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Query: PF02826.19; Q98GE4_RHILO/107-283; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, from PfamA32U

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFTALALLRQFRRVDRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVGHIAAHGFDLKVVATTRSMQPAPEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDDALIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMALast
1 -73.4005tx7_A mol:protein length:327 D-isomer specific 2-hydroxyacid dehydrogenase family protein  ali model follow..  38  108FALLLELCRRTALHDHRIRAGAWTQSPDWDSTQEELTGKTMGIVGFGNTGRRVGRI-ANALGMNVIAYAPRSRFDYRPFEHVGLDELFTSADVVSLHCPLTPETEGLVDARRLASMRPGSYLINTARGPLLDERAVAEALDSGRLAGAGLDVLSQEPPAADNPLLSAKNCLITPHLA 288
2 -73.1003gvx_A mol:protein length:290 Glycerate dehydrogenase related protein  ali model follow..  29  90FALLLAHAKNILENNELMKAGIFRQ-----SPTTLLYGKALGILGYGGIGRRVAH-LAKAFGMRVIAYTRSSVDQNVDVISESPADLFRQSDFVLIAIPLTDKTRGMVNSRLLANARKNLTIVNVARADVVSKPDMIGFLKERSDVWYLSDVWWNEPEITETNL---RNAILSPHVA 257
3 -72.7002cuk_A mol:protein length:311 glycerate dehydrogenase/glyoxylate reductase  ali model follow..  40  107LALLLAVARRVVEGAAYARDGLWKAWHPELLLGLDLQGLTLGLVGMGRIGQAVAK-RALAFGMRVVYHART--PKPLPYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALVEALR-GHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIG 279
4 -72.3002gcg_A mol:protein length:330 Glyoxylate reductase/hydroxypyruvate reductase  ali model follow..  35  118VSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIAR-RLKPFGVQRFLYTGRQPAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIG 297
5 -72.3005uog_A mol:protein length:344 NADPH-dependent glyoxylate/hydroxypyruvate reductase  ali model follow..  29  121IGLLLNTLRLLPQAEQWLRQGRWVREGAFPLSPLSLRGRTVGLFGLGRIGLAIAR-RLEAFGVSIAYHTRTPREGLGFTYHPTLVGMAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAGLDVFENEP-NVPEALLSFPNVSLLPHVA 295
6 -72.2001wwk_A mol:protein length:307 phosphoglycerate dehydrogenase  ali model follow..  38  108VGLMFSVARKIAFADRKMREGVWAKKE---AMGIELEGKTIGIIGFGRIGYQVAK-IANALGMNILLYDPYPNEEEVNGKFVDLETLLKESDVVTIHVPLVESTYHLINEERLKLMKKTAILINTSRGPVVDTNALVKALKEGWIAGAGLDVFEEEPLPKDHPLTKFDNVVLTPHIG 283
7 -71.8004g2n_A mol:protein length:345 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding  ali model follow..  33  130MLLVLNACRRGYEADRMVRSGSWPGWGPTQLLGMGLTGRRLGIFGMGRIGRAIAT-RARGFGLAIHYHNRTRLSHEGAIYHDTLDSLLGASDIFLIAAPGRPELKGFLDHDRIAKIPEGAVVINISRGDLINDDALIEALRSKHLFAAGLDVFANEP-AIDPRYRSLDNIFLTPHIG 307
8 -71.8001gdh_A mol:protein length:320 D-GLYCERATE DEHYDROGENASE  ali model follow..  28  109MLLLLGSARRAGEGEKMIRTRSWPGWEPLELVGEKLDNKTLGIYGFGSIGQALAK-RAQGFDMDIDYFDTHRASSSDATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTARGDLVDNELVVAALEAGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHIG 288
