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Query: PF13826.6; G7XTL7_ASPKW/119-243; Domain of unknown function (DUF4188 topsan), from PfamA32U

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst IVVFHLGARNHHPLGMFAPGMKELGDSAEKMQRDMRANPVKYGLLGSSQWLKCDSAAGNEFMTVFYLRDYAALHQFAHDEIHMEGVRWWARIAKDHPHLALYHETYLVPRGNWENIYINGWPTGLLast
1 -53.4003w08_A mol:protein length:352 Aldoxime dehydratase  ali model follow..  18  214IALIRSGQDWADAEAEERSLYLDILPTLQDGMDFLRDNGQPLGCYSNRFVRDLDGNFLDVSYNIGHWRSLEKLERWAEHPTHLRIFVTFFRVAAGLKKLRLYHEVSVSDAKSQVFEYINCHPTGM 343
2 -51.6003a15_A mol:protein length:373 Aldoxime dehydratase  ali model follow..  17  228IALIRSGQDADAEADERSLYLDEILPTLQSGMDFLRDNGPAVGCYSNRFVRDIDGNFLDLSYNIGHWASLDQLERWSEHPTHLRIFTTFFRVAAGLSKLRLYHEVSVFDAADQLYEYINCHPTGM 357
3 -24.4002go8_A mol:protein length:122 Hypothetical protein yqjZ  ali model follow..  18  14YAVIFSSVKSEN-----DTGYGETAERMVSLAADQP------GFLGVESVREADG----RGITVSYWDSMDAINHWRHHTEHQAA---------KEKGRSVWYESYAVRVAKVDRQR........ 106
4 -21.6001tz0_A mol:protein length:114 hypothetical protein  ali model follow..  14  9IETKTFTVKEGT------------SNIVVERFTGEGIIEKFEGFIDLSVLVKKVRRGDEEVVVMIRWESEEAWKNWETSEEHLAGHRAGRGKPKPDHIINVDHAVYYV................. 104
5 -19.3002zdp_A mol:protein length:110 Heme-degrading monooxygenase isdI  ali model follow..  5  5MAENRLQLQKGS------------AEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTDEVKILTIWESEDSFNNWLNSDVFKEAHKNVRLKSDDDGQQSPI-FKYDIGYHYQK........... 110
6 -19.0002zdo_A mol:protein length:109 Heme-degrading monooxygenase isdG  ali model follow..  8  6MAEARLTLTKGT------------AKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNEDESSPII--ITYDI................. 103
7 -18.9001xbw_A mol:protein length:109 hypothetical protein isdG  ali model follow..  6  6MAENRLTLTKGT------------AKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNEDESSPIINNKVITYDI............... 103
8 -17.4003hx9_A mol:protein length:124 Protein Rv3592  ali model follow..  12  4VKINAIEVPAGA---------PELEKRFAHRAHAVENSP---GFLGFQLLRPVKGE--ERYFVVTHWESDEAFQAWANGPAIAAHAGHRANPVATGASLLEFEVVLDVGGTG............. 102
9 -17.0005uq4_A mol:protein length:108 Monooxygenase  ali model follow..  12  7VKINAIEVPAGA---------PELEKRFAHRAHAVENSP---GFLGFQLLRPVKGE--ERYFVVTHWESDEAFQAWANGPAIAAHAGHRANPVATGASLLEFEVVLDVGGTG............. 105
10 -15.4001iuj_A mol:protein length:106 hypothetical protein TT1380  ali model follow..  10  1MFVTMNRIPVRP------EYAEQFEEAFRQRARLVDRMP---GFIRNLVLRPKNPG--DPYVVMTLWESEEAFRAWTESPAFKEGHARSGTLPKEAFLGPNRLEAFEV................. 97
11 -14.2002ril_A mol:protein length:99 Antibiotic biosynthesis monooxygenase  ali model follow..  12  7TLINPFKVPADK---------EAAIEYWEAHRDFMAQQP---GYLSTQLHQSIDEGATYQLINVAIWQSEADFYQAAQKMRQALGHVQVEGLCGNPALYRVIRT..................... 99
