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Query: PF00910.22; A7M6L1_9SECO/473-576; RNA helicase, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VYAYGESRTGKTLVVDKLITDFQNHFGLGKDTVYSRNPIDQYWSGYRRQPIVSIDDFGAVTCDPSMEAQMIPLVSSAPLPLTMAAIEEKGMMFDSKFIFCSSNLLast
1 -70.800PF00910.22; A7M6L1_9SECO/473-576; RNA helicase  ali  100  1VYAYGESRTGKTLVVDKLITDFQNHFGLGKDTVYSRNPIDQYWSGYRRQPIVSIDDFGAVTCDPSMEAQMIPLVSSAPLPLTMAAIEEKGMMFDSKFIFCSSNL 104
2 -16.500PF01695.17; Y4IQ_SINFN/60-238; IstB-like ATP binding protein  ali follow..  12  51ILLFGPPGGGKSHLAAAIGLALIENLVQKLQVARRELQLESAIAKLDKFDLLILDDLAYVTKDQAETSVLFELISA---------------RYERRSIMITANQ 150
3 -15.900PF00519.17; VE1_BPV5/184-617; Papillomavirus helicase  ali follow..  13  265LAFIGPPDTGKSLFTNSLMSFL------KGKVLNFANSASHFLAPLTEAKVALIDDA-THACLKYCDTYLRNFFDGYSVCIDRKHKNAVQIKAPP--MLLTSN. 359
4 -15.600PF01057.17; Q7TG44_9VIRU/193-485; Parvovirus non-structural protein NS1  ali follow..  8  138LWLFGHATTGKTNIAEAIAHAV------PFYGCVNWTNENFPFNDCVEKMIIWWEE---GKMTAKVVETAKAILGGSRVRVDQKCKASVPIEPTPVIITSNTNM 232
5 -15.000PF05496.12; RUVB_BACAN/21-179; Holliday junction DNA helicase RuvB P-loop domain  ali follow..  9  36VLLYGPPGLGKTTLANIIANEMGVNVRTTSGPAIERPGDLA--TSLQPGDVLFIDEIHRLHRSIEEVL-YPAMEDFCLDIVIGKGPSARSVRLDLPLVGATTR. 141
6 -15.000PF06431.11; Q8JUD5_POVJC/266-682; Polyomavirus large T antigen C-terminus  ali follow..  12  158WLFKGPIDSGKTTLAAALLDLC-------GGKSLNVNMPLE-LGVGIDQFMVVFEDIKGTGAESRDLPSGHGISNLDCLRDYLVNLERKKRTQVFPPGIVTMN. 265
7 -14.500PF04665.12; Q6TUP8_YMTV5/6-246; Poxvirus A32 protein  ali follow..  13  16IALVGGSGSGKTAYLLSLFNTFVEKYRITTKQKIEKYVKKQGNDKTTEMFLLILDDMGDKQIRSSCLLDFLN----------------HGRHLNTSIILLCQTY 138
8 -14.500PF03266.15; NTPTH_METAC/3-167; NTPase  ali follow..  14  2IAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGGIRTAEIRKE--RNALACDLVVIDEIGPMELISQSFVSAVEEVLESDAVLHHSSRHPLAQRFRKGFEVLTVD. 153
9 -13.700PF13337.6; R6V945_9CLOT/51-507; Putative ATP-dependent Lon protease  ali follow..  11  211LCELGPRSTGKSHIFKEISPNSILVSGGQTTVALFYNMGRKTVGLVGLWDCVAFDEVAGINFKDKDIQIMKDYMASGSFARGKEEKSASAS------MVFVGNI 310
10 -13.200PF13238.6; A0B5Y2_METTP/3-117; AAA domain  ali follow..  29  1IALTGTPGTGKTTVSGLLPFRVVNLNDLIRDGMS...................................................................... 34
11 -13.100PF07724.14; Q7PAG5_RICSI/595-759; AAA domain (Cdc48 subfamily)  ali follow..  16  6FLFLGPTGVGKTELTKALAGFL-----FDDRNAILRIDMSEYMEGYIGYDVILFDEVEKAHPD---FNIMLQILDE-----RLTDSQGITVDFKNTIIVLTSNL 125
12 -12.800PF08303.11; Q6CK12_KLULA/389-554; tRNA ligase kinase domain  ali follow..  16  2LVTIATIGCGKSTVSLTLNELFPESWGLVVNDNITSNKTD------DGKQFVLADKNNHQFRERAAVFEWIN................................ 77