9 -71.7003gg9_A mol:protein length:352 d-3-phosphoglycerate dehydrogenase oxidoreductase protein  ali model follow..  32  116WALVMAAQRRIPQYVASLKHGAWQQSGPNFGIGRVLKGQTLGIFGYGKIGQLVAGY-GRAFGMNVLVWGRENSKERARADAESKDALFEQSDVLSVHLRLNDETRSIITVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIG 302
10 -71.5004hy3_A mol:protein length:365 phosphoglycerate oxidoreductase  ali model follow..  29  133LGFALALARGIVDADIAFQEGTELWGGEGNASARLIAGSEIGIVGFGDLGKALRR-VLSGFRARIRVFDPWLPRSENGVEPASLEDVLTKSDFIFVVAAVTSENKRFLGAEAFSSMRRGAAFILLSRADVVDFDALMAAVSSGHIVAA-SDVYPEEPLPLDHPVRSLKGFIRSAHRA 310
11 -71.1003wnv_A mol:protein length:330 glyoxylate reductase  ali model follow..  28  120IFLMIGALRQAYVPITAIRAGEWHGKT---TLGHDPNGKTLGILGMGGIGREVAR-RARAFGMNIIYHNRNKLPPEDGAKYVSFDELLAQSDVFSLNLALNASTRHIIGEKELAKMKDGVVIVNTARGALIDEKALVRALESGKVASVGLDVYENEP-QVEPGLLNNPRAMLLPHIG 293
12 -71.1004dgs_A mol:protein length:340 Dehydrogenase  ali model follow..  32  129IALMLAVLRRVGDGDRLVREGRWAAGEQL-PLGHSPKGKRIGVLGLGQIGRALAS-RAEAFGMSVRYWNRSTLSGVDWIAHQSPVDLARDSDVLAVCVAASAATQNIVDASLLQALGPEGIVVNVARGNVVDEDALIEALKSGTIAGAGLDVFVNEP-AIRSEFHTTPNTVLMPHQG 302
13 -70.8003naq_A mol:protein length:357 Formate dehydrogenase  ali model follow..  28  134LMRILILMRNFVPGYNQVVKGEWNV-AGIAYRAYDLEGKTIGTVGAGRIGKLLLQ-RLKPFGCNLLYHDRLQMAPELEKETEDLNEMLPKCDVIVINMPLTEKTRGMFNKELIGKLKKGVLIVNNARGAIMERQAVVDAVESGHIGGYSGDVWDPQPAPKDHPWRYMPNQAMTPHTS 313
14 -70.7002w2k_A mol:protein length:348 D-MANDELATE DEHYDROGENASE  ali model follow..  27  122LYLILSVFRLASYSERAARTGDPETFNRVHLSAHNPRGHVLGAVGLGAIQKEIARKAVHGLGMKLVYYDVAPADAETEKAL-SLEELARRSDCVSVSVPYMKLTHHLIDEAFFAAMKPGSRIVNTARGPVISQDALIAALKSGKLLSAGLDVHEFEP-QVSKELIEMKHVTLTTHIG 306
15 -70.6003ba1_A mol:protein length:333 Hydroxyphenylpyruvate reductase  ali model follow..  40  123IGLILAVLRRICECDKYVRRGAWKFGDFK--LTTKFSGKRVGIIGLGRIGLAVAE-RAEAFDCPISYFSRSKKPNTNYTYYGSVVELASNSDILVVACPLTPETTHIINREVIDALGPKGVLINIGRGPHVDEPELVSALVEGRLGGAGLDVFEREP-EVPEKLFGLENVVLLPHVG 295
16 -70.4004s1v_D mol:protein length:332 D-3-phosphoglycerate dehydrogenase-related protein  ali model follow..  25  111WSLILAASRHLPSYIEQLHAGHWQQ-NGGLGLGRTLSGRTLGIWGLGKIGQRIAQF-GHVFGMPILVWGSEASRQKALQAAADKAEFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPDSLFVNTSRAELVESGALYSVMQANPMRQAAVDVYENEPLPNNEPLLSLPNVLCAPHLG 290
17 -70.2006bii_A mol:protein length:333 Glyoxylate reductase  ali model follow..  41  109WALLLAAARHVVKGDKFVRSGEWKRWHPKMFLGYDVYGKTIGIVGFGRIGQAIAK-RAKGFGMRILYTARSRKPEELGAEFKPLEELLRESDFVVLAVPLTKETYHMINEERLRLMKPTAVLVNVARGKVVDTKALIRALKEGWIAAAGLDVFEEEP-YYDEELFALDNVVLTPHIG 290
