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Query: PF18377.1; G1KHZ7_ANOCA/140-270; FERM F2 acyl-CoA binding protein-like domain, from PfamA32U

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130
# Score Template Links and tools%idFirst SAILDKSSFEYLFEQGKYDFINDVASLKDLRTEQEIHQFKNESLGMAVLHLCHIALKSGLSLEEVAQRTSFKECIPRSFCRQIQQNNYLTKFRIRNVFRRFLQRFQRHTMSTGKLTEQDIMHKYLATLENLLast
1 -64.900sp|P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 OS=Homo sapiens GN=JAK1 PE=1 SV=2  ali   44  1....DASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETL 127
2 -62.800sp|P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 OS=Homo sapiens GN=JAK1 PE=1 SV=2  ali   43  148.PLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETL 277
3 -57.800sp|P29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens GN=TYK2 PE=1 SV=3  ali   67  141MQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQ-----PGRLSQQMVMVKYLATLERL 266
4 -56.500sp|P29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens GN=TYK2 PE=1 SV=3  ali   68  1..........YLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQP-----GRLSQQMVMVKYLATLERL 116
5 -52.500sp|P52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 OS=Homo sapiens GN=JAK3 PE=1 SV=2  ali   32  127.AILDLPVLEHLFAQHRSDLVSGRLPVGLSLKE------QGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVA-----ACQADRHSLMAKYIMDLERL 245
6 -51.200sp|O60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 OS=Homo sapiens GN=JAK2 PE=1 SV=2  ali   35  143.PLLDDFVMSYLFAQWRHDFVHGWIK------VPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFS-----QCKATARNLKLKYLINLETL 261
7 -49.500sp|O60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 OS=Homo sapiens GN=JAK2 PE=1 SV=2  ali   35  1.........SYLFAQWRHDFVHGWIKVPVTHET------QEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFS-----QCKATARNLKLKYLINLETL 111
8 -41.400sp|Q14CM0|FRPD4_HUMAN FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1  ali   18  1....DPVAFEYLYVQSCNDVVQERFGPELK---------YDIALRLAALQMYIATQTQKISLKYIEKEWGLETFLPSAVLQSMKEKN------IKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDL 116
9 -39.500sp|P52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 OS=Homo sapiens GN=JAK3 PE=1 SV=2  ali   30  2................................VGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAA-----CQADRHSLMAKYIMDLERL 95
10 -35.600sp|Q14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta OS=Homo sapiens GN=PTK2B PE=1 SV=2  ali   16  1........LLYFYQQLRNDYMQRYASKVSEGMALQLGCLE---LRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQF--RKMIQQTFQQY-----------ASLREEECVMKFFNTLAGF 107
11 -34.800sp|Q5JV73|FRPD3_HUMAN FERM and PDZ domain-containing protein 3 OS=Homo sapiens GN=FRMPD3 PE=2 SV=2  ali   25  127....DPAAFEYLYIQSRNDVIRERFGMDPKPEM---------LLGLAALHIYATRPSQKISLKNVEKEWGLEPFLPPSLLQVIKEKN------LRKSLSQQLKAHQTHPSCGTKGSAIQAKLQYLRILNEL 242
12 -34.200sp|Q14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta OS=Homo sapiens GN=PTK2B PE=1 SV=2  ali   17  147....DRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLE---LRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQF--RKMIQQTFQQY-----------ASLREEECVMKFFNTLAGF 257
13 -33.100sp|Q5SYB0|FRPD1_HUMAN FERM and PDZ domain-containing protein 1 OS=Homo sapiens GN=FRMPD1 PE=1 SV=1  ali   18  126....DPVAFEYLYLQSCSDVLQERFAVEMKCSS---------ALRLAALHIQERIQPQKISLKYIEKDWGIENFISPTLLRNMKGKDI--KKAISFHMKRNQNLLEPR--QKQLISAAQLRLNYLQILGEL 243
14 -32.600sp|Q14CM0|FRPD4_HUMAN FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1  ali   18  151....DPVAFEYLYVQSCNDVVQERFGPELK---------YDIALRLAALQMYIATQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNI--KKALSHLVKANQNLVPPG----KKLSALQAKVHYLKFLSDL 266
