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Query: PF00389.30; Q9KCG9_BACHD/20-325; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, from PfamA32U

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst ILVSDAMSEQGLSPLLNDPRVECVQQNVADADDLHEYDALLVRSATTVTEELMEKMSSLKIIARAGVGVDNIDIDAATKHGIVVVNAPDGNTISTAEHTFAMICSLLRKIPQANASIKAGEWKRKAFQGTELRGKTLGIIGFGRIGSQIAKRAKAFEMTPYVFDPFLTKARAEKLGVTVASLDDVLQVADIITVHTPLTKETKGLLGMKNIGKTKKGVFLINCARGGIIDEEALKHYLREGHIAGAALDVFEEEPVADEELLAFDNVIATPHIAASTKEAQLNVAEQVSQEVLHFLEGNPVSNSINLast
1 -103.000[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  48  32VLVSDSIDQVGIDILKQVAQVDVKLSEAEIIDIVPEYDAIMLRSATKVTEKIIQAGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQEPLGESRLREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVN 339
2 -92.100[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  45  85ILVTEKLGEAGVNLLREFGDVDCSLSPEDLKKKVAESDALIVRSGTKVTREVFEAAKRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPSDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVN 394
3 -89.900[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  28  5VFNLREEEAPYVEKWKQSHDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDA--AKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIK 330
4 -88.900[K] KOG0067 Transcription factor CtBP  ali follow..  33  36VALLDGRDTVEMPILKDLATVAFQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRN 355
5 -77.100[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  20  10SPVNNDVVDGSSRRFHKAFKVLISHPPALELLRSRGAETIICQSVPPSRDEILQKVPGLRCVSTMSSGIDFVDIPEFQKRGIPLGHTPGVVKNAVADLAIGLMIAAGRHFHAGRTEIERSQWKIEQMMGQEIRDSVIGFFGFGGISQAIAKRLQCWDVAKIIYHTRTRKENDGDFKAEHVSFEQLLQESDFLVVAAPLTNETREKFNGKAFNLMKRSSVFVNVARGG--------------------LDVTTPEPPANSPLLNVPNCEGLKMSTTKPFKVLIAHTDVPPEGIEILKEQCEILQVIN 306
6 -12.100[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  17  173.................................FLGMLREVLAAEPGKWGKIAEAV--KGVTEETTTGVHRLHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRA--------------TDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEA-INALQALMDGYSVVTVDEAIEDADIVIT----ATGNKDIISFEQMLKMKDHALLGNIG.................................................................................. 345
7 -11.800[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  14  82..AAAAIAKAGISASTGIPVLP-----LPRLACLEGRNRRGVPVTGDLTNLIHSEYSQLLISKETTIGVHNLKMMVNGILKVPAIDVNDSATKSKFDNLYGCGIKQA--------------------TDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKT-IKALQAAMEGYEVTTMDEACQEGDVFVT----TTGCVDIILGQHFEQTKDDTIVCNTGYFDVMDVKWLNKNTVEKVNVKLQVDPYRLKNGRGIILLA--NLACAMGHPSFVRSNSFTSQVMAQIKLWT............ 355
8 -9.510[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  16  365......................................................................................................................................LKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFS-DLFEEHPEVIILCTSIL-STEKVLESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLPQD------FDILCTHPMNNLAFVFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVEM........... 530
9 -8.640[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  18  3........................................................................................................................................LGMIGLGRMGANIVRRLAKGGHDCVVYDH-MAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEE--ANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGT........................................................ 121
10 -8.480[O] COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family  ali follow..  9  10..........................AFLHQRPARNGLDCVLVEVTDVKGSAPRDAGAWMLVARDTIGGGQLEYMAIEHARKILSGGRDTPLDVPLGPEIGQCCGGRVSLSFRLMTHGLADELVGKVDTEIAMRPHVYIFGAGHVGGALARALSLTPVRVIMVD---TREAELMKFQEKWEPVFRPGFHGNYICDVPGVETCLSAIPEQAVRSAPPHSAFIILTHDHALDFLIAAEALQRQDAAYVGMNWLKREAGREDLFENLVCPIGGAVVKDKRPE---VIAALAAAEILTAVL......... 289
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Godzik A. Secondary structure prediction using segment similarity. Protein Eng. 1997 Oct;10(10):1143-53.