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Query: PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAEDLast
1 -91.600PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain  ali  100  1TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAED 179
2 -13.700PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  12  5TIAIMGYGSQGHAHARNLHESGLNVVVGLRKGS-----------------------SSWAKAESDGLKVMTVEEAAKAADVIMILLPDEKQAS-VYYSQIEPSLEAGNALVQIVPPKDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQD--ATGKARDLALAYAKGIGATRA.... 163
3 -13.000PF10727.9; Q743Y6_MYCPA/8-128; Rossmann-like domain  ali follow..  21  6KVGIISAGRVGTALGVALERADHVVV---------------------ACSAISHASRQRAQRRLPDTPVATPPEVAAGAELLLLAVPDSE---AGLVSGLAATVRAGTIVAHTSGANGVGILAPLTRQGCIPLAIH........................................... 120
4 -12.900PF00056.23; MDH_CHLAA/3-142; lactate/malate dehydrogenase, NAD binding domain  ali follow..  20  2KISIIGAGFVGSTTAHWLAAKELDIVLLDFVEGVPQGKALDLYEASP------------IEGFDVRVTGTNNYADTANSDVIVDLIKVNADITRACISQAAPLSPNAVIIVNNPLDAMTYLAAEVSGFPERVIG............................................. 140
5 -11.900PF01210.23; GPDA_COXBU/7-162; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus  ali follow..  14  2.IAILGAGSWGTALALVLARKGQKVRLWSYESDHVDE-----------QAEGVNNRYLPNYPFPETLKAYCDLKALEGVTDILIVVPSFA---HEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQVPMAVISGPSLATEVAANLPTAVSLASNNSQFS............ 156
6 -11.500PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  14  1QIGVVGLAVMGSNLARNFARNGHTVAVYNRSTDKTDK-----------------ISDYATDGNFIPTKTVEDFVAALEKPRRAIVMVQAGAATDAVINQLADAMEEGDIIIDGGNALYTDTVCREKEMAAR--GRHFVG........................................ 121
7 -11.200PF02056.16; CHBF_ECOLI/6-188; Family 4 glycosyl hydrolase  ali follow..  14  1KVVTIGGGSSYTPIKRYHELPVSELWLVDVEGGKPK---------LDIIFDLCQRMIDNAGVPMKLYKTLDRREALKDADFVTTQLLRTIPVIFDIVKDVEELCPNAWVINFTNPAGMVTEAVYRHTGFKRFIGV............................................ 166
8 -10.900PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  14  30RAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFELEKA----------------CLEADLVIGAVLPGAKAPKLVTNELVSRMKPGSVLIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELADR.......... 187
9 -10.900PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  12  25VAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANAK............................................................................. 126
10 -10.700PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  14  1.VAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADH------------LNKEGLTFVAKSGEHQPISVPLSSFSAEEAEVGFITVKS-----KALLPQLQRKKWDGLVFFQN--GMTHLEILRQIPARAICCGI............................................ 121
11 -10.000PF02254.18; Q92CZ9_LISMO/5-120; TrkA-N domain  ali follow..  15  1.FAVIGLGRFGGSICRSLVEQGMEVLAIDSDEERVNEYMSIATHAVIANSTDENALRQ---------------LGIRNFEHVIVAIGEDIQSSILTTLILKEMGVKYVTAKATNDK............................................................... 100
12 -9.900PF03721.14; UGDH_CAEEL/10-205; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain  ali follow..  13  2KVVCVGAGYVGGPTCAMIAHKCITVTVVDMNTAKIAE----WNSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVAPDLKYVESVSRTIAQYAGGPKIVVEK-STVPVKAAESIGCILREAQKNNLSNPEFLAE--RVLIGGESSPEGLQAVAELVR........... 195
13 -9.670PF06690.11; D7DUD4_METV3/2-259; Protein of unknown function (DUF1188 topsan)  ali follow..  13  43QAIIFGAYLSGNYIANTLKADCGEVILIDSQPHLEDIVTGNGIKFMDLNTFMLKLRNNKDKEINPDLIIDVT-PKSSFDKELMEAD--NTHKRLCVGHKKGSLKTFRSSKISKTSTLTVDVIMDSCIEIKELDGVLY.......................................... 201
14 -9.080PF13738.6; E4RQY1_LEAB4/3-286; Pyridine nucleotide-disulphide oxidoreductase  ali follow..  13  2...IIGGGPIGMACGIECKKAGLDYVILEKGCLV---------NSLYHYPTTMTFFSTSERLELDNIPFVSNSAKPTRAEALYRRVAQNQQLNIHLFEEVSDVYKVEKGFEVKTSKRTYSALATGFYDIPNLLGIYYKDPHFYAFQKIVVIG--ANNSAVDVALETFRKGADVTMVIRD 181
15 -9.050PF03059.16; A3DUI9_MALBX/3-277; Nicotianamine synthase protein  ali follow..  13  121KIAFVGSGPLPLTSIVLASNHLTKTSFYDINASANSKALGLVSS-DPDLSKRMVFHTTDIMDV-----------ALKDYEIVFLAVGMDKMEKLKIIDHLAKYMAPGATLMLRSAH............................................................... 230
16 -9.030PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali follow..  16  258IAVVCGYGDVGKGCAQSLRGQGARVIITEIDPICA------------------------LQAAMEGYEVKTLDEVVSYADIFVTTTGNTGIISAAQMEKM----KNRAIVGNIGHFIDMAGLKKIPG.................................................... 359
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.