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Query: PF03224.14; VATH_ORYSJ/2-323; V-ATPase subunit H, from PfamA32U

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst DHAELTTEQVLKRDIPWESYMANKLISGTCLQLLRRYDHKPESQRGPLLDEDGPSYVRVFLNILRNISKEDTVEYVLALIDEMLAVNPKRAALFYDNSLSGEDIYDPFLRLLLKGNWFVQEKSCKILTQIISARPKMQNGIVPNGEASNSKSKLTSTQDVLRGLVDWLCSQLRNPTHPNCSVPTAMHCLATLLREQYVRALFVQADGVKLLIPLISPASTQQSIQLLYETCLCIWLLSFYDAAVDYLSTTRVMPRLVEVVKGSTKEKVVRVVIMSIRNLLAKGAFAAQMIDLGLPHIVQNLKAQAWTDEDLLDALNQLEIGLLast
1 -49.700[C] COG5231 Vacuolar H+-ATPase V1 sector, subunit H  ali follow..  15  11THFNEIRSIIRSRSVAWDALARSEELSEIDASTAKALESILVKKNIGSGFKVNGKTLIPLIHLLSTSDNEDCKKSVQNLIAELLSSDKYGDDTVKFFQEDPKQLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINI-------------------LQNIEQMDTCYVCIRLLQELAVIPEYRDVIWLHEDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANELVQKSDFLDLLKLVKITIKEKVSRLCISIILQCCSTRVKQQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEIL 346
2 -37.700[C] KOG2759 Vacuolar H+-ATPase V1 sector, subunit H  ali follow..  20  6SVLQQQAADIRTRTINWASYMQSQMISEEDYKAISALDK----SRASFLAQNSSQVVKTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHDTAGKLKQIWGPFLNLLNRQDGFIVNMSSRILAKFACWGHETMPKSD-----------------------------------------------------------------LNFYLQFLKDQLASNNNEYIQSVARCLQMMLRVDEYRFAFVGVDGISTLIRILHDCAKEKVTRIILAVFRNLIEKPDHCIAMVQCKVLKQLSILEQRRFDDEDITADVEYLSEKL 272
3 -25.200[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  10  1....................................................................................................................................................MAQKPKVDPHVGRLGYLQALVTEFQE-TQSQDAKEQVLANLANFAYDPSNYEYLRQLQVLDLFLDSL----SEENETLVEFAIGGLCNLCPDRANKEHILHAGGVPLIINCLS-SPNEETVLSAITTLMHLSPGRSFLPELTATPVVQCMLRFSLS--ASARLRNLAQIFLEDF 167
4 -24.000[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  12  101.........................IQRAASVALGNL-AVNAENKALVVKLNG---LDLLIRQMMS-PHVEVQCNAVGCITNLATLDENKSKIA------HSGALGPLTRLAKSKDIRVQRNATGALLNMTHSYENRQQLVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDATSSPKVQCQAALALRNLASDERYQIEIVQSNALPSLLRLL----RSSYLPLILASVACIRNISIHPLNESPIIDAGFLRPLVDLLSCTENEEIQCHAVSTLRNLAASERNKRAIIEANAIQKLRCLILD--APVSVQSEMTACLAVL 403
5 -22.300[U] COG5064 Karyopherin (importin) alpha  ali follow..  15  93.........................LQLGAVTKFRKYLSKETHPPIDQVIACG--VVDRFVQFLES-EHHLLQFEAAWALTNIASGTTDQTRIVV-----DSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSACRDYVLG------------------NGVLQPLLNILQSSASDVSMLRNATWTLSNLCRKNPPPNWSTISVAVPILAKLL----YSEDVEIIVDACWAISYLS-PNEKIGAILDVGCAPRLVELLS-SPSVNIQTPALRSVGNIVTTDAQTQIIIDCGALNAFPSLLSH--QKENIRKEACWTISNI 359
6 -21.100[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  11  196..........................EQHEDLLLNTLPLLSILTENVSDLNFDSSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILA------KDGLCETIYNLLEKYKTLASTSEARALMKLACE-----------LIVLILTGDDSMHYLYTTPLLKNMVDWL--DSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNGVKDDVRLQHALLSALRNLVIPKPNKNAVIQAGLVQTILPMLE-IHQPPVVFKLLGTLRMTVDGQEKLALELNKTLIEQLVHWSKSS-DYAGVTGESLRLMAWL 473
