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Query: PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA, from PfamA32U

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVGLast
1 -17.900sp|Q6NXP6|CN148_HUMAN Pyrroline-5-carboxylate reductase-like protein C14orf148 OS=Homo sapiens GN=C14orf148 PE=2 SV=2  ali follow..  18  79VGIIGGGHLGKQLAGTLLQLGESLRISTRRPETLGELQKLGI--------------KCFYHNADLVSWADVIFLCCLPSQLPNICVEIYTSKASIVYSFVAAIPLPRLKLLLNHTNIL............................... 188
2 -17.200sp|Q658P3|STEA3_HUMAN Metalloreductase STEAP3 OS=Homo sapiens GN=STEAP3 PE=1 SV=2  ali follow..  14  31VGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQ---------------EEAVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPTNAEYLASLFPTCTVVKAFNVISAWTLQAGPALAMGFMPVDMGSLA. 196
3 -16.500sp|Q8NFT2|STEA2_HUMAN Metalloreductase STEAP2 OS=Homo sapiens GN=STEAP2 PE=1 SV=3  ali follow..  14  33VGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTH---------------HEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMNAEYLASLFPDSLIVKGFNVVSAWALQLGPARQLNFIPIDLGSLS. 196
4 -16.100sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens GN=STEAP4 PE=1 SV=1  ali follow..  13  22VCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGA----------------EVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLNAEYLAHLVPGAHVVKAFNTISAWALQSGAVRNLGLTPMDQGSLM. 184
5 -12.900sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  13  6IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVG------AQSLKEMVSKLKKPRRIILLVKA-AVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGN... 146
6 -12.400sp|Q8N335|GPD1L_HUMAN Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens GN=GPD1L PE=1 SV=1  ali follow..  11  8VCIVGSGNWGSAVAKIIGNNASTVKMWVFEEKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEK........ 162
7 -12.300sp|Q53H96|P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens GN=PYCRL PE=1 SV=2  ali follow..  12  11VGFVGAGRMAGAIAQGLIRAGQHILASAPTDRNLCHFQALGCRTTHSNQE--------------VLQSCLLVIFATKPHVLPAVLAEVAPVTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAI............... 136
8 -12.000sp|P21695|GPDA_HUMAN Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic OS=Homo sapiens GN=GPD1 PE=1 SV=4  ali follow..  14  6VCIVGSGNWGSAIAKIVGGNDPRVTMWVFEEDLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEK........ 160
9 -11.900sp|O15229|KMO_HUMAN Kynurenine 3-monooxygenase OS=Homo sapiens GN=KMO PE=1 SV=2  ali follow..  15  11VAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDL--------LTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVLIVGC-DG 168
10 -11.800sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   14  150VGVVGLGTMGRGIVISFARARIPVIALATANKMITSVLEKEASKMQQSGHPWSGPKPRLTSSVKELGGVDLVIEAVEMSLKKQVFAELSAVCKPEAFLCTNALDVDEIASSTDRPHLVIGT............................ 281
11 -11.700sp|P30043|BLVRB_HUMAN Flavin reductase OS=Homo sapiens GN=BLVRB PE=1 SV=3  ali follow..  9  6IAIFGAGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGD-------VLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAGVDKVVACTSAF.................................... 113
12 -11.300sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  14  30VTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVE---NELFKRLDKFAAEHTIFASNSLQITSIANATTRQDRFAGL............................ 169
13 -11.000sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1 PE=1 SV=3  ali follow..  15  270IGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEG--------------ARLGRTPAEVVSTCDITFACVSDPKAAK-----------DLVLGPSGV-----LQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLAPVSG 389
14 -10.900sp|Q14534|ERG1_HUMAN(removed signalp:1-43) Squalene monooxygenase OS=Homo sapiens GN=SQLE PE=2 SV=3  ali follow..  10  83VIIVGAGVLGSALAAVLSRDGRKVTVIERDLKVGEFLQPGGYHVLKDLGLGDTVEEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFI-------EGVVLQLLEEDDVVMGVQYKDKETGDIKELH----APLTVVA-DG 243
