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Query: PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain, from PfamA32U

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst APQVGAYHLMAANGGRGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVYRLast
1 -59.600[E] COG0686 Alanine dehydrogenase  ali follow..  60  141SIQAGAQTLEKSRGGSGLLLGGVPGVAPAKVVVLGGGVVGANAARMAIGLRADVTILDRNIDTLRKLDEEFQGRANVVYSTADAIEKYVLEADLVIGAVLIPGAAAPKLVTQQHIKRMKPGSAVVDVAIDQGGCFETSHPTTHAEPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPYIVKLANKGYQKALLEDAGFLKGLNVIHGKVTYK 353
2 -49.400[C] COG3288 NAD/NADP transhydrogenase alpha subunit  ali follow..  21  138GYRAVVEAAHEFGRFFTGQITAAGKVSPAKVFVAGAGVAGLAAIGAAGSLGAIVRAFDVRPEVKEQVQSMGAEFLEFNRKAAELYAAQAKDVDIIITTALIPGKPAPKLITKEMVDSMKAGSVIVDLAAANGGNCEYT---VKDQVITTDNGVKVIGYTDMVGRLPTQSSQLYATNLVNLLKLLCKEGNIDINFEDVVLRGVTVVKAGEITWP 369
3 -36.900[E] KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase  ali follow..  15  199..........RDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLHKLVAICDISADTGGSIEFMECTTIEHPFCMYDGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESSPVVRDAVITSNGTLPDK 458
4 -11.800[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  17  1............................MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDR---TTGVASLRELSQRLSAPRVVW--VMVPAGNITTAVIEELANTLEAGDIVID------GGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMARAEPIFATVAPG.......................... 156
5 -11.300[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  17  2........................SHTKPSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEILM----PGAVPSTADQAVKDADIVFLAV-------PLHKFRSVNPATLEGKIVIDTM..................................................................................... 94
6 -11.200[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  17  1.........................MSTMKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWK--VVEDAGVTVTDNDAEAASEAEIAV--LFTPFGKKTFEIAKNITNHLPEGAVIANTCT.................................................................................... 120
7 -11.100[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  20  143........................ELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVS-----------MDELLSTSDVI--SLHMPTKDSHHLINAKTIAQMKDGVYLVNTA--RGAVIDSQ........................................................................... 242
8 -10.800[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  22  246...............DGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVT--------VDEAIEDADIVITAT-----GNKDIISFEQMLKMKDHALLGNIG..................................................................................... 345
9 -10.600[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  19  181..............GCGIKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQAAMEG---------EVTTMDEACQEGDVFVTTT-----GCVDIILGQHFEQTKDDTIVCNTG..................................................................................... 281
10 -10.400[Q] COG5310 Homospermidine synthase  ali follow..  13  19.............................PVVMIGFGSIGRGTLPLIER--SRMTVLDPRDTDRKLLDERGIAFENNYKKLLTPLLTNGGGQGFCVNLS------VDTGSVDLMRLCRKLGVLYIDTVVEPW---LGFYFDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQALVNLATDLGLE............. 190
11 -10.400[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  23  24.............................NVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHAVSDSVKDADLVIEAIVENIDIKRKLFAETLITTNTSSLRLADIGLNLK--LEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYMFELYERGDASMEDIDVAMKLGAGYPMGPF... 254
12 -10.300[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  13  7AILGAGCYRTHAASGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVREAVADADFIMTWFPKGDMQPGII--DKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYH--PGAVPEMKGQVYSEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTA. 263
13 -10.200[R] COG2910 Putative NADH-flavin reductase  ali follow..  17  2............................AKIALIGAGNAGSRILKELSDRGHQVTAIARNPEKIAALPNV--VAKKGDVFDQAALSELLKGHDAVISSVHFTASDPATLIEAVRASGVQRYLVVGGAGS.................................................................................... 101
