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Query: PF15961.5; ZN839_HUMAN/7-805; Domain of unknown function (DUF4764 topsan), from PfamA32U

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst IQPQTARKSQLPRGNSCLVGLHIASPQLLRVQPLVRTEPQSCFLSDLCQPPAQGFVQRPLPALQVVPAKRVPAPKAPDEQGSMLTPLSASDPLAVTSLSSSSAHPFISNLHTRHTEKLKKSLKVKTRSGRVSRPPKYKAKDYKFIKTEDLADGHLSDSDDYSELCVEEDEDQRERHALFDLSSCSLRPKSFKCQTCEKSYIGKGGLARHFKLNPGHGQLDPEMVLSEKASGSTLRGCTEERTLSLTSLGLSMPADPCEGGARSCLVTESARGGLQNGQSVDVEETLPSEPENGALLRSERYQGPRRRACSETLAESRTAVLQQRRAAQLPGGPAAAGEQRASPSKARLKEFLQQCDREDLVELALPQLAQVVTVYEFLLMKVEKDHLAKPFFPAIYKEFEELHKMVKKMCQDYLSSSGLCSQETLEINNDKVAESLGITEFLRKKEIHPDNLGPKHLSRDMDGEQLEGASSEKREREAAEEGLASVKRPRREALSNDTTESLAANSRGREKPRPLHALAAGFSPPVNVTVSPRSEESHTTTVSGGNGSVFQAGPQLQALANLEARRGSIGAALSSRDVSGLPVYAQSGEPRRLTQAQVAAFPGENALEHSSDQDTWDSLRSPGFCSPLSSGGGAESLPPGGPGHAEAGHLGKVCDFHLNHQQPSPTSVLPTEVAAPPLEKILSVDSVAVDCAYRTVPKPGPQPGPHGSLLTEGCLRSLSGDLNRFPCGMEVHSGQRELESVVAVGEAMAFEISNGSHELLSQGQKQIFIQTSDGLILSPPGTIVSQEEDIVTVTDAEGRLast
1 -20.200IDP91521 C2 domain-containing protein [Toxoplasma gondii ME49] TGME49_040910 [Toxoplasma gondii ME49]  ali follow..  7 1267.............................ERRRILAQKEKQSREDAQRKARKQRRKAGHEGADNGAEDKQGAEGNEEEHGDAAAAAVAEESVSAEAVQGDEEPKKVVKKGAVPRVKKRSYDQVEGTEVAAIDFFTEAEAPDFKNLMSD--VEHAINTHLGLSPGRVRAFQARYAEKRIVFAVGPPMDDAT------------------------EADAVSSVALMEKLRDILPSMAHEEGRFQEVTGGGATLQWDGPGTNILDRIAQEQATAGEGEQQTSEGIPTRDMQVDGTAVLEEAGEKSDKKKKKKEKKEKKEKKEKKEKKEKKEKKKKKGGETAAEPEEASAVLA--VPVPAAAIPSVLLPADSE-----------DGEKEQPKEKKKEKKEKKKKKDGETDAEPEEASAVLAPPPVPVPAAAIPSILLPTDGEDGEKEKTKEKKTEKKKEKHTEKKHKKKSEALPESETTAVVTVTPGEEDETSPLVPVPSSIASSEAPEPPASTRVTPAPEPKAKPGLSMGAALLAVRARSRLQRKHLAQQLSSSSSSEVSASSASSLSPSSSSSSDFAETRAKADALRARLQAAQARLAAARETEVSSSETESSETSEASFLSSDGEWDALWQSQRAAAMERQQRLQKMVSGVKAAYRRLEEENTRLAATRRRDDKLQRQVEAERERAVELLKEATRRAKEEKDLIARQPPPARDWSDTVVLSTPQIFVNSQAACAPFADSGRDEGGRDEWYEVSDACSRRAESSNES-----------TTAGAKLRQQQ-----LDLAGR 1989
2 -13.100IDP91679 gene: vIRF-3; vIRF-3 [Human herpesvirus 8] HHV8GK18_gp64 [Human herpesvirus 8]  ali follow..  10  2....................................................................................................................................................................................................................................................................................................................................................AGRRLTWISEFIVGA-DRSTGTFLAP---DSLQFFIFKRECLSKGLHPRDLLGSPITAFGKICTTSRRL----------------RLPGEEYEVVQGIN--CRRWRLLCAEVKECWWCVHARTHLHSGSSLWEILYQHSVRLEKHRRRPRPFVGENSDSSEEDHPAFCDVPVTQTGAESEDSGDEGPSTRHSASGVQPVDDANADSPGSGDEGPSTRHSDSQPPPADETTVHT-----------DNVEDDLTLLDKESACALMYHVGQEMDMLMRAMCDEDLFDLLGIPEDVIATSQPGGDTDASGVVTEGSIAASAVGAGVEDVYLAGALEAQNVAGEYVLEISDEEVDDGAGLPPASRRRPVVGEFLWDDGPRRHERPTTRRIRHRKLRSAYYRVARPPVMITDRLGVEVERKVFILCSQNPLRVLLPKPD---VNLLAAVLRSASGLVIVSLRSG. 481
