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Query: PF15961.5; ZN839_HUMAN/7-805; Domain of unknown function (DUF4764 topsan), from PfamA32U

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst IQPQTARKSQLPRGNSCLVGLHIASPQLLRVQPLVRTEPQSCFLSDLCQPPAQGFVQRPLPALQVVPAKRVPAPKAPDEQGSMLTPLSASDPLAVTSLSSSSAHPFISNLHTRHTEKLKKSLKVKTRSGRVSRPPKYKAKDYKFIKTEDLADGHLSDSDDYSELCVEEDEDQRERHALFDLSSCSLRPKSFKCQTCEKSYIGKGGLARHFKLNPGHGQLDPEMVLSEKASGSTLRGCTEERTLSLTSLGLSMPADPCEGGARSCLVTESARGGLQNGQSVDVEETLPSEPENGALLRSERYQGPRRRACSETLAESRTAVLQQRRAAQLPGGPAAAGEQRASPSKARLKEFLQQCDREDLVELALPQLAQVVTVYEFLLMKVEKDHLAKPFFPAIYKEFEELHKMVKKMCQDYLSSSGLCSQETLEINNDKVAESLGITEFLRKKEIHPDNLGPKHLSRDMDGEQLEGASSEKREREAAEEGLASVKRPRREALSNDTTESLAANSRGREKPRPLHALAAGFSPPVNVTVSPRSEESHTTTVSGGNGSVFQAGPQLQALANLEARRGSIGAALSSRDVSGLPVYAQSGEPRRLTQAQVAAFPGENALEHSSDQDTWDSLRSPGFCSPLSSGGGAESLPPGGPGHAEAGHLGKVCDFHLNHQQPSPTSVLPTEVAAPPLEKILSVDSVAVDCAYRTVPKPGPQPGPHGSLLTEGCLRSLSGDLNRFPCGMEVHSGQRELESVVAVGEAMAFEISNGSHELLSQGQKQIFIQTSDGLILSPPGTIVSQEEDIVTVTDAEGRLast
1 -10.9006c23_A mol:protein length:739 Polycomb protein SUZ12  ali model follow..  12  398....................................................................................................QTIAVKESLTTDLQTRKEKDTPNENRQKLRIF---------YQFLYNNNTRQQTEARDD-------------------------------LHCPWCTLNCRKLYSLLKHLKL--CHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNR------HSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEK----------EVMKLWNLHVMK--HGFIADNQMNHACMLFVENYGQ-KNLCRNFMLHLVSMHDFNL-ISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEKEKALETDSVSGVSKQSKKQKL................................................................................................................................................................................................................................................................................................................. 739
2 -10.9003zms_C mol:protein length:509 INSULINOMA-ASSOCIATED PROTEIN 1  ali model follow..  10  168....................................................................................MGTAFSAGAEAARGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPR-----EPEAAARAEAREAPGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFP---KYCPATFYSSPGLTRHINKCHPSEN------RQVILLQVPVRPAC..................................................................................................................................................................................................................................................................................................................................................................................................... 509
3 -10.7002dmi_A mol:protein length:115 Teashirt homolog 3  ali model follow..  14  2..................................................................................................................SSGSSGKLYGSIFTGASKFRCKDCSAAYDTLTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 110
4 -10.3005z10_A mol:protein length:2547 Piezo-type mechanosensitive ion channel component 1  ali model follow..  8 1309LKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQMAYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLS-RAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLYVGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAGDLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRL--ILNHMVTASAASLVLPVL---VFLWAMLTIP----RPSKRFWMTAI--FTEVMVVTKYLFQFGFFPWNSYVVLRRYENKP-PPRILGLEKTLLCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQGKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTERKRPRHTQEKSKFRERMKAAGRRLQS.................................................................................................................................................................................................................... 1945
5 -10.2005und_A mol:protein length:202 Transcriptional repressor CTCF  ali model follow..  17  102..................................................................................................................ARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHD........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 202
6 -10.1005gjv_A mol:protein length:1873 Voltage-dependent L-type calcium channel subunit alpha-1S  ali model follow..  9 1477..............................................................................................................................................................................................................................................................................................................................................IKTEGNFEQANEELRAIIKK-TSMKLLDQVIPPIGD-VTVGKFY---------ATFLIQEHFRKF-------MKRQEEYYGYRPKKDTVQIQAGLRTIEEEAAPE-----RRTISGDLTAEEELERAMVEAAMEERIFRRTGGLFGQVDTFLERTNSLPPVMANQRPLQFAEIEMEELESPVFLEDFPQDARTNPLARANTNNANANVAYGNSNHSNNQMFSSVHCEREFPGEAETPAAGRGALSHSHRALGPHSKPCAGKLNGQLVQPGMPINQAPPAPCQQPSTDPPERGQRRTSLTGSLQDEAPQRRSSEGSTPRRPAPATALLIQEAADAGFVTATSQALADACQMEPEEVEVAATELLKARESVQGMASVPGSLSRRSSLGSLDQVQGSQETLIPPR............................................................... 1872
7 -9.8805k5h_A mol:protein length:122 Transcriptional repressor CTCF  ali model follow..  15  2.............................................................................................................................PLGSE--KPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENV..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 92
8 -9.6202gqj_A mol:protein length:98 Zinc finger protein KIAA1196  ali model follow..  26  52...........................................................................................................................................................................................QDALKCQHCRKQFKSKAGLNYHTMAEHSAKPSDAEASEGGESGPSS...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 97
9 -9.5705k5i_A mol:protein length:117 Transcriptional repressor CTCF  ali model follow..  14  17..................................................................................................................RDTYKLKRHMRTHSGE--KPYECYICHARFTQSGTMKMKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSH.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 117
10 -9.5205yel_A mol:protein length:176 Transcriptional repressor CTCF  ali model follow..  16  43..................................................................................................................ARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYASRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 150
11 -9.4502ctd_A mol:protein length:96 Zinc finger protein 512  ali model follow..  14  3...................................................................................................................................SGSSGRIRKEPPVYAAGSLEEQWYLEIVDKGSVSCPTQAVGRKTIEGLKKHMENCKQEMFTCHHCGKQLRSLAGMKYHVMANHNS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 88
12 -9.4502rsi_A mol:protein length:92 Zinc finger protein ZFAT  ali model follow..  13  2............................................................................................................................SSGSS--GKPYKCPQCSYASAIKANLNVHLRKHTGEKFACDY--SFTCLSKGHLKVHIERVHKKIKQHCRFCKKKYSDVKNLIKHIRDAHDPQD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 92
13 -9.4301zr9_A mol:protein length:124 Zinc finger protein 593  ali model follow..  18  1................................................................................................................................G-LEK--KRRRPDLDEIH-RELRPQGSARPQPDPNAEFDPDLPGGGL---------------HRCLACARYFIDSTNLKTHFR-SKDH....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 69
14 -9.4201x3c_A mol:protein length:73 Zinc finger protein 292  ali model follow..  16  26............................................................................................................................................................................................RPYRCQGCFAAFTIQQNLILHYQA---HKSDLPAFSAEVEEESGPSSG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 73
15 -9.3003jct_I mol:protein length:166 Bud site selection protein 20  ali model follow..  23  2................................................................................................................................GR-----RYKTK--RRTRDLDLIYNDLSTKESVQKLLNQPLDETKPGLG------------QHYCIHCAKYMETAIALKTHLK-GKVH....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 73
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Li Z, Szczurek E, Godzik A. Putative type IV secretion genes in Bacillus anthracis. Trends Microbiol. 2007 May;15(5):191-5. Epub 2007 Mar 26.