18 -70.1004xyb_A mol:protein length:391 Formate dehydrogenase  ali model follow..  28  156VMMILALVRNYLPSHKIAEEGGWNI-ADCVSRSYDLEGMHVGTVAAGRIGLAVLR-RLKPFDVKLHYTARHRSPRAIEDELATAEEMAEVCDVISIHAPLYPATEHLFNAKVLNKMRHGSYLVNTARAEICDRDDIVRALESGQLAGYAGDVWFPQPAPANHPWRNMPHNGMTPHMS 335
19 -69.9002gsd_A mol:protein length:402 NAD-dependent formate dehydrogenase  ali model follow..  28  156VMMVLGLVRNYIPSHDWARNGGWNI-ADCVARSYDVEGMHVGTVAAGRIGLRVLR-LLAPFDMHLHYTDRHRLPEAVEKELATREDMYGACDVVTLNCPLHPETEHMINDETLKLFKRGAYLVNTARGKLCDRDAIVRALESGRLAGYAGDVWFPQPAPNDHPWRTMPHNGMTPHIS 335
20 -69.9001qp8_A mol:protein length:303 FORMATE DEHYDROGENASE  ali model follow..  23  91LALLLAPYKRIIQYGEKMKRGDYGR----DVEIPLIQGEKVAVLGLGEIGTRVGK-ILAALGAQVRGFSRTPKEGP-WRFTNSLEEALREARAAVCALPLNKHTRGLVKYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDVWGRNDFAKDAEFFSLPNVVATPWVA 262
21 -69.8002dbq_A mol:protein length:334 Glyoxylate reductase  ali model follow..  40  109FALLLATARHVVKGDRFVRSGEWKKWHPKWFLGYDVYGKTIGIIGLGRIGQAIAK-RAKGFNMRILYYSRTRKEEELNAEFKPLEDLLRESDFVVLAVPLTRETYHLINEERLKLMKKTAILINIARGKVVDTNALVKALKEGWIAGAGLDVFEEEP-YYNEELFKLDNVVLTPHIG 290
22 -69.8004ebf_A mol:protein length:334 Thermostable phosphite dehydrogenase  ali model follow..  28  110IGLAVGLGRHLRAADAFVRSGQFRGWQPR-FYGTGLDNATVGFLGMGAIGLAMAD-RLQGWGATLQYHAAKATEQRLGLRQVACSELFASSDFILLALPLNADTLHLVNAELLALVRPGALLVNPCRGSVVDEAAVLAALERGQLGGYAADVFEMEPQQIDPALLAHPNTLFTPHIG 295
23 -69.8002ome_A mol:protein length:336 C-terminal-binding protein 2  ali model follow..  35  111ICHILNLYRRNTWLYQALREGTRVQSREVASGAARIRGETLGLIGFGRTGQAVAV-RAKAFGFSVIFYDPYLQDGIERSRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSAQGPLKDAPNLICTPHTA 295
24 -69.8005aov_A mol:protein length:336 GLYOXYLATE REDUCTASE  ali model follow..  39  109FALLLATARHVVKGDKFVRSGEWKRWHPKWFLGYELYGKTIGIVGFGRIGQAIAR-RAKGFNMRILYYSRTRKSQELGAEYRPLEEVLKESDFVILAVPLTKETMYMINEERLKLMKPTAILVNIARGKVVDTKALIKALKEGWIAGAGLDVFEEEP-YYNEELFSLDNVVLTPHIG 290
25 -69.6002g76_A mol:protein length:335 D-3-phosphoglycerate dehydrogenase  ali model follow..  30  125CGMIMCLARQIPQATASMKDGKWERKK---FMGTELNGKTLGILGLGRIGREVAT-RMQSFGMKTIGYDPIISPESFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEP-PRDRALVDHENVISCPHLG 299
26 -69.4003wr5_A mol:protein length:406 Formate dehydrogenase  ali model follow..  29  161VMMILGLVRNYIPSHDWARKGGWNI-ADCVEHSYDLEGMTVGSVAAGRIGLAVLR-RLAPFDVKLHYTDRHRLPEAVLVWHDTREDMYPHCDVVTLNVPLHPETEHMINDETLKLFKRGAYIVNTARGKLADRDAIVRAIESGQLAGYAGDVWFPQPAPKDHPWRTMKWEGMTPHIS 340
27 -69.4004lsw_A mol:protein length:318 D-2-hydroxyacid dehydrogensase protein  ali model follow..  28  109VAMMLAQSRGIIGAETWARSGKWAAEGLY-PLKRRVFGRRAGVLGLGRIGFEVAR-RLAGFDMQISYSDIAPKSYPDWTFVEDAVTLARDVDFLFVTLAASAATRHIVGRDVIEALGPEGMLINISRASNIDEEALIAALADGRLGSAALDVFEGEP-NFDPRFRDLPNVLLQPHHA 283