3 -11.200IDP92687 Ser-Asp rich fibrinogen/bone sialoprotein-binding protein SdrE [Staphylococcus aureus subsp. aureus str. Newman] YP_001331559 [Staphylococcus aureus subsp. aureus str. Newman]  ali follow..  10  1.........................................................................................................................................................................................................................................................................................................................................................................................MINRDNKKAITKKGMSNRLNKFS-----IRKY--------------TVGTASILVGTTLGLGN-----------------------QEAKAAENTSTENAKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNVTATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQTKPTTPQESTNIENSQPQPTPSKVDNQVTDATNPKEPVNVSKEELKNNPEKLKELVRNDSNTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTIKVGDGKDNVAAAHDGKDIEYDTE------TIDNKVKKGDTMTINYDKNV--------------IPSDLTDKNDPIDITDPSGEVIAKGT... 361
4 -10.400IDP92699 Ser-Asp rich fibrinogen/bone sialoprotein-binding protein SdrE [Staphylococcus aureus subsp. aureus USA300_TCH1516] YP_001574462 [Staphylococcus aureus subsp. aureus USA300_TCH1516]  ali follow..  8  1.........................................................................................................................................................................................................................................................................................................................................................................................MINRDNKKAITK-MISNRLNKFS-----IRKY--------------TVGTASILVGTTLGLGNQEAKAAENTSTENAKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNVTATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQTKPTTPQESTNIENSQPQPTPSKVDNQVTDATNPKEPVNVSKEELKNNPEKLKELVRNDSNTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTIK.................................................................................................................. 292
5 -10.400IDP06413 gene: vIRF-2; vIRF-2 [Human herpesvirus 8] YP_001129414 [Human herpesvirus 8]  ali follow..  8  1............................................................................................................................................................................................................................................................................................................................................................................MPRYTESEWLTDFIIDALDSGRPGRNRRERMPEGFDDFYEAFLEERRRHGLPEIPETETGLTANRARQERPFTIYKGVYLTQEPAMKNMLKALFGIYPHDDKHREKALRRSLRKKAQREAARKQAAAVATPTTSSAAEVSSRSQSEDTESSDSENELWVGAQGFVGRDMHSLFFEEPEPSGFGSSGQSSSLLAPDSPRPSTSQVQGPLHVHTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPATHPLESSAPGASVMGSGQELPDLGDLSELLCETASPQGPMQSEGGEEGSTESVSVLPATHPLESFQASDNVDDFIDC--VPLVVETGGIVICSQVQTLDRFSMGVVAIGTNMG. 595
6 -8.050IDP05002 hypothetical protein lmo0086 [Listeria monocytogenes EGD-e] lmo0086 [Listeria monocytogenes EGD-e]  ali follow..  9  1...........................................................................................................................................................................................................................................................................................................................................................MKKNI-------LVVIIVSVLAAIVSA--FFLMRIETEGFTYSPKGKVVD-FSSEAKYNDTWINNEKTITDKKEMKPINLKDGRIQ-FLGKSVAVKSASDLIELPSKTSITESKGSYKAKSDSNKTLAQLPKGTVVKLAE-KNKQGLNKKLPKNVLVSIDENKKVMLMGDKTIEELGGDDAYIEMENNHYHFDLKKEMLVSQTAKETDIDIRSIKVEIDDNAEKRSLKTAKETEKETTKDSTEKESEKQSNDASGQKSAQNNERSESKDDQTQDASGNNTNGSANNNTARSNGTGGSNSDTNGSQPGGTQNKPNEGDKANEIIKKLNEAENTNTFQVPIVDVNLTVKGQVAAAKLKLTDSSKRLNSLEAILYDSKNNIVKKEKLNSTKANQNNNLKYGETYQVVVQGSYKSASNKNQDTIFFREAKPVVLTPKVTERGEDYMKAELTATE.. 470