14 -10.100[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  18  4.............................TVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMSDEDLAQADLVIEAVTEDETVKRKIYGQAILATNTSSLSITRLASATD--VELVRGIATEEETFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINETLYEGVGTVDAIDTAMKLGANHPMGPL... 228
15 -9.800[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  10  45....................SNSNATPPLRIAIIGFGNYGQFLAETLISQGHILFAHSRSDHSSAARRL--------VSYFTDLHDLCERHPDVVLLCT--SILSIENILKTLPFQRLRRNTLFVDVLSVKEFAKTLLLQ-------YLPEDFDILCTHPMFGPQSVSSNHGWRGSRCESFLEIFVREGCEMVEMSVTDHDKFAAESQFITH. 237
16 -9.740[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  17  420........................DIRDSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTTRNRVSQDIEERFN-------AKKVDFETLLAESDFLIIASPLTKE-TLGLFNATVFNKMKETAVLVNVGVNQDDLYEALEPLPSNDKLLTLDNVVV--TPHVGYATRRTRVDAANLASRNVLKGLAGE.......................... 591
17 -9.660[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  11  4.............................NVLIIGAGGVAQVVAHKCAQVLGDIHIASRTVDKCRKIVESVREKHALDALDVEATKALIVSSQIVINVG------SAFVNMSVLRACMDTGVAYMDTAIHEEPNKICETPPWYGAAECKEKGITAIFDPGVVNAYARLAKDEYFDKI.................................... 171
18 -9.560[E] COG0287 Prephenate dehydrogenase  ali follow..  15  9.............................RIALIGIGLIGSSIARDVRELGLHVVISTRSEDTLKRAEELA-----LGTDYTVSAAEAVKDADLVIVSVPVGASES---VAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHMPENVHFILAGTEKSGPDAGFAGLFRERWCIFTAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPH. 195
19 -9.480[K] KOG0067 Transcription factor CtBP  ali follow..  17  177........................RIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQD--------GIERSLGVQRVYTLQDLLYQSDCV--SLHCNNEHNHHLINDFTIKQMRQGAFLVNAA--RGGLVDEKAFSFAQGPLKDAPNLICTASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPHPELNGATYRYPPGIV.. 392
20 -9.410[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  14  4...........................KGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGA--YSLEDLAAKLEKPRKVMMVRAGDVVDQFIEALLPHLEEGDIIID------GGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSINQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAGHFV.. 184
21 -9.400[R] KOG4288 Predicted oxidoreductase  ali follow..  21  1............................MKIVVLGGGFLGHNICKLAIAKGYEVVSVSRRGAGGLHNKEPWMDDVEWETKDPNSLLPVLRDASAVVNSV.................................................................................................................. 76
22 -9.360[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  19  3.............................TIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLKTVSGH-------AAVAKAADIIITMVPDTPQVADVLFGDNVASGLTRGKLVIDMSS.................................................................................... 96
23 -9.230[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  12  3............................ADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGA--TSIEDFISKLKRPRKVMLVKAGAPVDALINQIVPLLEKGDIIID------GGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSL-PHIKNIFQSISAK.......................... 162
24 -9.170[O] KOG2015 NEDD8-activating complex, catalytic component UBA3  ali follow..  15  36.....................NFEALQNTKILVIGAGGLGCELLKNLALSGFTIEVIDMDTIDVSNLNRQF----------------LFRESDV---------GKSKAEVAAAFVQQRVVGCQNYFNFIS---FRHNCRIEDKGQEFYRKFSIIICGLDSIP-------ARRWINGMLCDLVLEMADGKPDENTIIPMIDGGTEGFKGNAR.. 192
25 -9.070[H] COG0373 Glutamyl-tRNA reductase  ali follow..  14  156...IGGSAVSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCRMIVANRTRERALSL----AQQFGADVIALNEIPDYLAQADIVISST----ASPLPIIGKGMVESALKARLLVDIAV----------PRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQ.......................................... 311
26 -9.040[R] COG1064 Zn-dependent alcohol dehydrogenases  ali follow..  15  155.................LLCAGITLYSPLRVAIVGLGGLGHMGVKLAHAMGAEVTVLSQTLSKKEDGLKLGADHY-YATKDPETFTKLAGSFDLIICTV------AAEIDWNAYLNLLKVDGELVLVGIPENP---PVHAFSLVPARRSISGSMIGSIKETQEMLDFCGEHGIVSEIETIRMEQINEAYERVVRSDVRYRFVIDMES...... 344
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.