28 -69.3002d0i_A mol:protein length:333 dehydrogenase  ali model follow..  30  106VGLIINLMRKIHYADKFIRRGEWESHAKIFKRIESLYGKKVGILGMGAIGKAIAR-RLIPFGVKLYYWSRHRKVNELKARYMDIDELLEKSDIVILALPLTRDTYHIINEERVKKLE-GKYLVNIGRGALVDEKAVTEAIKQGKLKGYATDVFEKEPVREHELFKYEWETVLTPHYA 286
29 -68.9004lcj_A mol:protein length:349 C-terminal-binding protein 2  ali model follow..  35  126ICHILNLYRRNTWLYQALREGTRVQSREVASGAARIRGETLGLIGFGRTGQAVAV-RAKAFGFSVIFYDPYLQDGIERSRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSAQGPLKDAPNLICTPHTA 310
30 -68.8004prk_A mol:protein length:336 4-phosphoerythronate dehydrogenase  ali model follow..  31  111VTQAMYLNRKIGEFKANMDKGDFT--NPDSLISNEIYNKTIGLIGVGHIGSAVAQI-FSAMGAKVLAYDVIYNPEEPYLTYADFDTVLKEADIISLHTPLLKSTENMIGKKQFAEMKNDAILINAARGELVDTAALIEALEKHEIAAAGLDTLAHESSADYKKLAAMPNVIVTPHSA 297
31 -68.5002ekl_A mol:protein length:313 D-3-phosphoglycerate dehydrogenase  ali model follow..  26  110IGLMIAAARKMYTSMALAKSGIFKK-----IEGLELAGKTIGIVGFGRIGTKVGI-IANAMGMKVLAYDILDIREKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGKALLDYIKKGKVYAYATDVFWNEPPKEEWELLKHERVIVTTHIG 285
32 -68.5001hku_A mol:protein length:358 C-TERMINAL BINDING PROTEIN 3  ali model follow..  35  124LCHILNLYRRTTWLHQALREGTRVQSREVASGAARIRGETLGIIGLGRVGQAVAL-RAKAFGFNVLFYDPYLSDGIERARVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSSQGPLKDAPNLICTPHAA 308
33 -68.5002go1_A mol:protein length:401 NAD-dependent formate dehydrogenase  ali model follow..  28  156VMMILSLVRNYLPSHEWARKGGWNIAD-CVSHAYDLEAMHVGTVAAGRIGLAVLR-RLAPFDVHLHYTDRHRLPESVEKELATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAYIVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMPYNGMTPHIS 335
34 -68.4002fss_A mol:protein length:365 formate dehydrogenase  ali model follow..  28  129VMTMLVLVRNFVPAHEQIINHDWEV-AAIAKDAYDIEGKTIATIGAGRIGYRVLE-RLVPFNPKELLYYDYQALPKDAEEKVNIEELVAQADIVTVNAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQPAPKDHPWRDMRNNAMTPHYS 314
35 -68.2003kb6_A mol:protein length:334 D-lactate dehydrogenase  ali model follow..  32  106FAMILTLVKRLKRIEDRVKKLNFS--QDSEILARELNRLTLGVIGTGRIGSRVAMY-GLAFGMKVLCYDVVKREDEKGCVYTSLDELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVDTDALYRAYQRGKFSGLGLDVFEDEEILKILELACKDNVIITPHIA 296
36 -68.2005dn9_A mol:protein length:364 FDH  ali model follow..  28  128LMTMLVLVRNFVPAHEQIINHDWEV-AAIAKDAYDIEGKTIATIGAGRIGYRVLE-RLVPFNPKELLYYDYQALPKDAEEKVNIEELVAQADIVTINAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQPAPKDHPWRDMRNKAMTPHYS 313
37 -67.9002yq4_A mol:protein length:343 D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE  ali model follow..  30  112VTQAMYLLRKIGEFRYRMDHDHDFTWP-SNLISNEIYNLTVGLIGVGHIGSAVAEI-FSAMGAKVIAYDVAYNPEEPFLTYTDFDTVLKEADIVSLHTPLFPSTENMIGEKQLKEMKKSAYLINCARGELVDTGALIKALQDGEIAGAGLDTLAGESSEDYKTLAKMPNVVITPHSA 300