15 -10.600sp|O94851|MICA2_HUMAN Protein MICAL-2 OS=Homo sapiens GN=MICAL2 PE=1 SV=1  ali   13  89CLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGS---------IDHISIRQLQLILFKVALMLGVEI---HVNVEFVKVLE--PPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGA-DG 224
16 -10.600sp|Q7RTP6|MICA3_HUMAN Protein MICAL-3 OS=Homo sapiens GN=MICAL3 PE=1 SV=2  ali   12  89CLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDARNNVLHLWPFTIHDLRGLGAKKFYGKFCAGA---------IDHISIRQLQLILLKVALILG---IEIHVNVEFQGLIQ--PPEDQENERIGWRALVHPKTHPVSEYEFEVIIGG-DG 224
17 -10.400sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  15  314VVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPEGKRVVLLAEG............................................... 440
18 -10.400sp|Q9Y6N5|SQRD_HUMAN Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1  ali follow..  12  46VLVLGGGSGGITMAARMKRGAENVAIVEPSERHTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFKEGNAIFTFPNTPVK...................... 200
19 -10.400sp|Q6NUM9|RETST_HUMAN(removed signalp:1-18) All-trans-retinol 13,14-reductase OS=Homo sapiens GN=RETSAT PE=2 SV=2  ali follow..  35  52VVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKCCHTFGKNGLEFD........................................................................................................ 99
20 -10.200sp|Q9Y2Z2|MTO1_HUMAN Protein MTO1 homolog, mitochondrial OS=Homo sapiens GN=MTO1 PE=1 SV=2  ali   23  39VIVIGGGHAGTEAATAAARCGSRTLLLTHRVDTIGQMSCNPS........................................................................................................... 80
21 -10.000sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  14  42VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAG--------------EQVVSSPADVAEKADRIITMLPTSINAIEANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVG.... 176
22 -9.850sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4  ali follow..  14  216AVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENNGRRIILLAEG............................................... 342
23 -9.830sp|O60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase OS=Homo sapiens GN=UGDH PE=1 SV=1  ali follow..  12  7ICCIGAGYVGGPTCSVIAHMCPEVTVVDVNESRINAWNSPTLPIYEPGESCRGKNLFFSTNIDDAIKEADLVFISVNTKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESI..................................... 140
24 -9.820sp|Q8TDZ2|MICA1_HUMAN NEDD9-interacting protein with calponin homology and LIM domains OS=Homo sapiens GN=MICAL1 PE=1 SV=2  ali   27  87CLVVGAGPCGLRVAVELALLGARVVLVEKRTKFIHDLRALGAK.......................................................................................................... 141
25 -9.730sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   10  1.GVVGLGTMGRGIVISFARARIPVIALATANKMITSVLEKEASKMQQSGHPWSGPKPRLTSSVKELGGVDLVIEAVFE---KQVFAELSAVCKPEAFLCTNGTHFFSPAHVMKLLEVIPSQSSPTTIATVMNLSKKIKKIGVVVGNCFG 178
26 -9.710sp|P26374|RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens GN=CHML PE=1 SV=2  ali   23  11VVIIGTGLPESILAAACSRSGQRVLHIDSRSGNWASFSFSGLL.......................................................................................................... 56
27 -9.700sp|Q8NHU2|CT026_HUMAN Uncharacterized protein C20orf26 OS=Homo sapiens GN=C20orf26 PE=2 SV=3  ali   12  87IIVYGNTIDTYTTVETLLNLGVSIHLVQPPPASTDALGAAGVTMNDGLHPDPIYSASFTTPTKPFRLQCSMFFSFCEKNVDYETFKALNDA-----LVYDSRLVIDTNFHTNDIAIRAAGSLTKFSNRYYSNEWTHSNFSSKEIGFQLA 257
28 -9.640sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   15  33VLVLGSGYISEPVLEYLSRDGNEITVGSDMKNQIEQLGKK------NINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITN-KVNMVTASYITPALKELEKSVEDAGITIIGELGL---DPG................. 156
29 -9.640sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   21  245VVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDI............................................................................................. 300