15 -32.000sp|Q05397|FAK1_HUMAN Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2  ali   18  140....DKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLE---IRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTL--RKLIQQTFRQF-----------ANLNREESILKFFEILSPV 250
16 -28.200sp|Q5JV73|FRPD3_HUMAN FERM and PDZ domain-containing protein 3 OS=Homo sapiens GN=FRMPD3 PE=2 SV=2  ali   18  3.......................................PEMLLGLAALHIYITVPSQKISLKNVEKEWGLEPFLPPSLLQVIKEKNL--RKSLSQQLKAHQTHPSC----GTKGSAIQAKLQYLRILNEL 92
17 -26.900sp|Q05397|FAK1_HUMAN Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2  ali   17  1...............VKSDYMLEIADQVDQEIALKLGCLE---IRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTL--RKLIQQTFRQF-----------ANLNREESILKFFEILSPV 100
18 -26.400sp|Q5SYB0|FRPD1_HUMAN FERM and PDZ domain-containing protein 1 OS=Homo sapiens GN=FRMPD1 PE=1 SV=1  ali   16  3........................................SSALRLAALHIQERIQPQKISLKYIEKDWGIENFISPTLLRNMKGKDI--KKAISFHMKRNQNLLEPR--QKQLISAAQLRLNYLQILGEL 93
19 -16.200sp|Q9BZ67|FRMD8_HUMAN FERM domain-containing protein 8 OS=Homo sapiens GN=FRMD8 PE=1 SV=1  ali follow..  10  137LQIHDEEVLRLLYEEAKGNVLAARYPCD-----------VEDCEALGALVCRVQL-PGRPAACDLREK--LDSFLPAHLCKRGQSLFAALRGR-QGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHEL 264
20 -15.200sp|Q9BZ68|FKS43_HUMAN Putative FERM domain-containing protein FKSG43 OS=Homo sapiens GN=FKSG43 PE=5 SV=2  ali follow..  8  139..IPDEEVLRLLYEEAKGNVLAARYLCD-----------VEDCEALGALVCRVQL-PDWPAACDLREK--LDSFLPAHLCKRLRGRGARAGPGEQSLLNAYRKVQEVSSDGGCEAALGTHYRAYLLKCHKL 264
21 -14.700sp|Q9UKN7|MYO15_HUMAN Myosin-XV OS=Homo sapiens GN=MYO15A PE=1 SV=2  ali   11  6....NELYVTMHYNQVLPDYLKGLFSSV-----------PASRPSEQLLQQVSKLQHRAKDHFYLPSVREVQEYIPAQLYRTTAGSTW--LNLVSQHRQQT-----------QALSPHQARAQFLGLLSAL 111
22 -14.700sp|O00522|KRIT1_HUMAN Krev interaction trapped protein 1 OS=Homo sapiens GN=KRIT1 PE=1 SV=2  ali   13  72..IEDPLAILILFDEARYNLLKGFYTAP-----------DAKLITLASLLLQIVYYESKKHKQGFLNEENLKSIVPVTKLKSKAPH---WTNRILHEYKNL------STSEGVSKEMHHLQRMFLQNCWEI 182
23 -14.300sp|Q9Y4G6|TLN2_HUMAN Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4  ali   17  60....DPVQLNLLYVQARDDILNGSHPVS-----------FEKACEFGGFQA-QIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRG-----AEKRIFQEHKNC-----------GEMSEIEAKVKYVKLARSL 158
24 -14.200sp|Q9UKN7|MYO15_HUMAN Myosin-XV OS=Homo sapiens GN=MYO15A PE=1 SV=2  ali   12  156....NELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLA--------SLQHRAKDHFYLPSVREVQEYIPAQLYRTTAGSTW--LNLVSQHRQQT-----------QALSPHQARAQFLGLLSAL 261
25 -13.900sp|Q13402|MYO7A_HUMAN Myosin-VIIa OS=Homo sapiens GN=MYO7A PE=1 SV=1  ali   6  160....DNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFV-------------DYGSEMILERLLNLVPTYIPDREITPLKTL--------EKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARF. 264
26 -13.700sp|Q9Y490|TLN1_HUMAN Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3  ali   15  58....DPVQLNLLYVQARDDILNGSHPVS-----------FDKACEFAGFQC-QIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHK-----------------NCGQMSEIEAKVRYVKLARSL 155
27 -13.700sp|Q6PIF6|MYO7B_HUMAN Myosin-VIIb OS=Homo sapiens GN=MYO7B PE=2 SV=2  ali   11  104....VNADTILHYHQELPKYLRGFHKCS-----------REDAIHLAGLIYKAQFNNDRSQLASVPKI--LRELVPENLTRLMSSEEW--KKSILLAYDKH-----------KDKTVEEAKVAFLKWICRW 204
28 -13.600sp|Q8IVE3|PKHH2_HUMAN Pleckstrin homology domain-containing family H member 2 OS=Homo sapiens GN=PLEKHH2 PE=2 SV=2  ali   16  179....TDREKLLLMYQTNDQIINGLFPLN-----------KDLALEMAALLSQVEIGDFERPFSTPAGHVTIEKFYPKRYRDGCSEEQ----------LRQLCQRLSTRWMALRGHSAADCVRIYLTVARKW 296