38 -67.7006cdf_A mol:protein length:373 C-terminal-binding protein 1  ali model follow..  35  121LCHILNLYRRATWLHQALREGTRVQSREVASGAARIRGETLGIIGLGRVGQAVAL-RAKAFGFNVLFYDPYLSDGVERARVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSSQGPLKDAPNLICTPHAA 305
39 -67.4001dxy_A mol:protein length:333 D-2-HYDROXYISOCAPROATE DEHYDROGENASE  ali model follow..  27  110LTDTLYLLRNMGKVQAQLQAGDYEKAGT--FIGKELGQQTVGVMGTGHIGQVAIKL-FKGFGAKVIAYDPYPMKGHPDFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLIDTQAMLSNLKSGKLAGVGIDTYEYETEPLWDELLGMPNVVLSPHIA 297
40 -66.5003wwz_A mol:protein length:345 D-lactate dehydrogenase (Fermentative)  ali model follow..  35  120VGLILTLNRRLHRAYNRTREGDFSL---HGLTGFDLHGKRVGVIGTGQIGETFARI-MAGFGCELLAYDPYPNPRALGGRYLALDALLAESDIVSLHCPLTADTRHLIDAQRLATMKPGAMLINTGRGALVNAAALIEALKSGQLGYLGLDVYEEEADDVLARLLSFPNVVVTAHQA 307
41 -66.1002p9c_A mol:protein length:410 D-3-phosphoglycerate dehydrogenase  ali model follow..  32  117IGELLLLLRGVPEANAKAHRGVWNKLA---AGSFEARGKKLGIIGYGHIGTQLGI-LAESLGMYVYFYDIENKLPGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALASKHLAGAAIDVFPTEPAPFTSPLAEFDNVLLTPHIG 294
42 -66.0004xkj_A mol:protein length:335 D-lactate dehydrogenase  ali model follow..  31  111LTQTMRLIRNLPLFDARGAEQDFRW---AGLMAREIRSLTVGIIGAGRIGGTVARL-FKALGATVIANDIVERVEKDIVTYVSKEELLQAADVVTLHVPLMDSTTQLIDADALALMKNDAVLINASRGPVVDTDALIAALQNKQIAGAALDTLNGEESEQLKVLRTLPNVLITPHIG 297
43 -65.9001yba_A mol:protein length:410 D-3-phosphoglycerate dehydrogenase  ali model follow..  32  117IGELLLLLRGVPEANAKAHRGVWNKLA---AGSFEARGKKLGIIGYGHIGTQLGI-LAESLGMYVYFYDIENKLPGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPAPFTSPLCEFDNVLLTPHIG 294
44 -65.7004cuj_A mol:protein length:338 D-LACTATE DEHYDROGENASE  ali model follow..  29  110IGMMMTLNRRIHRAYQRTRDANFSL---EGLTGFTMHGKTAGVIGTGKIGVAALRI-LKGFGMRLLAFDPYPSTADLGVEYVDLQTLFAESDVISLHCPLTPENYHLLNHAAFDQMKNGVMIINTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDDVFRRLSACHNVLFTGHQA 297
45 -65.5001j49_A mol:protein length:333 D-LACTATE DEHYDROGENASE  ali model follow..  32  112AIQAARILRQDKAMDEKVARHDLRW---APTIGREVRDQVVGVVGTGHIGQVFMQI-MEGFGAKVITYDIFRNPEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDVYEGEVDARLADLIARPNVLVTPHTA 299
46 -65.4003wwy_A mol:protein length:358 D-lactate dehydrogenase  ali model follow..  33  129VGLILAVNRKINKAYVRTREGNFSI---NGLMGIDLYEKTAGIIGTGKIGQILIKI-LRGFDMKVIAYDLFPNQKELGFEYVSLDELYANSDIISLNCPLTKDTKYMINRRSMLKMKDGVILVNTGRGMLIDSADLVEALKDKKIGAVALDVYEEEENDILGRLLSFYNVLITSHQA 317
47 -65.4003k5p_A mol:protein length:416 D-3-phosphoglycerate dehydrogenase  ali model follow..  34  122IGEIIMLMRRIFPRSVSAHAGGWEKTA---IGSREVRGKTLGIVGYGNIGSQVGN-LAESLGMTVRYYDTSDKLQGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLINNARGSDVDLEALAKVLQEGHLAGAAIDVFPVEPASNSTPLQGLENVILTPHIG 299