7 -20.600[S] KOG2973 Uncharacterized conserved protein  ali follow..  10  2..........................................................AIFGLTFD-ANQTVAKDAVLSLINLTSEEEAAIKVFQLAKQPPFAIVEVAAKEITNEQSDLADPWSMVLSNLTRVESLVHEIL----------DTLERDDHTLPRLAKAFAQ--LDYNKKKAKLHYLAPIFCNLTQVSRGRELCCHRKY-ELLEKLLPFASFEGSVVRRGGTIGILKNVCFDTVYHDVIEQSSILVAILQPLTREEDPDLRKMLLECLLQLCSTRRSREILRSRGVYEILREYEAKVGKDSDCLLACENVVDIL 283
8 -19.700[S] KOG2734 Uncharacterized conserved protein  ali follow..  8  72.................AFEFDPELTEEERLNILKYVENEEADGDEKRNLKNQEMRIKFADSPEKFMDSEVELHTVIQELKGVATVPDLYPILV------DLHGLHSLLELLAHQNTDIAVAVVDLLQEVTDVDILGESQEGAESLIEALRKE-----QICALLVQNLERLNEQVKEEADGVHNTLAIVENLTEDSEFVKEAAEQGLLAWLLKRLRGKSPFDPNK-LYCSEILSILIQTENENRLLLGSLDGVDVLLQQLASNEEQEYMQNLFNCLCSALMARENRDRFLSGEGLQLMNLMLREK................. 370
9 -19.700[S] COG5369 Uncharacterized conserved protein  ali follow..  10  397......................DELQSSAACECLLSLSRSVYILRTGLADAD---VSEPLIKLLSD-PDTRVKSTATSAICNLVLKFSPLREKFL-----TTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLK-----------------KIGASKLVELC--NDEDLGVQEQMLQVLRNFTQKEESVDFLLKMVPMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDLRQTKLLLLVKEIMLQEAQREILLAGIWLCINILEDKERASILQNLGFGECLQMLQNH--SSPDVRERVKDALMYI 725
10 -19.700[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  10  397......................DELQSSAACECLLSLSRSVYILRTGLADAD---VSEPLIKLLSD-PDTRVKSTATSAICNLVLKFSPLREKFL-----TTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLK-----------------KIGASKLVELC--NDEDLGVQEQMLQVLRNFTQKEESVDFLLKMVPMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDLRQTKLLLLVKEIMLQEAQREILLAGIWLCINILEDKERASILQNLGFGECLQMLQNH--SSPDVRERVKDALMYI 725
11 -18.600[U] KOG0166 Karyopherin (importin) alpha  ali follow..  10  185.........................VQEQAVWALGNIAGDSTMCRDYVLDCN---ILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKV-----SPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVI-------------------AGVCRRLVELL--MHNDYKVVSPALRAVGNIVTDDIQTQVILNCSALQSLLHLL----SSPKESIKKEACWTISNIT-NRAQIQTVIDANIFPALISILQTA-EFRTRKEAAWAITNATSSAEQIKYLVELGCIKPLCDLLTV--MDSKIVQVALNGLENI 450
12 -18.200[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  12  30....................VASSTLLDDRRNAVRALKSLSKKYRLEV----GIQAMEHLIHVLQTRSDSEIIGYALDILYNIISNEEEEEVEFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIIL----------------VSPMGVSRLMDLL--ADSREVIRNDGVLLLQALTRNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLL-NNSNQNFFKEGSYIQRMKPWFEVGDENQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEV 340
13 -18.100[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  10  1.........................MEDVNFDAAFEFAHYPGAQNETSVKEDRFPLPVIFNALQTDPDIPGFENTLVTCLERLFKTKYGASLI--------PQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVVN--------------NGIYPLLLDYI--INSDDEVANAASETIKSLARFPDAMSVIFPSETN--DPTHLRNLAARCSSLARVRVLSLIVKLF-SRLVASEVKKSGLLDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQTSLIQLLCSIISGTSTGPYEKLRAMMISGRL 276
