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Query: PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, from PfamA32U

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAEDLast
1 -75.300[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  71  4TVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMSDEDRKRALSLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEEETFKAAKEFVAHLDKTVTVAED 182
2 -70.900[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  36  24NVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHADDAAASSVLDRIKMSTNVSDVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKD 208
3 -68.000[I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase  ali follow..  30  354EIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERGQNHVATHLNRQLKRQKISKLEREKIYNHLVPTIDYSAMKNADVVIEAVFEDLPLKHKVIRQIENVVGPNTIIASNTSALPIKDIAAASSRSDKVIGMHYFSPVEKMQLLEIITHDGTSKETLATAAQLGLKQGKLVVVVKD 532
4 -30.300[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  14  51AELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKGAIHFTHPEDLGFEIT-TDDREAVADADFIMTWFPKG-DMQPGIIDKFIDDIKPGAIV-THACTIPTTKFYKIFEEKHETLNVTSYHPGPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLP. 247
5 -12.100[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  18  5KVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHW------KVVEDAGVTVTDNDAEA------------ASEAEIAVLFTPFG-KKTFEIAKNITNHLPEGAVI-ANTCTVSPVVLYYVLERELRIASMH--HGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVP. 196
6 -11.800[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  12  39KIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEK------------------RASFQRATENGFKVGTYEELIPTADLVVNLTPD--KQHSKVVADVMPLMKKDSAFGYSHGF-DITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATG........ 199
7 -11.800[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  10  54RIAIIGFGNYGQFLAETLISQGHILFAHSRSD-----------------------HSSAARRLGVSYFTDLHDLCERHPDVVLLCT--SILSIENILKTLPQRLRRNTLFVLSVKEFAKTLLLQYLPEDFDILCTHMFGPLRFVYDKVRIGEERLRVSRCESFLEIFVREGCEMVEMS. 221
8 -11.100[E] COG0287 Prephenate dehydrogenase  ali follow..  19  9RIALIGIGLIGSSIARDVRELGLARHVV---------ISTRSEDTLKRAEELALGTDYTVSAA----------EAVKDADLVIVSVP--VGASESVAQQIAPYLKPSAIVVGSTKASVIAQMAPHMPENVHFIPGH---PLA--RWCIFTPLPGTDAAALERLKDFWRALGSRVDEMD. 179
9 -11.100[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  13  2QLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKA--------------------AGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKK---GIHLLDVWGRERGYCLMIG---DGDAFARAEPIFATVAPG...... 156
10 -11.000[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  12  7SIAILGAGRVGSSLARSAVAAGYEVKVAGSGAV--------------------DKIALTAEILMPGAVPSTADQAVKDADIVFLAV------PLHKFRSVNPATLEGKIVIDTMNHWSTSEIIAEFFAGSTMVKS--FNHIGYHEIEQAIAYATDDVDAGAQVAQLIKSFGFVPLNIGA 178
11 -11.000[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  13  17LIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAK-------AKARASGFEATTDFSRVSECDALILCV-PDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTLLPRVQEGGLVVGRDIYSP-ETRTIPKVIGG--HTPQCLEVGIALYEQAIDRVVPVSS 210
12 -10.700[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  21  3TIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLAD-----------LVAKGLKTVSGHAAV------------AKAADIIITMVPDTPQVADVLFGDASGLTRGKLVIDMSSISPIETKVFAGKINEL---GCDYLDPVS--SLTIMVGG---EEKAFERAKPVFEKMGKNITLVGP 163
13 -10.400[H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase  ali follow..  11  48GKKVLDIGCGGGILSEAMAQRGASVTGIDMGEAPLAVARLHQLESGVAVDYRQITAEQMAEEMPGQF------------DVVTCLMLEHVPDPASVIRACHRLVKPGGQVFLSTINRNPKAYLFAVIGAEYILGTHFIRPSELGAWSR............................... 193
14 -10.400[H] KOG1270 Methyltransferases  ali follow..  13  91...ILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCH--------KSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIAGTHFVSPETLESILE............................... 236
15 -9.740[O] KOG2018 Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis  ali follow..  14  128FVIVVGCGGVGSWVINMLARSGVKIRIVDFDQVSLSS-----RHSIATLQDVGTPKTLAIKKAIKKFAPWIEVDARGNPDFVIDAI-DNIQTKVDLLSKLPVIASTGSACKSDPTRVNIADISATSEDPLSRATRRRLRLLGIMEGIPVVFSTEKPDPRKASLLPLSEE.......... 312
16 -9.600[R] KOG2820 FAD-dependent oxidoreductase  ali follow..  15  7DVIVVGAGIFGSCTAYHCQRLGLRTLLLEQYSLGHSNGSSH-----SRIIRYAHTDPEYVPLVGDSYLQIEELEKKRGEKLWNKGHLKKHNIDHEVLTKITERYPQTALIDPMGGVIYANKWLKAFQEEFITLGGTIQDNEPVISYVKTSTGEYKTNKIIFTVGCWITKF......... 207
17 -9.460[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  16  5KIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLK----------------------DLQAKLGIRVSTDNAVIVRESDILILAV--KPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEASGIAPGKNATPEDLKAALEIFSAVGTAVQVPES 164
18 -9.390[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  13  3KIGIVGCGFIGGQICRAIDGGEVSAELYALCDSSESKALELAASL------------------TCKPSYMKIEELIRGVDLIIESASQNAVRFIVP----QALKAGCDVMILSVGALADEELRDTLFGLAKEHNCKLYFPSGAVVGIDGLNSASAAG...................... 138
19 -9.390[S] COG5495 Uncharacterized conserved protein  ali follow..  14  13NIAILSTGRVGVALE----RADQVVV---------------------ACSAVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCE---AGLMSGVAVTPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHFSGSDEDLSQCQLFGITKTDDVGYAIAQSLVLEMGGEPFCVVE 174
20 -9.290[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  13  4HIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVV-----------ISPNLSFTTDMKEIHNAFMIVEGVTSAG---RPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSAKEVLNGSPCSVVVSAYDSQTLKQIHEA...... 168
21 -9.270[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  13  4DFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDH-----------------LANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKK--GILFVGEEGARYGPSLMPG---SEEAWPHIKNIFQSISA....... 161
22 -9.200[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  22  37HVCVIGIGGVGSWAVEALARTGIELTLIDMDDVCVTNINRQIHAMTGTI---GKSKIEVMAERVKLINPECKVNLVKSFDYVLDAI-DSLKAKASLLAKIKVITVGGAGGQTDPTQITVADLTKTIQDP.................................................. 181
23 -9.050[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  20  260NVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINA------------------------LQALMDGYSVVTVDEAIEDADIVITATGNKDIISFEQMLKM----KDHALLGNIGHF............................................................... 347
24 -9.030[C] KOG1495 Lactate dehydrogenase  ali follow..  20  22KVTIVGIGQVGMASAFSILAQNVEVCLIDVCADKLQG-------------ELMDLQHGSNFLKNPQITASTDFAASANSRLCISLVQRNTDILKNIIPKLVEYSPDTILLVSNPVDIMTYVAWKLSGLPNRVIGS............................................ 161
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;