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Query: PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, from PfamA32U

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAEDLast
1 -76.100sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   29  63HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKD 241
2 -71.800sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   31  1..GVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSGPKPRL--TSSVKELGGVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGN 175
3 -70.900sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  36  29HVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKKAGDEFVEKTLSTIATSTDAASVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKD 213
4 -67.900sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   35  149SVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSGPKPRL--TSSVKELGGVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQ.......................... 299
5 -53.900sp|Q9Y2S2|CRYL1_HUMAN(removed signalp:1-22) Lambda-crystallin homolog OS=Homo sapiens GN=CRYL1 PE=1 SV=3  ali follow..  24  2................LFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSSVEEQLSLISGCPNIQEVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQ. 165
6 -42.700sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   30  1........................................................................................DLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKD 91
7 -32.900sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   27  213HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFE........................................................................................... 300
8 -10.900sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  11  5DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLA---------------NEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAK---GILFVGEEGARYGPSLMPG---NKEAWPHIKTIFQGIAAK...... 163
9 -10.700sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens GN=STEAP4 PE=1 SV=1  ali follow..  14  21TVCIFGTGDFGRSLGLKMLQCGYSVVF-------------------------GSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIH---EHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDDSKAKQRVMDIVRNLGLTPMDQGS 182
10 -10.700sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  21  41PVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKE-----------FQDAGEQVVSSPADV------------AEKADRIITMLPTSINAIEAYSGALKKVKKGSLLIDSSTIDPAVSKELAKEVEKM---GAVFMDPVS--NLTFMVGG---VEDEFAAAQELLGCMGSNVVYCGA 201
11 -10.500sp|Q8NFT2|STEA2_HUMAN Metalloreductase STEAP2 OS=Homo sapiens GN=STEAP2 PE=1 SV=3  ali follow..  12  32TVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHV------------------------VDVTHHEDALTKTNIIFVAI--HREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDNIQARQQVIELARQLNFIPIDLGS 194
12 -10.300sp|Q9NZJ6|COQ3_HUMAN Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial OS=Homo sapiens GN=COQ3 PE=1 SV=3  ali follow..  13  153....VGCG--GGLLTEPLGRLGASVIGIDPVDENIKTAQCH--------KSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIAGTHFVSPETLESILE............................... 295
13 -10.100sp|Q658P3|STEA3_HUMAN Metalloreductase STEAP3 OS=Homo sapiens GN=STEAP3 PE=1 SV=2  ali follow..  13  30KVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRT------------------------ARLFPSAAQVTFQEEAVSSPEVIFVAVFREHQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCT-------VKAFNVISAWTLQAQVPICGDQPEAKRAVSEMALAMGFMPVDMGS 194
14 -10.100sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1 PE=1 SV=3  ali follow..  18  269KIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDL-----------FIQEGARLGRTPAEV------------VSTCDITFACVSDPKAAKDLVLGPLQGIRPGKCYVDMSTVDADTVELAQVIVSR----GGRFLEPVS--MLVILAAG---DRGLYEDCSSCFQAMGKTSFFLGE 429
15 -10.100sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   19  94QVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICA------------------------LQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRM----KNSCIVCNMGHS............................................................... 181
16 -9.730sp|Q9BYZ2|LDH6B_HUMAN L-lactate dehydrogenase A-like 6B OS=Homo sapiens GN=LDHAL6B PE=1 SV=3  ali follow..  17  71KVSIIGTGSVGMACAISILLKGLELALVDLDEDKLKGETMDLQHGSPFTKMPNIVCSK-------------DYFVTANSNLVINLVQRNVAIFKLMISSIVQYSPHCKLIVSNPVDILTYVAWKLSAFPNRIIGS............................................ 210