48 -65.3001xdw_A mol:protein length:331 NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase  ali model follow..  28  111VTQAMMLLRHTAYTTSRTAKKNFKVDA--FMFSKEVRNCTVGVVGLGRIGRVAAQI-FHGMGATVIGEDVFEIKGEDYCTQVSLDEVLEKSDIITIHAPYIKENGAVVTRDFLKKMKDGAILVNCARGQLVDTEAVIEAVESGKLGGYGCDVLDGEASVFEKLVDLYPRVLITPHLG 299
49 -65.2003wx0_A mol:protein length:345 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding  ali model follow..  28  120IGMMMTLNRRIHRAYQRTRDANFSL---EGLTGFTMYGKTAGVIGTGKIGVAMLRI-LKGFGMRLLAFDPYPSAAELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFDQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDDVFRRLSACHNVLFTGHQA 307
50 -65.0001ygy_A mol:protein length:529 D-3-phosphoglycerate dehydrogenase  ali model follow..  37  108LALLLAASRQIPAADASLREHTWKRSS---FSGTEIFGKTVGVVGLGRIGQLVAQ-RIAAFGAYVVAYDPYVSPAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEP-CTDSPLFELAQVVVTPHLG 282
51 -64.9002dld_A mol:protein length:337 D-LACTATE DEHYDROGENASE  ali model follow..  30  112AIQAARVLRQDKRMDEKMAKRDLRW---APTIGREVRDQVVGVVGTGHIGQVFMRI-MEGFGAKVIAYDIFKNPEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDKSIAEMKDGVVIVNCSRGRLVDTDAVIRGLDSGKIFGFVMDTYEDEVDKRLADLIDRPNVLVTPHTA 299
52 -63.4005mh5_A mol:protein length:308 D-2-hydroxyacid dehydrogenase  ali model follow..  33  100AGYMLTFARRLHAYRDAQHDHAWDLPRYEE--PFTLAGERVCVVGLGTLGRGVVD-RAAALGMEVVGVRRSGDPVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVS 276
53 -63.3004zgs_A mol:protein length:386 Putative D-lactate dehydrogenase  ali model follow..  35  144VALIFALNRHLTDAYIRVRMGNYSL---SGLVGVEMRHKVVGVVGTGAIGQQAARI-LKGIGCKVFAYDIKPNPAAMGIPYVSLDELLAMSDIVTLHCPLLPSTRQLINKESIQKMKKGVMLINVSRGGLIDSAALFDALESGQIGALGLDVYENEGGRQFRTLLSYPQVLVTPHTA 337
54 -62.7003evt_A mol:protein length:324 Phosphoglycerate dehydrogenase  ali model follow..  31  103LAAMLSVVRGYHAAWLNQRGARQWALP---MTTSTLTGQQLLIYGTGQIGQSLAA-KASALGMHVIGVNTTGHPAHETVAFTATADALATANFIVNALPLTPTTHHLFSTELFQQTKQQPMLINIGRGPAVDTTALMTALDHHQLSMAALDVTEPEPLPTDHPLWQRDDVLITPHIS 278
55 -59.0004njm_A mol:protein length:309 D-3-phosphoglycerate dehydrogenase, putative  ali model follow..  27  113IGMMIFGFRKGFKEGK----------------GRELKDKTLGICGCGYVGKRVKE-IAEGIGMKIKVYDPFITTE---NQVKKIEELFEECQVISLHLPLTKETKGKIGYELIKKLPYGGMICNTARKEIIDEEGLIRIMREREDLIYITDVAPTSKVFNNEFK---GRFFATPKIG 267
56 -55.1003hg7_A mol:protein length:324 D-isomer specific 2-hydroxyacid dehydrogenase family protein  ali model follow..  33  108FGHLLSLMRQLPLYREQQKQRLWQSHPYQ-----GLKGRTLLILGTGSIGQHIAHT-GKHFGMKVLGVSRSGRERAGFDQVYALNKMLAQADVIVSVLPATRETHHLFTASRFEHCKPGAILFNVGRGNAINEGDLLTALRTGKLGMAVLDVFEQEPLPADSPLWGQPNLIITPHNS 281