7 -7.840IDP91949 pneumococcal histidine triad protein E [Streptococcus pneumoniae str. Canada MDR_19A] SpneCM_010100007099 [Streptococcus pneumoniae str. Canada MDR_19A]  ali follow..  10  767.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PKLNQGTTRTAGNKIPVTFMANAYLDNQSTYIVEVPILEKENQTDKPSILPQFKRNKAQENSKLDEKVEEPKTSEKVEKEKLSETGNSTSNSTLEEVPTVDPVQEKVAKFAESYGMKLENVLFNMDGTIELYLPSGEVIKKNMADFTGEAPQGNGENKPSENGKVSTGTVENQPTENKPADSLPEAPNEKPVKPENSTDNGMLNPEGNVGSDPMLDPALEEAPAVDPVQEKLEKFTASYGLGLMDGTIELRLPSGEVIKKNLSD-LI....................... 1038
8 -7.480IDP93859 pdu and cob operons regulatory protein [Yersinia enterocolitica subsp. enterocolitica 8081] YP_001006917 [Yersinia enterocolitica subsp. enterocolitica 8081]  ali follow..  16  183.................................................................................................................................................................................................................................................................................................................................................IRPVHPHDSKMKKALRYIDTHLSEELRLEEVAAKVYL-------------SPYYFSKLFKKFNAWVNQQRANAREMLQHSD------WSIA--SIAKNLGFSQTSY--RQTYNVTPQVFRSLSSERSEME............................................................................................................................................................................................................................................................................................................................................ 300
9 -7.340IDP00185 hypothetical protein YPO0639 [Yersinia pestis CO92]  ali follow..  11  16................................................................................................................................................................................................................................................................................................................................................................DNLAPEEYERIISPHAARICREYEF-MREREQRSSPDQPRPGGIREKEKLEKLVFSGDVVMLSDMYG--ARLFYINGE--GQLMSTDPHAFRFEGAAK----------------------------------------IKAFDDSVKCRNYQRTGGKPRSTQTRRLKSTTNTIPDRSMVTRASDESGRVLSAKWQSVTDSAKTLWEATPFTHDKATTEAARGRIADGAVGTLEGLGTLMGPSAQEYMAGAFNPEQAAINKVRQQNQQAAGKAIYDNTKGAVTDAYQRNGLAGAAAMVVTASVAELAGTKLGTVEKVGTLGDVAKLGKAVELEKLEGYLGTYKGQKVLLQNVDVVKMDYVRRSTADRNLLRKEFDNGVR-----KKFLKDIANNPEVVKRLDAFDRSVLAKG------VVPDGYQVHHKLPLNNNFDNLVLIST.... 423
10 -7.220IDP90350 hypothetical protein CT456 [Chlamydia trachomatis D/UW-3/CX] CT456 [Chlamydia trachomatis D/UW-3/CX]  ali follow..  6  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................MTNSISGYQPTVTTSTSSTTSASGASGSLGASSVSTTANATVTQTANATNSAATSSIQTTGETVVNYTNSASAPNVTVSTSSSSTQATATSNKTSQAVAGKITSPDTSESSETSSTSSSDHIPSDYDDVGSNSGDISNNYDDVGSNNGDISSNYDDAAADYEPIRTTENIYESIGGSRTSGPENTSGGAAAALNSLRGSSYSNYDDAAADYEPIRTTENIYESIGGSRTSGPENTSGGAAAALNSLRGSSYSNYDDAAADYEPIRTTENIYESIGGSRTSGPENTSDGAAAAALNSLRGSSYTTGPRNEGVFGPGPEGLPDMSLPSYD---MLENSGHFV-------TDRSSFILVPNGN.. 372
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.