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Query: PF02826.19; Q98GE4_RHILO/107-283; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, from PfamA32U

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFTALALLRQFRRVDRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVGHIAAHGFDLKVVATTRSMQPAPEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDDALIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMALast
1 -72.300IDP02277 glycerate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1434 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  31  107FALLLAAARRIPEGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAK-RAKAFGMNILYTGPNRKPEELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEP-KITEELKGLKNVVLAPHVG 284
2 -65.500IDP00460 gene: serA; D-3-phosphoglycerate dehydrogenase YPO0914 [Yersinia pestis CO92]  ali follow..  32  117LGELLLMFRGIPSANAKAHRGEWNKLA---VGSFEARGKKLGIIGYGHIGTQLGI-LAESIGMKVFFYDIENKLSGNAQQVRQLSDLLNMSDVVSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVFPEEPAPFNSPLCEFDNVLLTPHIG 294
3 -65.200IDP91791 gene: vanH; vancomycin resistance protein [Enterococcus faecium] AAA24789 [Enterococcus faecium]  ali follow..  36  112MMLILMAVRNVKSIVRSVEKHDFRL---DSDRGKVLSDMTVGVVGTGQIGKAVIER-LRGFGCKVLAYSRSRSI---EVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQGAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEQFLLKLQRMPNVIITPHTA 294
4 -52.900IDP00951 gene: ycdW; putative oxidoreductase STM1135 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  26  104VSQVLHWFRRFDDYQALKNQALWKPLPEY-----TREEFSVGIMGAGVLGAKVAE-SLQAWGFPLRCWSRSRKSWPGVESYVELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIA 277
5 -52.000IDP90773 erythronate-4-phosphate dehydrogenase [Vibrio cholerae O1 biovar eltor str. N16961] VC2108 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  30  107FSVLMVLAQQQ---------------------GFSVFDKTVGIIGAGQVGSYLAK-CLSGIGMKVLLNDPPKQAQGDEREFTELETLLKQADVITLHTPITRPTHHLIDAAILEQLRSDQILINAARGPVVDNAALKARLQQGDGFTAVLDVFEFEP-QVDMELLPL-LAFATPHIA 263
6 -50.300IDP90820 gene: pdxB; erythronate-4-phosphate dehydrogenase [Salmonella typhimurium LT2] STM2370 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  30  100FSALLMLAERD---------------------GFSLRDRTIGIVGVGNVGSRLQT-RLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEP-DLNVALLEAVD-IGTSHIA 256
7 -50.200IDP04474 gene: pdxB; putative D-isomer specific 2-hydroxyacid dehydrogenase [Yersinia pestis CO92] YPO2763 [Yersinia pestis CO92]  ali follow..  25  100FSALMMMAERD---------------------GFQLRDKTVGIIGVGNVGSRLNA-RLQALGVRTLLCDPPRADRGDNEAFWPLEKLVREADVLTFHTPLNKQSLHMADDELLAALPDGRILINACRGAVVDNAALLRALEKGKKLSVVLDVWEPEP-DLSLPLLARVD-IGTPHIA 256
8 -16.100IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  15  14...................................LQGKTVAVIGYGSQGHAQAQ-NLRDSGVEVVVGVRFEVAKADGFEVMSVSEAVRTAQVVQMLLP-DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPS...................................... 119
9 -14.200IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  13  16...................................IKSKKVAIIGFGSQGHAHAMNLRDN-GVNVTIGLREGSVKNAGFEVVSVSEASKIADVIMILAP-DEIQADIFNVEIKPNLSEGKAIAFAHGFNI............................................... 113
10 -13.700IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  17  15...................................LKEKKVAIIGYGSQGHAHANLRDNGFDVVVGLRKGKDKAKEDGFSVYTVAEAAKQADVVMILLP-DELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPV...................................... 120
11 -13.700IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali follow..  19  263................................IQMLAGKKIVVLGYGEVGKGCAQ-GLSGVGARVIVTECALQASMEGYQVSVLEDVVSEADIFIT----ATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCK........ 398
12 -11.800IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  24  249................................DVMLGGKRVVICGFGDVGKGCAA-AMKGAGARVVVTECALQAAMEGYSVSTLESQLATADIFISAT----GNKDIITARHMSQMKNNAIVGNIGH---FDNEVDMAGLLA................................... 354
13 -10.900IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  20  35...................................LKGKKVVIVGCGAQGLNQGLMRDSGLDVSYALRQAAIDEQRQGFNVGSYEQLIPTADLVINLTP--DKQHTSVVNAVMPLMKQGAALGYSHGFNIVAPKCPGTEVREEYKRGFGVPTL........................ 174
14 -10.500IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  15  15......................................KKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELVDLQHACEEAHLIVFASPV-EETKKLLHKLASFHLREDVIVTDVGKGSIMNEAEALFSKEISFIGGHPMAGSHKTGVESAKALFENAFYILTP... 159
15 -10.300IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  13  1...................................MTKANFGVVGMAVMGRNLALNIESR-GYTVAIYNRSKEKTEDVIASYDVESFVNSIEKPRRIMLMVQAGPGTDATIQLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGV......................... 127
16 -9.970IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  15  1...................................MENLQIGVVGVGVMGKSLALNFESK-GYSVALYDISKEKVDETIETHIVEEFVNSLESPRKILLMVNAGEITDKAIDVPHLDKGDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGV......................... 127
17 -9.880IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  14  2.......................................KIGWIGLGAMGTPMATRLRDA-GLEVSVYNRTESKAAPLKEKTSPIDLAAKVDLVFTMLSDKAAIDAVL-APKFWEQMSKKIVVNMSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGALLIL.......... 132
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205