12 -13.7001r6y_A mol:protein length:115 Protein ygiN  ali model follow..  10  1MLTVIAEIRTR-------PGQHHRQAVLDQFAKIVPTVLKEEGCHGYAPMVDCAAGAPDSIVMIEQWESIAHLEAHLQTP-HMKAYSEAVKGDVLEMNIRILQPG.................... 103
13 -13.6003fgv_A mol:protein length:106 uncharacterized protein with ferredoxin-like fold  ali model follow..  13  16VVIVKSTPQRGK-----------FNAFAELVGKLVSETRDFPGCLGAYLMLAPER---NEQVVMHIWETPDALEAYLTWRADRGDFLEINEYLEVEQDFKTYQLA.................... 106
14 -13.3003kng_A mol:protein length:125 SnoaB  ali model follow..  12  14EVTFVNRFTVH-------GAPAEFESVFARTAAFFARQP---GFVRHTLLRERDKD--NSYVNIAVWTDHDAFRRALAQPGFLPHATALRALSTSEHGL.......................... 100
15 -13.3003kg0_A mol:protein length:128 SnoaB  ali model follow..  12  16EVTFVNRFTVH-------GAPAEFESVFARTAAFFARQP---GFVRHTLLRERDKD--NSYVNIAVWTDHDAFRRALAQPGFLPHATALRALSTSEHGL.......................... 102
16 -13.1003fmb_A mol:protein length:118 Dimeric protein of unknown function and ferredoxin-like fold  ali model follow..  9  18..IVLFKLRDDVPVEEKLVVMNSFKEAIEALPAKIS------VIRKIEVGLNMNPGETWNIALYSEFDNLDDVKFYATHPEHVAAGKILAETKES.............................. 104
17 -12.9004oz5_A mol:protein length:155 Bacillus subtilis HmoB  ali model follow..  8  67AVLNNIAVTQEG---------PLFENKFKNRAGKVENEP---GFEAIRVLRPLDS---DTYVILTLWETERAFQDWQQSDSYKEAHKKIFSRPSYVTTYFA........................ 153
18 -12.8004kia_A mol:protein length:167 Lmo2213 protein  ali model follow..  9  73.............IHLRDEEIPIFLQMYQRASLHFSETP---GLQSTKLTKAMNM---NKFLIISFWDSEVFFHDWKKSPLSKEITNIMRKNNTQSGF--SHEDIYHYPEFSHDA.......... 166
19 -12.5004ae5_A mol:protein length:167 SIGNAL TRANSDUCTION PROTEIN TRAP  ali model follow..  13  68YCAIFIPSTEDH---------YQLEKKLISVDDNFRNFG---GFKSYRLLRPAKG---TTYKIYFGFADRHAYEDFKQSDAFNDHFSK-SHYFGSSGQHSSYFERYLYPIKE............. 167
20 -12.2001lq9_A mol:protein length:112 ACTVA-ORF6 MONOOXYGENASE  ali model follow..  10  10.FVAVVTFPVDGP-----ATQHKLVELATGGVQEWIR--EVPGFLSATYHASTDG---TAVVNYAQWESEQAYRVNFGADPRSAELREALSSLPG.............................. 93
21 -12.2004dpo_A mol:protein length:119 Conserved protein  ali model follow..  8  21RVVAKNQVKPEK-----------VQEFMNLCKSLIEETLKEEGCIDYGVYQELENP--EILTMLEEWKDEGSLDQHIRSDHFKEIFPLLSECLDKETEINIYRKKL................... 113
22 -12.1003tvz_A mol:protein length:172 Putative uncharacterized protein yhgC  ali model follow..  9  73AVLNNIAVTQEG---------PLFENKFKNRAGKVENEP---GFEAIRVLRPLDS---DTYVILTLWETERAFQDWQQSDSYKEAHKKRGTSAGIDT............................ 155
23 -11.7003gz7_A mol:protein length:115 Putative antibiotic biosynthesis monooxygenase  ali model follow..  6  14MIQEIASILVQP------GREADFEAGVAQARPLFMRAR---GCHGVALHRSIEAP--QRYTLVVDWETVDNMVDFRQSADFQEWRKLVGECFAEPPQVHHEQKVL................... 109
24 -11.7003bde_A mol:protein length:120 Mll5499 protein  ali model follow..  22  18TVVFTLKHASHS------LEEKRFLVDAKKILSAIR------GVTHFEQLRQISPKIDYHFGFSMEFADQAAYTRYNDHPDHVAFVRDRWV.................................. 96
