAKVSH... 224
7 -12.400[G] KOG3111 D-ribulose-5-phosphate 3-epimerase  ali follow..  17  2......TLRPFVCPSILNA--DLASLASECKKLLAAGADWLHLDV-FVPNLTFGHPVVESLRKSLGAEPFFDVHLMVSNP-------------------GQWVEPMAKAGASQFTF---GDVAVSELIEKIRKSGMKVGLSVKPGTSVEHILKHANHLDNALIMTVEPGFGG--QKFMENMMEKVRTIRSKPNLTIQVDGGVT-PENIEISAQAGANAIVSGTGIIK----AADQSVAMTTIRNAVEAAIS... 225
8 -12.200[G] COG0269 3-hexulose-6-phosphate synthase and related proteins  ali follow..  14  8...............VALDNQTMDSAYETTRLIAEE-VDIIEVGTILC--VGEG--------------------VRAVRDLKALYHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIGQVVYHRSRDAQAAGVAWGEADITAIKRLSD-MGFKVTVTGGLA-LEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAELWG....... 216
9 -11.200[E] COG0134 Indole-3-glycerol phosphate synthase  ali follow..  18  45LQATIAHGDPAVIAEIKKASPSKGRPAEIAISYELGGASCLSV---------------------LTDVHFFKGHDDYLSQARDACTLPVLRKDFTIDPYQVYEARVLGADCILLIVAALDDAQLVDLSGLALQLGMDVLVEVHDIDELERAIQIS---------APLIGINNRNSTFNVSLETTLTMKGLVPRDRLLVS-GILTSADVQRLRAAGVNAFLVGEAFMR........................... 249
10 -11.100[H] COG0294 Dihydropteroate synthase and related enzymes  ali follow..  11  66.............SFYEGSVTSPESALDVARKMVEDGATFLDLGARSTWRFSK----------PISKKEELDRLLPVLDSLEGDVDAVISVDTMFSEI----AEEALKRGAD--IINDV-FTVDPRMIEVVADHDCPAVVMASNKIPGDPMDAIIEALGSIIEAAGAGGIGWTDEKLPIYDFETLDDFERLKIFEKPLLAALSRKSFIGEVLGKTANDRLYGSLAAAAIA........................ 281
11 -11.100[H] COG2022 Uncharacterized enzyme of thiazole biosynthesis  ali follow..  15  30.......ADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAIIAAGVTLLPNTSGAKTAEEAIFAAH------------------LAREALGTNWLKLEIHPDLLPDPIETLKAAETLVQQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLE------AMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVA----DDPVNMAKAFRLAVEAGLLA.. 255
12 -10.400[E] KOG4201 Anthranilate synthase component II  ali follow..  14  172.MAHKRTGFPGLIAEVKKASPSRGDPVEIAQAYEKGGAACLSV---------------------LTDQKYFQGGFENLEAIRSAGKCPLLCKEFVVDPWQIYYARTKGADAVLLIAAVLADLEITFLLKICKKLSLAALVEV---HDEREMGRVLGIEGIELVGINNRSLETFEVDI-SNTKKLLEGEHGRQIREVVGESGLFTPDDIAYVQAAGVKAVLVGESIVKQNDPEKGIAGLFGR............. 397
13 -10.300[K] COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding)  ali follow..  12  1............................................MPXLHLLRQNPVIAAVKD------------NASLQLAIDSECQFISVLYGNICTISQIVKKIKNAGKYAFIHVDL--NKEVVIQFLKLVTEADGI-ISTKASMLKAARAEGFFCIHRLFIVDSISFHNIDKQVAQSMPKVLGWVTEKIRQPLIAGGLVCDEEDARNAINAGVVALSTTNTGV............................ 183
14 -10.100[H] COG0352 Thiamine monophosphate synthase  ali follow..  13  18......................VVDSVEWIERLLESGVRTIQLRIKDKR------------------DEEVEADVIAAIALGRRYNARLFINDY--------WRLAIKHRAYGVHL-DLETTDLKAIQAAGLRLGVS-------THDDMEIDVALAAKPSYIALGHVFPTTKQMPSAPQGLAQLASHIERLADYPT-VAIGGISLERAPAVLATGVGSI----AVVSAITQAADWREATAELLAIAGVGDE... 211
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Y, Stec B, Godzik A. Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure. 2007 Sep;15(9):1141-7.