57 -54.7005bqf_A mol:protein length:322 NADP-dependent 2-hydroxyacid dehydrogenase  ali model follow..  31  110VMQCLMHLRGQYGHDSHQRRREWAKLIAP-----EAAEVTVGVMGLGILGQDAVA-KLKVMGFNVIGWSRTRKTIEETFDAGELDRFLAKTDILVGLLPLTPETTGFYDSELFKKLRRDGVFINAGRGKSQIETDIVSAVREGTLGGASLDVFEVEPLATDSPLWELENVFITPHDA 287
58 -54.1004weq_A mol:protein length:341 NAD-dependent dehydrogenase  ali model follow..  32  123MMQCLLHLRQHRAYEALAKKHEWRDLSQP-----EAADVTVGIMGMGVLGQDAAR-KLAAMGFKVIGWSRSKRVIEETYDAAGLDAFLGRTDFLVGLLPLTPDTRGIFNAALFAKLSRNGVFINAGRGGSQVEADILECLDSGVLGGASLDVFEREPLSPESRFWDMPNVYVTPHVA 300
59 -53.6004zqb_A mol:protein length:316 NADP-dependent dehydrogenase  ali model follow..  32  108LAWTYYLFRDMPAYAAQQRARVWKGLPYK-----RPERTTVGVLGLGELGAAAAL-RLRDAGFDVHGWSRSPKEIAGVTCHATLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEALDSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHIS 281
60 -52.9005vg6_A mol:protein length:341 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding  ali model follow..  36  127LFCVLRHARDIPTFERAQREGRWHYVHPR-----TAAEIRVGVLGLGDLGAAAAL-ELARHGFDVRGWSRTPKALEGVSCFHALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDEAALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLA 300
61 -52.8003kbo_A mol:protein length:315 Glyoxylate/hydroxypyruvate reductase A  ali model follow..  26  107VSQVLHWFRRFDDYQALKNQALWKPLPEY-----TREEFSVGIMGAGVLGAKVAE-SLQAWGFPLRCWSRSRKSWPGVESYVELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIA 280
62 -52.6004n18_A mol:protein length:332 D-isomer specific 2-hydroxyacid dehydrogenase family protein  ali model follow..  29  118LWSVLWFQRHFDRALAHQRTQTWKLYPQR-----AAADFHIGIMGLGEIGGYIAD-QLARLGYRVSGWSRSEKQLAGVTCYRALDHFLGSLDGLINLLPLTAQTRGILAAPLFNRLPAGAVLINCGRGEHMVNDDVLAALESGQLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMA 291
63 -52.0005dt9_A mol:protein length:387 Erythronate-4-phosphate dehydrogenase  ali model follow..  30  107FSVLMVLAQQQ---------------------GFSVFDKTVGIIGAGQVGSYLAK-CLSGIGMKVLLNDPPKQAQGDEREFTELETLLKQADVITLHTPITRPTHHLIDAAILEQLRSDQILINAARGPVVDNAALKARLQQGDGFTAVLDVFEFEP-QVDMELLPL-LAFATPHIA 263
64 -51.6002o4c_A mol:protein length:380 Erythronate-4-phosphate dehydrogenase  ali model follow..  33  100LGCLLAMAEVR---------------------GADLAERTYGVVGAGQVGGRLVE-VLRGLGWKVLVCDPPRQAREPDGEFVSLERLLAEADVISLHTPLNRDTRHLLDEPRLAALRPGTWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEP--QADPELAARCLIATPHIA 256
65 -50.2003oet_A mol:protein length:381 Erythronate-4-phosphate dehydrogenase  ali model follow..  30  103FSALLMLAERD---------------------GFSLRDRTIGIVGVGNVGSRLQT-RLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEP-DLNVALLEAVD-IGTSHIA 259