13 -12.500PF05673.13; Q0K6N5_CUPNH/29-287; Protein of unknown function (DUF815 topsan)  ali follow..  16  61VLLTGARGTGKSSLIKACLNAFLRLVEVDKDDLGDLGDIVELVAQRPERFVIFCDDL-SFEEGESGYKSLKSALDGSVAAQS-----------DNVLIYATSN. 155
14 -12.400PF18751.1; S5Y5G5_9CAUD/1-187; P-loop Nucleotide Kinase3  ali follow..  14  6IYLVGQPGSGKSTLMSALTAGFDRHKIAPAPDYSSIIDKAAPWVRSQPYPLLLAERFIDAALEGGYEVTLVLLDHNDAEDWRKVRSKAIGKTQNPSWV...... 144
15 -12.300PF00308.18; DNAA_STRCO/317-535; Bacterial dnaA protein  ali follow..  18  37LFIYGESGLGKTHLLHAIGHYASEEFTNEFINSIRDGKGDSFRKRYREMDILLVDDIQFLADKESTQEEFFHTFNT--------------LHNANKQIVLSSD. 138
16 -12.200PF13671.6; B2JHT3_PARP8/20-178; AAA domain  ali follow..  13  2VFICGHAGTGKTTLAKRLIGPLMKATGEADSPLFLQHFRDPEYRGLFDTA-VIAVGPLSREVRERRLFDHVWLGVPKDAKISVVWVSTSEETARERI....... 134
17 -12.200PF07931.12; Q98FG2_RHILO/59-238; Chloramphenicol phosphotransferase-like protein  ali follow..  27  4VLLNGVGSAGKSSIARALQTIT.................................................................................. 25
18 -12.100PF07728.14; Q82S33_NITEU/475-632; AAA domain (dynein-related subfamily)  ali follow..  15  2LILQGPPGTGKTWLAKRLAFALMGQKDDSKVRAVQFHPNLSYEDFVRGKFVVVIEEINRGNPAQIFGELLTLLEAGKRTPNEALELCYPDADGKRRPVHIPENL 134
19 -12.000PF03215.15; RAD24_YEAST/58-237; Rad17 P-loop domain  ali follow..  10  48LLLSGPSGCSKSTVIKELSKILVPKYDLPQMESFSEFLKGARYLVMSNLSLILIEDLPNVFHID----------TRRRFQQLILQWLYSSEPLLPPLVICITE. 168
20 -11.900PF13521.6; A4CIV1_ROBBH/14-173; AAA domain  ali follow..  17  2VVLFGPESTGKTTLARELARHY---------------------------GEPWVPEYARLQEKWDRVQQTCAPEDLLPIARGQMRLENIGAREASRLLICDTDL 80
21 -11.900PF05729.12; G3V6C0_RAT/441-610; NACHT domain  ali follow..  11  2VAVLGKAGQGKSHWARTVSHIWAQGQLPQYDFVFYVPCQCDHIVRQPDRVLLILDAFEELEAQDSLLHGPCGPLSPEPCSLRGLLAG-QRKLLRGCTLLLTAR. 134
22 -11.800PF05272.11; Q2FYB7_STAA8/475-664; Virulence-associated protein E  ali follow..  10  55LTLYGPQGVGKSALLKKLGGAWFS-------DSLVSVTGKEAYEALQGVWLMEMAELAATR--KAEVEAIKHFISKQVDRFRVAYGHYIEDFPRQCIFIGTTN. 148
23 -11.500PF00693.18; KITH_VZVD/19-298; Thymidine kinase from herpesvirus  ali follow..  10  1....GAYGIGKTTAAEEFLHHF----AITPNRILLIGEPLSYWRNLAGED--AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPH............... 79
24 -11.300PF13173.6; F9Z5R0_ODOSD/18-152; AAA domain  ali follow..  8  4LILNGARQVGKTWLLHEFAKLEYKKEDFNVDRILRGLRAMTSVDITPGDTLIILDEIQDIPEALESLKYFKEEVPEYHIAVAGSLLGISLHQDVSYPV...... 118
25 -11.200PF18748.1; A0A0A0YSQ1_9CAUD/11-206; P-loop Nucleotide Kinase1  ali follow..  13  20FYVKACNGAGKSTIPSYCAERD.................................................................................. 41
26 -11.200PF00004.29; LON_BRECH/351-493; ATPase family associated with various cellular activities (AAA)  ali follow..  12  1LCLVGPPGVGKTSLARSVARALGRSLGGVRDEAEIRGHRRTYVGALPGRPVFLLDEIDKLASDGDPASALLEVLDPNQNDKFSDHYIEETYDLTNVMFITTAN. 122