25 -11.5002gff_A mol:protein length:106 LsrG Protein  ali model follow..  10  1MHVTLVEINVKE---------DKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIP--TRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAPLMTGPRKKTVFIGLM................... 95
26 -11.5004hl9_A mol:protein length:118 Antibiotic biosynthesis monooxygenase  ali model follow..  10  19KVIAQDFIKPEA-----------IDIVLPLYRELVEKTRQEPLCLAYDLFVDQKDP--GHFVFIEEWPDRAALDIHCATEHFTRLVPLINAHQRQDGTVVLMDAV.................... 110
27 -11.4002omo_A mol:protein length:124 DUF176  ali model follow..  7  19VTIVYASVKTDK-----------TEAFKEATRMNHEQSIREPGNMRFDILQSADDP--TRFVLYEAYKTRKDAAAHKETAHYLTWRDTVADWMAEPRKGVIYGGLYPTGDD.............. 116
28 -11.4003fj2_A mol:protein length:186 Monooxygenase-like Protein  ali model follow..  10  86.............IQLRDEEIPIFLQMYQHASLHFSETP---GLQSTKLTKAMNT---NQFLIVSFWDSEVFFQEWKKTPLHKEITSIMKKNNTQVGFSHE--DIYHYPEFSHDAK......... 180
29 -11.4003qmq_A mol:protein length:99 Autoinducer-2 (AI-2) modifying protein LsrG  ali model follow..  8  6VTLVEINVHEDK-----------VDEFIEVFRQNHLGSVQEEGNLRFDVLQDPEVN--SRFYIYEAYKDEDAVAFHKTTPHYKTCVAKLESLMTGPRKKRLFNGLM................... 98
30 -11.4002bbe_A mol:protein length:108 hypothetical protein SO0527  ali model follow..  10  15VCVASFLSKEGK-----------TEALIAALASLIPDTRREAGCIRYELNVSRDEP--RRVTFVEKFVDIAAFDEHCAKDAIQHYFHQVMPELVESFHVETYHQV.................... 106
31 -11.3004zos_A mol:protein length:106 protein YE0340 from Yersinia enterocolitica subsp. enterocolitica 8081  ali model follow..  13  24......................NRERVKELVLKFVEPARLETGCLYYDLYQKIDEP--DTFYIIDGWVNQEAVTSHAENPHVAEVMSDLQPLLTFGPSISLITRV.................... 104
32 -11.3001rjj_A mol:protein length:111 expressed protein  ali model follow..  8  9..LVVVKFKEDTKVDEILKGLENLVSQIDTVKSF----------WGEDKESHDMLRQGFTHAFSMTFENKDGYVAFTSHPLHVEFSAAFTAVIDK.............................. 92
33 -11.3005f9p_A mol:protein length:241 Anthrone oxidase-like protein  ali model follow..  11  10.LTVLNLFTTDTP---------EKQGKLIEEMTKIVDAATYEGWMSSTVHSGVDS---HGTLNFIQWRSGEDLEKRYAGEEFKHRTLPVFGEITTSIRL.......................... 95
34 -11.3003fez_A mol:protein length:186 uncharacterized ferredoxin fold protein related to antibiotic biosynthesis monooxygenases  ali model follow..  9  86.............IHLRDEEIPIFLQMYQRASLHFSETP---GLQSTKLTKAMNM---NKFLIISFWDSEVFFHDWKKTPLSKEITNIMKKNNTQSGF--SHEDIYHYPEFSHDA.......... 179
35 -10.8001y0h_A mol:protein length:102 hypothetical protein Rv0793  ali model follow..  7  18......................ARSALRALLDAMITPTRAEDGCRSYDLYESADG---GELVLFERYRSRIALDEHRGSPHYLNYRAQVGELLTRPVAVTVLAPL.................... 97
36 -10.8003bn7_A mol:protein length:120 Ferredoxin-like protein  ali model follow..  10  18QVFFWLKNPGDK----------ADRDKLIAGLKALKAIDVIQQLHVGVPAATEKRDVVDNSYDVSEFKSVEDQKRYRDHPLLQKFVADCSHLWSK.............................. 105