30 -9.590sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   16  64LAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRVKKKALTSFERDSIFSNL---TGQLDYQGFEKADMVIEAVDLSLKHRVLKEVEAVIPDHCIFASNGMHYFSPVDKMQLLEIITTETSKDTSASAVAVGLKQGKVIIVVKDGPG 244
31 -9.570sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   14  95VVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDINVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPDGKRIVLLAEG............................................... 221
32 -9.570sp|P00390|GSHR_HUMAN Glutathione reductase, mitochondrial OS=Homo sapiens GN=GSR PE=1 SV=2  ali follow..  11  234SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLW---AIGRVPNTKDLSLNKLGIQTDDKGHIIVDE-FQNTNVKGIYAVGDVCG 378
33 -9.500sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   17  214LAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRVKKKALTSFERDSIFSNL---TGQLDYQGFEKADMVIEAV......................................................................... 298
34 -9.480sp|A6ND91|ASPD_HUMAN Putative L-aspartate dehydrogenase OS=Homo sapiens GN=ASPDH PE=2 SV=2  ali follow..  15  9VGVVGYGRLGQSLVSRLLAQGPEVFVWNRDPGRMAGSVPPSLQLQN--------------LAALGERRPDLVVEVAHPKIIHESGAQILR-HANLLVGSPSALSDQTTERQL..................................... 110
35 -9.460sp|Q96NN9|AIFM3_HUMAN Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1  ali   15  35VVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFENNRVKFYMQTEVSELRKLKEVVLKSSKVVRADVCVVGI------GAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAA............................. 165
36 -9.360sp|Q8IWF2|FXRD2_HUMAN(removed signalp:1-26) FAD-dependent oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=FOXRED2 PE=1 SV=1  ali   15  7YCVLGAGPAGLQMAYFLQRAGRDYAVFERAPR--------GSFFTRYPRHRKLISINKRYTGKANAEDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTHYFILTDQKGQVHQCSVLFVATGLSVPNQVDFPG 168
37 -9.310sp|O75616|ERAL_HUMAN GTP-binding protein era homolog OS=Homo sapiens GN=ERAL1 PE=1 SV=2  ali follow..  17  116VVLLGAPNAGTLSNQLLGRKVFPVSVITEKETQVILLDTPGI-ISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVL..................................... 247
38 -9.300sp|Q9UBT2|SAE2_HUMAN SUMO-activating enzyme subunit 2 OS=Homo sapiens GN=UBA2 PE=1 SV=2  ali   17  20VLVVGAGGIGCELLKNLVLTG-HIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLI.................................................... 137
39 -9.280sp|Q8N2H3|PYRD2_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=PYROXD2 PE=2 SV=2  ali follow..  13  37AVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTPGFKFSR--ASYLLSLLRPQIYTDLELKKHGLRLHLRNPYSFTPMLEEGAGSKVPRCLLLGTDMAENKQIAQFSQK.................................. 154
40 -9.260sp|Q86VQ6|TRXR3_HUMAN Thioredoxin reductase 3 (Fragment) OS=Homo sapiens GN=TXNRD3 PE=1 SV=3  ali   10  76TLVVGASYVALECAGFLAGFGLDVTVMVRSEKVGSYMEQHGVKFEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAI---GRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAGDILEDKPELTPVAIQS............. 232
41 -9.200sp|O95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens GN=AIFM1 PE=1 SV=1  ali   13  3ITIIGGGFLGSELACALGRKGTEVIQLFPEKGNMGKIRREGVKVAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSD----FGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHVVSGRLAGENMTG 171
42 -9.160sp|P00367|DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens GN=GLUD1 PE=1 SV=2  ali follow..  16  304FVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSI--WNPDGIDPKEQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTK--SNAPRVKAKIIAEGANGPTTPEADKIFLERNIMV-----------PDLYLNAG........... 433
43 -9.020sp|Q9H9P8|L2HDH_HUMAN L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens GN=L2HGDH PE=1 SV=3  ali follow..  15  51IVIVGGGIVGLASARALILRSLSIGVLEKEKDLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALLYEYLIVAVEQEEIPRLQALYEK-------GLQNGVPGLRLIQQEDIKKKEPYCRGLMAIDCPHTGI............... 192
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.