27 -11.100PF05049.13; Q9DCE9_MOUSE/50-412; Interferon-inducible GTPase (IIGP)  ali follow..  12  38IAVTGDSGNGMSSFINALRIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDVESYLEEMQISTFDLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKL 152
28 -10.900PF08433.10; O46079_DROME/1-293; Chromatin associated protein KTI12  ali follow..  15  4VVITGLPASGKSTRARQLRDHFVERAGFGKNSHTGDSQKEKVVRSLNQEDLVILDAGNYIKGYRYELYCMSKVSRT............................ 103
29 -10.800PF01637.18; A8M939_CALMQ/15-228; ATPase domain predominantly from Archaea  ali follow..  20  23VVIYGPEGCGKSAFLKQAVEVLGEY............................................................................... 47
30 -10.700PF13479.6; F5YIK8_TREPZ/11-202; AAA domain  ali follow..  10  5CALFGPSGSGKTMTALRMAKGIADTMGVPFAVIDTEARSASKYADRIPFDVDDLD-----GKTVDHYIAAMNECVKAGYKVLVID................... 84
31 -10.700PF01591.18; F262_BOVIN/27-250; 6-phosphofructo-2-kinase  ali follow..  12  16IVMIGLPARGKTYVSKKLTRYLN-NLGVYRRQAVKSYKSYDFFRHDNEEQIAVFDATNTTRERRDLILNFAEENSFKVFFVESVCDDPD............... 137
32 -10.700PF13401.6; B2UJB3_RALPJ/42-210; AAA domain  ali follow..  15  7LLVCGPTGAGKTTLAKFMVENAHSQS.............................................................................. 32
33 -10.400PF03969.16; ZAPE_ECOLI/4-371; AFG1-like ATPase  ali follow..  14  71LYMWGGVGRGKTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTVLCFDEF-----------FVSDITDAMLLGGLMKALFARGI-----TLVATSN. 172
34 -10.300PF01443.18; RDRP_TMV/829-1085; Viral (Superfamily 1) RNA helicase  ali follow..  14  1VLVDGVPGCGKTKEGKQAAEMIRRRANSSGIIVATKDNVKTVDSTRCQFKRLFIDEGLMLHTG......................................... 86
35 -10.200PF01926.23; DER_CHLCV/3-119; 50S ribosome-binding GTPase  ali follow..  11  2IAILGRPNVGKSSLFNRM---CKRSLAIVNSQEGTTRDRLYGEIRGWSVPVQVIDTGGVDKDSEDHFQKHIYKQA............................. 73
36 -10.200PF09848.9; A1A222_BIFAA/236-699; Uncharacterized conserved protein (DUF2075 topsan)  ali follow..  24  4IFVQGVAGTGKTVLLSHLFYRIATE............................................................................... 28
37 -10.100PF07726.11; Q87G66_VIBPA/36-166; ATPase family associated with various cellular activities (AAA)  ali follow..  12  2ILVEGPPGLAKTRAVKSLSDCVEGDFDLTGTDIFRPETGETFQSGPIFNSLILADEINRAPAKVQ--AAMLEAMAEKQVTAGRHTYA------ELFLVMATQN. 111
38 -9.930PF10662.9; A6TJW6_ALKMQ/1-140; Ethanolamine utilisation - propanediol utilisation  ali follow..  18  4VILVGRTGSGKTSLSQRLNQQELIYKKTQAMEFSDR----------------VLDTPGEYIENRRFYYAIISASADCDVIGILQAIDEPNCIFPPGFG...... 85
39 -9.810PF00485.18; KPPR_SYNY3/10-192; Phosphoribulokinase / Uridine kinase family  ali follow..  14  2IGVAGDSGCGKSTFLRRLTDLFGEETVICLDDYHSLDRQGRKAAGVTALDPRANN--------DLMYEQIKTLKSGQSIMKPIYNHEDPPEKVEPNKVVVIEGL 104
40 -9.730PF07999.11; Q8T9M2_9TRYP/206-649; Retrotransposon hot spot protein  ali follow..  11  129NVLIGTPGIGKSFSVGSFLLYKLLHYEASQLQIIIYVVRGKAY............................................................. 171