66 -27.2005w3k_A mol:protein length:340 Ketol-acid reductoisomerase (NADP(+))  ali model follow..  20  6..........................YDQDVKTDALQGKKIAVVGYGSQGHAHAQ-NLKDNGYDVVIGIRPDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQP----------PADVDVFLVAPKGPGHLVRRFVEGSAVPSLF 150
67 -22.9003d4o_A mol:protein length:293 Dipicolinate synthase subunit A  ali model follow..  14  149...............................TDFTIHGANVAVLGLGRVGMSVAR-KFAALGAKVKVGARESDLLARIFHISKAAQELRDVDVCINTIP-----ALVVTANVLAEMPSHTFVIDLASGGTDFRYAEKRGIKALLVPGLPGIVA---PKTAGRILAD........... 283
68 -21.8004tsk_A mol:protein length:350 Ketol-acid reductoisomerase  ali model follow..  20  15...................................LADKRIAVIGYGSQGHAHAQ-NLRDSGFDVVIGLRPAKAEADGFRVMAVGEAVEESDVIMILLP-DERQPAVYEREIRPYLTAGKALAFAHGFNIHFSQIQPP---------KDVDVFMVAPKGPGHLVRR........... 138
69 -20.8002rir_A mol:protein length:300 Dipicolinate synthase, A chain  ali model follow..  13  120RKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVLGLGRTGMTIAR-TFAALGANVKVGARSSAHLAR-FHTDELKEHVKDIDICINTIP-----SMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGL........................... 270
70 -14.6004xdy_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  20  14...................................LRDKTIAVMGYGAQGDAQACLKDSGINVVIGETEIWEKAKEDGFEVLPIDKAAEKGDVVHILLP-DEVQPAIYENQIKPQLKAGKALCFSH................................................... 112
71 -14.4005yeq_A mol:protein length:340 Ketol-acid reductoisomerase (NADP(+))  ali model follow..  18  15...................................IKEKRVAVLGYGSQGRAWAL-NLRDSGIKVSVGLEREGNENDGFKPLRTEEAVRNSDIIIFLLP-DMIQRTVYLERVKPYLKEGMDLVFAH................................................... 108
72 -14.3001np3_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  19  14...................................IQGKKVAIIGYGSQGHAHACNLKDS-GVDVTVGLRSGSAEAHGLKVADVKTAVAAADVVMILTP-DEFQGRLYKEEIEPNLKKGATLAFAH................................................... 107
73 -14.0004kqw_A mol:protein length:350 Ketol-acid reductoisomerase  ali model follow..  16  25...................................IQGLKVGIIGYGSQGHAHALNLMDS-GVDVRVGLREGSSEEAGLKVTDMDTAAEEADVIMVLVP-DEIQPKVYQEHIAAHLKAGNTLAFAHGFNIHYGYIVPPEVRRQFTEGSGVPDL........................ 160
74 -14.0004xdz_A mol:protein length:343 Ketol-acid reductoisomerase  ali model follow..  24  15...................................IKNKTIAILGYGSQGRAWAL-NLRDSGLNVVVGLERRRAIDDGFKPMYTKDAVAIADIIVFLVP-DMVQKSLWLNSVKDFMKKGADLVFAH................................................... 108
75 -13.9005e4r_A mol:protein length:490 Ketol-acid reductoisomerase  ali model follow..  21  15...................................IKNKTIAILGYGSQGRAWAL-NLRDSGLNVVVGLERQGDIDDGFKPMYTKDAVAIADIIVFLVP-DMVQKSLWLNSVKDFMKKGADLVFAHGFNIHFKIIEPPK...................................... 121
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205