29 -13.100sp|Q9Y490|TLN1_HUMAN Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3  ali   16  208....DPVQLNLLYVQARDDILNGSHPVS-----------FDKACEFAGFQC-QIQFGPHNEQKHKAGFLDLKDFLPKEYVKQ-------GERKIFQAHKNC-----------GQMSEIEAKVRYVK..... 300
30 -13.100sp|Q13402|MYO7A_HUMAN Myosin-VIIa OS=Homo sapiens GN=MYO7A PE=1 SV=1  ali   7  6SPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFV-------------DYGSEMILERLLNLVPTYIPDREITPLKTL--------EKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARF. 114
31 -13.100sp|Q13402|MYO7A_HUMAN Myosin-VIIa OS=Homo sapiens GN=MYO7A PE=1 SV=1  ali   11  57....PMADSIFHYYQELPKYLRGYHKCT-----------REEVLQLGALIYRVKFEEDKSYFPSIPKL--LRELVPQDLIRQVSPDDW--KRSIVAYFNKH-----------AGKSKEEAKLAFLKLIFKW 157
32 -13.000sp|Q8IVE3|PKHH2_HUMAN Pleckstrin homology domain-containing family H member 2 OS=Homo sapiens GN=PLEKHH2 PE=2 SV=2  ali   15  29....TDREKLLLMYQTNDQIINGLFPLN-----------KDLALEMAALLSQVEIHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQ----------LRQLCQRLSTRWMALRGHSAADCVRIYLTVARKW 146
33 -13.000sp|Q7Z736|PKHH3_HUMAN(removed signalp:1-18) Pleckstrin homology domain-containing family H member 3 OS=Homo sapiens GN=PLEKHH3 PE=1 SV=2  ali   12  190....DGHELPFLFEQAHALLLRGRPPPP-----------DDTLRALAALRLQSLQRDFSPRVPL-----RLDRLLPPPAPPREDPPRP--TPRPPPSAALL----------AGALWSPGLAKRRAERARR. 288
34 -12.000sp|Q6PIF6|MYO7B_HUMAN Myosin-VIIb OS=Homo sapiens GN=MYO7B PE=2 SV=2  ali   14  99....DPVSTELIYRQVLRGVWSGEYSFEKEEELVELLARH-------------CYVQLGASAESKAVQELLPSCIPHKLYRTKPPDRWA---------SLVTAACAKAPYTQKQVTPLAVREQVVDAARL. 202
35 -11.500sp|Q9ULM0|PKHH1_HUMAN Pleckstrin homology domain-containing family H member 1 OS=Homo sapiens GN=PLEKHH1 PE=2 SV=2  ali   6  56....TDRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQL----------RHLADMLTTKWATLQGCSPPECIRIYLTVARKW 172
36 -11.000sp|Q68DX3|FRPD2_HUMAN FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=2  ali   15  138..LQHSLTRHQFYLQLRKDILEERLY-----------CNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRV--QVEVSEMHRLS-----------SALWGEDAELKFLRVTQQL 242
37 -10.900sp|Q96NE9|FRMD6_HUMAN FERM domain-containing protein 6 OS=Homo sapiens GN=FRMD6 PE=1 SV=1  ali   13  123..ISDRAARYYYYWHLRKQVLHSQCVLR-----------EEAYFLLAAFALQADLGNFKRN-KHYGKYFEPEAYFPSWVVSKRGKDYI--LKHIPNMHKDQ-----------FALTASEAHLKYIKEAVRL 226
38 -10.900sp|Q5SYB0|FRPD1_HUMAN FERM and PDZ domain-containing protein 1 OS=Homo sapiens GN=FRMPD1 PE=1 SV=1  ali   28  276....DPVAFEYLYLQSCSDVLQERFAVEM...................................................................................................... 300
39 -10.800sp|Q9Y4G6|TLN2_HUMAN Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4  ali   13  208..SRDPVQLNLLYVQARDDILNGSHPVS-----------FEKACEFGGFQA-QIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRG-----AEKRIFQEHKNCGEMSEIEA...................... 297
40 -10.400sp|Q8N878|FRMD1_HUMAN FERM domain-containing protein 1 OS=Homo sapiens GN=FRMD1 PE=2 SV=2  ali follow..  10  151RVISDHRARHLYYCHLKERVLRSQCA-----------HREEAYFLLAACALQADLGEHRES-AHAGRYFEPHSYFPQWIITKRGIDYI--LRHMPTLHRER-----------QGLSPKEAMLCFIQEACRL 256
41 -10.300sp|Q96AC1|FERM2_HUMAN Fermitin family homolog 2 OS=Homo sapiens GN=FERMT2 PE=1 SV=1  ali   7  2NEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLE--------LSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQI--TARILEAHQNV-----------AQMSLIEAKMRFIQAWQSL 115
42 -10.200sp|Q12923|PTN13_HUMAN Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2  ali   13  68SLIQHTLTCHQYYLQLRKDILEERMH-----------CDDETSLLLASLALQAEYGDYQPEVHG-VSYFRMEHYLPARVMEKLDLSYI--KEELPKLHNTY-----------VGASEKETELEFLKVCQRL 173
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 0   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.