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Query: PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain, from PfamA32U

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst APQVGAYHLMAANGGRGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVYRLast
1 -60.700sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   22  53AVVLAANHFGRFFTGQI---TAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKP----GELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDFDFGTMGHVIRGTVVMKDGKVIFP 287
2 -42.900sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   14  41..SSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHEHLVRKTDAVYDPAEYDKHPERYISRFTDIAPYTTCLINGIYWEQNTPRLLGVEGCPALPHKLVAICDISADTGGSIEFMECTTIEHPFCMYDGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLES---QNFSPVVRDAVIT.. 300
3 -37.400sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   24  2..................................................................................KLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKP----GELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKFYFDVKDDFDFGTMGHVIRGTVVMK 130
4 -28.000sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   16  1.........................................................................................PYTTCLINGIYWEQNTPRLLTRQDAPALPHKLVAICDISADTGGSIEFMECTTIEHPFCMYDGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNVVRDAVITSNGTLPDK 158
5 -15.500sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   19  203AVVLAANHFGRFFTGQIT---AAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKE......................................................................................................................... 291
6 -13.100sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   13  32.............................KVLVLGSGYISEPVLELSRDGNIEITVGSDMKNQIEQLGKKYNPVSMDICKQEEKLGFLVAKQDLVISLL------PYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNMNVMQSATYLLDGKVV.. 224
7 -12.200sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   21  90.........................FGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDG---------RLVKLNEVIRQVDIVITCT-----GNKNVVTREHLDRMKNSCIVCNMG..................................................................................... 179
8 -11.300sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  22  309.........................FGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDG---------RVVKLNEVIRQVDVVITCT-----GNKNVVTREHLDRMKNSCIVCNMG..................................................................................... 398
9 -10.500sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  16  1.........................MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVAQSLKEMVSKLKKPRRII--LLVKAGQAVDDFIEKLVPLLDTGDIIID------GGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFV.. 183
10 -10.400sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4  ali follow..  21  211.........................IAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEG---------EVTTMDEACQEGNIFVTTT-----GCIDIILGRHFEQMKDDAIVCNIG..................................................................................... 300
11 -10.300sp|P30043|BLVRB_HUMAN Flavin reductase OS=Homo sapiens GN=BLVRB PE=1 SV=3  ali follow..  21  1.........................MAVKKIAIFGAGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVARNIVAAMKAHGVDKVVACTSAF................................................................................ 113
12 -10.300sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  21  29.............................HVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKSTDAASVVHSTDLVVEAIVENLKVKNELFKRTIFASNTSSLQITSIANATT--VEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMELYERGDASKEDIDTAMKLGAGYPMGPF... 259
13 -9.700sp|Q5VVY1|NTM1B_HUMAN Alpha N-terminal protein methyltransferase 1B OS=Homo sapiens GN=METTL11B PE=2 SV=2  ali follow..  14  108..................FVGGPGRAGTDCALDCGSG-IGRVSKHVLLPVFNSVELVDMMESFLLEAQNYLQVKESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLASRCRDGLKENGIIIDNVAREGCILDLTRDMDILRSLIRKSGLVVLGQEGFPEQCIPVWMFAL........................................ 277
14 -9.600sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   17  121.AFFAERKANKWSTPSGASWKTASARPVSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGKELGGVDLVIEAVF-EEMSLKKQVFAELSAVCKPEAFL----CTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLL................................................ 293
15 -9.590sp|Q13363|CTBP1_HUMAN C-terminal-binding protein 1 OS=Homo sapiens GN=CTBP1 PE=1 SV=2  ali follow..  17  171........................RIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSD--------GVERALGLQRVSTLQDLLFHSDCV--TLHCGNEHNHHLINDFTVKQMRQGAFLVNTA--RGGLVDEKALAQALKE--RIRGAALDVHESEPFSFSQGPLKDAPNLICPHAAWYSEQASIEM--REEAAREIRRAITGRI... 343
16 -9.530sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   19  2................................VVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGKELGGVDLVIEAVF-EEMSLKKQVFAELSAVCKPEAFL----CTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKK.......................... 165
17 -9.480sp|P56545|CTBP2_HUMAN C-terminal-binding protein 2 OS=Homo sapiens GN=CTBP2 PE=1 SV=1  ali follow..  17  177........................RIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQD--------GIERSLGVQRVYTLQDLLYQSDCV--SLHCNNEHNHHLINDFTIKQMRQGAFLVNAA--RGGLVDEKAFSFAQGPLKDAPNLICTASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPHPELNGATYRYPPGIV.. 392
18 -9.430sp|P09417|DHPR_HUMAN Dihydropteridine reductase OS=Homo sapiens GN=QDPR PE=1 SV=2  ali follow..  10  1..................MAAAAAAGEARRVLVYGGGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKKVDAILCVAWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAAGAVHQLCQSLAGKNSGMPPGAAAIAV--LPVTLDTPMNRKSMPEA---LEFLVETFHDWITGKNRPSSGSLIQVVTT.... 233
19 -9.400sp|Q9BV86|NTM1A_HUMAN Alpha N-terminal protein methyltransferase 1A OS=Homo sapiens GN=METTL11A PE=1 SV=3  ali follow..  13  52.................FLREGPNKTGTSCALDCGAG-IGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEERNYFCCGLQDFTPEPDSYDVIWIVIGHLTDQHLAEFLRRCKGSLRPNGIIVDNMAQEGVILDVCRDLDVVRRIICSAGLSLLAEENLPDEIYHVYSFAL........................................ 222
20 -9.270sp|Q9Y2Z2|MTO1_HUMAN Protein MTO1 homolog, mitochondrial OS=Homo sapiens GN=MTO1 PE=1 SV=2  ali   30  29....................SAAPRTPHFDVIVIGGGHAGTEAATAAARCGSRTLLLTHRVDT...................................................................................................................................................... 71
21 -9.260sp|Q9UBQ7|GRHPR_HUMAN Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1  ali follow..  15  150........................GLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVS--------TPELAAQSDFIVVACSL-TPATEGLCNKDFFQKMKETAVFINIS--RGDVVNSPEPLPTNHPLLTLKNCVI--LPHIGSATHRTRNTMSLLAANNLLAGLRGE.......................... 320
22 -9.190sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   15  63.............................HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFEFEKADMVIEAVF-EDLSLKHRVLKEVEAVIPDHCIF----ASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLK.......................... 231
23 -9.020sp|Q9H1A3|METL9_HUMAN(removed signalp:1-18) Methyltransferase-like protein 9 OS=Homo sapiens GN=METTL9 PE=2 SV=1  ali follow..  14  119..................LLKINPDWKTHRLLDLGAGD---EVTKIMSPHFEEIYATELSETMIWQLQKKK-----YRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPGRVILALVLPFHPYVENVGGEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV.......... 300
24 -9.000sp|Q9H903|MTD2L_HUMAN Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 OS=Homo sapiens GN=MTHFD2L PE=2 SV=2  ali follow..  20  146........................QTFGKNVVVAGRSKN----------VGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAA------IPKLITSDMV---KEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVPMTVAMLLKNTLLAAKKII............................. 288
25 -9.000sp|O43709|WBS22_HUMAN Uncharacterized methyltransferase WBSCR22 OS=Homo sapiens GN=WBSCR22 PE=1 SV=2  ali follow..  13  44.................LELLYLPENKPCYLLDIGCG-TGLSG-SYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGS................................................................................ 157
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.