37 -10.7004npo_A mol:protein length:125 Uncharacterized protein  ali model follow..  9  19MVISHGTLSASA---------EHAAHLRQLLVHIAQATRQEDGCLLYLVSEDLSQP--GHFLITEHWDNLGAMHTHLALPGVTQAIDALKHLNVTDLKITAYEAG.................... 112
38 -10.6002fb0_A mol:protein length:94 conserved hypothetical protein  ali model follow..  8  4MIRLNVFVRVNE---------TNREKAIEAAKELTACSLKEEGCIAYDTFESSTRR--DVFMICETWQNAEVLAAHEKTAHFAQYVGIIQELAEMKLEKFEF....................... 94
39 -10.6003mcs_A mol:protein length:219 Putative monooxygenase  ali model follow..  9  115AVYTVIDVKPEN-----------DKEFAEIIKNIVETTFNEEGTLLVYLGTDRRNF--NKWCLFEVYKDIDSYLNHRSAKYFKDYITQTKDMIAGKKRAELQVLKIENKGGDYKKLY........ 219
40 -10.4001q8b_A mol:protein length:105 Protein yjcS  ali model follow..  12  26.....................KDLNEIMKEFKKLEEETNKEEGCITFHAYPLEPSE--RKIMLWEIWENEEAVKIHFTKK-HTIDV....................................... 87
41 -10.2003bm7_A mol:protein length:115 Protein of unknown function with ferredoxin-like fold  ali model follow..  9  16GVVATLKVQPAK---------AEFEKVFLDLAA--KVKANEPGCLVYQLTRSKTEE--GVYKVLELYASMDALKHHGGTDYFKAAGAAMGPTMAGAPVIEYLDAV.................... 108
42 -10.2001q4r_A mol:protein length:112 protein At3g17210  ali model follow..  4  14VLLASFKDGVSP---------EKIEELIKGYANLVNLIEPMKAFHWGKDVSIENLHQGYTHIFESTFESKEAVAEYIAHPAHVEFATIFLGSLDKVLVIDYKPTSVSL................. 112
43 -10.1003bgu_A mol:protein length:116 Ferredoxin-like protein of unknown function  ali model follow..  15  19IALFRWNDTVTP------DQVEQVITALSKLPAAIP------ELKNYAFGADLGLAAGNDFAVVADLDGEDGFRAYQDHPDHRAALAIIAPMLADRVAVQF........................ 108
44 -9.9503bb5_A mol:protein length:121 Stress responsive alpha-beta protein  ali model follow..  13  18LVMLEPEGEGAM------DRIMEAMAILDGLAPELP------GLTEFRHGPNRDFEQKSERYPYGFFTDKAALDAYAVHPTHQRAGGMLVASCRN.............................. 103
45 -9.9101x7v_A mol:protein length:99 PA3566 protein  ali model follow..  12  19......................HAEALERELRALVAPSRAEAGCLQYDLHQDRHDS--HLFYMIEQWRDDAALERHQNTE-HFLRFSRGNEALLQNVKIDQLYRL.................... 98
46 -9.6502qyc_A mol:protein length:103 Ferredoxin-like protein  ali model follow..  14  8VVMMEFDDGIDA------GFFRTVDEYVARMKRECD------GLLLYHFGENVAARSQGTHATSSAFVDAAAHDAYQVCPAHVAMKAFMGPRIKR.............................. 91
47 -9.6005b08_A mol:protein length:104 Olivetolic acid cyclase  ali model follow..  4  9LIVLKFKDEITE---------AQKEEFFKTYVNLVNIIPAMKDVYWGKDVTQKNKEEGYTHIVEVTFESVETIQDYIIHPAHVGFGDVYRSFWEK.............................. 94
48 -9.6001si9_A mol:protein length:108 stable protein 1  ali model follow..  9  12TLLTRFKDEITR----------EQIDNYINDYTNLLDLIPSMKSFNWGTDLGMESAELNRGYTHAFFESKSGLQEYLDSAALAAFAEGFLPTLSQRLVID--YFLY................... 108
49 -9.2505xzq_A mol:protein length:140 Hydroxynitrile lyase  ali model follow..  9  22IVFNRYKSQLSQ------KQIDQIIADYGNLQNIAPEMKE----WGTDLGPAVEDRADGTHAYESTFHSVADFLNFFYSPPALEFAKEFFPACEK.............................. 109
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.