41 -9.730PF12846.7; Q833R2_ENTFA/443-804; AAA-like domain  ali follow..  11  24AAFLGSLGGGKSFSNNLLVYYAVLF----------------------GGQAVIVD-------PKGERGGWKENLPEIADEINILNLTSK............... 83
42 -9.710PF06068.13; RUVB2_CAEEL/17-361; TIP49 P-loop domain  ali follow..  8  53LLVTGEPGAGKTAIAIAISKELGEDT-------FVSIVASEIYSNEINKTEALTQ--AFRRALGIQIKEETEVLEGEVISLEVDRSANGMGPKVGKLTMRTTD. 147
43 -9.710PF14532.6; C6X8G9_METGS/136-273; Sigma-54 interaction domain  ali follow..  11  24LLLIGEQGSGAELCAKFLHNPDTPWLSLTDYEQLATAPLDILEQVQEG--MLFIPEVADL---------------SKNQQKGLQLLLARADKYGARVVCVTAK. 109
44 -9.700PF04275.14; F8W4R0_DANRE/22-132; Phosphomevalonate kinase  ali follow..  7  1..FSGKRKSGKDYVTDLIQKRL------TAEICCILRLSAPLKEQYAKDHNLDYEELMGSGQYKESYRADMIHWGEMKRQEDSGFFCRLAIKHATQPVWIISDC 96
45 -9.560PF02367.17; A5G3Y0_GEOUR/8-137; Threonylcarbamoyl adenosine biosynthesis protein TsaE  ali follow..  13  24IALVGDLGSGKTQFAKGVAAGLITSPTYTLVNIYKGRLPLYHFDLYRLHGDQDIIDLGFEEYFYGNGVCLVEWAERLKDALPEEHLE................. 117
46 -9.500PF07475.12; HPRK1_OCEIH/130-300; HPr Serine kinase C-terminal domain  ali follow..  25  21VLIIGQSGVGKSETALELVKR-----------------------GHR----LVADDNVEIRQEDYD...................................... 59
47 -9.410PF11868.8; Q81A12_BACCR/70-259; Protein of unknown function (DUF3388 topsan)  ali follow..  15  57IGIRGMPRVGKTESIVAASVCANKRWLFVSSTLIKQTVRSQL-DEYSDDNIFILDGIVSTKRANERHWQLVREIMRLP.......................... 135
48 -9.180PF05872.12; Q2YMR9_BRUA2/13-501; Bacterial protein of unknown function (DUF853 topsan)  ali follow..  19  22GLVTGATGTGKTVSLQVLAESFSA----------------------AGVPVFCADDLSGIAAAGVLNDGL.................................. 72
49 -9.170PF13555.6; Q0A6A1_ALKEH/19-80; P-loop containing region of AAA domain  ali follow..  25  27.LLTGDIGSGKSTLVDAITTLLVPA............................................................................... 50
50 -9.130PF04310.12; MUKB_ECOLI/2-227; MukB N-terminal  ali follow..  17  29TTLSGGNGAGKSTTMAAFVTALI................................................................................. 51
51 -9.130PF17213.3; F6ZLU4_XENTR/1991-2193; Hydin Adenylate kinase-like domain  ali follow..  22  2IIVHGAPLTGKSSAAVTLAQHY.................................................................................. 23
52 -9.060PF01712.19; DCK_BACSU/12-212; Deoxynucleoside kinase  ali follow..  18  1ITVAGTVGVGKSTLTKTLAKRL.................................................................................. 22
53 -9.040PF08423.11; W1Q8L5_OGAPD/106-359; Rad51  ali follow..  15  42..VFGEFRTGKSQLCHTLAVTCQDNGGGEGKCLYIDTEG-----TFRPIRLVIARRFGLDENETLDNVAYARAYNADHQLQLLHQAASMMTESRFSLLIVDS.. 140
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.