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Query: PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst APQVGAYHLMAANGGRGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVYRLast
1 -88.600PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali  100  1APQVGAYHLMAANGGRGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVYR 213
2 -17.400PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  21  21.........................IAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVT--------METAAPLSNIFVTTT-----GCRDIVRGEHFAVMKEDAIVCNIG..................................................................................... 110
3 -14.000PF01488.20; HEM1_PSEAE/169-304; Shikimate / quinate 5-dehydrogenase  ali follow..  15  8.......................SDLHRSQALLIGAGETITLVARHLFEQGVKRIVVANRTLERAS---LLAEQFGAHAVLLSEIPEELANSDIVISST----ASQLPILGKGAVERALKQRFMVDIAV----------PRDIEPEVGELDDVYLYSVDDLHE.................................................. 135
4 -12.200PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  18  1.........................LKDKTIAIMGYGSQGHAHARNLHESGLNVVVGLRKGSSSWAKAESDG-------LKVMTVEEAAKAADVIM--ILLPDEKQASVYYSQIEPSLEAGNALV........................................................................................ 91
5 -12.100PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  17  1.............................QIGVVGLAVMGSNLARNFARNGHTVAVYNRSTDKTDKLISDYATDGNFIPT--KTVEDFVAALEKPRRAIMVQAGAATDAVINQLADAMEEGDIIID------GGNALYTDTVCREKEMAARGRHFVGAGISGGEEGALNGPSI-EALGPLLESIAAK.......................... 159
6 -11.100PF03059.16; A3DUI9_MALBX/3-277; Nicotianamine synthase protein  ali follow..  14  110..................ILSQHFTRMPIKIAFVGSGPLPLTSIVLASNHLTSFDNYDINASANSKALGLVSSDMVFHTTDIMDVTTALKDYEIVFLAALVGMDKMEK-IIDHLAKYMAPGATLM........................................................................................ 225
7 -11.000PF16912.5; I7BJ28_NATSJ/144-370; Glucose dehydrogenase C-terminus  ali follow..  17  33.............................SALVLGTGSLGLLTAAMLTETLEYDRVYDRPHPTIDIVDRLGATYIDSRETPVSEIPAAYEPMDLVYEATGYAK------HAFEAIEALAPNGVAALLGVPEDWAFEVDGGHLHRE--LVLSNKALVGSVNSNRGHFEAAIDTLSALPDWVLTEVVSG.......................... 187
8 -10.900PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain  ali follow..  14  1.............................TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQLAGVDLAIEAAT-EDETIKRKIFAQLCPVLNPEAIL----ATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTA.......................... 169
9 -10.800PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali follow..  21  254.........................MAGKIAVVCGYGDVGKGCAQSLRGQGARVIITEIDPICALQAAMEG---------EVKTLDEVVSYADIFVTTT-----GNTGIISAAQMEKMKNRAIVGNIG..................................................................................... 343
10 -10.800PF02254.18; Q92CZ9_LISMO/5-120; TrkA-N domain  ali follow..  18  1..............................FAVIGLGRFGGSICRSLVEQGMEVLAIDSDEERVNEYMSIATHAVIANSTDENALRQLIRNFEHVIVAI--GEDIQSSILTTLILKEMGVKYVTAKATNDKHAKL.............................................................................. 104
11 -10.500PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase  ali follow..  22  28........................SISGSTFVIQGLGNVGSWAAKLIHQKGGKIVAVGDVTGAIRNKSGIDIPALLKHRSEGGSLEDFYGECDVLVPCAIIEGANHPTDTEADEILAKKGVIVLPDIYANSGGVV.............................................................................. 167
12 -10.400PF04127.15; D7WCK1_9CORY/196-381; DNA / pantothenate metabolism flavoprotein  ali follow..  17  1............LEGKKVVISAGGTIDPVRFI--SSGRQGFALADIAVHRGADVTIVAGATDELFTPPGANIVRVRSTRDMEQAVNDAAEGADIIIMAAAVADYRPEEEATSKLLVDKHVPATIVGFAAETDTPLEHGKA......................................................................... 155
13 -10.400PF03721.14; UGDH_CAEEL/10-205; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain  ali follow..  17  1............................SKVVCVGAGYVGGPTCAMIAHKCITVTVVDMNTAKIAELDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMY---VSRTIAQYAGGPKIVVEKSTVPVKAAESIGCQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRI............................. 196
14 -10.300PF02882.19; FOLD1_ARATH/184-349; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain  ali follow..  23  35........................EIAGKNAVVIGRSIVGLPMSLLLQRHDATVSTVHAFT---------------------KDPEHITRKADIVIAAA------IPNLVRGSWL---KPGAVVIDVGTTPEDSSCEFGYRLVGDVCYEEALGVASAITPVPGGVPMTITMLLCNTL.................................... 161
15 -10.300PF02826.19; Q98GE4_RHILO/107-283; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain  ali follow..  15  35........................ELAGKTIGIVGLGAVGQAVGHIAHGFDLKVVATTRSMQPAPE------------KVGFLSIDALVEQSDIIVLCCPLTPE-TRGLISRERIARMKPNALLINVS--RGPVVDDALIEALREGRIGGAALDVFSTQPLSYNHP............................................... 163
16 -10.100PF06690.11; D7DUD4_METV3/2-259; Protein of unknown function (DUF1188 topsan)  ali follow..  11  32..................IKYYLEGEEFEQAIIFGAYLSGNYIANTLKADCGEVILIDSQPHLEDIVTGNGIKFMDLNTFMLKNNKDKEINPDLIIDVTGLGG------VDPNMLKDFDPKVLIIEKISKTSGTMTLTVDVDSCIEIKELDGVLY.......................................................... 201
17 -9.900PF03848.14; TEHB_HAEIN/91-282; Tellurite resistance protein TehB  ali follow..  11  19...............HGDVVDAAKIISPCKVLDLGCGQ-GRNSLYLSLL-GYDVTSWDHNENSIAFLNETKEKENLNISTALYDINAA-ENYDFIVSTVVF-NRERVPSIIKNMKEHTNVGGYNL........................................................................................ 130
18 -9.790PF01210.23; GPDA_COXBU/7-162; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus  ali follow..  10  1.............................PIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAEGVNPFPETLKAYCDLKASLEGVTDILIVV---PSFAFHEVITRMKPLIDAKTRIAWGT--KGLAKGSRLLHEVVATELGQVPMAVISGPSLATEVAANLPTAVS....................................... 147
19 -9.150PF03435.18; Q94BZ0_ARATH/41-165; Saccharopine dehydrogenase NADP binding domain  ali follow..  16  1..............................VLVLGGGRVGGSTATALSKLELKIVVGGRNREKGEAMVAKLGENSEFSQNDAKMLETSLRDVDLVVHAAGPFQQAPRCTVLEAAIKT---KTAYLDVC----DDTSYAFRAKSLEAEAIAANIPAL......................................................... 125
20 -9.130PF05219.12; METL9_HUMAN/56-317; DREV methyltransferase  ali follow..  15  82..................LLKINPDWKTHRLLDLGAGD---EVTKIMSPHFEEIYATELSETMIWQLQKKK-----YRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPGRVILALVLPFHPYVENVGGEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCE.............................. 243
21 -9.060PF13847.6; B2J9C6_NOSP7/55-253; Methyltransferase domain  ali follow..  15  1........................DTKEKVILDAGCG-TGYKSLVLAEA-GAKIVGIDISEESIKLAQQRLEHHAEFHVLPIQELPKLNYQFDYINCDELLYLFPDLAAALQGMISVLKPNGIIR........................................................................................ 105
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.