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Query: PF00621.20; Q54DW4_DICDI/1134-1313; RhoGEF domain, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180
# Score Template Links and tools%idFirst LAQELALSEEEYVDSLTYIYNVFLQPIKKSIDTPNQLVSYQENLEISSNFETLFSCHKTFLIALKERIAEWDSKPLMSDIFMEKAGFLKLYNYYVQNHTRSLQVLEHCIEKYPLFAIHLKRIESDQNTELKVLLAQPLRRVSKYYLVLREILQYTRPKHDDYDALNRVVANLKDQTDKFNLast
1 -83.800PF00621.20; Q54DW4_DICDI/1134-1313; RhoGEF domain  ali  100  1LAQELALSEEEYVDSLTYIYNVFLQPIKKSIDTPNQLVSYQENLEISSNFETLFSCHKTFLIALKERIAEWDSKPLMSDIFMEKAGFLKLYNYYVQNHTRSLQVLEHCIEKYPLFAIHLKRIESDQNTELKVLLAQPLRRVSKYYLVLREILQYTRPKHDDYDALNRVVANLKDQTDKFN 180
2 -7.760PF12210.8; G4VTD8_SCHMA/413-504; Hepatocyte growth factor-regulated tyrosine kinase substrate  ali follow..  12  1..........EFLDALRGSIEFFVNRLQSNSQRGRNISSDTTVQTLFLTLNKM---HPQLMDYKHYMEERRAYFEKMQD..................................................................................................... 66
3 -6.750PF06552.12; TO203_ARATH/7-193; Plant specific mitochondrial import receptor subunit TOM20  ali follow..  13  4............ILLFEQIRQDAENTYKSNPLDADNLLELSQFHSISDAKQMIQEAITKFEEALLIDPKKDEAVWCIGNAYTSFAFLTPDETEAKHNFDLATQFFQQAVDEQPSLEMTAKAPQLHAEAYKQGLGSQPMGRVEAPAPPSSKAVKNKKSSDAKYDAMGWVILAIGVVA.... 181
4 -6.400PF09808.9; Q21749_CAEEL/16-210; Small nuclear RNA activating complex (SNAPc), subunit SNAP43  ali follow..  9  3.............EDLDTLLRAYLQFKSVRFYDYKMMFERRGMVDIFNGNEHLLVQCLSYMEEEACPGMPRSLKERLFGLYS-------LYTFFFIQQESHVVQIRMNPDCARNFRKFAQFLLVEKIYDAYVVCKKLLQN........................................ 132
5 -6.300PF05426.12; Q9KWU1_SPHSX/70-343; Alginate lyase  ali follow..  11  81....VATGKPVYATCLLNMLDKWAKALLNYDPKSQSWYQVEWSAATAAFALSTMMAEPNVDTAQRERVVKW-----LNRVARHQTSFPGGDTSCCNNHSYEATIIGVISKDDELFRWGLGRYVQMGLINEDGSFVHEMTRYQNYAMLLTMIAETASRQGIDLYAYKENGRDIHSARKFV. 264
6 -6.050PF16591.5; A4VQJ2_PSEU5/57-311; Helical bimodular sensor domain  ali follow..  10  73QLKEQAGYNAQYQNSLNDMRK-----AYNQANGSRQVIDGA--TRLSELTASVSNHVIQLPEYDEDRFAQLLAISLIKEDVQRAQYLLRVYMA-----APGNDAAKAIYTQLDAAQATLGRHAGALDDDSGAAVQQIRSVLGEYRGAIESLETATQAIAKARQEMTDQQKEIVRISDSL. 240
7 -6.010PF07900.11; Q8TH36_METAC/30-238; Protein of unknown function (DUF1670 topsan)  ali follow..  11  59VIITIYDPEDCKVKNQRELLDKRIMRISNEAHTQGALLTQADIAILLGESTKTISRHIEALEENGELVPTRGKWKDIGPGVSHKKRILELYLK-----YEYTEIERKTQHSGEAIMRYVKDFARILVLTEEGFEDEELRIITGLS-TIQEYKE........................... 208
8 -5.700PF16535.5; Q2NVH6_SODGM/126-289; Type III cell invasion protein SipB  ali follow..  11  3............................................................LTYIMGNIIKLTGNKSLQQLSNNLAAYVAQSKGTQTAASAMSEVLKQATSQWAGCKDDLTAAQEHAD-QLQSAADQATQAASEALKSLKELQAQAAKEIADSGSVSPALQKKLDAAK... 118
9 -5.690PF10602.9; RPN7_SCHPO/77-250; 26S proteasome subunit RPN7  ali follow..  10  1........DSNFLNSMIKKNEEKLAEFDKAIEDAQELNGEHEILEAMKNKADYYTNICDRERGVQLCDETFERATLTGMKIDVLFSKIRLA--VYADMRVVGQLLEKLKPLIEKGGDWERKNRLKAYQGIYLMSIRNFSGAADLLLDCMSTFSSTELLPYYDVVRYAVISGAISL..... 166
10 -5.540PF04484.12; I1NG16_SOYBN/270-586; QWRF family  ali follow..  12  147......EDRIFDAHTLRLLYNRYVQ-VNARADATFMVQKLNAERHLWNAWVTISELRHS-VILKRIKLVLLRQKLKLTSILKGQISYLEEWALLDRDHSSSLLGATEALKAIADVPNLKDALGSAVDVAMASSIYSLSSKVEETNCLVAEILKVTSKE...................... 312
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.