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Query: PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, from PfamA32U

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst GGSLGRDAATGRGVMYATEALLTEYSESISGSTFVIQGLGNVGSWAAKLIHQKGGKIVAVGDVTGAIRNKSGIDIPALLKHRSEGGSLEDFYGAEVMDAAELLVHECDVLVPCALGGVLNRENAAEVKARFIIEGANHPTDTEADEILAKKGVIVLPDIYANSGGVVVSYFEWVQNIQGFMWDEEKVNRELQKYMKNAFQNIKDMCKSQNCNLRMGAFTLGVNRVAKATLLRGLast
1 -68.800sp|P00367|DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens GN=GLUD1 PE=1 SV=2  ali follow..  36  263GGIHGRISATGRGVFHGIENFINEATPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGF-PKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTVHSGLAYTMERSARQIMRTAMKYNLDLRTAAYVNAIEKVFKVYNEAG 554
2 -67.300sp|P49448|DHE4_HUMAN Glutamate dehydrogenase 2, mitochondrial OS=Homo sapiens GN=GLUD2 PE=1 SV=2  ali follow..  35  263GGIHGRISATGRGVFHGIENFINEASPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPK-AKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGLDLRTAAYVNAIEKVFKVYSEAG 554
3 -10.800sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   14  54..................EISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTG---DLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTGGSIEFMTE-CTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFG............ 266
4 -9.670sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   17  74...........................KVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAKEVDILISTALKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHLPSRMATQASTLYS................................................................ 239
5 -9.140sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   17  78................ILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVT-------------EIDPICALQACMDGFRLVKLNEVIRQVDI------VITCTGNKNVVTREHLDRMKNSCIVCNMGH............................................................................................... 180
6 -8.970sp|A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens GN=UBA6 PE=1 SV=1  ali   11  53......................DTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTE--KCQAWDLGTNFFL----SEDDVVNKRNRAEAVLKHIAELNPYVHV-TSSSVPFNETTDLSFLDKVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLT............. 246
7 -8.900sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  14  230GGIRGIVEESVTGVESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYIT-------------EIDPICALQACMDGFRVVKLNEVIRQVDV------VITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWER-VLLAEGRLL.................................................................. 443
8 -8.830sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   14  31...............................RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKN-------QIEQLGKKYNINPVSMDICKQEEKLGFLVAKQDLVILLPYVLHPLV-AKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPG..................................................................... 156
9 -8.810sp|Q8IZV5|RDH10_HUMAN(removed signalp:1-23) Retinol dehydrogenase 10 OS=Homo sapiens GN=RDH10 PE=1 SV=1  ali follow..  11  1..................RWLVRPKEKSVAGQVCLITGAGSLGRLFALEFARRRALLVLWDINTQSNEETRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAG-ECPDELIERTMMVNCHFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIR. 234
10 -8.770sp|Q9UBT2|SAE2_HUMAN SUMO-activating enzyme subunit 2 OS=Homo sapiens GN=UBA2 PE=1 SV=2  ali   15  1..............MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLD--------IDVSNLNRQFLFQKKHVGRSKAQ-VAKESVLQFYPKANIVAYHDSIMNPDYNVEFQFILVMNALNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTI............................................................... 151
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.