17 -9.710sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  19  313QVVVCGYGEVGKGCCAALKALGAIVYITEIDPICA------------------------LQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRM----KNSCIVCNMGHS............................................................... 400
18 -9.620sp|Q9UL12|SARDH_HUMAN Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1  ali   14  68NVVVIGGGSLGCQTLYHLAKLGMGAVLLERERELLAHTRRVVSRELEEETQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAE-----KTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIVETQHGSIQTPCVVNCAGVWASAVGRM...... 281
19 -9.520sp|O95352|ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1  ali   14  57KCLLLGAGTLGCNVARTLMGWGVHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVI..................................................... 187
20 -9.480sp|Q9P0Z9|SOX_HUMAN Peroxisomal sarcosine oxidase OS=Homo sapiens GN=PIPOX PE=2 SV=2  ali follow..  14  9DAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSH-----SRIIRKAYLEDFYTRMMHECYQIWAQLEHEAGTQLHRQANLSRQRVEHQCLSSEE---GEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEIVKTTSRSYQAKSLVITAGPWTNQL......... 209
21 -9.380sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   12  79KILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQVDILISTALIPGKKAPVLFKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPD.......... 252
22 -9.350sp|Q9UI17|M2GD_HUMAN(removed signalp:1-23) Dimethylglycine dehydrogenase, mitochondrial OS=Homo sapiens GN=DMGDH PE=1 SV=2  ali   15  28ETVIIGGGCVGVSLAYHLAKAGMDVVLLEKSEKKIHYDSIKLYEKLEEETQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEK-----QEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLVETPQGSMRANRIVNAAGFWAREVGKM...... 235
23 -9.330sp|Q16795|NDUA9_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens GN=NDUFA9 PE=1 SV=2  ali follow..  12  55VATVFGAGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIR-----------RVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEVSHLNANIKKPSDIFGRE-KQPVYVVDVSKGIVNAVKDPDANGKSFAFV............ 266
24 -9.300sp|P07864|LDHC_HUMAN L-lactate dehydrogenase C chain OS=Homo sapiens GN=LDHC PE=2 SV=4  ali follow..  19  22KITIVGTGAVGMACAISILLKDLELALVDVALDKLKG-------------EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIALVQRNVAIMKSIIPAIVHYSPDCKILVSNPVDILTYIVWKISGLPTRVIGS............................................ 161
25 -9.290sp|Q53H96|P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens GN=PYCRL PE=1 SV=2  ali follow..  22  10RVGFVGAGRMAGAIAQGLIRAGKHILASAPTDRNLCH------------------------QALGCRTTHSNQEVLQSCLLVIFAT--KPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEAIVMARGRHVGSSETNLLQHLLEACGRCEEVPEA 168
26 -9.140sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4  ali follow..  16  215VAVVAGYGDVGKGCAQALRGFGARVIITEIDPINA------------------------LQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQM----KDDAIVCNIGHFIDVKWLNENAVEKVNI............................................... 321
27 -9.140sp|O95352|ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1  ali   18  207KCLLLGAGTLGCNVARTLMGWGVHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFN...................................................................................................... 284
28 -9.090sp|P43304|GPDM_HUMAN(removed signalp:1-23) Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Homo sapiens GN=GPD2 PE=1 SV=3  ali   14  48DILVIGGGATGSGCALDAVTRGLKTALVERDDFS-----SGTSSRSTKLIHGG----------VRYLQKAIMKLDIEQYRMVKEALHE----RANLLEIAPHLSAPLPIMLPVYKWWQLPYYWVGIKLYDLVAGSNCLKSSYVLSKSRALE............................ 179
29 -9.060sp|P00338|LDHA_HUMAN L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2  ali follow..  17  22KITVVGVGAVGMACAISILMKDLELALVDVIEDKLKG-------------EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVINLVQRNVNIFKFIIPNVVKYSPNCKLLVSNPVDILTYVAWKISGFPNRVIGS............................................ 161
30 -9.060sp|Q8NCN5|PDPR_HUMAN Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens GN=PDPR PE=1 SV=2  ali   14  44QVVICGGGITGTSVAYHLSKMGWDIVLLEQGRQKMADYSNKLYYQLEQETRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKK-----AELHHLLNVHDLVGAMHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVVETDKGQIECQYFVNCAGQWAYELGLSNEE... 254
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;