14 -17.400[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  10  397..ILKLLQLLKVQNED---------VQRAVCGALRNLVFEDNDNKLEVAELNG---VPRLLQVLKQTRDLETKKQITDHTVNLRSRNGWPGAV---AHACNPSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGTIADDKATENCVCILHNLSSNPKGVEWLWHSIVIRMYLSLIA---KSVRNYTQEASLGALQNLTATSVAQTVVQKESGLQHTRKMLH-VGDPSVKKTAISLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSLIETTASACYTLNNI 802
15 -15.800[O] KOG2160 Armadillo/beta-catenin-like repeat-containing protein  ali follow..  12  132.......................................................................................................................................................KNFRTDGELIVQLIDQFRNFSRTLESEMRSKLDCLENLEYLLHQIDNALMFIDNGGLDDV--LLPIVVNDTSTSLRVSAMRVL-LASNNPKAQIKVFEKNFGSHLAQILTSSGNVGEISAALHAFGALLKFPLAQQRVLSTSGTQALIKVLQSPDVELRSKAKVVTLISDL 303
16 -12.900[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  11  550................................ACEGLSYLSLDADVKEWIVDDSLLLKALVLLA-KKAGALCVYTLATIYANLSDEEMVKLAQFAKHHVPETHPKDTEEYVEKRVRALVEEGAVPACVAVSKTESKNALELIARSLLAFAEYEDLRGRIIAEGGTVLCLRLTKEASGEGKIK--AGHAIAKLGAKADPMISFPGQRAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLSVSDSIRGRILKEKAIPKIEEFWFMTDHEHLRAAAAELLLNLLFFEKFYEETVAPGTDRLLWVLYSAEVEEERLSRASAAGFAIL 846
17 -11.900[R] KOG0567 HEAT repeat-containing protein  ali follow..  10  23.........................ERFRALFTLKNIGGAAIEAISKAFDDDSALLKHELAYCLGQMQDAQALDILTKVLKDTTQEPMVRHEAAEAMAIGHPDVLPILEEYKQDPVVEVAETCAIALDRVRWLQSGQKVDDSNPYASVDPSPPTAGDKS-----VTELKAIYLDAQQSLFDRYRAMFSLRNL--------------RTEESVLAIAEGLKDSSALFRHEVAFVL----------GQLQEPCSIPFLQENLEDRLENEMVRECAEALGAIATED----------CIQILNRYAED--DKRVVKESCVIALDMC 281
18 -10.600[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  8  597.................................................AGKGEKAIAKLKELNEKQDAFQLNPDQINGLEELFV--------LPTSSNYSSEVTQSAFEMSLQWPVEHLTPVLDFLRIALTHHSLNSYFC---------------DRERGQELVGRLIAILVSDPADVALKVLVCRCIANAFSHPVGRNLFAST--LSTLAPLVVRQVLNEKTVLQMSAATALANWSLSEQCEQLGPKEDLLRAILNGIESYLGEDAIIRLLQALVTVMWGDASVIRLAKNRNIAQIAARLKDAVSNDSGKNIARDIVEMT 855
19 -9.840[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  9  815...............................QIVSTILYR--NNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKARDLLPRLTPILRNRHEKVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLATLLNNLKV--QERQNRVIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMD-RDAVHRQTAASVIKHLS---LGCVGLGVEDAMIHLLNILWPNILEESVREGIDGIRNCI 1125
20 -9.630[U] COG5215 Karyopherin (importin) beta  ali follow..  8  7......................AQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENKLEGRILAALTLKNELVSKDSVKTQQFAQREAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGA----------------------PELMKIMVDNTGAEQPE-NVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGASTETSKAVRLAALNALADSLIKNNMEREGERNYLMQVVCEATQAE-DIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWST.. 292
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zmasek CM, Zhang Q, Ye Y, Godzik A. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007 Oct 24;8(10):R226 [Epub ahead of print]