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Query: PF02007.18; MTRH_METTH/6-301; Tetrahydromethanopterin S-methyltransferase MtrH subunit, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst KEQIVLDIAGTKIGGQPGEYPTVLAGTIFYGGHSIIEDEKAGVFDKDKAEALIKTQEEMSDVTGNPHIVQTFGQTPEAIVKYLEFVGDVTDAPFFIDSTSGEARIAGANYASEVGLEDRAIYNSVNMAADEAELEALKETKLSASIVLGFNPMDPTVDGKIGIWEDGAGTIDKGLLEMAAECGIDKYLMDVAVTPLGQGAGVAVRTSFAVKSKWGYPVGSGIHNVPSAWDWLREYKKDHKEAWPVCDVGSNLIQQMAGGDFVLYGPIENAKMAFPACAMADIFISEAAKDIGTEPVLast
1 -104.000PF02007.18; MTRH_METTH/6-301; Tetrahydromethanopterin S-methyltransferase MtrH subunit  ali  100  1KEQIVLDIAGTKIGGQPGEYPTVLAGTIFYGGHSIIEDEKAGVFDKDKAEALIKTQEEMSDVTGNPHIVQTFGQTPEAIVKYLEFVGDVTDAPFFIDSTSGEARIAGANYASEVGLEDRAIYNSVNMAADEAELEALKETKLSASIVLGFNPMDPTVDGKIGIWEDGAGTIDKGLLEMAAECGIDKYLMDVAVTPLGQGAGVAVRTSFAVKSKWGYPVGSGIHNVPSAWDWLREYKKDHKEAWPVCDVGSNLIQQMAGGDFVLYGPIENAKMAFPACAMADIFISEAAKDIGTEPV 296
2 -32.400PF03599.16; ACDD_ARCFU/128-451; CO dehydrogenase/acetyl-CoA synthase delta subunit  ali follow..  11  16........YTVTLGGER--HLPAIAIDVFDRRPMLAKAVRMDNPAEWARKCVKKFGADLVTLHLISTDPLLDDTPASEAVKVLEDVLQAVKCPIIVGGSDPEVLEKAAEVAEGE----RIMLASATLDMDWERIANAAKKYGHVVLSWTQMDINNQKTLNRYLLKRV-------------EMPRDSIVMDPTTAALGYGLDYAFTNMERIRISGDTDLNFPISSGTTNAWGAREAWMVDSPIEEIWEIITGLTLSLAGVDLFMMMHPVAVAVLKEVFNT----LGGKVSGGVADPG 318
3 -28.000PF00809.22; DHPS_NEIMB/21-266; Pterin binding enzyme  ali follow..  13  1........................MGIVNLTPDSFSDGGVNAQTALAHAEQLLKEGADILDIGGESTRSGAPEEEWARVEPVLAEVAG-WGVPISLDTRRTVIMEKALAL------GGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQIKYQDVVGEVARYLKARSAECIAAGIQRIILDPGFSGFGKPLQHNIALMRHLPELMAE-TGFPLLIGVSRKSTIGELTGANAAERVHGSVAAALASVARGAQIVRVH............................... 246
4 -7.490PF08010.11; Y12G_BPT4/11-150; Bacteriophage protein GP30.3  ali follow..  6  5...................................................................................CALSNFAQWPFVMDGIQFGGLEGFLQGCKVKNVEQQRRIFGLSGLAAQQAGRSYARAQDRGTLFWLGVPFSRYSPAWKELYTNAYFE------AAIQNKGFRDALQASKGKVLKHSIASGLDVLNLLRD.................................................................................... 140
5 -6.730PF16836.5; C5DRC4_ZYGRC/7-212; Shu complex component Psy3, DNA-binding description  ali follow..  9  6..............................................................................ISNFYHAVPQSLTLPSCIGSHCVSFVH--IEHNFKFTPFKRQIWNQCIECSVNDGSSILVSQGVHYMNSTSICNMEGLQNFLMQLQASPLEALQRCLIKDRLDKQISGIIID-NLSYLAHDLSSYSALIKILKQLRRT--GCWILTIGYGLEYYDGVENSTSTPNRTGALTKLPASYINEMDVIILRET............................. 205
6 -6.520PF00817.20; Q74KV6_LACJO/16-168; impB/mucB/samB family  ali follow..  11  17.......................................................................................SIRNKAVLIGGDPKKNKGHGVVATANYIARSYGAHSAMPTAKAVRLIPA------EKLVIIQPN-------EKYRAVSAEIHQLMHKITDRVESVALDEAYLD--VTENKLNLTDPVRIAALLQERIYQRIGLTSSFGVSYNKFLAKMGS........................................................... 152
7 -6.260PF00290.20; TRPA_MAIZE/94-347; Tryptophan synthase alpha chain  ali follow..  12  28..............................................EALRLLDGCGADVIELGV--PCSDPYIDTMDAVLEMLREVTPELSCPVVLLSYYKPIMSRSLAEMKEAGVHG-LIVPDLPYVAAHSLWSEAKNNNLELVLLTT----PAIPEDRMKEITKASE-------------GFVYLVSVNGVTGPRANVNPRVSLIQEVKKVTNKPVAVG---GISKPEHVKQIAQWGADGVIIGSAMVRQLGEAASPKQGLRRLEEYARGMKNALP.................. 254
8 -6.170PF06506.11; W0EDD6_9FIRM/23-195; Propionate catabolism activator  ali follow..  7  19..............................................HVARNMISQNPDRLALIA----------SGGATLKLLR--QDFGSLPWVNIYPTEYDLALALEQAKKLRCKIGVFFAEQEKIWIINTIASVLGFPVNVYVYRDWLELLTQIEKARHDRIELVIGAGEKIAAVVEQNGMQYISVMGGENTIRAALGRAKAILEAKRR.................................................................................... 172
9 -6.030PF10662.9; A6TJW6_ALKMQ/1-140; Ethanolamine utilisation - propanediol utilisation  ali follow..  10  2...................KKVILVGRTGSGKTSLSQRLNQQELIYKKTQA-MEFSDRVLDTPGE---------ENRRFYYAIISASADCDVIGILQAIDEPNCIFPPGFGNFFNKPVIGIITKIDLEHDSGNVESDLYAAGAQQIFRISAVTGEGLEELRVYMEE.................................................................................................................................. 140
10 -5.930PF08902.11; W0EUT5_9BACT/23-290; Domain of unknown function (DUF1848 topsan)  ali follow..  11  1..................................................................................IVSASRATDIPAFYAGWFFNRLRQGYVRWRNPYNGKDSYVSSKNPKPLLPFLPILKEMEIGCYIQYTLNDFVEGLEPNVPALAERIDTFKR----LVDELGIGAVVFDPLILTNKISTDDLLNKIEYIANQLRGYTDKLVFSFADISAYRKVGRNLSETEYEMIDFSHRLSELNLGLEL................................... 196
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.